[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100425766":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":33,"centralContacts":38,"locations":44,"responsibleParty":71,"collaborators":75,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":33,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":33,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":46,"whyStopped":33,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Vrije Universiteit Brussel","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental intervention","EXPERIMENTAL","10 weeks blended therapy delivered using a blended approach. The blended (online and on site) therapy consists of instructive video's, challenges to complete, 1-on-1 sessions with the therapist, online quizzes, online booklets, and online diaries\u002Fworkbooks. . The experimental group will receive a behavioral weight reduction program combined with pain neuroscience education plus cognition-targeted exercise therapy. The combined therapy will adhere to guidelines for patient-centered care",[13,14,15],"Behavioral: Pain Neuroscience Education","Behavioral: Cognition-targeted exercise therapy","Behavioral: Behavioral weight reduction program",{"label":17,"type":18,"description":19,"interventionNames":20},"Control intervention","ACTIVE_COMPARATOR","Identically to the experimental intervention, the therapy is provided in a blended format within 10 weeks. Also identical to the experimental intervention, the control intervention will adhere to guidelines for patient-centered care. The control group will receive pain neuroscience education in combination with cognition-targeted exercise therapy alone.",[13,14],[22,29,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"BEHAVIORAL","Pain Neuroscience Education","Increase pain coping skills and educating the patients that pain is in the brain, and that hypersensitivity of the central nervous system rather than local tissue damage contributes to their symptoms.",[17,9],[28],"Pain Education",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Cognition-targeted exercise therapy","Daily (physical) activity and exercise therapy. To confront the patient with movements and activities that are feared, avoided and\u002For painful using a gradual and cognition-targeted approach.",[17,9],null,{"type":23,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Behavioral weight reduction program","Changes in diet, behavior and a physical exercise to reach weight loss. It will include a lifestyle approach, incorporating behavioral theories and constructs to assist and facilitate healthy energy balance related behavior.",[9],[39],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},"Anneleen Malfliet, PhD","CONTACT","003224774503","anneleen.malfliet@vub.be",[45,58],{"facility":5,"status":46,"city":47,"state":33,"zip":33,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Brussels","Belgium","BE",{"type":51,"coordinates":52},"Point",[53,54],4.34878,50.85045,{"lat":54,"lon":53},[57],{"name":40,"role":41,"phone":33,"phoneExt":33,"email":43},{"facility":59,"status":46,"city":60,"state":33,"zip":33,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Rotterdam University of Applied Sciences","Rotterdam","Netherlands","NL",{"type":51,"coordinates":64},[65,66],4.47917,51.9225,{"lat":66,"lon":65},[69],{"name":70,"role":41,"phone":33,"phoneExt":33,"email":33},"Lennard Voogt, PhD",{"type":72,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"PRINCIPAL_INVESTIGATOR","Malfliet Anneleen","Prof. Dr. Anneleen Malfiet",[76],{"name":59,"class":6},"100425766","weight-reduction-in-clbp-100425766",false,"NCT04824248","Weight Reduction in CLBP","The Added Value of a Behavioral Weight Reduction Program to Blended Rehabilitation in Patients With Chronic Low Back Pain: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Overweight (BMI ≥ 25 kg\u002Fm2) or obese (BMI ≥ 30 kg\u002Fm2) with chronic low back pain\n* Non-specific low back pain for at least 3 months' duration\n* Currently seeking care for low back pain\n* Native Dutch speaker\n* Access to internet and computer\u002Ftablet\u002Fsmartphone\n\nExclusion Criteria:\n\n* Leg pain of 7 or higher (on a maximum of 10) on a numeric rating scale\n* Evidence of specific spinal pathology (e.g., hernia, spinal stenosis, spondylolisthesis, infection, spinal fracture or malignancy)\n* Evidence of a severe underlying comorbidity (e.g. diabetes, cardiovascular problems, metabolic diseases)\n* BMI ≥ 40 kg\u002Fm2\n* Being pregnant or given birth in the preceding year\n* Currently receiving dietary or exercise interventions","ALL","18 Years","65 Years",{"count":88,"type":89},84,"ESTIMATED","INTERVENTIONAL",[92],"NA","We will recruit overweight\u002F obese participants between the age of 18 and 65 with chronic nonspecific low back pain . The participants will be randomly assigned to one of two interventions (each lasting 10 weeks). All interventions will be delivered in a blended format and will be a combination of online education material and face-to-face sessions with a physical therapist. The first group (experimental intervention) will receive a behavioral weight reduction program combined with pain neuroscience education plus cognition-targeted exercise therapy. Participants in the second group (control intervention) will receive pain neuroscience education and cognition-targeted exercise therapy alone. Allocation to the groups will be at random. Participants and assessors will be blinded for group allocation. The primary outcomes is pain intensity. Secondary outcomes include other pain related outcomes, body composition, physical activity, sedentary behavior, dietary intake and function.",[95,96],"Chronic Low-back Pain","Overweight or Obesity",[98,99,100,101,102,103],"chronic low back pain","chronic pain","physiotherapy","physical therapy","weight reduction","pain management","2025-05-20",{"date":106,"type":107},"2025-05-25","ACTUAL",{"date":109,"type":107},"2025-05-01",{"date":111,"type":89},"2026-12-01",{"name":5,"class":6},2]