[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608706":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":31,"locations":40,"responsibleParty":57,"collaborators":59,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":18,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":88,"whyStopped":18,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Karachi","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Walking Intervention","EXPERIMENTAL","Participants will undergo a supervised walking program consisting of 30 minutes per session, 5 sessions per week, for 12 weeks. Exercise intensity will be maintained at 55-65% of age-predicted maximum heart rate, monitored by chest strap or optical heart rate sensors. Sessions will be supervised by an exercise physiologist, with adherence tracked through session logs and heart rate recordings. Participants will continue their usual levothyroxine regimen but will not initiate any new structured exercise program during the study period.",[13],"Behavioral: Supervised Walking Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Control (Usual Activity)","NO_INTERVENTION","Participants will continue their usual daily routines without a prescribed exercise program. They will be instructed not to initiate any new structured exercise during the study. Weekly check-ins will be conducted to record incidental activity and monitor health status. At study completion, control participants will be offered the walking program.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Supervised Walking Program","A structured walking program consisting of 30 minutes per session, 5 sessions per week, for 12 weeks at 55-65% of age-predicted maximum heart rate. Sessions will be supervised by an exercise physiologist, with adherence monitored by heart rate tracking and attendance logs. Participants will continue their standard levothyroxine treatment but will not begin any new structured exercise programs.",[9],[26],"Aerobic walking, treadmill walking, moderate-intensity exercise",[28],{"name":29,"affiliation":5,"role":30},"Sadaf Ahmed, Ph.D.","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"Shamoon Noushad, Ph.D.","CONTACT","+923333549258","shamoon@aeirc-edu.com",{"name":29,"role":34,"phone":38,"phoneExt":18,"email":39},"+923333061127","sadaf@aeirc-edu.com",[41],{"facility":5,"status":18,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Karachi","Sindh","78500","Pakistan","PK",{"type":48,"coordinates":49},"Point",[50,51],67.0104,24.8608,{"lat":51,"lon":50},[54],{"name":55,"role":34,"phone":56,"phoneExt":18,"email":36},"Shamoon Noushad","03333549258",{"type":30,"investigatorFullName":55,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Professor",[60],{"name":61,"class":6},"Advanced Education & Research Center","100608706","walking-for-hypothyroidism-trial-wht-100608706",false,"NCT07205042","Walking for Hypothyroidism Trial (WHT)","A Randomized Controlled Trial of a 12-Week Walking Program on Metabolic and Psychophysiological Outcomes in Women With Hypothyroidism","WHT","Inclusion Criteria:\n\n* Female, aged 35-55 years\n* Primary hypothyroidism with documented prior TSH \\>4.5 mIU\u002FL\n* Stable levothyroxine dose for at least 6 months\n* Sedentary lifestyle (\\\u003C150 minutes of moderate-vigorous activity per week)\n* BMI between 20-35 kg\u002Fm²\n* Able to walk unaided\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Pregnant or lactating, or planning pregnancy during the study period\n* Use of beta-blockers, systemic corticosteroids, or medications significantly affecting heart rate, HRV, or metabolism\n* Uncontrolled hypertension, insulin-dependent diabetes, symptomatic cardiovascular disease, or orthopedic conditions limiting walking\n* Major psychiatric hospitalization in the past 12 months\n* Participation in another interventional trial within the past 30 days","FEMALE","35 Years","55 Years",{"count":74,"type":75},120,"ESTIMATED","INTERVENTIONAL",[78],"NA","Women with hypothyroidism often report persistent fatigue, weight gain, autonomic dysregulation, and stress despite stable levothyroxine therapy. This single-center, parallel-group RCT will test whether a structured, supervised 12-week walking program improves basal metabolic rate (BMR) and psychophysiological outcomes compared with usual activity. One hundred twenty women aged 35-55 with stable primary hypothyroidism will be randomized 1:1 to intervention or control.",[81],"Hypothyroidism",[83,84,85,86,87],"Walking","Aerobic Exercise","Basal Metabolic Rate","Heart Rate Variability","Salivary Cortisol","NOT_YET_RECRUITING","2025-09-30",{"date":91,"type":92},"2025-10-03","ACTUAL",{"date":94,"type":75},"2025-11-01",{"date":96,"type":75},"2026-06-30",{"name":5,"class":6},1]