[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634808":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":19,"centralContacts":28,"locations":34,"responsibleParty":176,"collaborators":178,"id":205,"slug":206,"hasResults":207,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":213,"sex":214,"minAge":215,"maxAge":216,"enrollmentInfo":217,"targetDuration":19,"studyType":220,"phases":221,"briefSummary":223,"conditions":224,"keywords":230,"overallStatus":243,"whyStopped":19,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":253},{"fullName":5,"class":6},"Medical University of Graz","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"XR-based Resilience Training","EXPERIMENTAL","Participants in this arm receive an XR-based resilience training consisting of eight immersive sessions delivered over approximately ten weeks using a head-mounted display. The training focuses on behavioral, cognitive, and emotional coping strategies and aims to strengthen resilience and stress management skills. Each session lasts approximately 20 to 30 minutes and is completed individually.",[13,14],"Behavioral: XR-based Resilience Training","Other: Waitlist Control",{"label":16,"type":17,"description":18,"interventionNames":19},"Waitlist Control","NO_INTERVENTION","Participants in this arm are assigned to a waitlist control condition and continue with care as usual during the waiting period. They do not receive the XR-based resilience training during the first ten weeks of the study but are offered access to the intervention after completion of the post-intervention assessment.",null,[21,25],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":19},"BEHAVIORAL","The XR-based resilience training is delivered via a standalone extended reality head-mounted display and consists of eight immersive sessions over approximately ten weeks. The training addresses behavioral coping strategies such as problem solving, cognitive coping strategies such as appraisal and reappraisal of stressors, and emotional coping strategies including emotion regulation and positive self-care. Sessions last approximately 20 to 30 minutes and are completed individually with technical support available if needed.",[9],{"type":6,"name":16,"description":26,"armGroupLabels":27,"otherNames":19},"Participants assigned to the waitlist control condition receive no active intervention during the initial study period and continue with care as usual. After completion of the post-intervention assessment, participants are offered access to the XR-based resilience training.",[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":19,"email":33},"Nina Dalkner Research Prof. Priv.-Doz. Mag. rer.nat. Dr. rer.nat.","CONTACT","+43 316 385 30081","nina.dalkner@medunigraz.at",[35,55,73,92,113,132,147,160],{"facility":36,"status":19,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Medical University of Graz, Clinical Division of Psychiatry and Psychotherapeutic Medicine","Graz","Styria","8036","Austria","AT",{"type":43,"coordinates":44},"Point",[45,46],15.44197,47.06733,{"lat":46,"lon":45},[49,52],{"name":50,"role":31,"phone":32,"phoneExt":19,"email":51},"Melissa L Behrend, MSc","melissa.behrend@medunigraz.at",{"name":53,"role":54,"phone":19,"phoneExt":19,"email":19},"Nina Dalkner, Res.-Prof. Priv.-Doz. Mag. Dr.","PRINCIPAL_INVESTIGATOR",{"facility":56,"status":19,"city":57,"state":19,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":65,"contacts":66},"Klinika za psihijatriju Sveti Ivan","Zagreb","10000","Croatia","HR",{"type":43,"coordinates":62},[63,64],15.97798,45.81444,{"lat":64,"lon":63},[67,71],{"name":68,"role":31,"phone":69,"phoneExt":19,"email":70},"Ena Ivezic, mag. psih.","+385 1 3430 171","ena.ivezic@pbsvi.hr",{"name":72,"role":54,"phone":19,"phoneExt":19,"email":19},"Igor Filipcic, Prof. prim. dr. sc.",{"facility":74,"status":19,"city":75,"state":76,"zip":77,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"University Medical Center of Johannes Gutenberg University Mainz","Mainz","Rhineland-Palatinate","55131","Germany","DE",{"type":43,"coordinates":81},[82,83],8.28008,49.98185,{"lat":83,"lon":82},[86,90],{"name":87,"role":31,"phone":88,"phoneExt":19,"email":89},"Annika Hasch, MSc","+49 6131 89448 00","Annika.Hasch@lir-mainz.de",{"name":91,"role":54,"phone":19,"phoneExt":19,"email":19},"Klaus Lieb, Prof. Dr.",{"facility":93,"status":19,"city":94,"state":95,"zip":96,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Hospital José Joaquim Fernandes","Beja","Beja District","7801-849","Portugal","PT",{"type":43,"coordinates":100},[101,102],-7.86284,38.01469,{"lat":102,"lon":101},[105,108,111],{"name":106,"role":31,"phone":19,"phoneExt":19,"email":107},"Fátima Cano","fatima.cano@uevora.pt",{"name":109,"role":110,"phone":19,"phoneExt":19,"email":19},"Elisabete Alves","SUB_INVESTIGATOR",{"name":112,"role":54,"phone":19,"phoneExt":19,"email":19},"Lara Guedes de Pinho, Prof. PhD Dr.",{"facility":114,"status":19,"city":115,"state":116,"zip":117,"country":118,"countryCode":119,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Del Henares University Hospital","Coslada","Madrid","28822","Spain","ES",{"type":43,"coordinates":121},[122,123],-3.56129,40.42378,{"lat":123,"lon":122},[126,130],{"name":127,"role":31,"phone":128,"phoneExt":19,"email":129},"Javier C Fernández","+34 606896258","drocio.diaz@salud.madrid.org",{"name":131,"role":54,"phone":19,"phoneExt":19,"email":19},"Dania R D Rodríguez, Dr.",{"facility":133,"status":19,"city":116,"state":116,"zip":134,"country":118,"countryCode":119,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"Summa 112","28005",{"type":43,"coordinates":136},[137,138],-3.70256,40.4165,{"lat":138,"lon":137},[141,145],{"name":142,"role":31,"phone":143,"phoneExt":19,"email":144},"Cristina V Lorenzo","+34 638210690","cristina.veiras@salud.madrid.org",{"name":146,"role":54,"phone":19,"phoneExt":19,"email":19},"María J A Carretón, Dr.",{"facility":148,"status":19,"city":116,"state":116,"zip":149,"country":118,"countryCode":119,"cosmosGeoPoint":150,"geoPoint":152,"contacts":153},"Infanta Leonor University Hospital","28031",{"type":43,"coordinates":151},[137,138],{"lat":138,"lon":137},[154,158],{"name":155,"role":31,"phone":156,"phoneExt":19,"email":157},"María F González","+34 608732331","maria.fgonzalez@salud.madrid.org",{"name":159,"role":54,"phone":19,"phoneExt":19,"email":19},"Carmen B León, Dr.",{"facility":161,"status":19,"city":162,"state":116,"zip":163,"country":118,"countryCode":119,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"Infanta Sofía University Hospital","San Sebastián de los Reyes","28702",{"type":43,"coordinates":165},[166,167],-3.62733,40.55555,{"lat":167,"lon":166},[170,174],{"name":171,"role":31,"phone":172,"phoneExt":19,"email":173},"Marta G Granado","+34 638210687","marta.gonzalez.granado@salud.madrid.org",{"name":175,"role":54,"phone":19,"phoneExt":19,"email":19},"Inés C Hammel, Dr.",{"type":177,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[179,182,184,186,188,190,192,194,196,198,200,203],{"name":180,"class":181},"MINDCONSOLE GMBH","UNKNOWN",{"name":183,"class":181},"Medizinische Privatuniversität Burgenland",{"name":185,"class":6},"Central Institute of Mental Health, Mannheim",{"name":187,"class":6},"St. Pölten University of Applied Sciences",{"name":189,"class":6},"University of Évora",{"name":191,"class":181},"Leibniz Institute for Resilience Research (LIR), Mainz, Germany",{"name":193,"class":181},"Leuphana Universität Lünenberg",{"name":195,"class":6},"University of Lisbon",{"name":197,"class":6},"Sveti Ivan Psychiatric Hospital",{"name":199,"class":181},"mindconsole",{"name":201,"class":202},"PredictBy Research and Consulting, S.L","INDUSTRY",{"name":204,"class":181},"Servicio Madrileño de Salud (SERMAS)","100634808","xr2esilience---xr-based-resilience-training-for-stress-and-mental-health-in-healthcare-workers-100634808",false,"NCT07544498","XR2ESILIENCE - XR-Based Resilience Training for Stress and Mental Health in Healthcare Workers","A Pragmatic Randomized Controlled Trial Study Protocol: XR2ESILIENCE - Pioneering XR Technology for the Promotion of Resilience and Mental Health of the Healthcare Workforce","XR2ESILIENCE","Inclusion Criteria:\n\n1. working as a nurse in direct patient care within a clinical setting;\n2. working at least 10h\u002Fweek in their profession;\n3. speaking the language in which the RCT is conducted sufficiently well;\n4. able and willing to participate in all aspects of the study;\n5. understanding and signing the appropriate informed consent form.\n\nExclusion Criteria:\n\n1. a diagnosed severe mental disorder associated with alterations in reality perception (e.g., delusions, hallucinations, derealization, depersonalization, or dementia), including in particular schizophrenia, bipolar disorder, severe major depressive disorder, or other psychotic disorders (lifetime);\n2. a current major depressive episode or a current post-traumatic stress disorder (PTSD);\n3. an acute or clinically significant medical condition that may interfere with the safe use of an XR headset or study participation, including but not limited to epilepsy, pronounced dizziness, balance disorders, or acute cardiovascular conditions;\n4. an acute eye infection (e.g., conjunctivitis);\n5. unstable medication related to a mental health condition, defined as recent changes in dosage or class of psychotropic medication;\n6. initiation of psychotherapy or any structured stress-management training within the past three months.",true,"ALL","18 Years","65 Years",{"count":218,"type":219},232,"ESTIMATED","INTERVENTIONAL",[222],"NA","This study investigates the effectiveness of an extended reality (XR) based resilience training program designed to support the mental health and well-being of nurses working in hospital settings. Nurses are exposed to high emotional, cognitive, and organizational demands and show elevated levels of work-related stress and stress-associated mental health problems. Strengthening resilience and coping capacities is therefore an important preventive approach to support nurses' well-being and sustain quality of care.\n\nThe study is conducted as a pragmatic randomized controlled trial with a waitlist control group and includes approximately 232 nurses from hospitals in several European countries. Participants are randomly assigned either to an XR-based resilience training group or to a waitlist control group that continues with care as usual during the waiting period. The XR-based intervention consists of eight immersive training sessions delivered over approximately ten weeks using a head-mounted display. The training focuses on behavioral, cognitive, and emotional coping strategies and aims to enhance key resilience factors such as problem-solving, cognitive reappraisal, emotion regulation, and positive self-care.\n\nThe primary outcome is perceived stress, assessed using the Perceived Stress Scale. Secondary outcomes include resilience, occupational self-efficacy, quality of life, psychological distress, burnout symptoms, coping strategies, work-related rumination, and turnover intentions. Assessments are conducted at baseline, post-intervention, and at a 20-week follow-up. In addition, a subgroup of participants will optionally provide physiological data during selected XR sessions to explore digital biomarkers related to stress and recovery.\n\nThe findings of this study will provide evidence on the effectiveness, feasibility, and acceptance of XR-based resilience training for nurses and inform future implementation of digital mental health interventions in healthcare workplaces.",[225,226,227,228,229],"Occupational Stress","Work-Related Stress","Mental Health","Burnout","Resilience",[231,232,233,234,235,236,237,238,239,240,241,242],"Extended Reality","Virtual Reality","XR-based Intervention","Resilience Training","Stress Reduction","Nurses","Healthcare Workers","Occupational Health","Mental Well-Being","Digital Mental Health","Preventive Intervention","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-05-13",{"date":246,"type":247},"2026-05-18","ACTUAL",{"date":249,"type":219},"2026-09",{"date":251,"type":219},"2028-03",{"name":5,"class":6},8]