[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"3d-printing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:3d-printing":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,66,94,125,147,179,205,231,263],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100610535","effectiveness-comparison-of-3d-printed-and-conventional-ear-tip-comfort-in-individuals-with-hearing-loss-100610535",false,"NCT07228845","Effectiveness Comparison of 3D-Printed and Conventional Ear Tip Comfort in Individuals With Hearing Loss","Inclusion Criteria:\n\n* Bilateral, symmetric, sensorineural hearing loss, with thresholds between normal and severe degree of hearing loss\n* Normal otoscopy: patent ear canals with normal appearing eardrums and aerated middle ear, bilaterally.\n* English speaking.\n\nExclusion Criteria:\n\n* Self reported history of extensive or current outer or middle ear pathology.\n* Self reported history of extensive outer or middle ear surgery.\n* Self reported history of neurological or cognitive disorder.\n* Active ear infection","ALL","18 Years","89 Years",{"count":19,"type":20},32,"ESTIMATED","INTERVENTIONAL",[23],"NA","Access to affordable and timely hearing healthcare remains a major challenge for many individuals, partly due to the high cost and long turnaround time. This study will explore whether 3D-printed ear tips perform as well as or better than standard ear tips in terms of sound quality, comfort, and fit over a prolonged duration in a sample of individuals with bilateral hearing loss. It will also compare how long each method takes to make and how much each costs.",[26,27,28],"Hearing Aids","Hearing Loss, Bilateral Sensorineural","3D Printing",[30,31,32],"hearing aids","3D printing","hearing loss","RECRUITING","2026-04-30",{"date":36,"type":37},"2026-05-01","ACTUAL",{"date":39,"type":37},"2026-03-15",{"date":41,"type":20},"2027-04-25",{"name":43,"class":44},"University of Arizona","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":53,"targetDuration":4,"studyType":21,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":45},"100609619","effectiveness-comparison-of-3d-printed-and-conventional-ear-tip-comfort-in-individuals-with-hearing-in-the-normal-range-100609619","NCT07216937","Effectiveness Comparison of 3D-Printed and Conventional Ear Tip Comfort in Individuals With Hearing in the Normal Range","Inclusion Criteria:\n\n* Normal hearing thresholds (\\\u003C25 dB HL) at octave frequencies from 250-8000Hz.\n* Normal otoscopy: patent ear canals with normal appearing eardrums and aerated middle ear, bilaterally.\n* English speaking.\n\nExclusion Criteria:\n\n* history of extensive or current outer or middle ear pathology.\n* history of extensive outer or middle ear surgery.\n* history of neurological or cognitive disorder.",true,{"count":54,"type":20},30,[23],"Access to affordable and timely hearing healthcare remains a major challenge for many individuals, partly due to the high cost and long turnaround time. This study will explore whether 3D-printed ear tips perform as well as or better than standard ear tips in terms of sound quality, comfort, and fit. It will also compare how long each method takes to make and how much each costs.",[26,28],[30,31,59],"hearing healthcare accessibility",{"date":36,"type":37},{"date":62,"type":37},"2025-11-07",{"date":64,"type":20},"2026-06-14",{"name":43,"class":44},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100625985","performance-of-reinforced-3d-printed-versus-direct-bulk-filled-resin-composites-for-restoring-extensive-class-ii-cavities-in-vital-molars-100625985","NCT07429747","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\nPatient-related:\n\n* Adults aged 22 to 45 years.\n* Low to moderate caries risk.\n* Normal occlusion.\n* No signs or symptoms of temporomandibular joint disorders.\n* Satisfactory oral hygiene.\n* Medically fit to receive routine restorative dental treatment.\n\nLesion-related:\n\n* Permanent molar requiring a compound Class II restoration.\n* Primary carious lesion classified as ICDAS score 5.\n* Presence of an adjacent tooth and a sound opposing tooth in occlusion.\n* No clinical signs or symptoms of irreversible pulpitis in the involved, adjacent, or opposing teeth.\n* No radiographic evidence of periapical pathology.\n\nExclusion Criteria:\n\nPatient-related:\n\n* Bruxism.\n* Poor cooperation.\n* Inability or unwillingness to attend follow-up visits.\n* Anticipated travel during the study period.\n* Poor oral hygiene.\n* Chronic or advanced periodontitis.\n* Known allergy to any study materials.\n* Pregnant or breastfeeding women.\n\nLesion-related:\n\n* Teeth with visible fractures or cracks.\n* Rampant caries.\n* Defective restorations on adjacent or opposing teeth.\n* Atypical extrinsic staining that may interfere with evaluation.\n* Radiographic signs of apical pathology.","22 Years","45 Years",{"count":76,"type":20},50,[23],"Most published research on 3D-printed restorative materials is laboratory-based, focusing primarily on mechanical performance and material properties under controlled conditions. While such studies provide important foundational data, they do not fully replicate the complexity of the oral environment. Only a limited number of clinical investigations have directly compared 3D-printed restorations with conventional direct composite restorations in Class II cavities Furthermore, the integration of a digital workflow introduces additional costs and time requirements related to equipment, software, and training. These factors must be justified by demonstrable improvements in clinical outcomes or cost-effectiveness. By evaluating both clinical performance and economic impact, this trial aims to generate practical, real-world evidence that can guide clinicians in selecting appropriate restorative materials and techniques for routine dental practice.",[80,28,81,82,83],"Class II Lesions","Bulk Fill","Proximal Cavities of Posterior Teeth","Composite Restorations","NOT_YET_RECRUITING","2026-03-02",{"date":87,"type":37},"2026-03-04",{"date":89,"type":20},"2026-02-20",{"date":91,"type":20},"2027-10-01",{"name":93,"class":44},"Ahmed Reda Abd EL Rahman",{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":105,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":45},"100607949","clinical-evaluation-of-additive-and-subtractive-onlay-restorations-100607949","NCT07195201","Clinical Evaluation of Additive and Subtractive Onlay Restorations","Prospective Evaluation of Onlay Restorations Produced by Additive and Subtractive Manufacturing in Vital Posterior Teeth: A Split-Mouth","CIP-ONLAY","Inclusion Criteria:\n\nParticipant-Level Criteria\n\n* Adults aged 18-84 years\n* No active periodontal disease (probing depth ≤ 3 mm, no clinical attachment loss)\n* No parafunctional habits such as bruxism, clenching, or foreign object chewing\n* Willingness to attend regular follow-up visits during the study period\n* Adequate oral hygiene status\n* No history of systemic disease or medically stable condition if present\n* No history of similar restorative procedures involving the target teeth Tooth-Level Criteria\n* Vital posterior teeth (premolars or molars) confirmed by thermal or electric pulp testing; teeth requiring endodontic treatment or with necrosis will be excluded\n* Permanent posterior teeth located in functional occlusion (premolar or molar region)\n* Teeth with moderate structural loss suitable for onlay restorations, including mesio-occlusal (MO), disto-occlusal (DO), or mesio-occluso-distal (MOD) cavities with partial crown loss but sufficient remaining tooth structure not requiring full coverage\n* Periodontally healthy teeth with no mobility, no clinical attachment loss, and probing depth ≤ 3 mm\n* Teeth that can be matched in contralateral quadrants to allow split-mouth design (structurally and clinically comparable teeth)\n* Teeth free from cracks, fractures, or internal resorption; supporting tissues without structural defects that may compromise restoration success\n* Teeth with clearly defined preparation margins located in enamel or sound dentin; subgingival margins extending deep into the sulcus will not be included\n* Teeth without previous extensive prosthetic restorations (crowns, inlays\u002Fonlays, or implant-supported restorations)\n* Opposing natural teeth in stable occlusal contact with the restored tooth\n\nExclusion Criteria:\n\n* Teeth with pulp necrosis or a history of endodontic treatment (previous root canal therapy or non-vital teeth)\n* Teeth with excessive tissue loss requiring full crown coverage and unsuitable for onlay restoration\n* Teeth presenting with cracks, fractures, internal or external resorption, or structural defects compromising prognosis\n* Advanced periodontal disease, including clinical attachment loss, furcation involvement, mobility, or probing depth \\> 3 mm\n* Teeth with subgingival cavity margins extending deep into the gingival sulcus, increasing periodontal risk\n* Teeth with a history of fixed prosthetic restorations (previous crowns, inlays\u002Fonlays, or bridge restorations)\n* Teeth lacking proximal contacts due to adjacent tooth absence, leading to compromised contact stability and occlusal load distribution\n* Teeth in regions with orthodontic appliances or fixed retainers that may interfere with restorative procedures or evaluation\n* Opposing teeth absent or lacking stable occlusal contact with the restoration site\n* Patients with systemic diseases contraindicate elective dental treatment (e.g., uncontrolled diabetes, immunocompromised status)\n* Pregnant or breastfeeding women\n* Patients unable or unwilling to attend scheduled follow-up visits \\[baseline (1 week), 6 months, 12 months, and 18 months\\]","84 Years",{"count":104,"type":20},29,[23],"The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing \\[three-dimensional (3D) printing\\] and subtractive manufacturing \\[Computer-Aided Design\u002FComputer-Aided Manufacturing (CAD\u002FCAM) milling\\] perform equally well in vital posterior teeth. The main questions it aims to answer are:\n\n* Do 3D printed onlay restorations show similar marginal adaptation and clinical performance compared to CAD\u002FCAM milled onlays?\n* Are there any differences in biological compatibility, surface properties, or postoperative sensitivity between the two techniques over time? Researchers will compare onlay restorations fabricated with 3D printing and CAD\u002FCAM milling using a split-mouth study design.\n\nParticipants will:\n\n* Receive one onlay restoration produced by 3D printing and another produced by CAD\u002FCAM milling, placed on opposite sides of the mouth\n* Have checkups at baseline (1st week), 6 months, 12 months, and 18 months after treatment\n* Be evaluated using the Fédération Dentaire Internationale (FDI) criteria for marginal adaptation, surface quality, anatomical form, and biological compatibility",[108,109,28,110],"CAD-CAM","Prospective Study","Clinical Assessment",[112,113,114,31,115],"onlay restorations","cad-cam","additive manufacturing","FDI criteria","2025-09-23",{"date":118,"type":37},"2025-09-26",{"date":120,"type":20},"2025-11-15",{"date":122,"type":20},"2027-08-31",{"name":124,"class":44},"Ayse Tugba Erturk Avunduk",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":4},"100604829","esthetic-outcome-of-3d-printed-hybrid-ceramics-as-final-restorations-for-single-screw-retained-implant-100604829","NCT07154602","Esthetic Outcome of 3D Printed Hybrid Ceramics as Final Restorations for Single Screw Retained Implant.","Esthetic Outcome of 3D Printed Hybrid Ceramics as Final Restorations for Single Screw Retained Implant. A Clinical Randomized Clinical Trial","Inclusion Criteria:\n\n* Age: between 18 and 70 years old at the time of screening.\n* Patients with implants placed and in need for crown restoration\n* Medically free with no systemic diseases.\n* Good oral hygiene with no active periodontal disease.\n* Patient's having adequate interocclusal and mesiodistal restorative space for the fabrication of a single implant-supported crown.\n* Patients willing and able to provide written informed consent for participation in the study, understanding its risks, benefits, and alternative treatments.\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases (e.g., uncontrolled diabetes, severe cardiovascular disease, active autoimmune disorders, uncontrolled thyroid dysfunction).\n* Patients with composite restoration on the labial\u002Fbuccal surface implant's neighbouring.\n* Immunocompromised patients or those undergoing immunosuppressive therapy.\n* Patients undergoing radiation therapy to the head and neck region, or chemotherapy.\n* Patients currently on or with a history of medications known to significantly affect bone metabolism (e.g., long-term bisphosphonates, corticosteroids).\n* Pregnancy or lactation.\n* Known allergies to titanium, resin components, or any other materials used in the study (e.g., composite, zirconia).","70 Years",{"count":19,"type":20},[23],"clinical trial\n\nThe goal of this clinical trial is to record the esthetic outcome of the 3d printed hybrid resin crowns. It will also test which method of fabrication is advantageous than the other one. The main questions it aims to answer are:\n\nDoes any of the fabrication methods differ in its esthetic outcome?\n\nResearcher will compare 3d printing fabrication to conventional fabrication method which is the milling technique to see if 3d printing of hybrid resin serves patients a better crown's esthetic outcome.\n\nParticipants will:\n\nReceive a crown after implants are osseointegrated Visit the clinic once every 3 months for checkups and tests Keep records of level of patient's satisfaction.",[28],"2025-08-26",{"date":139,"type":37},"2025-09-04",{"date":141,"type":20},"2025-11-01",{"date":143,"type":20},"2026-11-01",{"name":145,"class":146},"International Dental Contiuing Education","NETWORK",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":21,"phases":156,"briefSummary":157,"conditions":158,"keywords":162,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":4},"100603448","custom-cadcam-insoles-for-plantar-pressure-improvement-in-foot-deformities-100603448","NCT07136649","Custom CAD\u002FCAM Insoles for Plantar Pressure Improvement in Foot Deformities","Effects of Custom CAD\u002FCAM Insoles on Plantar Pressure Distribution in Individuals With Foot Deformities: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Clinically diagnosed with a foot deformity (e.g., pes planus, pes cavus, hallux valgus)\n* Able to use custom insoles for at least six months\n* Able to stand and walk for pedobarographic measurements\n* Willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Presence of neurological or systemic diseases affecting foot function (e.g., diabetic neuropathy)\n* History of lower extremity surgery in the last six months\n* Severe musculoskeletal conditions impairing sensorimotor function\n* Any condition preventing compliance with insole use\n* Contraindications for participating in gait or pressure measurements","65 Years",{"count":54,"type":20},[23],"This randomized controlled trial will investigate the effects of custom CAD\u002FCAM insoles on plantar pressure distribution and gait parameters in individuals with foot deformities, such as pes planus, pes cavus, and hallux valgus. A total of 30 participants will be randomly assigned to either the intervention group, receiving custom CAD\u002FCAM insoles, or the control group, receiving no insole intervention.\n\nPlantar pressure measurements will be performed using the As200 Gait Scan Pedobarography System at baseline and after eight weeks. Static and dynamic plantar pressure variables, contact area, and center of pressure displacement will be assessed, along with gait parameters including step length, step time, and walking speed.\n\nThe results of this study may contribute to the development of effective conservative treatment strategies to improve foot biomechanics and reduce pressure-related complications in individuals with foot deformities.",[159,160,28,161],"Foot Deformities","Orthotic Device","CAD",[163,164,165,166,167,168,28,169],"Custom CAD\u002FCAM Insoles","Pes Planus","Pes Planovalgus","Pes Cavus","Pedobarography","Plantar Pressure","Orthotics","2025-08-21",{"date":172,"type":37},"2025-08-22",{"date":174,"type":20},"2025-09-01",{"date":176,"type":20},"2025-11-30",{"name":178,"class":44},"Fenerbahce University",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":15,"minAge":186,"maxAge":132,"enrollmentInfo":187,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":194,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":45},"100597354","evaluation-of-clinical-wear-and-surface-roughness-of-partial-restorations-produced-by-additive-and-subtractive-manufacturing-methods-a-split-mouth-randomized-controlled-clinical-trial-100597354","NCT07057401","Evaluation of Clinical Wear and Surface Roughness of Partial Restorations Produced by Additive and Subtractive Manufacturing Methods: A Split-Mouth Randomized Controlled Clinical Trial","Investigation of Clinical Wear and Surface Roughness of Partial Restorations Fabricated Using Additive and Subtractive Manufacturing Methods: A Split-Mouth Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Teeth with Devital and Vital Cusp Loss\n\nExclusion Criteria:\n\n* Root Canal Treated Teeth with Lesions\n* Symptomatic Vital Teeth","15 Years",{"count":54,"type":20},[23],"The aim of this study is to compare the surface roughness and wear values of crowns fabricated using currently utilized 3D printing and CAD-CAM technologies.\n\nIn recent years, crown restorations produced with CAD-CAM systems have been safely used in dentistry. These types of restorative materials are expected not to undergo significant wear themselves and also not to cause wear on natural teeth. Therefore, the structural resistance and hardness of the material are clinically very important. Restorations produced using 3D printing are among the latest technological developments in dentistry.\n\nAdditive manufacturing has been defined by the American Society for Testing and Materials (ASTM) as \"the process of joining materials layer upon layer to make objects from 3D model data, as opposed to subtractive manufacturing methodologies.\"\n\n3D printers have started to be used in various disciplines of dentistry such as dental education, oral surgery, dental implantology, orthodontics, pedodontics, prosthodontics, and restorative dentistry. In restorative clinics, they can especially be used in intracoronal restorations. However, studies in this area are quite limited.\n\nThe objective of this study is to evaluate the wear values using a Geomagic 3X device and the surface roughness values using a profilometer device over a 12-month period on single crown restorations applied to permanent first molars fabricated by CAD-CAM and 3D printing techniques.\n\nA total of 26 single crown restorations will be performed on first molars. Participants will be selected among individuals aged 18-50 who apply to the Department of Restorative Dentistry, Faculty of Dentistry, Çukurova University. Eligible individuals must be systemically healthy, have no periodontal attachment loss, have an indication for crown restoration, and have a natural opposing tooth in contact with the restored tooth.",[191,28,192,193],"CAD\u002FCAM Space Maintainer","Dental Treatment","Dental Disease",[195],"subtractive manufacturing, additive manufacturing, roughness, wear","2025-07-04",{"date":198,"type":37},"2025-07-09",{"date":200,"type":20},"2025-09-20",{"date":202,"type":20},"2027-06-20",{"name":204,"class":44},"Husna Selinay",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":21,"phases":215,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":4},"100586108","phase-2-sh-lps-system-in-preoperative-planning-for-liver-resection-100586108","NCT06911086","SH-LPS System in Preoperative Planning for Liver Resection","SH-LPS System in Preoperative Planning for Liver Resection: a Randomized Controlled Trial","Inclusion Criteria:\n\n* 18-80 years old;\n* Patients with a resectable tumor in the liver;\n* Eastern Cooperative Oncology Group Performance status score: 0;\n* Child-Pugh classification: A;\n* The Laboratory test results meet the following criteria and patients can tolerate surgery: Haemoglobin≥90g\u002FL, Neutrophil count≥1.5×10⁹\u002FL, Platelet count≥100×10⁹\u002FL, Aspartate or alanine aminotransferase≤5 upper limits of normal(ULN）, alkaline phosphatase≤2.5 ULN, Serum albumin≥30g\u002FL, serum creatinine\\\u003C1.5 ULN, International normalized ratios（INR）≤2 or rothrombin time（PT）exceed ULN≤6s, Creatinine clearance≥60 mL\u002Fmin.\n\nExclusion Criteria:\n\n* Patients with extra-hepatic metastasis;\n* Anti-cancer therapy or surgery such as radiotherapy, radiofrequency ablation in 28 days prior to the surgery;\n* Clinically significant bleeding or bleeding tendencies within 3 months prior to enrollment or on thrombolytic or anticoagulant therapy;\n* Severe lung disease (eg, acute lung disease, pulmonary fibrosis that affects lung function, interstitial lung disease), uncontrolled diabetes mellitus (fasting blood glucose ≥10 mmol\u002FL);\n* There are other unsuitable candidates for clinical trials, such as mental illness or alcohol dependence.","80 Years",{"count":214,"type":20},100,[216,217],"PHASE2","PHASE3","Effective preoperative planning and real-time intraoperative guidance are crucial for performing accurate liver resections. To address this need, the researchers have designed advanced 3D-printed liver models using a self-healing elastomer, created through the copolymerization of 4-acryloylmorpholine (ACMO) and methoxy poly(ethylene glycol) acrylate (mPEGA). These models demonstrate outstanding healing properties, swiftly restoring their structure within minutes at room temperature, and quickly recovering after incisions.\n\nIn previous studies, Professor Yuhua Zhang, the project applicant, collaborated with a team from Zhejiang University to develop a 3D-printed liver model that is self-healing and reusable for repeated cutting. They preliminarily explored the feasibility of applying this model for preoperative planning and surgical training for liver surgeries. The results were published in Nature Communications (Lu et al., Nat Commun. Dec 19;14(1):8447). Building on this, the applicant intends to establish a personalized liver surgery planning system (Personalized Liver Surgery Planning System Based on High-Fidelity 3D Printed Self-Healing Liver Models, SH-LPS), which will assess, through a randomized controlled trial, the value of SH-LPS in improving liver surgery efficiency and safety.",[220,28,221],"Liver Tumor; Surgery","Preoperative Planning","2025-04-02",{"date":224,"type":37},"2025-04-04",{"date":226,"type":20},"2025-04-15",{"date":228,"type":20},"2026-06-01",{"name":230,"class":44},"Zhejiang Cancer Hospital",{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":11,"sex":15,"minAge":238,"maxAge":239,"enrollmentInfo":240,"targetDuration":4,"studyType":21,"phases":242,"briefSummary":243,"conditions":244,"keywords":248,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":45},"100577422","evaluation-of-band-loop-space-maintainers-produced-with-three-dimensional-printer-and-conventional-technique-100577422","NCT06798090","Evaluation of Band-Loop Space Maintainers Produced With Three-Dimensional Printer and Conventional Technique","Evaluation of Clinical Success and Changes in Periodontal Tissues of Band-Loop Space Maintainers Produced With Three-Dimensional Printer and Conventional Technique","Inclusion Criteria:\n\n* Systemically healthy children\n* Bilateral early loss of deciduous first molar teeth in the lower jaw\n* Presence of radiographically confirmed permanent tooth germ under the extracted deciduous tooth\n* Radiographically determined 1,5 mm minimum of bone existence above the permanent tooth germ\n* Existence of flush terminal plane\u002Fmesial step in decidious dentition and Angle class 1 molar relationship in mixed dentition\n* Existence of radiographically and clinically healthy abutment teeth\n* Frankl score 3 and 4 children\n\nExclusion Criteria:\n\n* Patients with systemic diseases\n* Frankl score 1 and 2 children","5 Years","8 Years",{"count":241,"type":20},27,[23],"Our research is planned as a randomised clinical trial. The main aim of our study is to evaluate the clinical success of band and loop space maintainers produced by three-dimensional printer and conventional technique and the changes they cause in periodontal tissues.",[245,246,247,28],"Dental Health","Space Maintainer","Pediatric Dentistry",[249,250,251,252,253],"three dimensional printer","band and loop space maintainer","digital dentistry","PLAP-1","TNF-a","2025-01-27",{"date":256,"type":37},"2025-01-29",{"date":258,"type":37},"2024-10-15",{"date":260,"type":20},"2026-05-30",{"name":262,"class":44},"Aydin Adnan Menderes University",{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":21,"phases":272,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":45},"100539917","3d-printed-personalized-ostomy-appliance-100539917","NCT06310070","3D Printed Personalized Ostomy Appliance","3DPPOA","Inclusion Criteria:\n\n* 18-100 years old\n* Must have had current ostomy appliance for \\> 6 weeks - if patients with stomas less than 6 weeks are included, their personalized templates will not be useful once the stoma size has changed after their initial scan.\n* Must have experienced \\> 1 leakage in the week leading up to day of consent. - If patients are not experiencing leakages, then there will be no baseline data to compare effectiveness of the post-3D appliance intervention.\n* Participants must be able to consent for themselves\n* Access to phone AND computer with internet access. Patient must be able to provide electronic mailing address for e-consent documentation and REDCap surveys.\n\nExclusion Criteria:\n\n* Concern for patient being able to be reached over the phone or reliable internet access for REDCap survey completion\n* Existing peri-stomal skin breakdown including ulceration or mucocutaneous separation.\n* Diagnosis of infection around the peristomal region. (erythema is NOT an exclusion criteria)","100 Years",{"count":54,"type":20},[23],"The goal of this clinical trial is to learn about the effectiveness of using a 3D scan for a personal ostomy appliance. The main question it aims to answer is:\n\n• Whether or not a 3D scan of a stoma reduces leakages and improves patient quality of life in regard to using a personalized ostomy appliance.\n\nParticipants will\n\n* Spend 2 weeks with their standard of care ostomy appliance\n* Spend 2 weeks with their personalized ostomy appliance made from a 3D scan\n* Participate in daily surveys and weekly quality of life surveys conducted over the phone",[28,275,276],"Ostomy","Leakage","2025-01-20",{"date":279,"type":37},"2025-01-22",{"date":281,"type":37},"2024-05-10",{"date":283,"type":20},"2025-06-05",{"name":285,"class":44},"Carilion Clinic"]