[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"interventionName\":\"Physical Therapy\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":658},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,29,0,25,[9,48,75,101,130,156,182,203,225,250,282,303,325,348,381,400,430,460,486,512,524,554,579,611,635],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053401","phase-3-an-artificial-intelligence-driven-approach-to-optimize-patient-selection-for-a-transitional-pain-service-100053401",false,"NCT07296770","An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","TPS-Select","Patients may take part in this study if they:\n\n* Are 18 years or older\n* Are having a planned (elective) surgery at UCSF\n* Are identified as higher risk for chronic pain after surgery by a computer model\n* Agree to join the study and sign consent\n\nPatients cannot take part if they:\n\n* Have too much missing information in their medical record (more than 75%)\n* Have a surgery scheduled less than 1 month away\n* Have serious memory or thinking problems that make participation difficult\n* Are in another clinical study that would interfere with this one\n* Do not live in California\n* Choose not to participate or sign consent\n* Have severe depression with suicidal thoughts that requires urgent care\n* Are pregnant or breastfeeding\n\nA patient who has already joined may be removed from the study if they:\n\n* Cannot complete most of the scheduled follow-up phone calls or pre-surgery recommendations (up to 6 months after discharge)\n* Pass away between the surgery booking date and 6 months after leaving the hospital\n* Become pregnant in the 6 months after discharge\n\nPatients may remain enrolled but their data may not be used in the main study results if they experience:\n\n* A long-lasting infection after surgery\n* Hardware problems related to their surgery (for example, issues with implanted devices)\n* A major injury or life event that affects their pain levels, such as a significant fall or an emergency surgery\n* Difficulty completing the planned follow-up phone calls up to 6 months after discharge","ALL","18 Years",{"count":20,"type":21},126,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","The goal of this clinical trial is to learn whether a pain-management program called a Transitional Pain Service can help prevent long-term pain and reduce opioid needs after surgery in adult surgical patients who may be at higher risk for developing persistent pain. The main questions this trial aims to answer are: 1) Does the Transitional Pain Service help high-risk surgical patients manage pain better after surgery? 2) Can a computer tool (an algorithm) improve screening of patients for long-lasting pain after surgery? The investigators will compare patients who continue with their usual care to patients who receive support from the Transitional Pain Service to see if the program leads to better pain control and lower opioid use. Participants will share information about their pain levels and the pain-relief treatments they are using before and after surgery so researchers can better understand how the program affects recovery. Patients assigned to the Transitional Pain Service will also be offered additional coordinated support before and after their surgery to help optimize their pain control and overall recovery.",[27,28,29],"Postsurgical Pain Management","Postsurgical Pain, Chronic","Opioid Use After Surgery",[31,32,33,34],"Pain","Transitional Pain Service","Postsurgical Pain","Postoperative Opioid Use","NOT_YET_RECRUITING","2026-07-09",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":21},"2026-10-01",{"date":43,"type":21},"2028-07-01",{"name":45,"class":46},"University of California, San Francisco","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100479702","individualized-prehabilitation-for-enhancing-recovery-and-surgical-outcomes-in-patients-undergoing-radiotherapy-and-surgery-for-soft-tissue-sarcoma-100479702","NCT05526417","Individualized Prehabilitation for Enhancing Recovery and Surgical Outcomes in Patients Undergoing Radiotherapy and Surgery for Soft Tissue Sarcoma","Pre-Operative ERAS® (Enhanced Recovery After Surgery): Randomized Feasibility Trial of Implementing Individualized Prehabilitation for People Undergoing Neo-Adjuvant Radiotherapy and Lower Limb Soft-Tissue Sarcoma Surgery","Inclusion Criteria:\n\n* Histologically or cytologically-proven deep soft tissue sarcoma (STS) of the lower extremity\n* Localized\n* Adults, 18 and older\n* All gender types\n* Subjects must be able to provide appropriate consent or have an appropriate representative available to do so\n\nExclusion Criteria:\n\n* Soft tissue sarcomas that are in a superficial location relative to fascia\n* Patients with metastatic disease (distant or nodal)\n* Both and upper and lower extremity involvement",{"count":56,"type":21},33,[58],"NA","This clinical trial evaluates whether patients with deep soft tissue sarcomas who receive a tailored prehabilitation exercise regimen during standard radiotherapy and prior to standard of care surgery have better recovery and surgical outcomes than those who do not. Patients undergoing surgery to soft tissue sarcomas are at high risk for post-operative disability, which is associated with high rates of depression and poor health-related quality of life. Prehabilitation is the practice of exercising before surgery to ensure that the patient is in the best possible condition. It allows patients to prepare their bodies for recovery after surgery, which may result in better surgical outcomes, recovery, and quality of life after surgery.",[61,62,63,64],"Soft Tissue Sarcoma","Stage I Soft Tissue Sarcoma of the Trunk and Extremities","Stage II Soft Tissue Sarcoma of the Trunk and Extremities","Stage III Soft Tissue Sarcoma of the Trunk and Extremities","RECRUITING","2026-06-18",{"date":68,"type":39},"2026-06-22",{"date":70,"type":39},"2022-06-08",{"date":72,"type":21},"2028-06-08",{"name":74,"class":46},"Mayo Clinic",{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":12,"sex":17,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":47},"100604747","spinal-cord-stimulation-combined-with-physical-therapy-in-post-stroke-upper-limb-motor-hemiparesis-100604747","NCT07153536","Spinal Cord Stimulation Combined With Physical Therapy in Post-Stroke Upper-Limb Motor Hemiparesis","Inclusion Criteria:\n\n1. Experienced an ischemic or hemorrhagic stroke that resulted in arm and hand hemiparesis more than 6 months prior to the time of enrollment (Prior strokes that did not cause upper extremity motor deficits are not exclusionary.)\n2. Age 22 to 70 years old\n3. Upper extremity motor score higher than 20 and lower than or equal to 45 on the Fugl-Meyer Assessment (FMA) scale\n4. FMA upper extremity sensory score higher than 6 points (out of 12 points)\n5. The ability to communicate, understand, give appropriate consent and follow two-step commands\n\nExclusion Criteria:\n\n1. Presence of any serious disease or disorder (ex. Neurological conditions other than stroke, cancer, severe cardiac or respiratory disease, renal failure, etc.) that could affect their ability to participate in this study\n2. Considered to be at high-risk of recurrent stroke as evident from their medical history or upon judgment of the study physician\n3. Presence of post-stroke central pain, other forms of pain or other constraints such as joint contractures in the paretic arm that are serious enough to prevent or affect the correct execution of the physical training protocol as judged by the study therapist\n4. A score on the Short Blessed Test assessment scale lower than 9\n5. Female participants of child-bearing age who are pregnant or breastfeeding during the study\n6. Participants that cannot suspend their antiplatelets and\u002For anticoagulant therapy for two weeks around the time of surgery\n7. Existence of any implanted medical device that is not MRI safe and\u002For any active medical devices even if it is MRI safe\n8. Implanted spinal fusion and stabilization devices such as plates and rods between the C2 and T3 spinal vertebra\n9. Obstructed or restricted epidural spinal canal to the point of hindering or increasing the risk of implant of the spinal leads as judged by the study surgeon upon screening imaging\n10. Severe claustrophobia that prevents execution of the required MRI imaging sessions\n11. Taking anti-spasticity or anti-epileptic medications\n12. T-score higher than 63 on the 18-question Brief Symptoms Inventory (BSI-18) who have undergone discussions with and been deemed unsuitable by the Principal Investigator and a study physician\n\nPotential participants who may be excluded on initial screening may discuss possible medication changes with their physician.","22 Years","70 Years",{"count":84,"type":21},20,[58],"This study plans to use systems that have been developed by Medtronic to investigate the use of cervical spinal cord stimulation to treat adults with upper limb hemiparesis resulting from a stroke. The spinal cord stimulation (SCS) will be combined with physical training to improve arm and hand motor control. The study is divided into three phases. In the first phase, after baseline assessments, participants will undergo a Physical Training Protocol (PTP) for 6 weeks including 3 sessions of 90 mins\u002Fsession per week. After receiving the Medtronic implantable system, in Phase 2, they will then repeat the same PTP program in combination with spinal cord stimulation during the entirety of each of the rehabilitation sessions. Finally, in Phase 3, participants will go home, will not be able to use the stimulation at home but will participate in monthly assessments in the laboratory in which the functionality of the Medtronic system and their motor performances will be assessed for up to 6 months.",[88,89,90],"Stroke","Spinal Cord Injuries and Disorders","Hemiparesis After Stroke",[92],"spinal cord stimulation","2026-06-17",{"date":68,"type":39},{"date":96,"type":39},"2026-01-06",{"date":98,"type":21},"2028-01-01",{"name":100,"class":46},"Marco Capogrosso",{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":108,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":111,"phases":4,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":47},"100643541","physical-therapy-program-and-treatment-expectations-in-knee-osteoarthritis-100643541","NCT07618403","Physical Therapy Program and Treatment Expectations in Knee Osteoarthritis","Evaluating The Predictive Effect of Treatment Expectations on Response to A Physical Therapy Program in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Agreeing to participate in the study\n* Being over 50 years of age\n* Having a clinically and radiographically confirmed diagnosis of knee osteoarthritis\n* Having grade 2-3-4 knee osteoarthritis according to the Kellgren-Lawrence grading system\n* Being literate\n\nExclusion Criteria:\n\n* Previous knee surgery\n* Conditions that prevent exercise (such as incurable malignancy, active systemic infection, non-union fracture)\n* Presence of accompanying neurological disease affecting the lower extremity\n* Severe cognitive impairment (neuropsychiatric disease or condition that will impede cooperation, such as psychosis, dementia)\n* History of having received injections or other procedures to the knee joint or physical therapy within the last 6 months","50 Years",{"count":110,"type":21},84,"OBSERVATIONAL","To our knowledge, no studies have been conducted in the literature investigating the relationship between the success of physical therapy programs applied in knee osteoarthritis and patients' pre-treatment expectations. The rationale for this study is to demonstrate the possible relationship between treatment expectations and the benefits seen from conventional physical therapy programs in patients with knee osteoarthritis, and to provide clinicians with a different perspective in knee osteoarthritis treatment planning.",[114,115,116],"Gonarthrosis; Primary","Physical Therapy","Patients' Expectations",[118,119,120],"treatment expectations","gonarthrosis","physical treatment","2026-06-08",{"date":123,"type":39},"2026-06-10",{"date":125,"type":39},"2026-01-01",{"date":127,"type":21},"2027-09-15",{"name":129,"class":46},"Gazi University",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":12,"sex":17,"minAge":108,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":47},"100582901","early-versus-delayed-rehabilitation-after-reverse-total-shoulder-arthroplasty-for-proximal-humerus-fracture-100582901","NCT06869343","Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture","A Randomized Controlled Trial of Early Versus Delayed Rehabilitation After Reverse Total Shoulder Arthroplasty for Proximal Humerus Fracture","Inclusion Criteria:\n\n* aged 50-85 undergo reverse Total Shoulder Arthroplasty by a single surgeon for proximal humerus fractures\n\nExclusion Criteria:\n\n* previous rTSA to ipsilateral shoulder\n* undergoing elective rTSA\n* Prisoners\n* unwilling to be randomized\n* unwilling or unable to attend follow up visits","85 Years",{"count":139,"type":21},10,[58],"Proximal humerus fractures can be a debilitating injury in the elderly, impacting the ability to function independently or complete activities of daily living due to pain and restricted shoulder motion. Evidence has shown that reverse total shoulder arthroplasty (rTSA) is an effective option to improve pain and function for patients with acute displaced proximal humerus fractures. Given that patients undergoing rTSA for proximal humerus fractures typically experience worse functional outcomes, worse patient-reported outcomes, and higher rates of complication compared to those with elective indications for surgical intervention, it is critical to determine a secure path to recovery for these patients after surgery. Early rehabilitation has been proposed to be safe and effective for patients who undergo rTSA for elective indications; however, there is a paucity of research evaluating safety and effectiveness of timing of rehabilitation for rTSA patients in the trauma setting. Currently, there exists a great variability in postoperative rehabilitation protocols across orthopaedic practices. This study's objective is to determine the safety and effectiveness of early postoperative rehabilitation on the outcomes and postoperative complications of patients undergoing rTSA for proximal humerus fractures in order to provide more specific recommendations for this patient population.",[143,144,145,146],"Orthopedic Disorder","Humerus Fracture","Shoulder Arthroplasty","Reverse Shoulder Replacement","2026-06-05",{"date":149,"type":39},"2026-06-09",{"date":151,"type":39},"2025-05-19",{"date":153,"type":21},"2026-12-31",{"name":155,"class":46},"University of Virginia",{"id":157,"slug":158,"hasResults":12,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":168,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":4},"100643685","timing-of-rehabilitation-following-cervical-spinal-surgery-in-degenerative-myelopathy-100643685","NCT07636135","Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy","Feasibility of Early Post-operative Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy","Inclusion Criteria:\n\n* adult (\\>18 years of age) with diagnosis of degenerative cervical myelopathy, within 2 weeks of spinal decompression surgery\n* plan to be discharged home from acute care (i.e., not admitted to another facility for post-operative rehabilitation)\n* able to stand with a maximum of one-person assist (+\u002F- use of gait aid)\n* persistent functional impairment in lower extremity strength, balance, coordination, and\u002For gait\n* ability to attend an 8-week in-person rehabilitation program in Edmonton, Alberta\n\nExclusion Criteria:\n\n* discharge from acute care facility \\> 2 weeks post-operative\n* intra-operative or early post-operative complication delaying discharge or precluding participation in early rehabilitation",{"count":84,"type":21},[58],"The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical spine surgery. The main question it aims to answer is:\n\nDoes starting rehabilitation earlier improve walking, balance, physical activity, quality of life, and nervous system function after surgery?\n\nResearchers will compare participants who begin rehabilitation two weeks after surgery with participants who begin rehabilitation six weeks after surgery to see if earlier rehabilitation leads to better recovery outcomes and participation.\n\nParticipants will:\n\nBe randomly assigned to begin rehabilitation either two weeks or six weeks after surgery.\n\nAttend physical therapy sessions twice per week for eight weeks focused on strength, balance, and walking.\n\nComplete assessments of walking ability, balance, physical activity, quality of life, and nervous system function over several months after surgery.\n\nProvide feedback about their experience with the rehabilitation program, including satisfaction and any side effects or challenges related to participation.",[167],"Cervical Myelopathy",[169,170,171,172,173],"physical therapy","post-operative rehabilitation","walking","degenerative cervical myelopathy","spinal cord injury","2026-06-04",{"date":149,"type":39},{"date":177,"type":21},"2026-06-15",{"date":179,"type":21},"2027-12-31",{"name":181,"class":46},"University of Alberta",{"id":183,"slug":184,"hasResults":12,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":22,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":201,"locationsCount":47},"100638566","prehabilitation-physical-therapy-and-relaxation-intervention-program-to-promote-resiliency-and-operative-success-among-adults-receiving-lung-cancer-surgery-roar-lcs-trial-100638566","NCT07584239","Prehabilitation Physical Therapy and Relaxation Intervention Program to Promote Resiliency and Operative Success Among Adults Receiving Lung Cancer Surgery, ROAR-LCS Trial","LiveWellLung: A Prehabilitation Intervention Program to Promote Resiliency and Operative Success Among Adults Receiving Lung Cancer Surgery (ROAR-LCS) With Biospecimen Collection","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosed with: potentially resectable non small cell lung cancer (NSCLC) stage (9th edition: IB-IIIB)\n* Intent to receive surgery following neoadjuvant systemic therapy from the Ohio State University Comprehensive Cancer Center (OSUCCC) Thoracic Oncology Clinic\n* Patients who are at least 6 weeks out of the surgery date are eligible to participate\n* Willingness to participate and adhere to the study intervention program\n* Ability to understand and willingness to sign an informed consent document\n\nExclusion Criteria:\n\n* Prisoners are excluded from participation\n* There is NO exclusion criteria pertaining to Eastern Cooperative Oncology Group (ECOG) performance status, laboratory values, or prior cancer diagnoses\n* Patients already enrolled on a therapeutic clinical trial will be excluded from this study as to not confound any exploratory outcomes associated with this trial and\u002For any clinical trials evaluating novel anti-cancer therapies unless granted permission by the local site principal investigator (PI)",{"count":190,"type":21},30,[58],"This clinical trial tests two different physical therapy and relaxation interventions, one in-person and at-home called Resiliency and Operative Success for Adults Receiving Lung Cancer Surgery (ROAR-LCS) and one virtually called BeFitMe. These programs that take place before and after standard of care lung cancer surgery, called prehabilitation programs, promote resiliency and patient outcomes (operative success) for adults receiving lung cancer surgery. Lung cancers occur in the chest and often cause symptoms for patients. Poor physical performance and negative mood are two risk factors for a decline in functional status after surgery. Physical therapy and relaxation interventions (i.e. progressive muscle relaxation) are two such interventions that may improve physical and emotional recovery including a potential shortened hospital stay for patients receiving surgery for lung cancer. Starting these intervention programs early alongside cancer treatment can improve symptoms, improve functional status and quality of life, help with emotional needs of patients, improve recovery time, and may even prolong life. ROAR-LCS and BeFitMe may promote resiliency and operative success for adults receiving lung cancer surgery.",[194],"Resectable Lung Non-Small Cell Carcinoma","2026-05-21",{"date":197,"type":39},"2026-05-26",{"date":199,"type":21},"2026-07-15",{"date":153,"type":21},{"name":202,"class":46},"Ohio State University Comprehensive Cancer Center",{"id":204,"slug":205,"hasResults":12,"nctId":206,"briefTitle":207,"officialTitle":208,"acronym":4,"eligibilityCriteria":209,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":22,"phases":212,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":47},"100548709","a-bowel-management-program-retrograde-rectal-enema-for-the-treatment-of-low-anterior-resection-syndrome-in-rectal-cancer-patients-100548709","NCT06424522","A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients","Low Anterior Resection Syndrome: Retrograde Enema Program vs Medical Management","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Moderate to Severe LARS diagnosis\n* Patients with history of rectal cancer that was treated with proctectomy\n* Has undergone standard medical management without improvement of symptoms for 3-6 months\n\nExclusion Criteria:\n\n* Patients presenting with significant stricture that need a definitive surgical management strategy; patients with minor or clinically negligible strictures can still be candidates. Patients who are able to pass the catheter and the balloon per rectum may be candidates after a digital rectal exam at their initial visit\n* Patients with any chemo or radiation therapy in the last 6 months\n* Patients who currently have colorectal cancer\n* Patients with recurrent colorectal cancer\n* Patients who have undergone a colorectal surgical procedure within the last three months\n* Patients with progressive neurological disease\n* Patients with active or recurrent sacral infection\n* Patients \\\u003C 18 years old\n* Active sacral nerve simulator\n* Pregnant or planning to become pregnant during the treatment portion of the study\n* Altered mental status or mental disability that would alter ability to self-administer enema\n* Any reason the research team believes the subject is not an appropriate candidate for this study (i.e., transportation issues, history of no-show appointments, lack of reliable communications, vulnerable population(s), etc.)",{"count":211,"type":21},80,[58],"This clinical trial studies if a bowel management program with a retrograde rectal enema (RRE) for the treatment of low anterior resection syndrome (LARS) in rectal cancer patients is better than medical management alone. Rectal cancer treatment can include a procedure where part of the rectum with cancer is removed and the remaining part of the rectum is reconnected to the colon, this is called a low anterior resection of the rectum. LARS is a common condition that can develop after undergoing a low anterior resection of the rectum. LARS consists of any change in how the body performs defecation, the discharge of feces from the body, after undergoing a resection procedure. Patients with LARS may experience fecal urgency, incontinence, increased frequency, constipation, feelings of incomplete bowel movement, or bowel emptying difficulties. Patients may experience individual symptoms of LARS or a combination of them. A bowel management program assists patient's with identifying a specific bowel management regimen that works best for managing symptoms of LARS. A RRE consists of inserting a catheter through the anus into the rectum. The RRE is designed to assist fecal emptying. Medical management of LARS can include the use of fiber, loperamide hydrochloride, or pelvic floor physical therapy. Fiber may help relieve constipation, feelings of incomplete bowel movement, or bowel emptying difficulties. Loperamide hydrocholoride may help lessen fecal urgency, incontinence, or increased frequency. Pelvic floor physical therapy may help restore strength in the rectum possibly helping to improve symptoms of LARS. Participating in a bowel management program with a RRE may be more effective in treating LARS than medical management alone.",[215,216],"Low Anterior Resection Syndrome","Rectal Carcinoma","2026-04-16",{"date":219,"type":39},"2026-04-21",{"date":221,"type":21},"2026-08-15",{"date":223,"type":21},"2028-12-31",{"name":202,"class":46},{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":22,"phases":234,"briefSummary":235,"conditions":236,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":246,"leadSponsor":248,"locationsCount":47},"100477120","impowr-me-project-1-trial-of-yoga-and-physical-therapy-onsite-at-opioid-treatment-programs-100477120","NCT05492825","IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs","Randomized Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs for Patients With Chronic Back Pain and Opioid Use Disorder","Inclusion Criteria:\n\n1. age ≥18 years old\n2. English or Spanish proficiency (i.e., be able to participate in study interventions and interviews in English or Spanish)\n3. receiving methadone or buprenorphine treatment for OUD in the Montefiore OTP network for at least 12 weeks, with no dose change in 14 days\n4. Chronic low or mid back pain, with at least moderate pain severity (score of ≥4 on the Pain, Enjoyment of Life and General Activity (PEG) Scale)\n5. Willingness to participate in all study components\n6. ability to provide informed consent, assessed using consent teach-back\n\nExclusion Criteria:\n\n1. severe disabling conditions that could make participation in yoga or PT hazardous (e.g., spinal canal stenosis; severe scoliosis; vertebral fracture, history of spine surgery, or joint surgery in the past six months; severe or progressive neurological deficits, or cardiovascular or neurological disease requiring hospitalization in the past six months; unable to stand for at least 60 seconds; regular use of a wheelchair or motorized scooter, or regular use of a walker and inability to walk at least 4 steps without it; 3 or more falls in the prior year with at least one being non-mechanical;; or other severe disabling conditions deemed by the study clinician or MPI to preclude safe or adequate participation in the study)\n2. acute exacerbation of psychiatric conditions that preclude the ability to participate in the study (e.g., acute mania, active suicidality\u002Fhomicidality, psychosis)\n3. cancer pain related to malignancy\n4. yoga practice or PT in the prior 60 days",{"count":233,"type":21},180,[58],"This is a pragmatic, open label, randomized controlled trial with 1:1:1 allocation to 12 weeks of: (1) onsite yoga at opioid treatment programs (OTPs), (2) onsite physical therapy (PT) at OTPs, or (3) treatment as usual (TAU). Participants will be 180 individuals with chronic back pain receiving treatment for opioid use disorder (OUD) in community-based OTPs. Through research visits at screening, baseline, and months 1, 2, 3, 6, and 9, the investigators will evaluate pain and opioid use outcomes and implementation outcomes.",[237,238,239,240],"Substance Use Disorders","Chronic Pain","Opioid Use Disorder","Back Pain Lower Back Chronic","2026-03-26",{"date":243,"type":39},"2026-03-31",{"date":245,"type":39},"2023-02-27",{"date":247,"type":21},"2026-11-02",{"name":249,"class":46},"Albert Einstein College of Medicine",{"id":251,"slug":252,"hasResults":12,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":4,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":257,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":266,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":4},"100629163","neuromodulation-induced-cortical-prehabilitation-in-high-grade-glioma-near-the-motor-pathway-cortical-plasticity-assessed-by-navigated-transcranial-magnetic-stimulation-ntms-100629163","NCT07471100","Neuromodulation-Induced Cortical Prehabilitation in High Grade Glioma Near the Motor Pathway: Cortical Plasticity Assessed by Navigated Transcranial Magnetic Stimulation (nTMS)","Neuromodulation-Induced-Cortical-Prehabilitation In High Grade Glioma Close To The Motor Pathway: Analysis Of The Cortical Brain Plasticity Through Navigated Transacranial Magnetic Stimulation","Inclusion Criteria:\n\n1. Age 18-80\n2. Suspect of High Grade Glioma in MRI\n3. Any case of cortical\u002Fsubcortical HGG radiologically close to Motor Pathway and, thus, where intraoperative monitoring assistance is usually required\n4. Preservation of motor function (at least ≥ 3 according to Medical Research Council classification)\n5. Signed informed Consent\n\nExclusion Criteria:\n\n1. Refusal to Study participation\n2. Multifocal\u002FBilateral Disease","80 Years",{"count":259,"type":21},63,[58],"The goal of this clinical trial is to learn whether Neuromodulation-Induced-Cortical-Prehabilitation (NICP)-using physical therapy (constraint-induced movement training, CIM) alone or combined with repetitive transcranial magnetic stimulation (rTMS)-can promote motor-cortex neuroplasticity before surgery in adults with high-grade gliomas near the motor pathway. It will also learn about the feasibility and safety of these prehabilitation strategies around the time of surgery. The main questions it aims to answer are:\n\n1. Does CIM (with or without rTMS) produce measurable motor-cortex plasticity from baseline to pre-surgery as assessed by neuronavigated TMS (nTMS)?\n2. Does adding rTMS to CIM lead to greater neuroplastic changes than CIM alone?\n3. What clinical, radiological, and neurophysiological outcomes are observed after surgery in participants who receive prehabilitation compared with controls?\n\nResearchers will compare standard care (control) vs CIM-based physical therapy vs CIM plus rTMS to see if these approaches induce preoperative neuroplastic changes that may support better surgical outcomes. Participants will:\n\n1. Be randomized to one of three groups: control, CIM physical therapy, or CIM + rTMS• Undergo nTMS motor mapping and excitability testing at baseline (T0) and the day before surgery (T1)\n2. Undergo planned tumor surgery (according to standard methods of care) and complete postoperative clinical, imaging, and neurophysiological follow-up assessments.",[263,264,265],"Brain Tumor Adult","Glioma","Glioma, High Grade",[267,268,269,270,271,272,169],"prehabilitation","neuromodulation","brain plasticity","cortical plasticity","rTMS","nTMS","2026-03-11",{"date":275,"type":39},"2026-03-13",{"date":277,"type":21},"2026-04-01",{"date":279,"type":21},"2030-03-31",{"name":281,"class":46},"Azienda Sanitaria dell'Alto Adige",{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":289,"targetDuration":4,"studyType":22,"phases":290,"briefSummary":291,"conditions":292,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":47},"100544549","neuromuscular-electrical-stimulation-in-foot-and-ankle-surgery-100544549","NCT06370325","Neuromuscular Electrical Stimulation in Foot and Ankle Surgery","Neuromuscular Electrical Stimulation in Foot and Ankle Surgery: A Pilot Study","Inclusion Criteria:\n\n* Capable and willing to provide informed consent\n* Undergoing a procedure that involves repairing an ankle fracture.\n\nExclusion Criteria:\n\nPatients with medical histories that include:\n\n* Rheumatoid arthritis\n* Connective tissue disorders\n* Chronic corticosteroid use\n* Implanted electrical devices\n* Neurological disorders\n* Non-ambulatory status\n* Recent surgery (within the last 3 months) that is not related to the study\n* Scheduled to undergo surgery in the near future\n* Epilepsy\n* Diagnosed with cancer\n* Have suffered acute trauma or recently have had a surgical procedure (not related to the study)\n* Have cardiac problems or cardiac disease\n* Have an abdominal hernia\n* Have venous thrombosis",{"count":84,"type":21},[58],"This is a pilot randomized controlled trial, wherein the intervention group will undergo NMES five days a week beginning three weeks postoperative and lasting for ten weeks. Both the control and intervention groups will start standard physical therapy six weeks postoperative. Primary outcome measure will be the isometric strength of the gastrocnemius muscle. The secondary outcomes will comprise subjective clinical evaluations (using the Lower Extremity Functional Scale \\[LEFS\\]), functional assessments such as the sit-to-stand test, 2-minute walk test, stair climb test and objective clinical evaluation using contralateral comparison of calf circumference.",[293],"Ankle Fractures","2026-02-25",{"date":296,"type":39},"2026-02-27",{"date":298,"type":39},"2025-06-19",{"date":300,"type":21},"2026-12-30",{"name":302,"class":46},"NYU Langone Health",{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":4,"eligibilityCriteria":308,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":309,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":312,"briefSummary":313,"conditions":314,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":47},"100277373","the-effects-of-dry-needling-on-patients-with-knee-pain-100277373","NCT02890485","The Effects of Dry Needling on Patients With Knee Pain","Inclusion Criteria:\n\n* 18-40 years-of-age\n* Referred for physical therapy\n* Presence of anterior knee pain around the patella during ascending\u002Fdescending stairs, squatting, and\u002For running for at least 3 months.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Bilateral patellofemoral pain syndrome\n* Received previous dry needling treatments\n* Pregnancy\n* History of pain less than 3 months\n* Imaging demonstrating the presence of confounding internal abnormality (e.g. chondral defects, ligamentous injury, and\u002For meniscal pathology),\n* Patellar instability\n* Presence of a neurological condition that would affect movement\n* Contraindications to dry needling techniques (e.g. a history of bleeding disorders, phobia of needles, an active cancer diagnosis, and presence of other systemic illness such as fever or signs of infection)\n* Actively receiving treatment for knee pain outside of the current study protocol while enrolled in the study;\n* received active and supervised PT treatment for knee pain within the last 4 weeks;\n* history of knee surgery less than 6 months ago\n* history of surgical correction of the patellofemoral complex (e.g. MPFL reconstruction, patellar realignment surgery, etc)","40 Years",{"count":311,"type":21},120,[58],"This study is testing the effectiveness of \"dry needling\" for pain management and on muscle strength and leg function for those with knee pain. Dry needling consists of small, monofilament needles that are administered directly into the tissue and manipulated to make the muscle relax for pain relief. This technique is used to treat dysfunctions in skeletal muscle and connective tissue to help diminish pain, reduce impairments of body structure and restore function.",[315,316],"Patellofemoral Pain Syndrome","Anterior Knee Pain Syndrome","2026-02-23",{"date":294,"type":39},{"date":320,"type":39},"2016-08",{"date":322,"type":21},"2030-12",{"name":324,"class":46},"Ohio State University",{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":22,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":346,"leadSponsor":347,"locationsCount":47},"100602522","a-brief-psychological-intervention-to-improve-emotional-well-being-during-neoadjuvant-therapy-for-pancreatic-cancer-100602522","NCT07124611","A Brief Psychological Intervention to Improve Emotional Well-Being During Neoadjuvant Therapy for Pancreatic Cancer","Testing the Feasibility of Incorporating Psychosocial Oncology During Neoadjuvant Therapy for Patients With Pancreatic Cancer","Inclusion Criteria:\n\n* Adults ≥ 18 years of age\n* Patient:\n\n  * Newly diagnosed patients with localized pancreatic ductal adenocarcinoma (PDAC) presenting to Ohio State University Wexner Medical Center-Comprehensive Cancer Center (OSUMC-CCC)\n  * Plans to initiate neoadjuvant therapy prior to surgical resection\n  * Neoadjuvant therapy (NT) and\u002For surgery may occur at another facility\n\nExclusion Criteria:\n\n* Prisoners\n* Persons unable to provide consent\n* Patients unlikely to undergo surgical resection following NT based on anatomical or performance status considerations\n* Confirmed or presumed metastatic disease\n* Already received ≥ 2 cycles of chemotherapy",{"count":333,"type":21},60,[58],"This clinical trial tests how well a psychosocial oncology intervention during neoadjuvant therapy works for patients with pancreatic cancer that has not spread to other parts of the body (localized). Chemotherapy and\u002For radiation therapy is often recommended prior to surgeryf or patients with pancreatic cancer; this is known as neoadjuvant therapy (NT). The primary advantages of NT include: reducing the size of the cancer mass and\u002For reducing the spread of cancer, to improve the likelihood of getting all the cancer during surgery, and because receiving chemotherapy after pancreas surgery can be challenging. Other research has shown that NT can lead to improved survival and a lower rate of the cancer returning. Despite these positive effects, NT can be associated with significant physical and emotional side effects. To prepare patients for future surgery and maintain health during chemotherapy and\u002For radiation, prehabilitation is often recommended. This can include nutritional and physical therapy to help with physical health. An oncology (cancer) psychosocial intervention during NT may be feasible and helpful to patients with localized pancreatic cancer.",[337,338,339,340],"Localized Pancreatic Ductal Adenocarcinoma","Stage 0 Pancreatic Cancer AJCC v8","Stage I Pancreatic Cancer AJCC v8","Stage IIA Pancreatic Cancer AJCC v8","2026-02-17",{"date":343,"type":39},"2026-02-19",{"date":345,"type":39},"2025-12-22",{"date":153,"type":21},{"name":202,"class":46},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":12,"sex":17,"minAge":356,"maxAge":257,"enrollmentInfo":357,"targetDuration":4,"studyType":22,"phases":359,"briefSummary":360,"conditions":361,"keywords":368,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":47},"100523389","embolization-treatment-of-chronic-refractory-shoulder-tendinopathy-100523389","NCT06095050","Embolization Treatment of Chronic Refractory Shoulder Tendinopathy","Efficacy of Lipiodol Embolization for Chronic Tendinopathy of the Rotator Cuff","ELECTRC","Inclusion Criteria:\n\n1. Male, female, transgender female, transgender male, non-binary\n2. Moderate to severe shoulder pain (VAS \\> 40)\n3. Pain refractory to at least 6 months of physician-directed conservative therapy (analgesics or injections or PT), including a minimum of 6 weeks of PT\n4. Willing, able, and mentally competent to provide informed consent and to tolerate angiography and physical therapy\n\nExclusion Criteria:\n\n1. History of peripheral arterial disease or peripheral artery disease symptoms including claudication, diminished or absent upper\u002Flower extremity pulses, or known upper extremity arterial atherosclerosis or occlusion that would limit selective angiography\n2. Known history of anaphylaxis to iodinated contrast agents or gadolinium based contrast\n3. Acute kidney injury\n4. Allergy to poppy seeds or lipiodol\n5. Renal dysfunction as defined by serum creatinine \\>1.6 dl\u002Fmg or eGFR \\\u003C60 obtained within 30 days of procedure.\n6. Uncorrectable coagulopathy (platelet count \\\u003C 50,000, international normalized ratio \\>1.8 within 30 days of procedure\n7. Active systemic or local upper extremity infection\n8. Patient pregnant, intending to become pregnant during the study.\n9. Prior shoulder replacement surgery\n10. Prior rotator cuff repair surgery\n11. Previous history of complete full-thickness tear of the rotator cuff\n12. Presence of non-MRI compatible devices (e.g., non-compatible cardiac pacemaker).","21 Years",{"count":358,"type":21},41,[58],"This is a randomized controlled trial in which patients with moderate to severe shoulder pain (Visual Analog Scale (VAS) \\> 40), in the setting of rotator cuff tendinopathy refractory to conservative treatment, will be enrolled.\n\nThe primary aim of the study is to estimate the effect of transcatheter arterial embolization (TAE) with physical therapy (PT) vs PT alone on the change in shoulder pain at 12-month follow up. Scientific objectives also include an assessment of safety of the intervention, assessment of changes in Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity score, Shoulder Pain and Disability Index (SPADI) scores, MRI Tendinopathy Score between the TAE + PT and PT groups.",[362,363,364,365,366,367],"Shoulder Pain","Tendinopathy","Rotator Cuff Tendinitis","Rotator Cuff Tendinosis","Embolization","Arterial Occlusion",[369,370,371],"pain","shoulder pain","tendinopathy","2026-02-04",{"date":374,"type":39},"2026-02-06",{"date":376,"type":39},"2025-01-16",{"date":378,"type":21},"2028-04-21",{"name":380,"class":46},"Brigham and Women's Hospital",{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":4,"eligibilityCriteria":387,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":388,"targetDuration":4,"studyType":22,"phases":390,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":399,"locationsCount":47},"100623120","telerehabilitation-for-shoulder-surgery-recovery-100623120","NCT07392502","Telerehabilitation for Shoulder Surgery Recovery","Telerehabilitation for Shoulder Surgery Recovery: A Randomized Trial Assessing the Effectiveness of the Band Connect Platform","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Scheduled for primary arthroscopic rotator cuff repair Surgery to be performed by Dr. Young Kwon, Dr. Mandeep Virk, Dr. Dennis DeBernardis, or Dr. Jie Yao\n* Planning to complete postoperative physical therapy at selected NYU physical therapy locations\n* Access to home internet and a wireless cell phone compatible with the Band Connect App\n\nExclusion Criteria:\n\n* Patients undergoing revision RCR\n* Patients whose post operative rehabilitation has to be delayed or modified.\n* Pregnant individuals\n* Shoulder injuries related to workers compensation or involved in any pending litigation\n* Patients unable to provide informed consent",{"count":389,"type":21},68,[58],"This study aims to evaluate the effectiveness of a telerehabilitation protocol utilizing the Band Connect platform in patient recovery following rotator cuff repair surgery. This will be a randomized control trial with patients assigned into a traditional rehabilitation or a telerehabilitation protocol.",[393],"Rotator Cuff Injuries","2026-01-30",{"date":374,"type":39},{"date":397,"type":21},"2026-03-01",{"date":223,"type":21},{"name":302,"class":46},{"id":401,"slug":402,"hasResults":12,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":257,"enrollmentInfo":408,"targetDuration":4,"studyType":22,"phases":410,"briefSummary":411,"conditions":412,"keywords":414,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":47},"100586153","emg-control-assistance-virtual-reality-interface-coupled-with-cerebellar-itbs-for-arm-recovery-after-stroke-erica-100586153","NCT06911671","EMG Control Assistance Virtual Reality Interface Coupled With Cerebellar-iTBS for Arm Recovery After Stroke (ERICA)","Innovative Upper Limb Stroke Rehabilitation Approach Combining Myoelectric Control Assistance in Virtual Reality and Cerebellar TBS Plasticity Enhancement","ERICA","Inclusion Criteria:\n\n* First ever ischemic stroke with mild to moderate motor impairment of upper limb;\n* Left or right sub-cortical or cortical lesion of the middle cerebral artery;\n* Age\\>18, \\\u003C80 years;\n* No visuospatial, cognitive, or attention deficits;\n* Fugl-Meyer score\\\u003C56.\n\nExclusion Criteria:\n\n* History of seizures;\n* Treatment with Benzodiazepines, Baclofen;\n* Pregnancy status;\n* Intracranial metal implant;\n* Cardiac pace-maker;\n* Orthopedic upper limb limitation;\n* Upper limb pain;\n* Patients with neurological diseases beyond stroke or with neuropsychiatric disorders or with neuropsychological disorders that could potentially compromise informed consent or compliance during the study.",{"count":409,"type":21},45,[58],"The investigators hypothesize that a myoelectric (EMG) controlled virtual reality (VR) interface allows for effective upper limb motor recovery of stroke patients. EMG control offers the possibility to alter visual feedback according to the recorded muscle activity in real-time. By manipulating the motion of a virtual hand associated with the recorded muscle patterns, assistance can be provided to stroke patients by correcting the error between the actual (dysfunctional) and a reference (functional) muscle pattern. Thus, through such an assistive EMG control algorithm, patients will be able to perform reaching movements with the virtual hand despite their motor impairment. By gradually reducing assistance, it is hypothesized that the salient error in the task space provided as visual feedback will systematically change the muscle patterns, thereby driving adaptation of the dysfunctional muscle patterns, enhancing motor recovery. Moreover, due to its relevant role in motor learning, it is expected that cerebellar stimulation will favor the underlying processes of adapting cerebello-cortical plasticity involved in motor learning. Therefore, it is hypothesized that an assistive EMG control algorithm in combination with cerebellar transcranial magnetic stimulation will further enhance upper limb recovery.",[88,413],"Stroke, Cardiovascular",[415,416,417,418,419,420,421],"Virtual Reality","Brain Stimulation","Myoelectric Control","Transcranial Magnetic Stimulation","Cerebellar Stimulation","Motor Recovery","Tailored Assistance",{"date":423,"type":39},"2026-02-03",{"date":425,"type":39},"2025-04-01",{"date":427,"type":21},"2027-10-01",{"name":429,"class":46},"I.R.C.C.S. Fondazione Santa Lucia",{"id":431,"slug":432,"hasResults":12,"nctId":433,"briefTitle":434,"officialTitle":435,"acronym":4,"eligibilityCriteria":436,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":437,"enrollmentInfo":438,"targetDuration":4,"studyType":22,"phases":440,"briefSummary":441,"conditions":442,"keywords":446,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":456,"leadSponsor":458,"locationsCount":47},"100621914","effect-of-sleeping-posture-guidance-on-sleep-quality-in-patients-with-rotator-cuff-syndrome-100621914","NCT07376811","Effect Of Sleeping Posture Guidance On Sleep Quality In Patients With Rotator Cuff Syndrome","Effect Of Sleeping Posture Guidance On Sleep Quality In Patients With Rotator Cuff Syndrome Undergoing Physical Therapy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Clinical and\u002For radiological diagnosis of Rotator Cuff Syndrome (RCS).\n* Presence of shoulder pain for at least 3 months (chronic pain).\n* Patients aged between 18 and 65 years.\n* Patients referred for conservative physical therapy treatment.\n* Ability to understand and answer the assessment questionnaires (PSQI, MSQ, ASES, and VAS).\n* Voluntarily signing the Informed Consent Form (ICF).\n\nExclusion Criteria:\n\n* History of surgical procedures on the affected shoulder.\n* Presence of fractures or recent acute trauma in the shoulder or upper limb.\n* Associated neurological disorders, inflammatory systemic diseases (e.g., Rheumatoid Arthritis), or adhesive capsulitis (frozen shoulder).\n* Previous diagnosis of primary sleep disorders unrelated to pain (e.g., severe obstructive sleep apnea) already under clinical treatment.\n* Recent history of corticosteroid injections in the shoulder (within the last 3 months).","65 Years",{"count":439,"type":21},64,[58],"This study investigates sleep quality in patients with Rotator Cuff Syndrome (RCS) undergoing physical therapy treatment. Existing literature presents a gap regarding longitudinal studies evaluating the impact of physical therapy and different sleeping positions on sleep quality within this specific population. The central hypothesis is that physical therapy, combined with guidance on the best sleeping positions, reduces pain, improves shoulder function, and consequently promotes an improvement in sleep quality for RCS patients over time. The justification for this research lies in the need to better understand the relationship between physical therapy and sleep quality in RCS patients, aiming for the development of more effective and less invasive interventions. Previous studies have demonstrated that chronic pain, a common symptom of RCS, is intrinsically linked to sleep disturbances, which can lead to deleterious effects such as dopamine reduction, alterations in the descending pain modulation system, and central sensitization. Improvements in sleep quality have been observed after surgical procedures such as shoulder arthroscopy and arthroplasty, often associated with improved function and pain reduction. Thus, this study seeks to longitudinally evaluate whether physical therapy is capable of promoting a sustained improvement in sleep quality for patients with RCS",[443,444,445],"Rotator Cuff Syndrome","Rotator Cuff Injury","Sleep Disorder (Disorder)",[447,448,449,169,450,370,451],"rotator cuff syndrome","sleep quality","sleeping position","randomized controlled trial","rehabilitation","2026-01-25",{"date":454,"type":39},"2026-01-29",{"date":397,"type":21},{"date":457,"type":21},"2029-11-01",{"name":459,"class":46},"Federal University of São Paulo",{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":466,"targetDuration":4,"studyType":22,"phases":468,"briefSummary":469,"conditions":470,"keywords":474,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":485,"locationsCount":47},"100584565","the-utilization-of-a-shoe-insert-on-individuals-with-unilateral-greater-trochanteric-pain-syndrome-on-single-leg-stance-biomechanics-and-pain-intensity-100584565","NCT06891001","The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, Biomechanics, and Pain Intensity","Inclusion Criteria:\n\n* Subjects with a history of unilateral hip pain lasting more than three months.\n* Subjects with a VAS pain score of at least 3\u002F10 localized to the lateral hip.\n* Subjects with pain with palpation to lateral hip.\n* Subjects with pain with either resisted hip abduction in relative adduction testing position and\u002For single leg stance test\n\nExclusion Criteria:\n\n* Subjects wearing custom foot orthoses at the time of recruitment.\n* Subjects who endorse current low back pain ≥ 3 on the NRS or lumbar radiculopathy\n* Subjects with a medical history of spinal or lower limb surgery in the past 6 months.\n* Subjects with a medical history of total joint replacement of hip, knee, or ankle on the symptomatic side\n* Subjects who have had a corticosteroid injection at the hip within the last 12 months;\n* Subjects demonstrating clinical signs and symptoms of intra-articular hip joint pathology with ≥ 3\u002F10 groin pain including imaging confirmed significant labral tearing requiring surgery or osteoarthritis \\> 2 (mild) on Kellgren-Lawrence score on radiographs.\n* Subjects previously diagnosed with systemic inflammatory conditions; active cancer\u002Fmalignant tumors; or neurological conditions that would affect gait\n* Subjects who have had physical therapy within the past 3 months for hip pain\n* If subjects are unable to commit to 12 weeks of therapy with one supervised session weekly\n* Subjects who have the intention to perform treatments outside of this study including, but not limited to, dry needling or acupuncture, extracorporeal shockwave, therapeutic ultrasound, a TENEX procedure, medication injection therapies, platelet-rich plasma injections, stem cell injections, and surgery.",{"count":467,"type":21},36,[58],"We hypothesize that the addition of a unilateral neutral shoe insert combined with standard physical therapy (PT+SI) will have greater improvements in pain and function at 12 weeks and 6 months compared to physical therapy with sham inserts (PT+Sham) and physical therapy (PT) alone. In addition, we hypothesize that the addition of a neutral shoe insert in the involved limb will immediately improve biomechanics and pain with the single-leg stance test.",[471,472,473],"Gluteus Medius Muscle Strength","Lateral Hip Pain","Greater Trochanter Pain Syndrome, Gluteus Medius Tendinopathy, Gluteus Minimus Tendinopathy",[475,476,477],"Gluteus medius tendinopathy","Gluteus minimum tendinopathy","Greater trochanteric pain syndrome","2026-01-20",{"date":480,"type":39},"2026-01-22",{"date":482,"type":21},"2027-01-01",{"date":484,"type":21},"2029-01-01",{"name":74,"class":46},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":493,"sex":17,"minAge":494,"maxAge":495,"enrollmentInfo":496,"targetDuration":4,"studyType":22,"phases":498,"briefSummary":499,"conditions":500,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":503,"startDateStruct":505,"completionDateStruct":507,"leadSponsor":509,"locationsCount":511},"100476754","muscle-o2-saturation-and-hemoglobin-levels-during-rehabilitation-from-arthroscopic-surgery-100476754","NCT05488054","Muscle O2 Saturation and Hemoglobin Levels During Rehabilitation From Arthroscopic Surgery","Use of a Wearable Muscle Oxygen Saturation Sensor in the Rehabilitation of High-School and Collegiate Athletes Recovering From Arthroscopic Hip and Knee Surgery","Inclusion Criteria:\n\n* Age range: Patients age 14 to 30 years\n* Patients with ACL injury requiring surgical correction\n* Patients undergoing arthroscopic hip surgery\n* Healthy individuals with no history of ACL, arthroscopic knee or arthroscopic hip surgery\n\nExclusion Criteria:\n\n* Patients below 14 years or above 30 years\n* Non-English-speaking subjects\n* Pregnant individuals",true,"14 Years","30 Years",{"count":497,"type":21},226,[58],"This study will utilize the Moxy wearable sensor to measure muscle oxygen saturation levels in athletes following lower extremity surgery (ACL or Hip arthroscopy) to evaluate their Return-to-Play. The acquired data will complement current protocols utilized by Dr. Voos and Dr. Salata in this regard and will add quantifiable evidence to enable a robust measurement of the surgical limb versus non-surgical limb.",[501,502],"ACL Injury","Hip Injuries",{"date":504,"type":39},"2025-12-24",{"date":506,"type":39},"2022-08-08",{"date":508,"type":21},"2026-12",{"name":510,"class":46},"University Hospitals Cleveland Medical Center",2,{"id":513,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":22,"phases":515,"briefSummary":25,"conditions":516,"keywords":517,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":523,"locationsCount":47},"100615758",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34],"2025-12-18",{"date":345,"type":39},{"date":521,"type":21},"2026-05-01",{"date":43,"type":21},{"name":45,"class":46},{"id":525,"slug":526,"hasResults":12,"nctId":527,"briefTitle":528,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":493,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":530,"targetDuration":4,"studyType":22,"phases":532,"briefSummary":534,"conditions":535,"keywords":539,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":47},"100230929","phase-4-adhesive-capsulitis-prospective-analysis-of-efficacy-and-financial-impact-for-use-of-physical-therapy-in-treatment-100230929","NCT02283996","Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment","Inclusion Criteria:\n\n* Patient must be 18 years or older\n* Must meet the following definition for adhesive capsulitis as defined by the American Academy of Orthopedic Surgeons: Self-limiting condition resulting from any inflammatory process about the shoulder in which capsular scar tissue is produced, resulting in pain and limited range of motion; also called frozen shoulder\n* Must be amenable to randomization into either cohort\n\nExclusion Criteria:\n\n* Non-English speaking patients\n* Pregnant women (women of childbearing potential will be advised to undergo regular pregnancy testing)\n* Patients who had previously undergone operative therapy for the condition",{"count":531,"type":21},260,[533],"PHASE4","The purpose of this study is to identify individuals 18 or older who have diagnostic presentation of adhesive capsulitis and randomize them into two arms, distinguished by use of physical therapy and steroid injections compared with steroid injections followed by watchful waiting. This prospective study will be used to determine whether there is a significant impact on patient outcome and whether the additional financial burden is justified. There are no experimental interventions for this study. The use of physical therapy, oral and parenteral corticosteroids, and watchful waiting are offered following the standard of care for adhesive capsulitis. Our hypothesis is that patients will not have a significant difference in outcome between the two study arms. One group will undergo regular physical therapy with corticosteroid injections (Arm 1) and the other will have steroid injections during the inflammatory phase only and then be regularly observed (Arm 2). We also hypothesize there will be a significant financial burden associated with the PT arm that is not justified with the possibility of increased symptom reports in that arm.",[536,537,538],"Adhesive Capsulitis","Frozen Shoulder","Shoulder Frozen",[536,537,538,115,540,541,542,543,544],"Corticosteroid Injections","Hydrodilation, Hydro-dilation","Watchful Waiting","Prospective","Glenohumeral Ligament","2025-10-24",{"date":547,"type":39},"2025-10-27",{"date":549,"type":39},"2014-11",{"date":551,"type":21},"2027-12",{"name":553,"class":46},"Massachusetts General Hospital",{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":17,"minAge":561,"maxAge":4,"enrollmentInfo":562,"targetDuration":4,"studyType":22,"phases":564,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":570,"lastUpdatePostDateStruct":571,"startDateStruct":573,"completionDateStruct":575,"leadSponsor":577,"locationsCount":47},"100520150","phase-2-geriatric-assessment-guided-interventions-to-accelerate-functional-recovery-after-car-t-therapy-for-patients-60-years-and-older-with-b-cell-non-hodgkin-lymphoma-or-multiple-myeloma-gocart-study-100520150","NCT06052826","Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study","Geriatric (G) Assessment Guided Optimization (O) to Accelerate Functional Recovery After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Patients 60 Years and Older With B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma (GOCART)","Inclusion Criteria:\n\n* Ability to provide informed consent\n* Patient's physician must agree for patient participation. A physician may elect to provide blanket agreement for participation of any eligible CAR-T patient under their care\n* Ability to read English, or Spanish. Other languages will be acceptable with site principal investigator (PI) agreement if surveys are available and language does not preclude completing study procedures\n* Age: \\>= 60 years at the time of enrollment\n* Scheduled to receive an Food and Drug Administration (FDA)-approved CAR-T for treatment of multiple myeloma or B-cell non- Hodgkin lymphoma\n* Willing and able to complete study requirements\n* Patients expect to be able to participate at least once before lymphodepletion with trimodality optimization visits\n\nExclusion Criteria:\n\n* Prior CAR-T therapy\n* Any condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures\n* Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility\u002Flogistics)","60 Years",{"count":563,"type":21},164,[565],"PHASE2","This clinical trial compares the effectiveness of geriatric assessment (GA) guided interventions to accelerate functional recovery after chimeric antigen receptor T-cell (CAR-T) therapy compared to standard of care (SOC) in patients 60 years and older with B-cell non-Hodgkin lymphoma (NHL) or multiple myeloma (MM). A large number of patients diagnosed with cancer are over the age of 60, yet most cancer treatments are developed for younger patients. Therefore, older patients may be less likely to be offered stronger treatments, such as CAR-T therapy, due to possible side effects. Geriatric assessment is a multi-dimensional health assessment tool combining patient reported and objective measures covering physical function, mental processes (cognitive), and nutrition. Pre-treatment assessments may identify weaknesses in older adults and may guide interventions for physical therapy, cognitive changes and nutrition to decrease CAR-T therapy side effects and improve care in older adults with NHL or MM.",[568,569],"B-Cell Non-Hodgkin Lymphoma","Multiple Myeloma","2025-10-02",{"date":572,"type":39},"2025-10-06",{"date":574,"type":39},"2023-06-23",{"date":576,"type":21},"2026-10-05",{"name":578,"class":46},"City of Hope Medical Center",{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":585,"eligibilityCriteria":586,"healthyVolunteers":12,"sex":17,"minAge":309,"maxAge":561,"enrollmentInfo":587,"targetDuration":4,"studyType":22,"phases":589,"briefSummary":590,"conditions":591,"keywords":595,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":47},"100566346","intra-articular-corticosteroid-with-hyaluronic-acid-plus-physiotherapy-for-hip-pathologies-non-op-hip-100566346","NCT06653985","Intra-articular Corticosteroid With Hyaluronic Acid Plus Physiotherapy for Hip Pathologies (NON-OP HIP)","Intra-articular Corticosteroid With Hyaluronic Acid Plus Physiotherapy for Hip Pathologies (NON-OP HIP) - a Randomized Controlled Trial","NON-OP HIP","Inclusion Criteria:\n\n1. Patients aged 40-60 years old.\n2. Patients with mild hip arthritis (Kellgren-Lawrence grade 2 or lower) with or without a labral tear and\u002For femoroacetabular impingement and\u002For mild hip dysplasia.\n3. Patients who demonstrate more than 50% reduction in hip pain following a diagnostic injection (ultrasound guided intra-articular anaesthetic only).\n4. Able to subsidize private physiotherapy services.\n5. Able to provide informed consent.\n\nExclusion Criteria:\n\n1. Active infection\n2. Osteonecrosis of the hip, moderate to severe arthritis (Kellgren-Lawrence grade 3 or higher), or moderate-to-severe hip dysplasia\n3. Previous hip fracture, pelvic fracture, or lower limb fracture,\n4. Previous surgery to the pelvis, hip or lower limb\n5. Hypermobility disorder or connective tissue disease (e.g. Ehler's-Danlos syndrome, Marfan's syndrome etc.)\n6. Patients with chronic low back pain and\u002For sciatica\n7. Patients who received an intra-articular steroid hip injection within 3 months\n8. Patients who have previously received a hyaluronic acid injection\n9. Injuries sustained in a motor vehicle collision.\n10. Injuries sustained in the workplace and have a worker's compensation claim.\n11. Injuries resulting in a medico-legal dispute.\n12. Patients who are pregnant of planning to become pregnant\n13. Currently enrolled in a study that does not permit co-enrollment\n14. Unable to obtain informed consent\n15. Unable to comply with the study protocol\n16. Contraindication to corticosteroid or hyaluronic acid injection\n17. Prior enrollment in the study.",{"count":588,"type":21},100,[58],"Hip pathologies that cause pain and functional limitations are common in the general population. These can include femoroacetabular impingement (FAI), labral tears and mild osteoarthritis (OA) among others. While more severe and symptomatic cases may require surgical intervention, the treatment of mild-to-moderate cases is often treated without surgery to relieve pain, improve function, and delay surgical intervention.\n\nNon-operative treatments of hip pathologies consist of a multitude of options. A common non-operative intervention includes intra-articular injections, including corticosteroids and hyaluronic acid. Evidence has demonstrated that corticosteroids have fast acting effects which tend to diminish within a few months, while hyaluronic acid has a delayed time of onset and demonstrates clinical benefit for a longer period of time. Studies have evaluated combinations of corticosteroid and hyaluronic acid, hoping to take advantage of the fast-acting relief of corticosteroid and the longer lasting benefits of corticosteroid.\n\nPhysiotherapy is also a frequent non-operative intervention used to relieve pain and increase function in patients with hip pathologies. While many studies have looked at intra-articular injections and physiotherapy as independent non-operative possibilities for hip conditions, the combined effect of these two have not received much evaluation. The purpose of this study is to evaluate the effect of physiotherapy in conjunction with a combined corticosteroid and hyaluronic acid intraarticular injection on patient outcomes when compared to a corticosteroid and hyaluronic acid intraarticular injection alone.",[592,593,594],"Osteoarthritis","Femoroacetabular Impingement Syndrome","Labrum Injury of the Hip Joint",[596,592,597,598,599,600,115,601],"Hip","Femoroacetabular impingement","Labral tear","Hyaluronic acid","Corticosteroid","Physiotherapy","2025-09-27",{"date":570,"type":39},{"date":605,"type":39},"2024-05-01",{"date":607,"type":21},"2026-10-31",{"name":609,"class":610},"ArthroBiologix Inc.","INDUSTRY",{"id":612,"slug":613,"hasResults":12,"nctId":614,"briefTitle":615,"officialTitle":616,"acronym":4,"eligibilityCriteria":617,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":618,"targetDuration":4,"studyType":22,"phases":620,"briefSummary":621,"conditions":622,"keywords":624,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":47},"100472650","somatosensory-tinnitus-rct-100472650","NCT05434637","Somatosensory Tinnitus RCT","Developing Tools and a Care Path for Somatosensory Tinnitus","Inclusion Criteria:\n\n* Constant, chronic tinnitus (6-months in duration)\n* bothersome tinnitus based on TFI score and self-reported loudness\n* able to modulate tinnitus perception with head, neck, and\u002For jaw maneuvers\n\nExclusion Criteria:\n\n* Middle ear pathology\n* not a candidate for physical therapy\n* injury to the temporomandibular area in past 3 months\n* active pathology in the orofacial region",{"count":619,"type":21},72,[58],"The purpose of this study is to learn more about a type of tinnitus (ringing in the ears) known as \"somatosensory tinnitus.\" This type of tinnitus is suspected when the tinnitus perception changes following head and\u002For neck movements. This study is also exploring a possible way to treat somatosensory tinnitus.",[623],"Tinnitus",[623],"2025-09-11",{"date":627,"type":39},"2025-09-17",{"date":629,"type":39},"2023-11-01",{"date":631,"type":21},"2027-09-30",{"name":633,"class":634},"VA Office of Research and Development","FED",{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":4,"eligibilityCriteria":641,"healthyVolunteers":12,"sex":17,"minAge":356,"maxAge":82,"enrollmentInfo":642,"targetDuration":4,"studyType":22,"phases":643,"briefSummary":644,"conditions":645,"keywords":647,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":649,"lastUpdatePostDateStruct":650,"startDateStruct":652,"completionDateStruct":654,"leadSponsor":656,"locationsCount":47},"100324865","transcutaneous-spinal-stimulation-and-exercise-for-locomotion-100324865","NCT03509558","Transcutaneous Spinal Stimulation and Exercise for Locomotion","Transcutaneous Spinal Stimulation With Intensive Physical Therapy for Locomotion","Inclusion Criteria:\n\n* Has spinal cord injury (T12 or higher level) of at least 1-year duration\n* Is between 21 and 70 years of age\n* Has difficulty with leg functions and mobility in activities of daily living (e.g. walking, transferring surface to surface, standing)\n* Has stable medical condition without cardiopulmonary disease or frequent autonomic dysreflexia that would contraindicate participation in lower extremity rehabilitation or testing activities\n* Is capable of performing simple cued motor tasks\n* Has ability to attend up to 5 sessions per week physical therapy sessions and testing activities\n* Has adequate social support to be able to participate in training and assessment sessions, up to 5 sessions per week, for the duration of up to 11 months within the study period\n* Is volunteering to be involved in this study\n* Cleared for gait training by the primary physician of the subject\n* Has the ability to read and speak English\n\nExclusion Criteria:\n\n* Has autoimmune etiology of spinal cord dysfunction\u002Finjury\n* Has history of additional neurologic disease, such as stroke, multiple sclerosis, traumatic brain injury, etc.\n* Has peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.)\n* Has rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.)\n* Has significant medical disease; including uncontrolled systemic hypertension with values above 170\u002F100 mmHg; cardiac or pulmonary disease; uncorrected coagulation abnormalities or need for therapeutic anticoagulation.\n* Has active cancer\n* Has cardiovascular or musculoskeletal disease or injury that would prevent full participation in physical therapy intervention\n* Has unhealed fracture, contracture, pressure sore, urinary tract infection, or other illnesses that might interfere with lower extremity rehabilitation or testing activities\n* Has any condition that would render the patient unable to safely cooperate with the study tests as judged by the screening physician\n* is pregnant\n* is dependent on ventilation support\n* Has implanted stimulator (e.g. epidural stimulator, vagus nerve stimulator, pacemaker, cochlear implant, etc)\n* Has depression or anxiety based on the Center for Epidemiologic Studies Depression Scale (CESD) (score \\>16\u002F60) and General Anxiety Disorder-7 item Questionnaire (score \\>9\u002F21), respectively\n* Has alcohol and\u002For drug abuse\n* Has cognitive impairment based on Short Portable Mental Status Questionnaire (SPMSQ) (score \\>2\u002F10)\n* is unable to read and\u002For comprehend the consent form\n* is unable to understand the instructions given as part of the study\n* Has established osteoporosis and taking medication for osteoporosis treatment\n* Has bone mineral density T scores ≤ -3.5 or Z scores ≤ -2.5 in the anteroposterior lumbar spine and\u002For proximal femur measured by a DEXA scan for subjects weight bearing and ambulating outside of a body-weight supporting exoskeleton (if participants are clear for other criteria and have not been examined by Dual Energy Xray Absorptiometry (DEXA) at the screening, we will ask participants to undergo DEXA to reveal any risk of weight bearing activity)\n* Has low-energy fracture history before or after spinal cord injury\n* History of orthopedic surgery in lower extremities that may be a confounding factor for interpretation of the results (such as tendon transfer, tendon or muscle lengthening for spasticity management, arthrodesis, etc.)\n* fixed lower extremity joint contractures\n* is taller than 80 inches and\u002For more than 350 pounds body weights, due to the limitation of the experimental equipment such as the body weight support system\n* lacks the ability to fully comprehend and\u002For perform study procedures in the investigator's opinion\u002Fjudgement\n* has history of severe allergy (i.e. allergic reaction that could not be treated with antihistaminic medication)\n* has malabrosption syndrome, primary hyperthyroidism, and\u002For hypogonadism\n* has a history of seizures\n* has chronic headaches or migraines\n* has deep brain stimulators, metallic devices in the head such as aneurysm clips\u002Fcoils and stents, vagus nerve stimulators",{"count":84,"type":21},[58],"Growing evidence indicates that electrical spinal cord stimulation improves motor functions both immediately and over the long term via modulating the excitability of spinal circuitry in patients with spinal cord injury. Recently, a novel, non-invasive, well-tolerated, and painless lumbosacral transcutaneous electrical stimulation strategy was demonstrated to be effective in improving lower limb motor function in participants with spinal cord injury. Our current project, cervical transcutaneous electrical stimulation and intensive exercise for arms and hands are also revealing a significant improvement in upper extremity function. Additionally, the subject and caregiver noted that stair climbing ability has been substantially enhanced starting from the first week of cervical stimulation treatment and continues to date.\n\nThis study is a prospective efficacy trial of combined transcutaneous cervical and lumbosacral electrical stimulation with physical therapy for improving locomotion in people with anatomically incomplete tetraplegia and paraplegia.\n\nThis experiment design consists of testing walking function with and without transcutaneous spinal cord stimulation. A two to four-phase intervention program will include physical therapy and spinal cord stimulation with physical therapy. The length of any intervention phase, and number of measurements performed during that phase, will be determined by multiple factors, including participants' health condition, availability, and response to intervention. Between each intervention, washout periods of up to one month may be used to determine any after-effects of the interventions.\n\nThe intervention arms will be repeated if the functional improvement does not reach a plateau during the first two months of intervention. Physical therapy will include functional training (e.g., walking training) and strength training. Each spinal cord stimulation with physical therapy intervention block can use transcutaneous lumbosacral stimulation or cervical and lumbosacral stimulation. Both immediate and lasting improvements in lower extremity function and autonomic function via transcutaneous spinal cord stimulation and intensive physical therapy may be evaluated.",[646],"Spinal Cord Injuries",[648],"Spinal electrical stimulation","2025-07-31",{"date":651,"type":39},"2025-08-05",{"date":653,"type":39},"2018-02-28",{"date":655,"type":21},"2026-09-30",{"name":657,"class":46},"University of Washington",""]