[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640355":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":21,"responsibleParty":37,"collaborators":7,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":23,"whyStopped":7,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Westlake University","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Ju-Sheng Zheng, PhD","PRINCIPAL_INVESTIGATOR",[13,17],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},"CONTACT","86-0571-86915303","zhengjusheng@westlake.edu.cn",{"name":18,"role":14,"phone":19,"phoneExt":7,"email":20},"Jiang-Hua Zhang, Bachelor","86-18258119536","zhangjianghua@westlake.edu.cn",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Hangzhou","Zhejiang","310024","China","CN",{"type":30,"coordinates":31},"Point",[32,33],120.16142,30.29365,{"lat":33,"lon":32},[36],{"name":10,"role":14,"phone":15,"phoneExt":7,"email":16},{"type":38,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100640355","westlake-frequent-sampling-cohort-2-100640355",false,"NCT07606885","Westlake Frequent-sampling Cohort 2","WeF2","Inclusion Criteria:\n\n* Participants reside in Hangzhou\n\nExclusion Criteria:\n\n* Refusing or unable to give informed consent\n* Participants with chronic gastrointestinal diseases and take daily relevant medications\n* Participants with metabolic diseases including diabetes, hypertension and cardiovascular diseases (CVD)\n* Participants with craniocerebral trauma, cancer, liver disease, kidney disease, or other critical illness, or history of operation or medication\n* Participants with bulimia nervosa, post-traumatic stress disorder (PTSD), chronic anxiety and depression or other critical neuronal disorder or history of relevant medication\n* Being or to be pregnant or lactating.\n* Participants with history of alcohol or drug addiction, or smoke above 15 cigarettes per day\n* Concurrently participating other clinical trials.",true,"ALL","18 Years","40 Years",{"count":51,"type":52},20,"ESTIMATED","OBSERVATIONAL","This observational follow-up study extends a previously completed 15-day intensive longitudinal study (WeF) of the gut microbiome in healthy adults. The objective of WeF2 is to characterize the long-term stability and dynamics of the gut and oral microbiota in the same cohort across multiple timescales, and to determine whether the day-to-day variability patterns observed at baseline persist over months and years. Participants who completed the WeF baseline protocol will be invited to attend periodic follow-up visits for low-frequency biospecimen collection and to repeat the original 15-day high-frequency sampling protocol at planned intervals, beginning approximately six months after the WeF baseline and continuing at extended intervals thereafter. By combining sparse routine sampling with recurring high-density sampling windows, the study aims to distinguish the stable core microbiome from transient and seasonal fluctuations, to track gradual community shifts under free-living conditions, and to further explore relationships among microbiome dynamics, dietary intake, and host glycemic regulation over an extended observation period.",[56,57],"Health Adults","Stability of Microbiome",[59],"Microbiome","2026-05-19",{"date":62,"type":63},"2026-05-26","ACTUAL",{"date":65,"type":52},"2026-05-08",{"date":67,"type":52},"2030-12-31",{"name":5,"class":6},1]