[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529083":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":29,"responsibleParty":180,"collaborators":182,"id":218,"slug":219,"hasResults":220,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":220,"sex":225,"minAge":226,"maxAge":227,"enrollmentInfo":228,"targetDuration":10,"studyType":231,"phases":10,"briefSummary":232,"conditions":233,"keywords":236,"overallStatus":32,"whyStopped":10,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":251},{"fullName":5,"class":6},"Imperial College London","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"OSCC group",null,"Patients with histopathology confirmed, treatment naive OSCC",[13],"Other: Exhaled breath sampling",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-cancer controls","Patients who are undergoing an endoscopy for non-specific upper gastrointestinal (GI) symptoms and are shown to have either:\n\n1. A healthy upper GI tract\n2. Benign upper gastrointestinal disease",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Exhaled breath sampling","Participants will maintain a clear fluid diet for a minimum of 6 hours prior to breath collection. Participants will be asked to provide a breath sample by exhaling into single-use breath collection bags. Using a custom designed gas sampling pump, the breath VOCs will be transferred onto TD tubes at a controlled flow rate. This breath sampling procedure will be repeated once. When the participants' breath sampling is complete, room air (Blank) samples must be taken onto additional TD tubes using the same procedure. The TD tubes will be sealed with long-term storage caps using the CapLok Tool.",[15,9],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Sameera Sharma, MBBS; MRCS","CONTACT","07576583519","vison@imperial.ac.uk",[30,51,64,76,84,95,106,117,125,136,147,158,169],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Imperial College Healthcare NHS Trust","RECRUITING","London","Greater London","W12 0NN","United Kingdom","UK",{"type":39,"coordinates":40},"Point",[41,42],-0.12574,51.50853,{"lat":42,"lon":41},[45,49],{"name":46,"role":26,"phone":47,"phoneExt":10,"email":48},"George Hanna, PhD; FRCS","02033122124","g.hanna@imperial.ac.uk",{"name":25,"role":26,"phone":27,"phoneExt":10,"email":50},"ssharma@ic.ac.uk",{"facility":52,"status":32,"city":53,"state":54,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":55,"geoPoint":59,"contacts":60},"Hull University Teaching Hospitals NHS Trust","Cottingham","Hull",{"type":39,"coordinates":56},[57,58],-0.7554,52.50243,{"lat":58,"lon":57},[61],{"name":62,"role":63,"phone":10,"phoneExt":10,"email":10},"Terence Lo","PRINCIPAL_INVESTIGATOR",{"facility":65,"status":66,"city":67,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Cardiff and Vale University Health Board","NOT_YET_RECRUITING","Cardiff",{"type":39,"coordinates":69},[70,71],-3.18,51.48,{"lat":71,"lon":70},[74],{"name":75,"role":63,"phone":10,"phoneExt":10,"email":10},"Tarig Abdelrahman",{"facility":77,"status":66,"city":67,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":78,"geoPoint":80,"contacts":81},"Velindre NHS Trust",{"type":39,"coordinates":79},[70,71],{"lat":71,"lon":70},[82],{"name":83,"role":63,"phone":10,"phoneExt":10,"email":10},"Betsan Thomas",{"facility":85,"status":32,"city":86,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"University Hospitals Coventry and Warwickshire NHS Trust","Coventry",{"type":39,"coordinates":88},[89,90],-1.51217,52.40656,{"lat":90,"lon":89},[93],{"name":94,"role":63,"phone":10,"phoneExt":10,"email":10},"Martin Scott-Brown",{"facility":96,"status":32,"city":97,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"University Hospitals of Leicester NHS Foundation Trust","Leicester",{"type":39,"coordinates":99},[100,101],-1.13169,52.6386,{"lat":101,"lon":100},[104],{"name":105,"role":63,"phone":10,"phoneExt":10,"email":10},"Alex Boddy",{"facility":107,"status":66,"city":108,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Liverpool University Hospitals NHS Foundation Trust","Liverpool",{"type":39,"coordinates":110},[111,112],-2.97794,53.41058,{"lat":112,"lon":111},[115],{"name":116,"role":63,"phone":10,"phoneExt":10,"email":10},"Andrew Moore",{"facility":118,"status":32,"city":108,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":119,"geoPoint":121,"contacts":122},"The Clatterbridge Cancer Centre NHS Foundation Trust",{"type":39,"coordinates":120},[111,112],{"lat":112,"lon":111},[123],{"name":124,"role":63,"phone":10,"phoneExt":10,"email":10},"Alia Alchawaf",{"facility":126,"status":66,"city":127,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Bedfordshire Hospitals NHS Foundation Trust","Luton",{"type":39,"coordinates":129},[130,131],-0.41748,51.87967,{"lat":131,"lon":130},[134],{"name":135,"role":63,"phone":10,"phoneExt":10,"email":10},"Periyathambi Jambulingam",{"facility":137,"status":32,"city":138,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"Newcastle Upon Tyne Hospitals NHS Trust","Newcastle",{"type":39,"coordinates":140},[141,142],-5.88979,54.21804,{"lat":142,"lon":141},[145],{"name":146,"role":63,"phone":10,"phoneExt":10,"email":10},"Shajahan Wahed",{"facility":148,"status":32,"city":149,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Norfolk and Norwich University Hospitals NHS Foundation Trust","Norwich",{"type":39,"coordinates":151},[152,153],1.29834,52.62783,{"lat":153,"lon":152},[156],{"name":157,"role":63,"phone":10,"phoneExt":10,"email":10},"Bhaskar Kumar",{"facility":159,"status":32,"city":160,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":161,"geoPoint":165,"contacts":166},"Oxford University Hospitals NHS Trust","Oxford",{"type":39,"coordinates":162},[163,164],-1.25596,51.75222,{"lat":164,"lon":163},[167],{"name":168,"role":63,"phone":10,"phoneExt":10,"email":10},"Somnath Mukherjee",{"facility":170,"status":66,"city":171,"state":10,"zip":10,"country":36,"countryCode":37,"cosmosGeoPoint":172,"geoPoint":176,"contacts":177},"Portsmouth Hospitals University NHS Trust","Portsmouth",{"type":39,"coordinates":173},[174,175],-1.09125,50.79899,{"lat":175,"lon":174},[178],{"name":179,"role":63,"phone":10,"phoneExt":10,"email":10},"Philip Pucher",{"type":181,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[183,184,186,187,188,189,190,191,193,194,195,197,198,200,202,204,206,208,210,212,214,216],{"name":31,"class":6},{"name":52,"class":185},"OTHER_GOV",{"name":148,"class":6},{"name":85,"class":6},{"name":159,"class":6},{"name":77,"class":185},{"name":65,"class":185},{"name":192,"class":6},"Newcastle-upon-Tyne Hospitals NHS Trust",{"name":107,"class":185},{"name":126,"class":6},{"name":196,"class":6},"University Hospitals, Leicester",{"name":118,"class":6},{"name":199,"class":185},"Portsmouth Hospitals NHS Trust",{"name":201,"class":6},"University Hospital Plymouth NHS Trust",{"name":203,"class":185},"NHS Tayside",{"name":205,"class":6},"NHS Highlands",{"name":207,"class":6},"The Christie NHS Foundation Trust",{"name":209,"class":6},"North Cumbria University Hospitals NHS Trust",{"name":211,"class":6},"Maidstone & Tunbridge Wells NHS Trust",{"name":213,"class":6},"University Hospitals of Derby and Burton NHS Foundation Trust",{"name":215,"class":185},"Bradford Teaching Hospitals NHS Foundation Trust",{"name":217,"class":185},"East and North Hertfordshire NHS Trust","100529083","volatile-organic-compounds-as-breath-biomarkers-in-squamous-oesophageal-neoplasms-100529083",false,"NCT06169163","Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms","ViSON","Inclusion Criteria: Participants with all the following characteristics will be eligible for inclusion in the study:\n\n1. Cancer cohort (n=259): Patients with treatment naïve, histopathology confirmed OSCC.\n2. Control cohort (n=259): Patients who have undergone or are undergoing an endoscopy (OGD) as part of their investigation for upper GI symptoms and are found to have either:\n\n   * A normal upper gastrointestinal tract\n   * Benign upper gastrointestinal disease\n\nExclusion Criteria: Participants with the following characteristics will not be eligible for inclusion in the study:\n\n1. Received some form of treatment (chemotherapy, radiotherapy, immunotherapy, endoscopic resection, or surgery) for OSCC\n2. History of another cancer in the last five years\n3. Non-squamous cell oesophageal cancer\n4. Barrett's oesophagus (with or without dysplasia)\n5. Previous oesophageal or gastric resection\n6. Unable to provide written consent or lack capacity.\n7. Pregnant women","ALL","18 Years","90 Years",{"count":229,"type":230},518,"ESTIMATED","OBSERVATIONAL","Oesophageal Squamous Cell Carcinoma (OSCC) is a cancer of the food pipe that affects around 2000 patients in the UK every year. It is often detected at an advanced stage, resulting in poor survival (5-year survival less than 20%). Early detection can improve survival (5-year survival \\>70%). Therefore, early detection is vital to improving survival.\n\nThere are no national screening guidelines, and an endoscopy (A camera test to look at the food pipe) is the only available test to detect OSCC.\n\nEarly detection of OSCC is challenging for many reasons. Firstly, early disease symptoms are non-specific, which patients often overlook. Secondly, 'Alarm' symptoms such as weight loss, difficulty swallowing or vomiting blood are signs of advanced stage. Lastly, endoscopy is an invasive test with associated risks and significant discomfort.\n\nThe investigators propose to develop a breath test for patients with non-specific symptoms. Breath testing has the ideal characteristics for a triage test because it is non-invasive, simple to perform, cost-effective and highly acceptable to patients. The test is based on identifying volatile organic compounds (VOCs, small molecules) that are produced by the cancer and released in breath.\n\nThe breath test will be offered by General Practitioners (GPs) to patients with non-specific symptoms. Those who test positive will be referred for an urgent camera test, and those who test negative can be reassured.",[234,235],"Oesophageal Squamous Cell Carcinoma","Oesophageal Cancer",[237,238,239,240,241],"Breath biomarker","Early detection","Oesophageal cancer","Oesophageal squamous cell cancer","Volatile organic compounds","2025-04-29",{"date":244,"type":245},"2025-05-02","ACTUAL",{"date":247,"type":245},"2023-12-01",{"date":249,"type":230},"2026-12-31",{"name":5,"class":6},13]