[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535657":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":27,"collaborators":10,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":33,"sex":38,"minAge":39,"maxAge":40,"enrollmentInfo":41,"targetDuration":10,"studyType":44,"phases":10,"briefSummary":45,"conditions":46,"keywords":10,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":53,"completionDateStruct":55,"leadSponsor":57,"locationsCount":10},{"fullName":5,"class":6},"Western Sydney Local Health District","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Acute tubular injury (ATI) only",null,"Kidney biopsy with features of acute tubular injury only, no other pathology detected",[13],"Other: Retrospective review of histological features",{"label":15,"type":10,"description":16,"interventionNames":17},"Concurrent diagnosis of acute tubular injury with any other pathology","Kidney biopsy with features of acute tubular injury AND other pathology. Non-ATI pathology includes but not limited to diagnosis of any type of glomerulonephritis, vasculitis, hereditary nephritis, thrombotic microangiopathy, kidney transplant rejection, podocytopathy, diabetic or hypertensive nephropathy, interstitial nephritis, pyelonephritis, amyloidosis, malignancy or paraneoplastic related kidney disease.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Biopsies with no acute tubular injury (neg control)","Kidney biopsy with any diagnosis other than (no features of) acute tubular injury",[13],[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"Retrospective review of histological features","Correlate histopathology characteristics of acute kidney injury with molecular signatures, kidney function and aetiology of acute kidney injury to derive clinically validated scoring system for acute kidney injury and acute tubular injury",[9,19,15],{"type":28,"investigatorFullName":29,"investigatorTitle":30,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Jennifer Li","CPI, Nephrologist and Transplant Physician","100535657","western-sydney-kidney-injury-biopsy-study-100535657",false,"NCT06254677","Western Sydney Kidney Injury Biopsy Study","WESTKiD","Inclusion Criteria:\n\n1. Had a kidney biopsy (native kidney or transplant kidney included) after year 2000\n2. Kidney biopsy sample sent to Westmead Hospital for clinical interpretation\n\nExclusion Criteria:\n\n1. Patients who have never had a kidney biopsy performed\n2. Biopsy sample not available at Westmead Hospital\n3. No information on kidney function (serum creatinine or eGFR)","ALL","18 Years","80 Years",{"count":42,"type":43},1000,"ESTIMATED","OBSERVATIONAL","The investigators aim to develop a clinically validated, histological acute tubular injury (ATI) scoring system to help improve diagnostic precision and predict clinical outcomes following ATI.\n\nTo use an unbiased, data-driven approach, correlating pathological features (including digital pathology), key signatures using spatial technologies (transcriptomics or proteinomics) with relevant clinical outcomes. Spatial technologies (including spatial transcriptomics and spatial proteinomics) allow the use of 'precision pathology' to study the critical link between molecular characteristics to histological structure.",[47],"Kidney Injury","NOT_YET_RECRUITING","2024-04-22",{"date":51,"type":52},"2024-04-24","ACTUAL",{"date":54,"type":43},"2024-05-01",{"date":56,"type":43},"2040-01-01",{"name":5,"class":6}]