[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100472995":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":25,"locations":26,"responsibleParty":47,"collaborators":50,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":25,"eligibilityCriteria":113,"healthyVolunteers":109,"sex":114,"minAge":115,"maxAge":25,"enrollmentInfo":116,"targetDuration":25,"studyType":119,"phases":120,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":29,"whyStopped":25,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"The Second Hospital of Nanjing Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"midgut","EXPERIMENTAL","A soft TET tube is inserted into the colon via the paraffin-lubricated gastroscope channel. If patients cannot tolerate endoscopy or anesthesia, or it is difficult to confirm the bypass intestine under endoscopy, a nasojejunal tube will be inserted under digital fluoroscopy.",[13],"Other: washed microbiota transplantation",{"label":15,"type":10,"description":16,"interventionNames":17},"colonic","A soft TET tube is inserted into the colon via the paraffin-lubricated colonoscope channel.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"washed microbiota transplantation","Each patient will receive washed microbiota transplantation each day for three consecutive days. After WMT, participants will receive free diet plus home enteral nutrition (solution at a 750ml daily dosage that provides 750 kcal energy) at home for 8 weeks.",[15,9],[24],"home enteral nutrition",null,[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"The Second Affiliated Hospital of Nanjing Medical University","RECRUITING","Nanjing","Jiangsu","210000","China","CN",{"type":36,"coordinates":37},"Point",[38,39],118.77778,32.06167,{"lat":39,"lon":38},[42],{"name":43,"role":44,"phone":45,"phoneExt":25,"email":46},"Faming Zhang","CONTACT","+86-25-56662093","fzhang@njmu.edu.cn",{"type":48,"investigatorFullName":43,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Associate professor, Gastroenterology",[51,53,55,57,60,62,64,66,68,70,73,75,77,79,81,83,85,87,89,91,93,95,97,99,101,103,105],{"name":52,"class":6},"The First Affiliated Hospital of Guangdong Pharmaceutical University",{"name":54,"class":6},"Nanjing Medical University",{"name":56,"class":6},"Wuxi No. 2 People's Hospital",{"name":58,"class":59},"Jiangxi University of Chinese Medicine Affiliated Hospital","UNKNOWN",{"name":61,"class":6},"Hubei Hospital of Traditional Chinese Medicine",{"name":63,"class":6},"The Affiliated Hospital Of Southwest Medical University",{"name":65,"class":6},"Tang-Du Hospital",{"name":67,"class":6},"Huzhou Central Hospital",{"name":69,"class":6},"West China Fourth Hospital",{"name":71,"class":72},"The Affiliated People's Hospital of Ningbo University","OTHER_GOV",{"name":74,"class":59},"Guangzhou First People Hospital of Guangzhou Medical University",{"name":76,"class":6},"The First Affiliated Hospital of Anhui University of Chinese Medicine",{"name":78,"class":59},"Beijing Rectum Hospital",{"name":80,"class":6},"Dazhou Central Hospital",{"name":82,"class":6},"The Second Affiliated Hospital of Dalian Medical University",{"name":84,"class":6},"Second Affiliated Hospital of Guangzhou Medical University",{"name":86,"class":6},"PLA No. 901 Hospital of the Joint Support Force",{"name":88,"class":59},"YI'AN PEOPLE'S HOSPITAL",{"name":90,"class":59},"Hunan Aerospace Hospital",{"name":92,"class":59},"Jiamusi City Hospital of Traditional Chinese Medicine",{"name":94,"class":6},"The First People's Hospital of Kunshan",{"name":96,"class":6},"LanZhou University",{"name":98,"class":59},"Jingxing xian yiyuan",{"name":100,"class":59},"TAIHE country people's hospital",{"name":102,"class":59},"Tailai County People's Hospital",{"name":104,"class":59},"Armed Police Characteristic Medical Center",{"name":106,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","100472995","washed-microbiota-transplantation-for-malnutrition-after-nonphysiological-reconstruction-of-the-upper-gastrointestinal-tract-100472995",false,"NCT05439135","Washed Microbiota Transplantation for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract","An Open-label, Multicenter, Randomized Clinical Trial for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract: Washed Microbiota Transplantation Via Mid-gut Tube Versus Colonic Transendoscopic Enteral Tube","Inclusion Criteria:\n\n* Patients undergone nonphysiological reconstruction of the gastrointestinal tract (such as Billroth-II, Roux-en-Y, Child, Whipple reconstruction)\n* Aged over 18 years old;\n* Malnutrition is assessed by Nutritional Risk Screening 2002 score≥3 and Patient Generated Subjective Global Assessment (PG-SGA) score≥4;\n* Written informed consent;\n\nExclusion Criteria:\n\n* Expected survival time \\\u003C 3 months;\n* Still on anti-tumor therapy or it is expected during the visit;\n* Complicated with ascites or edema caused by malnutrition;\n* Known organic gastrointestinal disease (e.g., gastrointestinal infection, inflammatory bowel disease, or radiation enteritis);\n* Undergone other gastrointestinal surgery (e.g., enterectomy, enterostomy, or gastrostomy) except appendectomy or anal fistula surgery;\n* Complicated with contraindications of enteral nutrition such as ileus, active gastrointestinal bleeding, and shock;\n* Cannot tolerate gastroscopy or colonoscopy;\n* Severe comorbidities (e.g., diabetes, cardiopulmonary failure, severe liver or or kidney diseases);\n* Complicated with other wasting diseases (e.g., active tuberculosis, hyperthyroidism, diabetes, HIV, active hepatitis, hip fracture, craniocerebral injury, etc.);\n* A history of anti-infective treatment within 30 days before enrollment; or need anti-infective treatment at the time of enrollment; or unwilling to stop taking drugs that affect gut microbes, such as probiotics;\n* Can not tolerate oral enteral nutrition;\n* Women who are pregnant or breastfeeding;\n* Participating in another clinical trial;\n* Deemed unsuitable for inclusion by the investigators.","ALL","18 Years",{"count":117,"type":118},62,"ESTIMATED","INTERVENTIONAL",[121],"NA","This is a prospective, randomized, multicenter study to evaluate WMT in improving nutritional status in malnourished patients who underwent nonphysiological reconstruction of the upper gastrointestinal tract. In this multicenter trial, sixty-two patients will be enrolled in forteen Chinese sites. Participants will be randomized at a ratio of 1:1 to receive three WMTs through either mid-gut tube or colonic TET. After WMT, each participant will receive free diet plus home enteral nutrition. Home enteral nutrition should last for 2 months at home, with blood, urine and stool samples taken and stored at baseline and 2 months after WMT.",[124,125],"Malnutrition","Gastroenterostomy",[20,127,128,129,130,131,132,133],"fecal microbiota transplant","malnutrition","enteral nutrition","cachexia","upper gastrointestinal rerouting surgery","delivery","nonphysiological reconstruction of the upper gastrointestinal tract","2025-07-06",{"date":136,"type":137},"2025-07-10","ACTUAL",{"date":139,"type":137},"2024-10-20",{"date":141,"type":118},"2025-10-31",{"name":5,"class":6},1]