[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627373":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":64,"collaborators":25,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":25,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":86,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Low dose RRT","ACTIVE_COMPARATOR","dose of CRRT 10-15ml\u002Fkg\u002Fhr",[13],"Procedure: low intensity of CRRT",{"label":15,"type":10,"description":16,"interventionNames":17},"standard dose RRT","usual intensity CRRT at dose determined by clinical team",[18],"Procedure: usual intensity of CRRT",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","low intensity of CRRT","usual intensity CRRT",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"usual intensity of CRRT","usual intensity",[15],[31],{"name":32,"affiliation":33,"role":34},"Gillian Radcliffe","Guy's & St. Thomas Hospital","STUDY_CHAIR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Marlies Ostermann, PhD","CONTACT","+442071883036","m.ostermann@nhs.net",{"name":32,"role":38,"phone":42,"phoneExt":25,"email":43},"00442071883036","gill.radcliffe@nhs.net",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Guy's & St Thomas' Hospital","RECRUITING","London","Greater London","SE1 7EH","United Kingdom","UK",{"type":54,"coordinates":55},"Point",[56,57],-0.12574,51.50853,{"lat":57,"lon":56},[60],{"name":61,"role":38,"phone":62,"phoneExt":25,"email":63},"Marlies Ostermann","07742514213","Marlies.Ostermann@gstt.nhs.uk",{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100627373","wisdom-uk-low-dose-intensity-versus-standard-dose-intensity-crrt-in-critically-ill-patients-100627373",false,"NCT07447791","WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity CRRT in Critically Ill Patients","WISDOM UK: Low Dose-intensity Versus Standard Dose-intensity Continuous Renal Replacement Therapy in Critically Ill Patients: a Randomized Trial","WISDOM UK","Inclusion Criteria:\n\n* age ≥ 18 years\n* patient weight ≥ 55 kg\n* plan to start CRRT or within 24 hours of having started CRRT for AKI\n* expected to survive and receive CRRT for a duration of ≥ 48 hours\n\nExclusion Criteria:\n\n* indication for sustained higher dose-intensity CRRT\n* end-stage kidney disease receiving maintenance dialysis\n* previous receipt of RRT for AKI during the current hospitalization\n* inability to comply with the requirements of the study protocol","ALL","18 Years",{"count":77,"type":78},20,"ESTIMATED","INTERVENTIONAL",[81],"NA","Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy. Renal replacement therapy is a treatment that removes toxins and excess fluid from the blood stream. It consists of having a small plastic catheter in a vein in the neck or in the groin through which blood flows through a dialysis machine and is cleansed and excess water is removed. The cleansed blood is then returned to the patient via the same catheter.\n\nOne of the major areas of uncertainty for doctors in the ICU is \"What is the right intensity of renal replacement therapy for patients with acute kidney injury?\" A higher intensity indeed removes more toxins but also removes other substances in the blood, including vitamins, nutrients and important medications. The current usual dose is around 25 ml\u002Fkg\u002Fhr but clinical practice in the UK is very variable and some patients routinely receive higher doses and some get lower doses. Data from large databases worldwide have suggested that a lower dose is safe and effective and may potentially allow the kidneys to recover faster but confirmation is lacking.\n\nIn this study, the investigators investigate whether renal replacement therapy at a lower intensity is as effective and safe as currently used doses. Participants will be randomised to receiving renal replacement therapy at usual or lower intensity. There will be no change to any other aspects of treatment.\n\nThe results will inform the investigators whether the study protocol is feasible and how best to design a future larger research study.",[84,85],"Acute Kidney Injury (Nontraumatic)","Dialysis; Complications",[87,88,89],"renal replacement therapy","dose","acute kidney injury","2026-03-03",{"date":92,"type":93},"2026-03-05","ACTUAL",{"date":95,"type":93},"2025-02-15",{"date":97,"type":78},"2027-03-30",{"name":5,"class":6},1]