[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524278":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":41,"responsibleParty":78,"collaborators":81,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":88,"sex":94,"minAge":95,"maxAge":96,"enrollmentInfo":97,"targetDuration":10,"studyType":100,"phases":10,"briefSummary":101,"conditions":102,"keywords":107,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Offspring of smokers who received Vitamin C",null,"In the original VCSIP study, pregnant women were randomized to receive either extra Vitamin C every day (500mg\u002Fday) or placebo.",[13],"Dietary Supplement: No active intervention in this protocol (previously randomized to Vitamin C)",{"label":15,"type":10,"description":11,"interventionNames":16},"Offspring of smokers who received Placebo",[17],"Other: No active intervention in this protocol (previously randomized to Placebo)",{"label":19,"type":10,"description":10,"interventionNames":10},"Offspring of non-smokers",[21,26],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DIETARY_SUPPLEMENT","No active intervention in this protocol (previously randomized to Vitamin C)","In the original VCSIP study, pregnant women were randomized to receive either extra Vitamin C every day (500mg\u002Fday) or placebo. This trial is a follow-up trial with no active intervention.",[9],{"type":6,"name":27,"description":24,"armGroupLabels":28,"otherNames":10},"No active intervention in this protocol (previously randomized to Placebo)",[15],[30],{"name":31,"affiliation":5,"role":32},"Cindy McEvoy, MD, MCR","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","503-494-0223","mcevoyc@ohsu.edu",{"name":39,"role":35,"phone":36,"phoneExt":10,"email":40},"Kristin Milner, BS, CMA, CCRP","milner@ohsu.edu",[42,62],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Indiana University","RECRUITING","Indianapolis","Indiana","46902","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-86.15804,39.76838,{"lat":54,"lon":53},[57,60],{"name":58,"role":35,"phone":10,"phoneExt":10,"email":59},"Christina Tiller","ctiller@iu.edu",{"name":61,"role":32,"phone":10,"phoneExt":10,"email":10},"Robert Tepper, MD",{"facility":63,"status":44,"city":64,"state":65,"zip":66,"country":48,"countryCode":49,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Oregon Health and Science University (OHSU)","Portland","Oregon","97217",{"type":51,"coordinates":68},[69,70],-122.67621,45.52345,{"lat":70,"lon":69},[73,76],{"name":74,"role":35,"phone":75,"phoneExt":10,"email":40},"Kristin Milner","971-404-0223",{"name":77,"role":32,"phone":10,"phoneExt":10,"email":10},"Cindy McEvoy, MD",{"type":32,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Cynthia McEvoy","Principal Investigator",[82,83],{"name":43,"class":6},{"name":84,"class":85},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100524278","vitamin-c-to-decrease-effects-of-smoking-in-pregnancy-on-infant-lung-function-vcsip-longer-term-follow-up-100524278",false,"NCT06106646","Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up","Assessing the Effect of Vitamin C on Infant Lung Function When Given to Pregnant Women Who Smoke - (Long Term Follow-up of a Randomized Trial)","VCSIP","Inclusion Criteria:\n\n* Women and their offspring randomized to vitamin C versus placebo during pregnancy as well as pregnant nonsmokers and their offspring enrolled as the reference group in the original VCSIP study\n\nExclusion Criteria:\n\n* participants who specifically withdraw consent","ALL","6 Years","16 Years",{"count":98,"type":99},225,"ESTIMATED","OBSERVATIONAL","The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring. This is an additional continuation of the Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) trial, to follow the offspring through 10 years of age. The hypothesis for this protocol is an extension of the VCSIP trial that supplemental vitamin C in pregnant smokers can significantly improve their children's airway function tests. The investigators aim to demonstrate sustained improvement in airway\u002Fpulmonary function and trajectory through 10 years of age.",[103,104,105,106],"Asthma","Pulmonary Function","Wheezing","In Utero Nicotine",[103,104,108,109,110,111,112,113,114,115,116],"Pulmonary Function Testing","Wheeze","Vitamin C","Antioxidants","Forced Expiratory Flows","Spirometry","Lung Function","Epigenetics","High resolution CT scans","2025-03-17",{"date":119,"type":120},"2025-03-18","ACTUAL",{"date":122,"type":120},"2023-10-11",{"date":124,"type":99},"2028-08",{"name":5,"class":6},2]