[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583455":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":34,"locations":43,"responsibleParty":57,"collaborators":60,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":81,"whyStopped":10,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Internist.Ro","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Historical control group",null,"Control Group (Historical Cohort):\n\nPatients who underwent Vitamin C testing based on traditional clinical judgment, meaning testing was performed \"as needed\" at the discretion of the treating physician.\n\nNo standardized criteria were applied for selecting patients for Vitamin C testing.\n\nData will be collected from medical records retrospectively (prior to the introduction of a systematic screening approach).",{"label":13,"type":10,"description":14,"interventionNames":15},"Prospective Cohort","Active Group (Systematic Screening Cohort):\n\nPatients who underwent Vitamin C testing based on a predefined, rigorous suspicion framework (SFI - Scurvy Suspected upon Hemorrhagic Risk).\n\nTesting was systematically performed in patients with predefined hemorrhagic risk factors, including:\n\nHematuria (macroscopic or detected via dipstick\u002Fmicroscopy). Ecchymoses (bruising). Petechiae. Epistaxis. Gastrointestinal bleeding (melena, hematemesis, positive fecal occult blood test).\n\nCerebral hemorrhage. The selection for testing was systematic and protocol-driven, ensuring a more structured and standardized approach.",[16],"Diagnostic Test: systematical screening of at risk patients based on predefined hemorrhagic criteria",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","systematical screening of at risk patients based on predefined hemorrhagic criteria","Patients selected if condition present:\n\nHematuria (blood in urine)\n\nMacroscopic hematuria (visible blood in urine) Hematuria detected by urine dipstick or microscopic analysis Ecchymoses (bruising)\n\nEpistaxis (nosebleeds)\n\nPetechiae (small pinpoint hemorrhages on the skin)\n\nGastrointestinal bleeding\n\nUpper GI bleeding: Hematemesis (vomiting blood) Lower GI bleeding: Melena (black tarry stools) Positive fecal occult blood test (FOBT) Cerebral hemorrhage (brain bleeding)",[13],[24,28,31],{"name":25,"affiliation":26,"role":27},"Adrian Purcarea MD","Transylvania Univeristy, Faculty of Medicine, Brasov, Romania","STUDY_DIRECTOR",{"name":29,"affiliation":26,"role":30},"Silvia Sovaila MD","PRINCIPAL_INVESTIGATOR",{"name":32,"affiliation":33,"role":30},"Remy Bouquet MD","Gueret Hospital, Creuse, France",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Adrian PURCAREA MD","CONTACT","0040751141636","adrian.purcarea@internist.ro",{"name":29,"role":37,"phone":41,"phoneExt":10,"email":42},"0040753020253","sovaila.silvia@gmail.com",[44],{"facility":45,"status":10,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":10},"Gueret Hospital","Guéret","Creuse","23000","France","FR",{"type":52,"coordinates":53},"Point",[54,55],1.87166,46.17185,{"lat":55,"lon":54},{"type":30,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Purcarea Adrian","MD, PhD",[61],{"name":62,"class":6},"Centre Hospital Regional Universitaire de Limoges","100583455","vitamin-c-deficiency-in-hospitalized-adults-systematic-screening-vs-traditional-judgment---a-before-and-after-observational-study-100583455",false,"NCT06876545","\"Vitamin C Deficiency in Hospitalized Adults: Systematic Screening Vs. Traditional Judgment - a Before-and-After Observational Study\"","Identification of Vitamin C Deficiency in Hospitalized Adults Through a Systematic Approach Vs. Traditional Medical Judgment: a Before-and-After Observational Study","Inclusion Criteria:\n\nHospitalized adult patients (≥18 years old) who had Vitamin C testing performed during their hospital stay.\n\nDocumented hemorrhagic manifestations in medical records, including at least one of the following:\n\nHematuria (macroscopic or detected via urine dipstick\u002Fmicroscopy). Ecchymoses (bruising). Petechiae. Epistaxis (nosebleeds). Gastrointestinal bleeding (melena, hematemesis, or positive fecal occult blood test).\n\nCerebral hemorrhage. Medical records available with sufficient clinical and laboratory data to assess eligibility and study variables.\n\nPatients from two distinct periods:\n\nHistorical Control Group: Patients tested for Vitamin C \"as needed\" based on traditional medical judgment.\n\nActive Group: Patients tested systematically according to Scurvy Suspicion upon Hemorrhagic Risk (SFI) criteria after protocol implementation.","ALL","18 Years",{"count":73,"type":74},150,"ESTIMATED","OBSERVATIONAL","Brief Summary of the Study The goal of this observational study is to assess the incidence of vitamin C deficiency among hospitalized adults presenting with hemorrhagic signs. The study will also evaluate the effectiveness of a standardized screening protocol compared to traditional clinical judgment.\n\nThe main questions it aims to answer are:\n\nWhat is the incidence of vitamin C deficiency in hospitalized patients with hemorrhagic symptoms? Is a standardized screening protocol more effective than traditional clinical judgment in identifying vitamin C deficiency? Is vitamin C deficiency associated with anemia, other micronutrient deficiencies (folate, B12, albumin, iron), or infectious conditions? Does vitamin C deficiency impact hospital length of stay? Researchers will compare a systematic screening approach based on predefined hemorrhagic criteria (e.g., hematuria, ecchymosis, epistaxis, petechiae, gastrointestinal bleeding, or intracranial hemorrhage) to the traditional physician-judgment approach to determine its effectiveness in identifying vitamin C deficiency.\n\nStudy Design\n\nParticipants will:\n\nBe hospitalized adults (≥18 years old) presenting with documented micro- or macroscopic hemorrhagic signs.\n\nUndergo vitamin C level assessment either as part of the standardized screening protocol (prospective arm) or based on physician judgment (retrospective control group).\n\nHave additional clinical and laboratory data collected, including hemoglobin levels, platelet count, iron status, vitamin B9\u002FB12 levels, and other relevant parameters.\n\nThis non-interventional study will not modify the standard of care but will systematically assess the prevalence of vitamin C deficiency in at-risk patients and evaluate the utility of a structured screening protocol.",[78],"Scurvy",[80],"Scurvy, vitamin C defficiency, hospitalized","NOT_YET_RECRUITING","2025-03-10",{"date":84,"type":85},"2025-03-14","ACTUAL",{"date":87,"type":74},"2025-04-01",{"date":89,"type":74},"2025-04-30",{"name":5,"class":6},1]