[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"ADIR Association\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":157},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,75,103,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100582700","hybrid-prehabilitation-before-thoracic-surgery-100582700",false,"NCT06866717","Hybrid Prehabilitation Before Thoracic Surgery","Relative Effectiveness of a Hybrid Prehabilitation Program (Home-based and Center-based) Compared to a Center-based Prehabilitation Program Before Non-small Cell Lung Cancer Surgery: A Randomized Controlled Equivalence Study","HYBREATH","Inclusion Criteria:\n\n* Age \\> 18 years\n* Patient scheduled to undergo lung resection for the treatment of diagnosed or suspected bronchial cancer\n* Referred for prehabilitation before lung resection surgery\n* Patient living at home with another adult present during exercise sessions\n* Surgery date not established at the time of inclusion in the program, or at least 4 weeks away\n* Peak oxygen uptake below 20 ml\u002Fkg\u002Fmin\n* Affiliated with a health insurance system\n* Able to read and understand the information letter and sign the consent form\n\nNon-Inclusion Criteria\\*:\n\n* Oxygen therapy during exercise\n* Cardiological contraindication to exercise training\n* Refusal to participate in a center-based prehabilitation training program\n* Orthopedic, neurological, vascular, or neuromuscular conditions limiting exercise training on a cycle ergometer\n* Patient under guardianship or curatorship\n* Pregnant or breastfeeding women\n\nExclusion Criteria:\n\n-Withdrawal of consent\n\n\\*The eligibility criteria were revised in May 2026 following approval of a protocol amendment by the French Ethics Committee (CPP Île-de-France IV). The former non-inclusion criterion of patients receiving concomitant neoadjuvant chemoradiotherapy was removed to better reflect the study population to current clinical practice, as neoadjuvant treatments are increasingly integrated into the care pathway of patients undergoing thoracic surgery for non-small cell lung cancer and referred for pulmonary prehabilitation. The previous restriction had been too limiting and had slowed recruitment. This amendment was proposed to improve the feasibility of recruitment and to increase the representativeness of the study population, while ensuring the safety of the participants as no additional safety concerns were identified and all other exclusion criteria related to safety were unchanged.","ALL","18 Years",{"count":20,"type":21},38,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background and study aims:\n\nLung cancer is a leading cause of cancer-related deaths worldwide. Patients with non-small cell lung cancer often undergo lung surgery to remove the tumor. Before surgery, patients may participate in prehabilitation programs to improve their physical fitness and overall health, which can lead to better surgical outcomes. Traditionally, these programs are conducted entirely in specialized centers, but places are scarce, limiting access. This study aims to compare the relative effectiveness of a hybrid prehabilitation program, combining home-based and center-based sessions, with the standard center-based program. The primary goal is to assess changes in aerobic capacity, measured by peak oxygen uptake, before and after participation in the prehabilitation program.\n\nWho can participate?\n\nAdults over 18 years old who are scheduled for lung resection surgery to treat diagnosed or suspected non-small cell lung cancer can participate. Participants should be referred for respiratory prehabilitation in a preoperative context and live at home with another adult, present during exercise sessions. The surgery date should be either not yet established at the time of inclusion or scheduled for at least four weeks later. Participants should have a peak oxygen uptake of less than 20 ml\u002Fkg\u002Fmin, be beneficiaries of a social security system, and have read and understood the information letter and signed the consent form.\n\nWhat does the study involve?\n\nThis is a single-center, randomized controlled trial with two groups:\n\nCenter-based prehabilitation group: Participants will attend 15 sessions over three weeks (five sessions per week) at the center. The program includes an initial session of therapeutic education and exercise training, followed by 13 prehabilitation sessions, and a final session with educational reinforcement.\n\nHybrid prehabilitation group: Participants will have three sessions at the center and 13 sessions at home over the same period. They will be provided with equipment such as a cycle ergometer, pulse oximeter, physical activity sensor, and a tablet application (TELEREHAPP) to guide and monitor their home-based exercises. Regular phone contact with healthcare professionals will be maintained for support.\n\nAll participants will undergo assessments before and after the program, including an incremental exercise test on a cycle ergometer to measure peak oxygen uptake.\n\nWhat are the possible benefits and risks of participating?\n\nParticipants may experience improved physical fitness, which could lead to better surgical outcomes and reduced postoperative complications. The study will also provide insights into the relative effectiveness of hybrid prehabilitation, potentially offering more flexible options and facilitating access to care for future patients. Risks may include muscle soreness, fatigue, or injury related to exercise, independently of group allocation. All exercise sessions will be supervised or monitored to minimize these risks. Participants will receive instructions on how to perform exercises safely and will be encouraged to report any adverse effects promptly.",[27],"Non-Small Cell Lung Cancer",[29,30,31,32,33],"Non-small cell lung cancer","Prehabilitation","Telerehabilitation","Hybrid prehabilitation","Home-base exercise training","RECRUITING","2026-06-12",{"date":37,"type":38},"2026-06-15","ACTUAL",{"date":40,"type":38},"2025-05-30",{"date":42,"type":21},"2028-11",{"name":44,"class":45},"ADIR Association","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100589617","intermittent-intrapulmonary-deflation-and-dyspnea-following-exercise-in-people-with-chronic-obstructive-pulmonary-disease-100589617","NCT06956742","Intermittent Intrapulmonary Deflation and Dyspnea Following Exercise in People With Chronic Obstructive Pulmonary Disease","Effect of Intermittent Intrapulmonary Deflation on the Sensory Dimension of Dyspnea After Exercise in Patients With Chronic Obstructive Pulmonary Disease: A Double-blind, Randomized Crossover Study","DEFLA-DYSPNEA","Inclusion Criteria:\n\n* Age \\> 18 years;\n* COPD stage GOLD II to IV;\n* Had completed a pulmonary rehabilitation programme at the investigational site;\n* 6-minute walk test \\\u003C 350 meters before and\u002For after completing the pulmonary; rehabilitation program;\n* mMRC dyspnea scale ≥ 2;\n* Pulmonary hyperinflation (ratio between residual volume to total lung capacity superior to 50%, and either total lung capacity superior to 130% or functional residual capacity superior to 130%);\n* With or without oxygen supplementation;\n* Stable condition (no exacerbation or change in treatment in the last 4 weeks);\n* Naïve to intermittent intrapulmonary deflation.\n* Regulatory criteria (social security affiliation; adult patient who has read and understood the information letter and signed the informed consent form).\n\nNon-inclusion Criteria:\n\n* Pregnant women or likely to be;\n* Patients under guardianship or curatorship;\n* Inability to consent;\n* Primary diagnosis of another chronic obstructive respiratory disease such as asthma or primary bronchiectasis;\n* Orthopedic, neurological, vascular, or neuromuscular conditions that limit walking or require walking aids;\n* Severe or unstable cardiovascular disease (uncontrolled cardiac arrhythmias, severe heart failure, recent myocardial infarction, unstable angina);\n* Patients actively requiring assistance with inspiration (e.g. ventilatory assistance with endotracheal tube, tracheostomy tube, or ventilated with a mask; patients with neuromuscular disease with respiratory muscle weakness; patients with inability to cough forcefully and independently);\n* Hemodynamic instability;\n* Recent pneumothorax (within the last 3 months);\n* Recent pulmonary or upper airway surgery (within the last month);\n* Referral to a pulmonary rehabilitation program in preparation for thoracic surgery (lung volume reduction, lung transplantation, or lung resection for non-small cell lung cancer);\n* Use of an electrical mechanical device for airway clearance during the study period (in-exsufflator, high-frequency chest oscillation, etc.);\n* Active cancer;\n* Severe episode of hemoptysis in the last 3 months;\n* Severe tracheomalacia.\n\nExclusion Criteria:\n\n* Withdrawal of consent;\n* Acute COPD exacerbation between visits or onset of cardiorespiratory instability;\n* Use of an electrical mechanical device for airway clearance during the study period (in-exsufflator, high-frequency chest oscillation, etc.).",{"count":56,"type":21},33,[24],"Chronic obstructive pulmonary disease is a long-term lung condition that causes breathing difficulties. People living with this disease often feel short of breath, especially during physical activity, which can make daily tasks more challenging. This breathlessness is partly caused by mucus accumulation within the airways and air getting trapped in the lungs. Both of these reduce the amount of fresh air that can enter with each breath and increase the effort required to breathe.\n\nTo manage symptoms, people with chronic obstructive pulmonary disease may use medications, oxygen therapy, or be referred to pulmonary rehabilitation programs. These programs often include exercise training, self-management strategies, and airway clearance techniques. While chest physiotherapists typically guide patients in these techniques, certain medical devices can also help individuals manage their condition independently at home.\n\nOne such device uses a method called intermittent intrapulmonary deflation, which involves applying gentle pressure changes through a mouthpiece to help loosen mucus and release trapped air from the lungs. Although some individuals already use this kind of device as part of their daily care, more scientific evidence is needed to determine whether the improvements in airway clearance and reduced air trapping actually lead to measurable relief of breathlessness.\n\nThe goal of this clinical trial is to find out whether this type of medical device designed to remove airway mucus and trapped air in the lungs (using intermittent intrapulmonary deflation) can help reduce breathlessness (dyspnea) after physical activity in people with COPD.\n\nThe main questions this study aims to answer are:\n\n* Does using the device at home for one week reduce the intensity of breathlessness after walking?\n* Does it also improve walking distance, reduce the feeling of muscle fatigue, or increase satisfaction with the airway clearance method?\n\nResearchers will compare the active device to a placebo device that looks and feels identical but does not deliver the active treatment. This comparison will help determine whether the observed effects are due to the device itself or other factors such as expectations or chance.\n\nParticipants in this study will be adults diagnosed with moderate to very severe chronic obstructive pulmonary disease. All participants must have recently completed a pulmonary rehabilitation program, continue to experience breathlessness while walking, and show signs of lung hyperinflation (when air remains trapped in the lungs). People will not be included if they have other serious health conditions that could make walking difficult or unsafe, or if they have any contraindications to using the device.\n\nParticipants who agree to participante in the study will:\n\n* Attend a visit at the pulmonary rehabilitation center for baseline testing and to learn how to use the device;\n* Be randomly assigned to use either the active device or the placebo device at home for 7 days;\n* Return to the center for walking tests, lung function tests, and questionnaires about breathing and fatigue;\n* After a one-week break, use the device with alternative settings (the one not used in the first phase) for another 7 days;\n* Complete a final visit at the end of the study to repeat the same tests.\n\nParticipants will also be invited to take part in an ancillary study during their first clinic visit to examine how a single session with the device affects breathlessness immediately after walking.\n\nThis research will help determine whether this non-pharmacological, device-based method of clearing mucus and reducing trapped air can bring meaningful improvement in breathlessness for people with chronic obstructive pulmonary disease, especially when used at home. If effective, it may offer a simple and convenient way to help people breathe more comfortably during everyday activities.\n\nParticipants will receive compensation for their time and travel.",[60],"Chronic Obstructive Pulmonary Disease (COPD)",[62,63,64,65,66],"COPD","Chronic obstructive pulmonary disease","Intermittent intrapulmonary deflation","Dypsnea","Exercise","2026-06-01",{"date":69,"type":38},"2026-06-02",{"date":71,"type":38},"2025-06-01",{"date":73,"type":21},"2028-02-28",{"name":44,"class":45},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},"100594894","telerehabilitation-versus-centre-based-pulmonary-rehabilitaztion-for-patients-with-chronic-obstructive-pulmonary-disease-100594894","NCT07025382","Telerehabilitation Versus Centre-based Pulmonary Rehabilitaztion for Patients With Chronic Obstructive Pulmonary Disease","Relative Effect of Home-based Telerehabilitation Compared to Center-based Pulmonary Rehabilitation for Patients With Chronic Obstructive Pulmonary Disease: A Multicenter Randomized Controlled Non-inferiority Study","TELEREHA-COPD","Inclusion Criteria:\n\n* Age between 45 and 80 years\n* Confirmed diagnosis of chronic obstructive pulmonary disease, GOLD stage II to IV\n* Stable condition (no exacerbation in the last month prior to participation)\n* Referred to a pulmonary rehabilitation program\n* With or without oxygen during exercise\n* No pulmonary rehabilitation program in the last 12 months prior to participation\n* Living at home with another adult present during exercise sessions\n* Affiliated with a health insurance system\n* Able to read and understand the information letter and sign the consent form\n\nNon-inclusion criteria:\n\n* Referred to pulmonary rehabilitation before lung cancer surgery\n* Referred to pulmonary rehabilitation before lung volume reduction surgery scheduled within the next four months\n* Visual, cognitive, or auditory impairments incompatible with participation in a tele-pulmonary rehabilitation program\n* Orthopedic, neurological, cardiovascular, or neuromuscular conditions limiting exercise training on a cycle ergometer\n* Active cancer\n* Unable to provide informed consent\n* Under legal guardianship or curatorship\n* Pregnant or breastfeeding women\n\nExclusion Criterion:\n\n* Withdrawal of consent","45 Years","80 Years",{"count":86,"type":21},90,[24],"Background and study aims:\n\nChronic obstructive pulmonary disease is a leading cause of mortality worldwide. Pulmonary rehabilitation is recommended for patients to improve dyspnea, exercise capacity, and quality of life. Paradoxically, as few as 5 to 10% of eligible patients undergo pulmonary rehabilitation due to barriers such as transportation difficulties and limited availability of pulmonary rehabilitation centers. Home-based pulmonary rehabilitation using advanced telehealth technologies (telerehabilitation) may offer a solution to improve access.\n\nThis study aims to compare the relative effectiveness of a home-based telerehabilitation program with center-based program. The primary objective is to assess changes in exercise endurance capacity, measured by endurance time, before and after participation of the rehabilitation program.\n\nWho can participate?\n\nAdults between 45 and 80 years old who are referred for pulmonary rehabilitation and have a confirmed diagnosis of chronic obstrucitve pulmonary disease (GOLD stage II to IV) at any of the participating centers are eligible to participate, whether or not they use oxygen during exercise. Participants must live at home with another adult who is present during exercise sessions. They must not have experienced any exacerbation in the month prior to study inclusion, nor have participated in a pulmonary rehabilitation program within the past year. Participants must not have any scheduled surgery within the next four months, including surgery for lung cancer resection. They must not have active cancer, and must not present any contraindication to exercise or any condition that would limit their ability to use the telerehabilitation system.\n\nEligible participants must be beneficiaries of a social security system and must have read and understood the information letter and signed the informed consent form.\n\nWhat does the study involve?\n\nThis is a multi-center, randomized controlled trial with two groups:\n\nCenter-based rehabilitation group: Participants will attend 24 sessions over eight weeks (three sessions per week) at the center. The program includes an initial session of therapeutic education and exercise training, followed by 24 rehabilitation sessions, and a final assessment with educational reinforcement.\n\nHome-based rehabilitation group: Participants will have 24 sessions at home over the same period (eight weeks). The program includes an initial in-center assessment session, followed by 24 rehabilitation sessions and a final in-center session for assessment. They will be provided with equipment such as a cycle ergometer, pulse oximeter, physical activity tracker, and a tablet application (TELEREHAPP) to guide and monitor their home-based exercises. Regular phone contact with healthcare professionals will be maintained for support.\n\nAll participants will undergo assessments before and after the program, including a constant work rate endurance test on a cycle ergometer to measure exercise endurance capacity.\n\nWhat are the possible benefits and risks of participating?\n\nParticipants may experience improved physical fitness, which could lead to better dyspnea management and better quality of life. Risks may include muscle soreness, fatigue, or injury related to exercise, independently of group allocation. All exercise sessions will be supervised or monitored to minimize these risks. Participants will receive instructions on how to perform exercises safely and will be encouraged to report any adverse effects promptly.",[60],[31,91,92,93,60],"Pulmonary rehabilitation","Center-based exercise training","Home-based exercise training","2025-08-25",{"date":96,"type":38},"2025-08-29",{"date":98,"type":38},"2025-08-14",{"date":100,"type":21},"2030-12",{"name":44,"class":45},4,{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":113,"phases":4,"briefSummary":114,"conditions":115,"keywords":116,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":46},"100570139","predictive-properties-of-the-6-minute-stepper-test-for-mortality-in-copd-100570139","NCT06703359","Predictive Properties of the 6-Minute Stepper Test for Mortality in COPD","Evaluation of the Predictive Properties of the 6-Minute Stepper Test for Long-term Mortality in Patients with COPD","SixSTeM-COPD","Inclusion Criteria:\n\n* Age \\> 18 years;\n* Covered by a social security scheme;\n* COPD (all stages);\n* Referred for pulmonary rehabilitation;\n* Completed a 6-Minute Stepper Test at the start of their program.\n\nNon-inclusion Criteria:\n\n* Patients under guardianship or legal supervision;\n* Pregnant or breastfeeding women.\n\nExclusion Criteria:\n\n* Not applicable.",{"count":112,"type":21},250,"OBSERVATIONAL","Retrospective study aimed to answer the following research questions :\n\n* What are the predictive properties of the 6-minute stepper in COPD for 2-year mortality in individuals with COPD ?\n* What are the predictive properties of the 6-minute stepper in COPD for 5-year mortality in invididuals with COPD ?",[62],[62,117,91,118],"Six-minute stepper test","Exercise testing","2024-11-27",{"date":121,"type":38},"2024-12-02",{"date":123,"type":38},"2024-06-01",{"date":125,"type":21},"2029-06-30",{"name":44,"class":45},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":133,"eligibilityCriteria":134,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":148,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":46},"100530144","niv-versus-hfo-for-acute-exacerbations-of-interstitial-lung-diseases-100530144","NCT06182956","NIV Versus HFO for Acute Exacerbations of Interstitial Lung Diseases","Evaluation of Physiological Effects of Noninvasive Mechanical Ventilation and High-flow Oxygen Therapy for Acute Exacerbations of Interstitial Lung Diseases","IRAPIDPhysio","Inclusion criteria:\n\n* Age \\> 18 yrs\n* Hospitalization in intensive care unit\n* Acute exacerbation of a previously\u002Fpresently documented diffuse (fibrotic) interstitial lung disease\n* Dyspnea majoration since at least 1 month\n* Alveolar or ground-glass opacities on CT-scan that are superposed to interstitial lung disease and not explained by left heart failure or volume overload\n* Hypoxemia requiring oxygen flows \\> 6 L\u002Fmin\n\nExclusion criteria:\n\n* Contraindication to noninvasive ventilation or high-flow oxygen therapy\n* Immediate indication to endotracheal intubation or hemodynamic assistance\n* Body mass index \\> 40\n* Presence of a pacemaker or an implantable defibrillator\n* Presence of cutaneous lesions where Pulmovista® belt should be placed\n* Moribund patient\n* Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception\n* Protected adult patient (tutorship or curatorship)\n* Patient deprived of liberty by court or administrative decision\n* No possibility to install nasogastric tube\n* Endotracheal or tracheostomy tube requirement during the study\n* Hemodynamic assistance requirement during the study",{"count":136,"type":21},18,[24],"The objectives of this study are to compare the physiological consequences of high-flow oxygen therapy and noninvasive mechanical ventilation on ventilation, respiratory work and hemodynamics during acute respiratory failure in diffuse interstitial pneumonia.",[140,141],"Interstitial Lung Disease","Acute Respiratory Failure",[143,144,145,146,147],"Noninvasive mechanical ventilation","Nasal high-flow oxygen therapy","Respiratory work","Hemodynamics","Diaphragm","NOT_YET_RECRUITING","2023-12-13",{"date":151,"type":38},"2023-12-27",{"date":153,"type":21},"2024-01-01",{"date":155,"type":21},"2026-12-31",{"name":44,"class":45},""]