[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640776":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":43,"locations":51,"responsibleParty":71,"collaborators":47,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":47,"enrollmentInfo":84,"targetDuration":47,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":96,"whyStopped":47,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"University of Sao Paulo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Volume-Stable Collagen Matrix","EXPERIMENTAL","Participants in this group will receive root coverage surgery using a volume-stable xenogeneic collagen matrix associated with a coronally advanced flap.",[13],"Device: Volume-stable xenogeneic collagen matrix (VCMX)",{"label":15,"type":16,"description":17,"interventionNames":18},"Subepithelial Connective Tissue Graft","ACTIVE_COMPARATOR","Participants in this group will receive root coverage surgery using an autogenous subepithelial connective tissue graft associated with a coronally advanced flap.",[19],"Procedure: Subepithelial connective tissue graft (SCTG)",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Volume-stable xenogeneic collagen matrix (VCMX)","A volume-stable xenogeneic collagen matrix will be used as a soft-tissue substitute for root coverage surgery. The matrix will be placed over the recession defects and covered by a coronally advanced flap.",[9],[27,28],"VCMX","Fibro-Gide",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"PROCEDURE","Subepithelial connective tissue graft (SCTG)","An autogenous subepithelial connective tissue graft will be harvested from the palate and used for root coverage surgery. The graft will be placed over the recession defects and covered by a coronally advanced flap.",[15],[35],"SCTG",[37,40],{"name":38,"affiliation":5,"role":39},"Arthur Belem Novaes Jr, DDS, PhD","PRINCIPAL_INVESTIGATOR",{"name":41,"affiliation":5,"role":42},"Edgar Daniel Vargas Quiroga, DDS, MSc","STUDY_CHAIR",[44,49],{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","+551633153000",null,"edgar.vargasquiroga@usp.br",{"name":38,"role":45,"phone":47,"phoneExt":47,"email":50},"novaesjr@forp.usp.br",[52],{"facility":53,"status":47,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"School of Dentistry of Ribeirão Preto, University of Sao Paulo","Ribeirão Preto","São Paulo","14040-904","Brazil","BR",{"type":60,"coordinates":61},"Point",[62,63],-47.81028,-21.1775,{"lat":63,"lon":62},[66,67,68,69],{"name":41,"role":45,"phone":46,"phoneExt":47,"email":48},{"name":38,"role":45,"phone":47,"phoneExt":47,"email":50},{"name":38,"role":39,"phone":47,"phoneExt":47,"email":47},{"name":41,"role":70,"phone":47,"phoneExt":47,"email":47},"SUB_INVESTIGATOR",{"type":39,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":47,"oldOrganization":47},"Arthur Belem Novaes Jr","Principal Investigator","100640776","volume-stable-collagen-matrix-versus-subepithelial-connective-tissue-graft-for-multiple-gingival-recessions-100640776",false,"NCT07613775","Volume-Stable Collagen Matrix Versus Subepithelial Connective Tissue Graft for Multiple Gingival Recessions","Volume-Stable Xenogeneic Collagen Matrix Versus Subepithelial Connective Tissue Graft for the Treatment of Multiple Gingival Recessions: A 12-Month Randomized Controlled Clinical Trial","VCMX-SCTG","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Presence of at least two Cairo RT1 gingival recessions in anterior teeth and\u002For premolars.\n* Gingival recession depth greater than or equal to 2 mm.\n* Presence of at least 2 mm of keratinized gingiva apical to the gingival recession.\n* Indication for root coverage treatment due to esthetic concern and\u002For dentin hypersensitivity.\n* Sites with non-carious cervical lesions may be included if they are previously restored and, after restoration, present residual gingival recession greater than or equal to 2 mm.\n* Good plaque control, defined as full-mouth plaque score and full-mouth marginal gingival bleeding score below 20%.\n\nExclusion Criteria:\n\n* Current smokers or individuals who stopped smoking less than 12 months before enrollment.\n* Decompensated systemic diseases.\n* Pregnancy or lactation.\n* Active periodontal disease.\n* Untreated root caries.\n* Previous mucogingival surgery in the study area.","ALL","18 Years",{"count":85,"type":86},40,"ESTIMATED","INTERVENTIONAL",[89],"NA","Gingival recession is a clinical condition in which the gingival margin is displaced apically, exposing the root surface. This condition may be associated with esthetic concerns, dentin hypersensitivity, and difficulties in oral hygiene. Subepithelial connective tissue grafting is considered a standard surgical approach for root coverage, but it requires harvesting tissue from the palate, which may increase postoperative discomfort. Volume-stable xenogeneic collagen matrices have been proposed as an alternative biomaterial to reduce the need for a palatal donor site.\n\nThis randomized controlled clinical trial will compare a volume-stable xenogeneic collagen matrix with an autogenous subepithelial connective tissue graft for the treatment of multiple gingival recessions. Participants will be allocated to one of two treatment groups. The test group will receive root coverage surgery using a volume-stable collagen matrix, while the control group will receive root coverage surgery using a subepithelial connective tissue graft. Clinical, patient-reported, esthetic, and digital outcomes will be assessed at baseline and during follow-up visits up to 12 months.\n\nThe primary outcome will be the change in gingival recession depth from baseline to 12 months. Secondary outcomes will include keratinized tissue width, gingival thickness, percentage of root coverage, complete root coverage, dentin hypersensitivity, patient-reported satisfaction, early wound healing, and digital volumetric changes assessed by intraoral scanning.",[92],"Gingival Recession",[94,9,15,95],"Multiple Gingival Recessions","Coronally Advanced Flap","NOT_YET_RECRUITING","2026-05-30",{"date":99,"type":100},"2026-06-02","ACTUAL",{"date":102,"type":86},"2026-10-01",{"date":104,"type":86},"2027-12-01",{"name":5,"class":6},1]