[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100464331":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":40,"centralContacts":48,"locations":54,"responsibleParty":86,"collaborators":88,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":97,"acronym":98,"eligibilityCriteria":99,"healthyVolunteers":94,"sex":100,"minAge":101,"maxAge":10,"enrollmentInfo":102,"targetDuration":10,"studyType":105,"phases":10,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":56,"whyStopped":10,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"iOMEDICO AG","INDUSTRY",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Waldenström's Macroglobulinemia",null,"75 patients (excluding screening failures, patients with off-label use or with violation of inclusion\u002Fexclusion criteria identified after treatment start) receiving zanubrutinib (Brukinsa®)",[13],"Drug: Zanubrutinib",{"label":15,"type":10,"description":16,"interventionNames":17},"Chronic Lymphocytic Leukemia","450 patients (excluding screening failures, patients with off-label use or with violation of inclusion\u002Fexclusion criteria identified after treatment start) receiving zanubrutinib (Brukinsa®)",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Marginal Zone Lymphoma","40 patients (excluding screening failures, patients with off-label use or with violation of inclusion\u002Fexclusion criteria identified after treatment start) receiving zanubrutinib (Brukinsa®)",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Follicular Lymphoma","40 patients (excluding screening failures, patients with off-label use or with violation of inclusion\u002Fexclusion criteria identified after treatment start) receiving zanubrutinib (Brukinsa®) in combination with obinutuzumab (Gazyvaro®)",[13,26],"Drug: Obinutuzumab",[28,35],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"DRUG","Zanubrutinib","according to the Summary of Product Characteristics (SmPC).",[15,23,19,9],[34],"Brukinsa®",{"type":29,"name":36,"description":31,"armGroupLabels":37,"otherNames":38},"Obinutuzumab",[23],[39],"Gazyvaro®",[41,45],{"name":42,"affiliation":43,"role":44},"Jens Kisro, Dr.","Lübecker Onkologische Schwerpunktpraxis","PRINCIPAL_INVESTIGATOR",{"name":46,"affiliation":47,"role":44},"Richard Greil, Prof.","Universitätsklinikum Salzburg, Klinik für Innere Medizin III",[49],{"name":50,"role":51,"phone":52,"phoneExt":10,"email":53},"Daniel Kummer, Dr.","CONTACT","+49761152420","ariadne@iomedico.com",[55,71],{"facility":47,"status":56,"city":57,"state":10,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"RECRUITING","Salzburg","A-5020","Austria","AT",{"type":62,"coordinates":63},"Point",[64,65],13.04399,47.79941,{"lat":65,"lon":64},[68],{"name":46,"role":51,"phone":69,"phoneExt":10,"email":70},"+435725525800","r.greil@salk.at",{"facility":43,"status":56,"city":72,"state":73,"zip":74,"country":75,"countryCode":76,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Lübeck","Schleswig-Holstein","D-23562","Germany","DE",{"type":62,"coordinates":78},[79,80],10.68729,53.86893,{"lat":80,"lon":79},[83],{"name":42,"role":51,"phone":84,"phoneExt":10,"email":85},"+4945170797226","jens-kisro@t-online.de",{"type":87,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[89],{"name":90,"class":91},"BeOne Medicines I GmbH Switzerland","UNKNOWN","100464331","zanubrutinib-in-patients-with-waldenstrms-macroglobulinemia-chronic-lymphocytic-leukemia-marginal-zone-lymphoma-and-follicular-lymphoma-100464331",false,"NCT05326308","Zanubrutinib in Patients With Waldenström's Macroglobulinemia, Chronic Lymphocytic Leukemia, Marginal Zone Lymphoma and Follicular Lymphoma","Zanubrutinib (Brukinsa®) in Patients With Waldenström's Macroglobulinemia (WM), Chronic Lymphocytic Leukemia (CLL), Marginal Zone Lymphoma (MZL) and Follicular Lymphoma (FL) - a Prospective Multicenter Observational Cohort Study","ARIADNE","Inclusion Criteria:\n\n* Waldenström's macroglobulinemia (all treatment lines) OR\n* Chronic lymphocytic leukemia (all treatment lines) OR\n* Marginal zone lymphoma (≥2 treatment line and at least one anti-CD20 antibody-based previous therapy)\n* Follicular lymphoma (≥3 treatment line)\n* Signed and dated informed consent form\n* Treatment with zanubrutinib according to current SmPC for WM, CLL and MZL\n* Treatment with zanubrutinib + obinutuzumab for FL according to current SmPC\n* Treatment decision before inclusion into this non-interventional study\n* Age ≥18 years.\n\nExclusion Criteria:\n\n* Contraindications according to SmPC for patients with WM, CLL, MZL or FL\n* Participation in an interventional clinical trial during zanubrutinib treatment.","ALL","18 Years",{"count":103,"type":104},705,"ESTIMATED","OBSERVATIONAL","The objective of this NIS is to evaluate medical resource utilization, where data is rare in all cohorts, patient's QoL and effectiveness of zanubrutinib treatment in adult patients with WM, CLL, MZL and FL in a real-world setting.",[9,15,19,23],[9,30,109,15,19,23],"Brukinsa","2025-09-18",{"date":112,"type":113},"2025-09-23","ACTUAL",{"date":115,"type":113},"2022-04-26",{"date":117,"type":104},"2028-08",{"name":5,"class":6},2]