[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643852":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":34,"locations":40,"responsibleParty":56,"collaborators":10,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":82,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"vNOTES Group",null,"Patients undergoing elective gynecological surgery via Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES).",[13],"Procedure: vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Laparoscopic Surgery Group","Patients undergoing elective gynecological surgery via conventional laparoscopic surgery.",[18],"Procedure: Laparoscopic Gynecological Surgery",[20,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","vNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery","Elective gynecological surgery performed via vaginal natural orifice transluminal endoscopic surgery with lower Trendelenburg angle and insufflation pressure compared to conventional laparoscopy.",[9],[26,27],"Vaginal NOTES","Natural Orifice Transluminal Endoscopic Surgery",{"type":21,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Laparoscopic Gynecological Surgery","Conventional laparoscopic gynecological surgery performed with standard pneumoperitoneum and Trendelenburg positioning.",[15],[33],"Laparoscopy",[35],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Selvinaz Yüksel Tanrıverdi, MD","CONTACT","+0902242955000","yukselselvinaz@gmail.com",[41],{"facility":5,"status":10,"city":42,"state":43,"zip":44,"country":45,"countryCode":10,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Bursa","Yıldırım","16350","Turkey (Türkiye)",{"type":47,"coordinates":48},"Point",[49,50],29.06013,40.19559,{"lat":50,"lon":49},[53],{"name":54,"role":37,"phone":55,"phoneExt":10,"email":39},"Selvinaz YÜKSEL TANRIVERDİ, MD","+90(258)2966000",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Selvinaz Yüksel Tanrıverdi","Anesthesiologist","100643852","vnotes-vs-laparoscopy-respiratory-mechanics-and-hemodynamics-100643852",false,"NCT07667907","vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics","Comparison of the Effects of vNOTES and Laparoscopic Gynecological Surgery on Intraoperative Respiratory Mechanics and Hemodynamics: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years\n* Patients scheduled for elective gynecological surgery\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Cardiac arrhythmia\n* ASA physical status IV or above\n* Patients developing intraoperative hemodynamic instability\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","FEMALE","18 Years","75 Years",{"count":71,"type":72},30,"ESTIMATED","OBSERVATIONAL","Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics. These conditions increase the risk of ventilator-induced lung injury (VILI) and highlight the importance of lung-protective ventilation strategies.\n\nvNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) is a minimally invasive technique that requires less Trendelenburg tilt and lower insufflation pressures compared to conventional laparoscopic surgery, and may therefore offer a more favorable intraoperative profile.\n\nThis prospective, observational, single-center, parallel-group cohort study aims to compare respiratory mechanics parameters (Ppeak, Pplateau, DP, MPtot, MPdyn, Crs) and hemodynamic parameters (MAP, HR, vasopressor requirement) between vNOTES (n=15) and laparoscopic gynecological surgery (n=15) groups at four intraoperative time points.",[76,77],"Respiratory Mechanics","Hemodynamics",[79,33,76,77,80,81],"vNOTES","Pneumoperitoneum","Trendelenburg","NOT_YET_RECRUITING","2026-06-19",{"date":85,"type":86},"2026-06-25","ACTUAL",{"date":88,"type":72},"2026-07-01",{"date":90,"type":72},"2027-07-01",{"name":5,"class":6},1]