[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556735":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":22,"locations":28,"responsibleParty":44,"collaborators":46,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":17,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":30,"whyStopped":17,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"University of Delaware","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Western Diet","EXPERIMENTAL","Consumption of 10 days of a diet high in added sugars (25% of total caloric intake)",[13],"Other: Western Diet",[15],{"type":6,"name":9,"description":11,"armGroupLabels":16,"otherNames":17},[9],null,[19],{"name":20,"affiliation":5,"role":21},"Christopher Martens, Ph.D.","PRINCIPAL_INVESTIGATOR",[23],{"name":24,"role":25,"phone":26,"phoneExt":17,"email":27},"Kevin Decker, Ph.D.","CONTACT","(302) 831-8137","Deckerkp@udel.edu",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Newark","Delaware","19713","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-75.74966,39.68372,{"lat":40,"lon":39},[43],{"name":20,"role":25,"phone":17,"phoneExt":17,"email":17},{"type":45,"investigatorFullName":17,"investigatorTitle":17,"investigatorAffiliation":17,"oldNameTitle":17,"oldOrganization":17},"SPONSOR",[47],{"name":48,"class":49},"National Institute of General Medical Sciences (NIGMS)","NIH","100556735","western-diet-on-cardiometabolic-and-immune-function-100556735",false,"NCT06528977","Western Diet on Cardiometabolic and Immune Function","Effects of a 10-day Western Diet on Cardiometabolic and Immune Function in Midlife Adults","WD","Inclusion Criteria:\n\n* ability to provide informed consent\n* men and postmenopausal women aged 50-64 years\n* systolic blood pressure \\\u003C 130 mmHg; diastolic blood pressure \\\u003C 90 mmHg\n* body mass index (BMI) \\\u003C30 kg\u002Fm2 and % body fat \\\u003C 25% for men and \\\u003C 33% for women\n* fasting triglycerides \\\u003C 200 mg\u002Fdl (\\\u003C 2.3 mmol\u002FL)\n* low density lipoprotein (LDL) cholesterol \\\u003C160 mg\u002Fdl (4.14 mmol\u002FL)\n* fasting plasma glucose \\\u003C126 mg\u002Fdl (\\\u003C7.0 mmol\u002FL)\n* weight stable in the prior 6 months (≤ 2 kg weight change)\n* blood chemistries indicative of normal liver enzymes and renal function (estimated glomerular filtration rate using the Modification of Diet in Renal Disease (MDRD) prediction equation must be \\>60 ml\u002Fmin\u002F1.73 m\\^2)\n\nExclusion Criteria:\n\n* current use of medications or supplements known to lower blood triglycerides or cholesterol (e.g., fibrates, statins, high dose niacin, high dose omega-3 supplement)\n* chronic clinical diseases (e.g., coronary artery\u002Fperipheral artery\u002Fcerebrovascular diseases, heart failure, diabetes, chronic kidney disease requiring dialysis, neurological or autoimmune conditions affecting cognition (e.g. Alzheimer's disease or other forms of dementia, Parkinson's disease, epilepsy, multiple sclerosis, large vessel infarct)\n* major psychiatric disorder (e.g. schizophrenia, bipolar disorder)\n* current or past (i.e., last 3 months) use of anti-hypertensive or other cardiovascular-acting medications known to influence vascular function and\u002For arterial stiffness\n* current medication use likely to affect central nervous system (CNS) functions (e.g. long active benzodiazepines)\n* concussion within last 2 years and ≥ 3 lifetime concussions\n* heavy alcohol consumption (≥8 drinks\u002Fweek for women and ≥15 drinks\u002Fweek for men)\n* recent major change in health status within the previous 6 months (i.e., surgery, significant infection, or illness)\n* current smoking within the past 3 months.",true,"ALL","50 Years","64 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","This study will implement a Western Diet (WD) to understand cardiometabolic and immune function in middle-aged adults (50- 64 years old). Vascular health, intestinal permeability, and T-cell function will be examined before, during, and after the WD. The WD is a 10-day diet and will consist of 25% of total energy from added sugars.",[70,71],"Aging","Diet, Healthy",[73,74,75,76,77],"added sugars","western diet","cardiometabolic health","T-cell function","intestinal permeability","2024-07-29",{"date":80,"type":81},"2024-07-30","ACTUAL",{"date":83,"type":81},"2024-07-17",{"date":85,"type":64},"2027-07",{"name":5,"class":6},1]