[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632441":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":40,"locations":46,"responsibleParty":64,"collaborators":31,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":70,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":31,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":31,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Al-Azhar University","OTHER",[8,16,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Topical Vitamin C","ACTIVE_COMPARATOR","Patients will be instructed to apply ( L- Ascorbic acid 1000 mg) containing gel in 5 ml distilled water, Polyethylene Glyco (PEG), Potassium Sorbate, in addition to Sodium Carboxymethyl Cellulose (CMC)\\] and Carbomer once daily for 1 months",[13,14,15],"Drug: Topical Vitamin C ( control Arm)","Procedure: Vitamin C mesotherapy","Procedure: Microneedling technique",{"label":17,"type":18,"description":19,"interventionNames":20},"microneedling with topical Vitamin C gel","EXPERIMENTAL","Microneedling was performed on the gingival tissue using a dermal pin device until the appearance of pinpoint bleeding, indicating adequate micro-injury to stimulate tissue remodeling. The treated area was subsequently irrigated with normal saline and gently dried with sterile gauze. This procedure was repeated after a two-week interval to enhance the clinical effect.",[13,14,15],{"label":22,"type":18,"description":23,"interventionNames":24},"Vitamin C Mesotherapy","vitamin C mesotherapy was administered by delivering intra-mucosal microinjections of L-ascorbic acid into pigmented gingival tissues at the epithelium-connective tissue junction, providing targeted delivery to melanocyte-rich layers. . The treatment will be repeated 3 times with 1 week .",[13,14,15],[26,32,36],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Topical Vitamin C ( control Arm)","Topical application of L-Ascorbic Acid gel (1000 mg in 5 ml distilled water with CMC and PEG), applied once daily on gingival hyperpigmented areas for 1 month.",[9,22,17],null,{"type":33,"name":34,"description":23,"armGroupLabels":35,"otherNames":31},"PROCEDURE","Vitamin C mesotherapy",[9,22,17],{"type":33,"name":37,"description":38,"armGroupLabels":39,"otherNames":31},"Microneedling technique","Gingival microneedling was performed using a Derma Pen A6 (12-needle row), with penetration depth adjusted to gingival thickness at 700 cycles\u002Fmin (mode 6). Each gingival side was treated 30-40 seconds per tooth until bleeding points appeared.",[9,22,17],[41],{"name":42,"role":43,"phone":44,"phoneExt":31,"email":45},"khawlah Q al-khalidi, BDS, MSc","CONTACT","00201556811594","khawlahalkhalidi555@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Al-Azhar University Faculty of Dentistry ( Girls )","RECRUITING","Cairo","Cario Governorate","11651","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.24967,30.06263,{"lat":59,"lon":58},[62],{"name":63,"role":43,"phone":44,"phoneExt":31,"email":45},"khawlah Q alkhalidi, BDS, MSc",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Khawlah Qaism Ahmed Alkhalidi","Dentist and Postgraduate Student in Periodontology","100632441","vitamin-c-for-gingival-depigmentation-100632441",false,"NCT07513727","Vitamin C for Gingival Depigmentation","Clinical and Histological Evaluation of Topical Vitamin C Application Using Three Modalities in Gingival Depigmentation","VitC-DePg","Inclusion Criteria:\n\n\\- 1- Both genders aged from 20-35 years. 2- Patients clinically diagnosed with physiologic gingival melanin pigmentation in the maxillary and mandibular keratinized gingiva.\n\n3- Patients complaining of compromised esthetics. 4- Patients should be systemically free any disease as verified by a medical history diagnostic sheet or via health questionnaire\n\nExclusion Criteria:\n\n\\- 1- Patient clinically diagnosed with periodontitis and \u002F or manifest poor oral hygiene with high plaque and gingival indices 2- Pregnant or lactating females. 3- Patients with clinical diagnosed lesion in the area of interest primarily the gingivae encompassing the maxillary \u002Fmandibular anterior teeth e.g. pigmented lesion of intestinal polyposis syndrome, McCune-Albright syndrome and fibro-osseous lesions as florid osseous dysplasia.\n\n4- Patient with previous treatment of gingival hyperpigmentation. 5- Patients with history of being allergic to the vitamin C. 6- Patients with any systemic disease ( e.g. Addison disease ) or drugs consumed that may cause clinical gingival hyperpigmentation 7- Patients who are active or previous smokers.","ALL","20 Years","40 Years",{"count":80,"type":81},30,"ESTIMATED","INTERVENTIONAL",[84],"NA","The purpose of this study is to evaluate the clinical and histopathological efficacy of topical vitamin C applications using three modalities (topical gel, microneedling , and mesotherapy) in gingival depigmentation. Assessment includes clinical evaluation, CIELAB analysis via DOPI, and histopathological examination (Fontana-Masson staining).",[87,88],"Gingival Hyperpigmentation","Gingival Melanin Pigmentation","2026-03-31",{"date":91,"type":92},"2026-04-07","ACTUAL",{"date":94,"type":92},"2025-07-29",{"date":96,"type":81},"2026-05-01",{"name":5,"class":6},1]