[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621558":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":36,"responsibleParty":58,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":10,"studyType":78,"phases":10,"briefSummary":79,"conditions":80,"keywords":10,"overallStatus":86,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Marquette University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Smokers",null,"Subjects are qualified as smokers if they report smoking ≥10 cigarettes\u002Fday for ≥5 years, and maintain a 8ppm carbon monoxide concentration or higher via smokerlyzer test.",[13],"Other: observational study",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-smokers","Subjects qualify as nonsmokers if they have never smoked and upon confirmation by the smokerlyzer test of carbon monoxide concentation of less than 8ppm.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"observational study","Observational study; alveolar ridge preservation",[15,9],[24],{"name":25,"affiliation":5,"role":26},"Vrisiis Kofina, DDS, MS","PRINCIPAL_INVESTIGATOR",[28,32],{"name":25,"role":29,"phone":30,"phoneExt":10,"email":31},"CONTACT","516-817-0393","vrisiis.kofina@marquette.edu",{"name":33,"role":29,"phone":34,"phoneExt":10,"email":35},"McKenna Schnack, DDS, MS","515-822-3552","mckenna.schnack@marquette.edu",[37],{"facility":38,"status":10,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Marquette University School of Dentistry Graduate Periodontics Clinic","Milwaukee","Wisconsin","53233","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-87.90647,43.0389,{"lat":48,"lon":47},[51,53,57],{"name":25,"role":29,"phone":52,"phoneExt":10,"email":31},"4142886521",{"name":54,"role":29,"phone":55,"phoneExt":10,"email":56},"Arndt Guentsch, DMD, PhD, MHBA, MS","4142886089","arndt.guentsch@marquette.edu",{"name":25,"role":26,"phone":10,"phoneExt":10,"email":10},{"type":26,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Vrisiis Kofina","Director, Advanced Education in Periodontics Program, Assistant Professor of Periodontics",[62],{"name":63,"class":64},"LifeNet Health","INDUSTRY","100621558","wound-healing-following-extraction-and-ridge-preservation-in-smokers-and-non-smokers-100621558",false,"NCT07372183","Wound Healing Following Extraction and Ridge Preservation in Smokers and Non-smokers","Inclusion Criteria:\n\n* Adult patients (18-75 years)\n* Good general health (controlled conditions)\n* Smokers (≥10 cigarettes\u002Fday for ≥5 years) and never smokers. Confirmation of smoking status will be done via use of a smokerlyzer. The cut-off point for distinguishing smokers from non-smokers is 8 carbon monoxide parts per million (ppm).\n* Periodontal status: periodontal health, gingivitis on intact or reduced periodontium, treated periodontitis\n* Intact post-extraction bony walls or less than 50% bone dehiscence\n* Distance at least 8 mm of vertical bone height between bone crest and anatomical structures (i.e. sinus floor, inferior alveolar nerve (IAN) canal, mental foramen)\n* Extracted tooth root in the same three-dimensional position as the future implant placement so that the bone core biopsy can be taken from a site totally within the confines of the former tooth socket without inclusion of surrounding native alveolar bone\n* Scheduled for single tooth extraction with bone graft placement and membrane\n\nExclusion Criteria:\n\n* Uncontrolled periodontal disease\n* Uncontrolled systemic disease\n* Pregnancy\n* Use of therapy and\u002For medication that impairs wound healing (e.g., bisphosphonates, steroids, chemotherapy, radiotherapy etc.)",true,"ALL","18 Years","75 Years",{"count":76,"type":77},12,"ESTIMATED","OBSERVATIONAL","The goal of this study is to evaluate bone wound healing following extraction and alveolar ridge preservation (bone graft and membrane) clinically, histologically and in relation to gene expression in smokers and non-smokers. Data from a small group of participants will be analyzed after age-matched subjects undergo extraction and alveolar ridge preservation prior to implant placement. The data obtained in this pilot study will be used to plan a full-fledged study involving a larger number of smoking and non-smoking participants to compare the two groups.",[81,82,83,84,85],"Smoking, Cigarette","Alveolar Bone Grafting","Wound Healing","Bone Healing","Tooth Extraction Site Healing","NOT_YET_RECRUITING","2026-01-20",{"date":89,"type":90},"2026-01-28","ACTUAL",{"date":92,"type":77},"2026-01-25",{"date":94,"type":77},"2028-10-01",{"name":5,"class":6},1]