[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642154":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":25,"responsibleParty":179,"collaborators":10,"id":182,"slug":183,"hasResults":184,"nctId":185,"briefTitle":186,"officialTitle":186,"acronym":187,"eligibilityCriteria":188,"healthyVolunteers":184,"sex":189,"minAge":190,"maxAge":10,"enrollmentInfo":191,"targetDuration":10,"studyType":194,"phases":10,"briefSummary":195,"conditions":196,"keywords":202,"overallStatus":210,"whyStopped":10,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":220},{"fullName":5,"class":6},"Hospital Las Higueras","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"AKI Patients Receiving CRRT With Net Ultrafiltration",null,"Adult critically ill patients with acute kidney injury receiving continuous renal replacement therapy with prescribed net ultrafiltration. Participants will be prospectively evaluated using a multiparametric monitoring strategy including clinical, hemodynamic, ultrasound, perfusion, and biochemical assessments. Patients will subsequently be classified according to the development or absence of ultrafiltration intolerance during the observation period.",[13],{"name":14,"affiliation":15,"role":16},"Gonzalo Ramírez-Guerrero, MD","Hospital Las Higueras de Talcahuano","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+56981746173","ramirezguerrero.g@gmail.com",{"name":23,"role":19,"phone":10,"phoneExt":10,"email":24},"Cristian Pedreros-Rosales, MD","cpedreros@me.com",[26,42,57,70,83,100,115,130,145,164],{"facility":27,"status":10,"city":28,"state":10,"zip":10,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Hospital Cárdio Pulmonar","Salvador","Brazil","BR",{"type":32,"coordinates":33},"Point",[34,35],-38.49096,-12.97563,{"lat":35,"lon":34},[38],{"name":39,"role":19,"phone":40,"phoneExt":10,"email":41},"Maria Gabriela Guimarães, MD","+5571982121211","Gabrielaguimar@hotmail.com",{"facility":43,"status":10,"city":44,"state":10,"zip":10,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Hospital Clínico Regional de Concepción","Concepción","Chile","CL",{"type":32,"coordinates":48},[49,50],-73.04977,-36.82699,{"lat":50,"lon":49},[53],{"name":54,"role":19,"phone":55,"phoneExt":10,"email":56},"Marcos Hernandez, MD","+56976685604","md.hernandezdiaz@gmail.com",{"facility":58,"status":10,"city":59,"state":10,"zip":10,"country":45,"countryCode":46,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Complejo Asistencial Dr. Victor Ríos Ruiz","Los Ángeles",{"type":32,"coordinates":61},[62,63],-72.35366,-37.46973,{"lat":63,"lon":62},[66],{"name":67,"role":19,"phone":68,"phoneExt":10,"email":69},"Carolina Carrasco, MD","+56975583888","carolina.carrascoa@gmail.com",{"facility":71,"status":10,"city":72,"state":10,"zip":10,"country":45,"countryCode":46,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Hospital Clínico Dra. Eloísa Díaz Insunza de La Florida","Santiago",{"type":32,"coordinates":74},[75,76],-70.64827,-33.45694,{"lat":76,"lon":75},[79],{"name":80,"role":19,"phone":81,"phoneExt":10,"email":82},"Eduardo Chinchón, MD","+56994514773","doctorchinchon@gmail.com",{"facility":15,"status":10,"city":84,"state":10,"zip":10,"country":45,"countryCode":46,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Talcahuano",{"type":32,"coordinates":86},[87,88],-73.11684,-36.72494,{"lat":88,"lon":87},[91,92,93,96,98],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},{"name":23,"role":19,"phone":10,"phoneExt":10,"email":24},{"name":94,"role":95,"phone":10,"phoneExt":10,"email":10},"Rodrigo Ulloa, MD","SUB_INVESTIGATOR",{"name":97,"role":95,"phone":10,"phoneExt":10,"email":10},"Jonathan Alarcón, MD",{"name":99,"role":95,"phone":10,"phoneExt":10,"email":10},"Ricardo Ferrada, MD",{"facility":101,"status":10,"city":102,"state":10,"zip":10,"country":103,"countryCode":104,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Hospital Universitario San José de Popayán","Popayán","Colombia","CO",{"type":32,"coordinates":106},[107,108],-76.61316,2.43823,{"lat":108,"lon":107},[111],{"name":112,"role":19,"phone":113,"phoneExt":10,"email":114},"David Ballesteros, MD","+573105542506","david.ballesteros.c@gmail.com",{"facility":116,"status":10,"city":117,"state":10,"zip":10,"country":118,"countryCode":119,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Hospital General Enrique Garces","Quito","Ecuador","EC",{"type":32,"coordinates":121},[122,123],-78.52495,-0.22985,{"lat":123,"lon":122},[126],{"name":127,"role":19,"phone":128,"phoneExt":10,"email":129},"Darío Jiménez, MD","+593992773176","dxjimenezmd@gmail.com",{"facility":131,"status":10,"city":132,"state":10,"zip":10,"country":133,"countryCode":134,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Ospedale San Bortolo","Vicenza","Italy","IT",{"type":32,"coordinates":136},[137,138],11.5475,45.54672,{"lat":138,"lon":137},[141],{"name":142,"role":19,"phone":143,"phoneExt":10,"email":144},"Matteo Marcello, MD","+393925743247","matteo.marcello92@gmail.com",{"facility":146,"status":10,"city":147,"state":10,"zip":10,"country":148,"countryCode":149,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Hospital General de Mexico","Mexico City","Mexico","MX",{"type":32,"coordinates":151},[152,153],-99.12766,19.42847,{"lat":153,"lon":152},[156,160],{"name":157,"role":19,"phone":158,"phoneExt":10,"email":159},"Pablo Galindo, MD","+525551564682","drgalindo@nefrologoscdmx.com",{"name":161,"role":19,"phone":162,"phoneExt":10,"email":163},"Sandra Ávila, MD","+524778808890","sandrapav@hotmail.es",{"facility":165,"status":10,"city":166,"state":10,"zip":10,"country":167,"countryCode":168,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Hospital Nacional Cayetano Heredia","Lima","Peru","PE",{"type":32,"coordinates":170},[171,172],-77.02824,-12.04318,{"lat":172,"lon":171},[175],{"name":176,"role":19,"phone":177,"phoneExt":10,"email":178},"Raúl Valenzuela, MD","+51999308278","raul.valenzuela.cordova@gmail.com",{"type":16,"investigatorFullName":180,"investigatorTitle":181,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Gonzalo Ramirez Guerrero","Principal Investigator - Nephrologist","100642154","volume-removal-intolerance-during-net-ultrafiltration-in-acute-kidney-injury-patients-100642154",false,"NCT07643597","Volume Removal Intolerance During Net Ultrafiltration in Acute Kidney Injury Patients","VINKO","Inclusion Criteria:\n\n* Age ≥18 years\n* Admission to an Intensive Care Unit\n* Acute kidney injury according to KDIGO criteria\n* Prescription of continuous renal replacement therapy (CRRT) with net ultrafiltration\n* Clinical stability considered sufficient to initiate net ultrafiltration according to the treating clinical team\n\nExclusion Criteria:\n\n* Chronic kidney replacement therapy prior to ICU admission\n* Pregnancy\n* Limitation of therapeutic effort or goals-of-care decisions at admission or during the observation period\n* Inability to perform hemodynamic or perfusion assessment\n* Extracorporeal membrane oxygenation (ECMO)\n* Refusal to participate in the study","ALL","18 Years",{"count":192,"type":193},128,"ESTIMATED","OBSERVATIONAL","Acute kidney injury (AKI) is common in critically ill patients and is frequently associated with fluid overload, which can worsen clinical outcomes. Continuous renal replacement therapy (CRRT) allows fluid removal through net ultrafiltration (UFNET), but some patients develop hemodynamic instability or signs of poor tissue perfusion during this process.\n\nThe purpose of this prospective observational study is to evaluate tolerance to net ultrafiltration in critically ill patients with AKI receiving CRRT. The study will assess clinical, hemodynamic, ultrasound, perfusion, and biochemical parameters before and during fluid removal to identify factors associated with ultrafiltration intolerance.\n\nThe investigators hypothesize that alterations in hemodynamic, perfusion, and congestion-related parameters can identify patients at increased risk of ultrafiltration intolerance before the development of overt hypotension. The results may help improve individualized fluid removal strategies and optimize the safety of CRRT in critically ill patients.",[197,198,199,200,201],"Acute Kidney Injury","Fluid Overload","Fluid Overload in Dialysis Patients","Critical Illness","Renal Replacement Therapy for Acute Kidney Injury in ICU",[203,204,205,206,207,198,208,209],"Net Ultrafiltration","Continuous Renal Replacement Therapy","Fluid Removal","Ultrafiltration Intolerance","Tissue Hypoperfusion","VExUS","Point-of-Care Ultrasound","NOT_YET_RECRUITING","2026-06-13",{"date":213,"type":214},"2026-06-16","ACTUAL",{"date":216,"type":193},"2026-07-06",{"date":218,"type":193},"2027-12-01",{"name":5,"class":6},10]