[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626161":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":28,"locations":10,"responsibleParty":38,"collaborators":10,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":55,"studyType":56,"phases":10,"briefSummary":57,"conditions":58,"keywords":65,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":10},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"Functional Surgery plus Rehabilitation (FS Group)",null,[12],"Procedure: Functional Surgery plus Rehabilitation",{"label":14,"type":10,"description":10,"interventionNames":15},"Physical Exercise Alone (PE Group)",[16],"Behavioral: Physical Exercise",[18,23],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Functional Surgery plus Rehabilitation","FS group underwent individualized surgical correction aimed at improving foot alignment, restoring muscle-tendon balance, and optimizing walking mechanics. Surgical procedures included soft tissue release, tendon transfers to augment weakened muscles, and calcaneal osteotomy for hindfoot malalignment. Arthrodesis was reserved for rigid deformities or painful osteoarthritis not amenable to realignment. All surgically treated participants followed a standardized postoperative rehabilitation program, consisting of an initial 2-week period of immobilization with non-weight-bearing, followed by partial weight-bearing with a removable orthosis from weeks 2 to 6, progression to full weight-bearing between weeks 6 and 12, and a structured rehabilitation phase from weeks 12 to 24 emphasizing strengthening, balance training, and task-specific gait retraining. Afterward, participants continued rehabilitation using the same protocol applied to the physical therapy group.",[9],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"BEHAVIORAL","Physical Exercise","Participants in the PE group received structured physical therapy without surgical intervention. Programs were individualized based on disease severity and functional capacity to improve walking ability, balance, and lower-limb coordination. Therapy included aerobic exercise, ankle mobility exercises, lower-limb stretching, and balance training, all performed within the available range of motion. After an initial supervised phase, participants transitioned to a home-based, self-supervised program performed approximately twice weekly for up to 12 months. Aerobic training was conducted at moderate intensity using a stationary bicycle or seated alternatives when needed. Exercises were modified as necessary to avoid pain or excessive fatigue.",[14],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Zhuoqi Wei, MD","CONTACT","+8613838384087","13838384087@163.com",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},"Yang Lv, MD, PhD","+8618513112060","lvyang42@126.com",{"type":39,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zhou Fang","Principal Investigator","100626161","walking-function-outcomes-following-surgical-correction-with-rehabilitation-versus-physical-therapy-alone-in-charcot-marie-tooth-disease-a-bidirectional-cohort-study-100626161",false,"NCT07432035","Walking Function Outcomes Following Surgical Correction With Rehabilitation Versus Physical Therapy Alone in Charcot-Marie-Tooth Disease: A Bidirectional Cohort Study","CMT-WALK","Inclusion Criteria:\n\n* Participants aged 12 years or older at the time of enrollment\n* Genetically or clinically confirmed CMT, based on established diagnostic criteria\n* Presence of foot deformity and\u002For gait impairment attributable to CMT, as determined by a treating clinician\n* Ability to ambulate at least 10 meters, with or without assistive devices\n* Medically eligible for either functional surgical intervention or structured physical therapy, as determined by the treating team\n* Willingness and ability to participate in longitudinal follow-up assessments\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previous major foot or ankle surgery that substantially altered lower-limb biomechanics\n* Presence of non-CMT-related neurological disorders affecting gait (eg, stroke, Parkinson disease, multiple sclerosis)\n* Severe musculoskeletal conditions unrelated to CMT that limit walking ability (eg, advanced hip or knee osteoarthritis)\n* Active lower-limb infection, ulceration, or acute injury at the time of enrollment\n* Severe cognitive impairment or psychiatric condition precluding reliable participation\n* Medical contraindications to surgery or exercise-based rehabilitation, when relevant\n* Inability to complete baseline functional assessments or anticipated inability to complete follow-up","ALL","12 Years","60 Years",{"count":53,"type":54},200,"ESTIMATED","5 Years","OBSERVATIONAL","The goal of this study is to compare changes in walking ability in people with Charcot-Marie-Tooth disease (CMT) who receive two different treatment approaches for foot deformities that affect walking.\n\nCMT is an inherited nerve condition that can cause muscle weakness, loss of sensation, and foot deformities. These changes often make walking difficult and can reduce independence and quality of life. Treatment options commonly include physical therapy alone or surgery to correct foot alignment followed by rehabilitation. However, it is not clear whether one approach leads to better long-term walking outcomes.\n\nThe main question this study aims to answer is whether individuals who undergo functional foot surgery followed by rehabilitation experience different changes in walking ability over time compared with those who receive structured physical therapy alone.\n\nResearchers will compare walking performance between these two treatment groups over a period of up to two years. Walking ability will be evaluated using standardized walking tests and patient questionnaires.\n\nParticipants included in this study are individuals with CMT-related foot deformities that affect walking and who received either surgery followed by rehabilitation or physical therapy alone. Researchers will analyze changes in walking ability over time and determine how many participants achieve meaningful improvement.\n\nThe findings from this study may help clinicians and individuals with CMT better understand how different treatment strategies influence walking function over time.",[59,60,61,62,63,64],"Charcot Marie Tooth Disease (CMT)","Pes Cavovarus","Surgery","Exercise Training","Neuromuscular Diseases (NMD)","Gait Disorders",[66,67,68,69,70,71],"Charcot Marie Tooth disease","Walking performance","Functional surgery","Physical therapy","Gait impairment","Propensity score matching","NOT_YET_RECRUITING","2026-02-24",{"date":75,"type":76},"2026-02-25","ACTUAL",{"date":78,"type":54},"2026-02-11",{"date":80,"type":54},"2028-02-10",{"name":5,"class":6}]