[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632041":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":50,"locations":33,"responsibleParty":57,"collaborators":33,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":62,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":33,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":83,"overallStatus":93,"whyStopped":33,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":33},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Group (Group A)","ACTIVE_COMPARATOR","Group A (Control Group): Patients will receive selected physical therapy treatment, 3 sessions per week for 8 weeks. The session will contain:\n\n* Strength resistance training:\n\nCore strengthening, Squat \\& set up, sit to stand exercise, calf raises \\& squats, Seated leg ex, Straight leg raising exercise, clamshell, Dorsi flexion exercise, Quad set - Stretching \\& flexibility: Stretch for lower limb (Hamstring, Calf)\n\n\\- Balance training: Single leg stance (Stable surface then unstable one), Gait training with obstacles \\& alternating speed \\& different directions (side steps, steps over cones), Balane board.",[13],"Other: Traditional exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Study Group (Group B)","EXPERIMENTAL","Group B (Study Group): Patients will receive the same selected physical therapy as in group (A) in addition to 15 min of Whole-body vibration therapy 3 sessions per week for 8 weeks, as follow:\n\n* Duration: about 15 minutes per session\n* Vibration Frequency: 18-40 Hz (starting at lower frequency and progressing)\n* Position: Standing on the platform with slight knee flexion to activate muscles, progressing to squats and dynamic movements over time. The patient may start standing.\n* Progression Plan:\n* Weeks 1-2: Low frequency (18-25 Hz) for short intervals\n* Weeks 3-5: Increase frequency to (25-35 Hz) with longer intervals\n* Weeks 6-8: Progress to higher frequency (35-40 Hz) with the introduction of additional balance exercises while on the platform (e.g., squats, heel raises).",[19,13],"Device: Whole Body Vibration",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Whole Body Vibration","15 min of Whole-body vibration therapy 3 sessions per week for 8 weeks, as follow: 24\n\n* Duration: about 15 minutes per session\n* Vibration Frequency: 18-40 Hz (starting at lower frequency and progressing)\n* Position: Standing on the platform with slight knee flexion to activate muscles, progressing to squats and dynamic movements over time. The patient may start standing.\n* Progression Plan:\n* Weeks 1-2: Low frequency (18-25 Hz) for short intervals\n* Weeks 3-5: Increase frequency to (25-35 Hz) with longer intervals\n* Weeks 6-8: Progress to higher frequency (35-40 Hz) with the introduction of additional balance exercises while on the platform (e.g., squats, heel raises).",[15],[27,28],"Whole-Body Vibration","WBV",{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Traditional exercise","-Strength resistive training: Core strengthening, Squat \\& set up, sit to stand exercise, calf raises \\& squats, Seated leg ex, Straight leg raising exercise, clamshell, Dorsi flexion exercise, Quad set\n\n-Stretching \\& flexibility: Stretch for lower limb (Hamstring, Calf)\n\n\\- Balance training: Single leg stance (Stable surface then unstable one), Gait training with obstacles \\& alternating speed \\& different directions (side steps, steps over cones), Balane board.",[9,15],null,[35,39,43,47],{"name":36,"affiliation":37,"role":38},"Bothina Sayed Mohamed, Bachelor's Degree","Physical Therapist at Department of clinical oncology and nuclear medicine, Cairo university Hospitals (Kasr El-Einy); Bachelor's Degree from Faculty of Physical Therapy, Cairo University","PRINCIPAL_INVESTIGATOR",{"name":40,"affiliation":41,"role":42},"Mohamed Abd El-Rahman Hassan, Professor of Clinical Oncology","Professor of Clinical Oncology, Department of clinical oncology and nuclear medicine, Faculty of Medicine, Kasr El-Einy, Cairo University.","STUDY_DIRECTOR",{"name":44,"affiliation":45,"role":46},"Nahed Ahmed Salem, Professor of Physical Therapy","Professor of Physical Therapy for Neurology and Neurosurgery, Faculty of Physical Therapy, Cairo University","STUDY_CHAIR",{"name":48,"affiliation":49,"role":42},"Mohamed Helayel Marzouk, Lecture of Physical Therapy","Lecture of Physical Therapy for Neurology and Neurosurgery, Faculty of Physical Therapy, Cairo University",[51],{"name":52,"role":53,"phone":54,"phoneExt":55,"email":56},"Bothina Sayed Mohamed Sayed, Bachelor's Degree","CONTACT","01016108245","01143077366","1300153@st.pt.cu.edu.eg",{"type":38,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Bothina Sayed Mohamed Sayed","Principle investigator, Physical Therapist at Cairo University Hospitals (Kasr El-Einy) Center of Radiation Oncology and Nuclear Medicine; Bachelor's Degree from Faculty of Physical Therapy, Cairo University","100632041","whole-body-vibration-on-balance-risk-of-falling-and-quality-of-life-in-chemotherapy-induced-peripheral-neuropathy-100632041",false,"NCT07508527","Whole-Body Vibration on Balance, Risk of Falling and Quality of Life in Chemotherapy-Induced Peripheral Neuropathy","Effect of Whole Body Vibration on Balance, Risk of Falling, and Quality of Life in Patients With Chemotherapy Induced Peripheral Neuropathy","WBV\u002FQOL\u002FCIPN","Inclusion Criteria:\n\n* 30 patients diagnosed with chemotherapy-induced peripheral neuropathy from both genders.\n* Their ages will range from 30-60 years old.\n* All patients included in this study will be on chemotherapy from at least one cycle as a treatment of malignant tumor.\n* The patients will be mild to moderate neuropathy according to mTNS.\n* They were medically stable.\n\nExclusion Criteria:\n\n* History of other types of neuropathies (i.e., hereditry peripheral neuropathy associated with nutritional agents and paraneoplastic syndrome-related neuropathy…etc).\n* Unstable medical condition during chemotherapy\n* Patients who are starting new therapy or dose modification during study period\n* Morbid obesity body mass index \\>40%\n* History of non-surgically repaired nerve compression injuries such as carpal tunnel, brachial plexopathy, spinal stenosis, and spinal nerve root compression\n* History of central nervous system primary or metastatic malignancy.","ALL","30 Years","60 Years",{"count":72,"type":73},30,"ESTIMATED","INTERVENTIONAL",[76],"NA","The goal of this clinical trial is to evaluate the efficacy of Whole-body vibration in improving postural control, risk of falling, and quality of life in patients with chemotherapy-induced peripheral neuropathy. The main questions it aims to answer are:\n\nDoes Whole-body vibration have a significant effect on postural control, risk of falling, and quality of life in patients with chemotherapy-induced peripheral neuropathy?\n\nResearchers will compare whole body vibration in addition to traditional exercise to traditional exercise alone to see if Whole-body vibration have a significant effect on postural control, risk of falling, and quality of life in patients with chemotherapy-induced peripheral neuropathy.\n\nParticipants will:\n\n* age between 30-60 years old.\n* be on chemotherapy for at least one cycle as a treatment of malignant tumors with peripheral neuropathy.\n* have mild to moderate neuropathy according to mTNS.\n* be assigned randomly into two equal groups (control group (A) and study group (B)).\n* Take three sessions per week for eight weeks.\n* The control group (A) will be treated by selected physical therapy treatment (Strength resistive training, Stretching \\& flexibility, Balance training)\n* The study group (B) will be treated with selected physical therapy treatment in addition to whole-body vibration therapy.",[23,79,80,81,82],"Chemotherapy Induced Peripheral Neuropathy (CIPN)","Fall Risk, Fall Prevention","Balance","Quality of Life",[28,84,85,86,81,87,88,89,90,91,92],"Whole body vibration","CIPN","Chemotherapy induced peripheral neuropathy","Risk of fall","falling","postural control","fall","QOL","Quality of life","NOT_YET_RECRUITING","2026-03-31",{"date":96,"type":97},"2026-04-02","ACTUAL",{"date":99,"type":73},"2026-04",{"date":101,"type":73},"2027-06",{"name":5,"class":6}]