[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100483723":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":39,"responsibleParty":64,"collaborators":11,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":11,"enrollmentInfo":76,"targetDuration":11,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":42,"whyStopped":11,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Strategy A: PEEP 15 cmH2O → PEEP 5 cmH2O","EXPERIMENTAL",null,[13],"Procedure: PEEP decrease",{"label":15,"type":16,"description":11,"interventionNames":17},"Strategy B: PEEP 5 cmH2O → PEEP 15 cmH2O","ACTIVE_COMPARATOR",[18],"Procedure: PEEP increase",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","PEEP increase","Positive End Expiratory Pressure (PEEP) will be increased from 5 to 15 cmH2O.",[15],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"PEEP decrease","Positive End Expiratory Pressure (PEEP) will be decreased from 15 to 5 cmH2O.",[9],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"François Beloncle, MD","CONTACT","+33 241 35 58 65","francois.Francois.Beloncle@chu-angers.fr",{"name":36,"role":32,"phone":37,"phoneExt":11,"email":38},"UH Angers DRCI","+33 2 41 35 54 96","DRCI-Promotion-Interne@chu-angers.fr",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Angers Hospital","RECRUITING","Angers","Maine et Loire","49933","France","FR",{"type":49,"coordinates":50},"Point",[51,52],-0.55202,47.47156,{"lat":52,"lon":51},[55,58,61],{"name":31,"role":32,"phone":56,"phoneExt":11,"email":57},"+33 2 41 58 65","Francois.Beloncle@chu-angers.fr",{"name":59,"role":32,"phone":60,"phoneExt":11,"email":38},"UH Angers DRCI UH Angers","+33 5 41 35 54 96",{"name":62,"role":63,"phone":11,"phoneExt":11,"email":11},"francois beloncle, MD","PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100483723","vq-matching-variations-with-peep-in-ards-according-to-compliance-based-phenotypes-france-100483723",false,"NCT05578742","V\u002FQ Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)","Effect of PEEP on Ventilartion\u002FPerfusion Ratios According to Different Phenotypes in Patients With ARDS (France)","MISMATCHED FR","Inclusion criteria:\n\n* intubated patients with moderate and severe ARDS (Berlin definition, PaO2\u002FFiO2 ≤200 mmHg at PEEP 5 cmH2O)\n* undergoing deep sedation\n* on controlled mechanical ventilation\n* between 24 hours and 5 days after intubation.\n\nExclusion criteria:\n\n* age \\\u003C18 years old; pregnancy\n* patient undergoing legal protection\n* contra-indications to EIT (e. g. severe chest trauma or wounds)\n* pneumothorax; patient undergoing ECMO\n* patient with BMI ≥35 kg\u002Fm2\n* hemodynamic instability with MAP \\\u003C60 mmHg despite vasopressors.","ALL","18 Years",{"count":77,"type":78},50,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation\u002Fperfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation\u002Fperfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).",[84],"ARDS",[86,87,88,89],"pulmonary perfusion","ventilation-perfusion mismatch","compliance","recruitability","2025-12-02",{"date":92,"type":93},"2025-12-08","ACTUAL",{"date":95,"type":93},"2024-02-08",{"date":97,"type":78},"2026-09",{"name":5,"class":6},1]