[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589523":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":49,"responsibleParty":71,"collaborators":75,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":75,"eligibilityCriteria":81,"healthyVolunteers":78,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":75,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":75,"overallStatus":52,"whyStopped":75,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Asian Institute of Gastroenterology, India","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"To assess the efficacy of vonapraprazon 20mg better than esomeprazole drug","ACTIVE_COMPARATOR","healing rate will be checked during endoscopy at 8 weeks",[13],"Drug: Vonoprazan",{"label":15,"type":16,"description":17,"interventionNames":18},"To see the healing rate of grade B esophagitis","PLACEBO_COMPARATOR","healing rate will be checked during endoscopy at 8 weeks in patients receiving esomeprazole 40mg",[19],"Drug: Esomeprazole 40mg",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Vonoprazan","a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis.",[9],[27],"per oral endoscopy myotomy",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Esomeprazole 40mg","It is a proton pump inhibitor which reduces the excessive acid secretion in the stomach and it heals grade B esophagitis (\\>5mm ulcer between two mucosal folds in esophagus)",[15],[27],[34],{"name":35,"affiliation":36,"role":37},"Mohan Dr Ramchandani, MD DM","Asian Institute of Gastroenterology","STUDY_DIRECTOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Rajesh Goud Mr Maragoni, M.Pharm","CONTACT","04023378888","312","rajeshgoud761@gmail.com",{"name":46,"role":41,"phone":42,"phoneExt":47,"email":48},"Zaheer Nabi Dr Mohammed, MD DNB","427","zaheernabi1978@gmail.com",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Asian Institute of Gastroenterology \u002FAig Hospitals","RECRUITING","Hyderabad","Telangana","500082","India","IN",{"type":59,"coordinates":60},"Point",[61,62],78.45636,17.38405,{"lat":62,"lon":61},[65,68],{"name":66,"role":41,"phone":42,"phoneExt":67,"email":48},"ZAHEER DR NABI, MBBS MDDNB","503",{"name":69,"role":41,"phone":42,"phoneExt":70,"email":44},"Rajesh Goud Mr Maragoni, M.Pharm MBA","301",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":75,"oldOrganization":75},"PRINCIPAL_INVESTIGATOR","Mohan Ramchandani","Director",null,"100589523","vonaprazan-versus-esomeprazole-for-healing-of-la-grade-b-or-higher-esophagitis-after-poem-100589523",false,"NCT06955520","Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM","Inclusion Criteria:\n\n* Age ≥18 years\n* History of POEM for achalasia\n* Endoscopic confirmation of LA grade B, C, or D reflux esophagitis at 3 months post-POEM\n* GERD symptoms (heartburn, regurgitation) for ≥4 weeks\n* Willingness to provide informed consent and comply with study procedures\n\nExclusion Criteria:\n\n* History of prior anti-reflux surgery\n* Presence of Barrett's esophagus, esophageal stricture, or malignancy\n* Severe gastroparesis or esophageal motility disorder unrelated to achalasia\n* Pregnancy or breastfeeding\n* Severe hepatic or renal impairment (ALT\u002FAST \\>3× ULN, eGFR \\\u003C30 mL\u002Fmin)\n* Regular use of NSAIDs, steroids, or anticoagulants affecting esophageal healing","ALL","18 Years","75 Years",{"count":86,"type":87},300,"ESTIMATED","INTERVENTIONAL",[90],"NA","Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis. Proton pump inhibitors (PPIs) like Esomeprazole are the standard treatment, but Vonaprazan, a potassium-competitive acid blocker (P-CAB), offers superior acid suppression and may provide enhanced healing in post-POEM reflux esophagitis.\n\nPrimary Objective:\n\n• To compare the healing rates of LA grade B or higher reflux esophagitis at 8 weeks in patients receiving Vonaprazan 20 mg versus Esomeprazole 40 mg.\n\nSecondary Objectives\n\n* To assess improvement in reflux symptoms using the GERD-Q score at 8 weeks.\n* To evaluate the incidence of adverse events in each treatment group.",[93],"GERD","2026-04-22",{"date":96,"type":97},"2026-04-27","ACTUAL",{"date":99,"type":97},"2025-04-30",{"date":101,"type":87},"2028-12-25",{"name":5,"class":6},1]