[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633999":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":30,"responsibleParty":57,"collaborators":61,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":19,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":19,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":86,"whyStopped":19,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Western University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Hyperpolarized Xenon MRI","EXPERIMENTAL","Participants will undergo pulmonary function tests, 129 Xenon MRI at the visit.",[13],"Device: Hyperpolarized Xenon MRI",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Hyperpolarized noble gas imaging using Xenon-129 has been used to explore structural and functional relationships in the lung in patients with lung disease and healthy controls. In contrast to proton-based MRI imaging, 129Xe gas is used as a contrast agent to directly visualize the airways, and thus ventilation. Whereas the normal density of gas is too low to produce an easily detectable signal, this is overcome by artificially increasing the amount of polarization per unit volume using optical pumping.",[9],null,[21,27],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},"Hana Serajeddini, MD, FRCPC","CONTACT","(519) 646-6100","66288","hana.serajeddini@lhsc.on.ca",{"name":28,"role":23,"phone":19,"phoneExt":19,"email":29},"Tommy Li, Msc","zli3569@uwo.ca",[31],{"facility":32,"status":19,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"St Joseph's Healthcare London","London","Ontario","N6A 4V2","Canada","CA",{"type":39,"coordinates":40},"Point",[41,42],-81.23304,42.98339,{"lat":42,"lon":41},[45,46,48,50,52,55],{"name":22,"role":23,"phone":24,"phoneExt":25,"email":26},{"name":47,"role":23,"phone":19,"phoneExt":19,"email":29},"Tommy Li",{"name":22,"role":49,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"name":51,"role":49,"phone":19,"phoneExt":19,"email":19},"Alexei Ouriadov, PhD",{"name":53,"role":54,"phone":19,"phoneExt":19,"email":19},"Anurag Bhalla, MD, FRCPC","SUB_INVESTIGATOR",{"name":56,"role":54,"phone":19,"phoneExt":19,"email":19},"Grace Parraga, PhD",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Alexei Ouriadov","PhD, professor, scientist",[62],{"name":63,"class":6},"St. Joseph's Health Care London","100633999","xexenon-mri-program-100633999",false,"NCT07533981","¹²⁹Xe(XENON) MRI Program","HARDWARE AND SOFTWARE DEVELOPMENT FOR PULMONARY MAGNETIC RESONANCE IMAGING USING INHALED INERT HYPERPOLARIZED ¹²⁹XENON GAS","Inclusion Criteria:\n\n* Patient understands study procedures and is willing to participate in the study as indicated by the patient's signature.\n* Provision of written, informed consent prior to any study specific procedures.\n* Males and females aged 18 to 85 years.\n* Participant must be able to perform a breath-hold for 16s.\n* Participant has a BMI between 18 and 40\n* Participant must be able to perform reproducible pulmonary function tests (i.e., the 3 best acceptable spirograms have forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater)\n* Participants are judged to be in stable health on the basis of medical history\n\nExclusion Criteria:\n\n* Patient has an MR incompatible implanted mechanically, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and\u002For ear implants) (at the discretion of the MRI Technologist).\n* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI or CT, such as severe claustrophobia.\n* Participants who are pregnant, breastfeeding or have a positive pregnancy test at initial screening visit.\n* Participant is unable to perform spirometry maneuvers.\n* Participant is unable to perform MRI and CT breath-hold maneuvers.\n* Participant has a history of chronic or acute respiratory disease\n* FEV1 \\\u003C70%\n* Participant has a history of cardiovascular disorders including coronary insufficiency, cardiac arrhythmias, severe hypertension (≥160 over ≥100)\n* Participant has a daytime room air oxygen saturation ≤ 92% ± 2% while supine",true,"ALL","18 Years","85 Years",{"count":76,"type":77},200,"ESTIMATED","INTERVENTIONAL",[80],"NA","Healthy volunteers aged 18 to 85 will undergo hyperpolarized Xenon-129 (¹²⁹Xe) MRI and pulmonary function testing. The study aims to develop evaluation tools for ventilation defect percent (VDP), signal-to-noise and contrast-to-noise ratios (SNR\u002FCNR) of ¹²⁹Xe dissolved-phase images, and spectroscopy-based analysis.",[83],"Healthy Volunteers - Male and Female",[85],"129 Xe MRI","NOT_YET_RECRUITING","2026-04-13",{"date":89,"type":90},"2026-04-16","ACTUAL",{"date":92,"type":77},"2026-07-01",{"date":94,"type":77},"2031-04-30",{"name":59,"class":6},1]