[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100153436":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":36,"centralContacts":40,"locations":45,"responsibleParty":64,"collaborators":66,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":28,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":28,"enrollmentInfo":79,"targetDuration":28,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":28,"overallStatus":48,"whyStopped":28,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"M.D. Anderson Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Diagnostic (widefield multispectral imaging and HRME)","EXPERIMENTAL","Patients undergo evaluation of oral cavity using a widefield multispectral imaging device and a high-resolution optical system (HRME) at baseline, after induction of general anesthesia, and prior to surgery.",[13,14,15],"Procedure: High-Resolution Microendoscopy","Procedure: Multispectral Imaging","Drug: Proflavine",[17,24,29],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","High-Resolution Microendoscopy","Undergo evaluation of oral lesions using a high-resolution microendoscope",[9],[23],"HRME",{"type":18,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"Multispectral Imaging","Undergo evaluation of oral cavity using a widefield multispectral imaging",[9],null,{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DRUG","Proflavine","Proflavine) used to stain the mouth tissue after initial imaging.",[9],[35],"Proflavine hemisulfate",[37],{"name":38,"affiliation":5,"role":39},"Ann Gillenwater","PRINCIPAL_INVESTIGATOR",[41],{"name":38,"role":42,"phone":43,"phoneExt":28,"email":44},"CONTACT","713-792-8841","agillenw@mdanderson.org",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"M D Anderson Cancer Center","RECRUITING","Houston","Texas","77030","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-95.36327,29.76328,{"lat":58,"lon":57},[61,63],{"name":62,"role":42,"phone":43,"phoneExt":28,"email":28},"Ann M. Gillenwater",{"name":62,"role":39,"phone":28,"phoneExt":28,"email":28},{"type":65,"investigatorFullName":28,"investigatorTitle":28,"investigatorAffiliation":28,"oldNameTitle":28,"oldOrganization":28},"SPONSOR",[67],{"name":68,"class":69},"National Cancer Institute (NCI)","NIH","100153436","wide-field-and-high-resolution-in-vivo-imaging-in-visualizing-lesions-in-patients-with-oral-neoplasia-undergoing-surgery-100153436",false,"NCT01269190","Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery","Wide-Field and High Resolution In Vivo Imaging of Oral Neoplasia Using Topical Fluorescent Dyes: A Feasibility Study","Inclusion Criteria:\n\n* Adult subjects with oral lesions undergoing surgical resection (i.e., only patients who are scheduled to undergo a surgery of the head \\& neck area to remove or biopsy oral lesions will be eligible to participate in the study); patients with previous treatment are eligible\n* Ability to understand and the willingness to sign a written informed consent document (ICD)\n\nExclusion Criteria:\n\n* Known allergy to proflavine or acriflavine\n* Pregnant or nursing females\n* The participant will be excluded from participation in another clinical research trial (i.e., a trial in which an agent is actively administered to the study subject), while being imaged (on active treatment) on this protocol","ALL","18 Years",{"count":80,"type":81},275,"ESTIMATED","INTERVENTIONAL",[84],"NA","This clinical trial studies wide-field and high resolution in vivo imaging in visualizing lesions in patients with abnormal or uncontrolled oral cell growth (neoplasia) undergoing surgery. Diagnostic procedures, such as wide-field and high resolution in vivo imaging, are devices that let researchers look at a wide area of the lining of the mouth by shining different colors inside the mouth and taking pictures and this may help doctors to decide if a mouth lesion has a high risk of being pre-cancerous or cancerous.",[87],"Oral Cavity Neoplasm","2026-02-09",{"date":90,"type":91},"2026-02-11","ACTUAL",{"date":93,"type":91},"2010-12-30",{"date":95,"type":81},"2028-12-31",{"name":5,"class":6},1]