[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100538089":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":10,"centralContacts":28,"locations":10,"responsibleParty":34,"collaborators":36,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":10,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":10,"overallStatus":58,"whyStopped":10,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":10},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8,14,17,20],{"label":9,"type":10,"description":11,"interventionNames":12},"bvYOD",null,"Neuropsychological assessment and driving simulator task.",[13],"Other: Neuropsychological assessment, driving simulator task",{"label":15,"type":10,"description":11,"interventionNames":16},"non-bvYOD",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Patients with frontal brain damage",[13],{"label":21,"type":10,"description":11,"interventionNames":22},"Healthy controls",[13],[24],{"type":6,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"Neuropsychological assessment, driving simulator task","Neuropsychological assessment consisting of test measuring general cognitive abilities and social cognition. Driving simulator task measuring risk-taking.",[21,18,9,15],[29],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Gelmers","CONTACT","+31 50 361 46 64","f.gelmers@umcg.nl",{"type":35,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[37],{"name":38,"class":6},"ZonMw: The Netherlands Organisation for Health Research and Development","100538089","yod-risoco-social-cognition-and-risk-taking-behaviour-in-patients-with-young-onset-dementia-100538089",false,"NCT06286293","YOD-RiSoCo: Social Cognition and Risk-taking Behaviour in Patients with Young-onset Dementia","YOD-RiSoCo: the Role of Social Cognition and Better Identification of Risk-taking Behaviour in Patients with Young-onset Dementia","YOD-RiSoCo","Inclusion Criteria:\n\nAll subjects\n\n* Sufficient command of the Dutch language\n* In possession of a driver's license with any driving experience throughout life\n* Age 18 to 65\n\nbvYOD subjects\n\n* Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG\u002FPIB-PETscans, CSF biomarkers or genetic counseling were discussed.\n* Nosological diagnosis of bvFTD or bvAD\n\nNon-bvYOD subjects\n\n* Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG\u002FPIB-PETscans, CSF biomarkers or genetic counseling were discussed.\n* YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD.\n\nFrontal brain injury subjects\n\n\\- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients).\n\nExclusion Criteria:\n\nAll subjects\n\n* Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness\n\nYOD subjects:\n\n\\- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia.\n\nFrontal brain injury subjects:\n\n\\- Presence of serious psychiatric disorders or other neurological comorbidities.\n\nHealthy control subjects:\n\n* Presence of serious psychiatric disorders\n* History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).",true,"ALL","18 Years","70 Years",{"count":52,"type":53},140,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about social cognition and risky behaviour in patients with young-onset dementia (YOD). The investigators want to\n\n* Examine differences in performance on social cognition test and measures of risky behaviour between behavioural variant YOD patients, patients with frontal brain injury, non-behavioural YOD patients and healthy controls.\n* Examine if there is a relation between social cognition tests and measures of risky behaviour.\n\nParticipants will be administered a neuropsychological assessment including social cognition measures and patients will complete a driving simulator task in which risky behaviour will be elicited.",[57],"Young-onset Dementia","NOT_YET_RECRUITING","2025-01-08",{"date":61,"type":62},"2025-01-10","ACTUAL",{"date":64,"type":53},"2025-02-04",{"date":66,"type":53},"2027-03-31",{"name":5,"class":6}]