[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464423":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":48,"responsibleParty":71,"collaborators":70,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":70,"enrollmentInfo":83,"targetDuration":70,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":50,"whyStopped":70,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"VA Office of Research and Development","FED",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Written Exposure Therapy","EXPERIMENTAL","Written Exposure Therapy (WET) plus Treatment As Usual (TAU). WET is a 5 session, evidence-based trauma-focused written narrative exposure treatment. At each session, patients are instructed to write about the same trauma event and therapists provide feedback about adherence and offer suggestions. The first session includes psychoeducation about PTSD and a treatment rationale prior to general trauma narrative writing instructions, and specific instructions for completing the first writing session, before completing the first writing (30 minutes) session. Participants are instructed to write about the same trauma event at each following session, with an emphasis on delving into their deepest emotions and thoughts, in as much detail as possible, about the event. All writing sessions begin with specific instructions from the therapist followed by 30 minutes of writing by the participant.",[13],"Behavioral: Written Exposure Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Neutral Topic Writing","ACTIVE_COMPARATOR","Treatment As Usual (TAU) augmented by a neutral topic writing condition. The neutral topic writing condition involves writing about an assigned topic during each of the five writing sessions. As opposed to writing about trauma, the specific focus of this condition is on writing for 30 minutes about topics related to their life without writing about emotions or opinions. Rather, they are asked to write about specific objects or events in detail, as accurately as possible, and with as much description as possible. All writing sessions begin with specific instructions from the therapist followed by 30 minutes of writing by the participant.",[19],"Behavioral: Neutral Topic Writing",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Written Exposure Therapy is a 5 session treatment in which individuals write about their trauma event in a specified manner.",[9],[26],"Trauma-focused Treatment",{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":30},"Treatment as Usual augmented by 5 sessions of Neutral Topic Writing which involves writing about specific objects (e.g., what they have eaten over the past week) or events (e.g., what they did since yesterday) in detail without discussing thoughts or feelings.",[15],[31],"Control Writing",[33],{"name":34,"affiliation":35,"role":36},"Sarah Meshberg-Cohen, PhD MS BS","VA Connecticut Healthcare System West Haven Campus, West Haven, CT","PRINCIPAL_INVESTIGATOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Vera Bici, BA","CONTACT","(203) 932-5711","15448","Vera.Bici@va.gov",{"name":45,"role":40,"phone":41,"phoneExt":46,"email":47},"Amanda O'Brien, MA","1-4841","amanda.obrien3@va.gov",[49],{"facility":35,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"RECRUITING","West Haven","Connecticut","06516-2770","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-72.94705,41.27065,{"lat":60,"lon":59},[63,65,69],{"name":45,"role":40,"phone":64,"phoneExt":46,"email":47},"203-932-5711",{"name":66,"role":40,"phone":41,"phoneExt":67,"email":68},"Diana DeNegre","5217","diana.denegre@yale.edu",{"name":34,"role":36,"phone":70,"phoneExt":70,"email":70},null,{"type":72,"investigatorFullName":70,"investigatorTitle":70,"investigatorAffiliation":70,"oldNameTitle":70,"oldOrganization":70},"SPONSOR","100464423","written-exposure-therapy-for-veterans-with-sud-and-ptsd-100464423",false,"NCT05327504","Written Exposure Therapy for Veterans With SUD and PTSD","Written Exposure Therapy (WET) as a Brief Trauma Treatment for Veterans With Co-occurring Substance Use Disorders and PTSD","WET","Inclusion Criteria:\n\n* Veterans ages 18 years old or older;\n* Meets DSM-5 criteria for at least one substance use disorder (SUD);\n* Meets DSM-5 criteria for PTSD;\n* Approved for SUD treatment at VA Connecticut Healthcare System.\n\nExclusion Criteria:\n\n* Veterans who meet current criteria for schizophrenia, schizophrenia-type disorders, or unmedicated mania or bipolar disorder as determined by QuickSCID-5;\n* current suicidal or homicidal risks necessitating a higher level of care;\n* Veterans who have received an Evidence-Based Psychotherapy for PTSD protocol within the past 6 months;\n* Problems that would prevent a participant from completing the writing intervention or study assessments (e.g., illiteracy). To assess for literacy, participants will read parts of the consent out loud.","ALL","18 Years",{"count":84,"type":85},170,"ESTIMATED","INTERVENTIONAL",[88],"NA","The proposed project will evaluate the efficacy of written exposure therapy (WET) among Veterans engaged in substance use disorder (SUD) treatment, who present with co-occurring posttraumatic stress disorder (PTSD). While SUD treatment programs traditionally do not address PTSD, effective trauma treatments have been used successfully among those with substance use comorbidities. WET is a brief trauma-focused intervention shown to effectively treat PTSD. In a recent acceptability and feasibility pilot study among Veterans with co-occurring SUD and PTSD, results showed a decrease in PTSD symptoms among participants receiving WET. The goal of the present study is to improve outcomes for Veterans who present for SUD treatment with comorbid SUD\u002FPTSD.",[91,92],"Substance Use Disorders","Posttraumatic Stress Disorder",[94,95,96,97,98],"Addiction","Trauma and Stress Related Disorders","Substance Use Disorder","PTSD","Comorbidity","2026-02-17",{"date":101,"type":102},"2026-02-19","ACTUAL",{"date":104,"type":102},"2022-09-26",{"date":106,"type":85},"2027-06-30",{"name":5,"class":6},1]