[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Abant Izzet Baysal University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":666},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,51,0,25,[9,49,72,100,124,149,175,201,229,249,275,306,325,348,372,401,420,444,473,505,528,561,585,616,643],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100053742","the-effect-of-comorbid-alcoholsubstance-use-100053742",false,"NCT07692984","The Effect of Comorbid Alcohol\u002FSubstance Use","The Effect of Comorbid Alcohol\u002FSubstance Use on Social Inclusion and Clinical Outcome in Individuals With Severe Mental Illness Enrolled in a Community Mental Health Center: A Cross-Sectional Case-Control Study","Inclusion Criteria:\n\n* Being 18 years of age or older,\n* Having a diagnosis of Schizophrenia Spectrum Disorder and Other Psychotic Disorders or Bipolar Disorder according to DSM-5 diagnostic criteria,\n* Being actively followed up at the TRSM for at least 6 months.\n\nExclusion Criteria:\n\n* Individuals diagnosed with organic brain damage or neurodevelopmental disorders (intellectual disability, etc.),\n* Individuals with severe cognitive impairment that prevents them from communicating adequately.","ALL","18 Years","65 Years",{"count":21,"type":22},297,"ESTIMATED","OBSERVATIONAL","Study Design This study was designed as a comparative, cross-sectional case-control study examining the effect of comorbid alcohol and substance use disorder (ASUD) on clinical course and social inclusion among individuals with severe mental illness followed at a Community Mental Health Center (CMHC). The study did not involve any interventions.\n\nAim The aim of this study is to examine the effect of comorbid alcohol and substance use on clinical course parameters-such as number of hospitalizations and medication dosages-and on social inclusion indicators-such as employment, social participation, and social adjustment-among individuals with severe mental illness followed at the CMHC, in comparison with a matched control group without substance use.\n\nResearch Questions\n\nWhat are the rates of comorbid alcohol and substance use among patients with severe mental illness followed at the CMHC? What are the current addiction symptoms, number of hospitalizations, and employment rates among individuals with severe mental illness and comorbid ASUD? What is the level of continuity of CMHC engagement and social participation among individuals with severe mental illness and comorbid ASUD, and what factors influence it? How does the level of social inclusion among individuals with severe mental illness and comorbid ASUD compare with that of individuals without ASUD?\n\nHypotheses\n\nH1: The average annual number of hospitalizations among individuals with a dual diagnosis (severe mental illness + ASUD) followed at the CMHC is significantly higher than among those without substance use.\n\nH2: Among individuals with a dual diagnosis, the daily medication doses (e.g., chlorpromazine equivalents) required to control psychotic or manic symptoms are higher than in the control group.\n\nH3: Social inclusion is lower among patients with substance use compared with the control group.\n\nH4: Employment rates among individuals with a dual diagnosis are significantly lower than among those with severe mental illness alone.\n\nH5: Substance use negatively affects patients' social participation, including involvement in activities and friendships.\n\nH6: Attendance rates at CMHC workshops and rehabilitation programs are lower among individuals with substance use compared with the control group.",[26,27,28,29,30,31,32],"Alcohol Abuse","Alcohol Use Disorder","Substance Use Disorders","Severe Mental Disorder","Schizophrenia","Bipolar Disorder","Ostracism",[34,28,29,35],"alcohol use disorder","ostracism","RECRUITING","2026-07-10",{"date":39,"type":40},"2026-07-13","ACTUAL",{"date":42,"type":40},"2026-06-20",{"date":44,"type":22},"2026-12-30",{"name":46,"class":47},"Abant Izzet Baysal University","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100597543","bladder-and-bowel-functions-participation-and-quality-of-life-in-children-with-intellectual-disabilities-100597543","NCT07059858","Bladder and Bowel Functions, Participation and Quality of Life in Children With Intellectual Disabilities","Evaluation of Bladder and Bowel Functions, Participation and Quality of Life in Children With Intellectual Disabilities","Inclusion Criteria:\n\nFor Children with Intellectual Disabilities:\n\n* Aged between 5 and 12 years\n* Diagnosed with mild, moderate, or severe intellectual disability as documented by the ÇÖZGER (Child Special Needs Report)\n* Both the parent and the child agree to participate in the study\n\nFor Typically Developing Children\n\n* Aged between 5 and 12 years\n* Both the parent and the child agree to participate in the study\n\nExclusion Criteria:\n\nFor Children with Intellectual Disabilities:\n\n* Having a diagnosis of physical disability\n* Presence of a neurological anomaly affecting bladder and bowel functions\n* Parent does not consent to participate in the study\n* Having undergone trauma or surgery affecting bladder and bowel functions within the last 6 months\n* Diagnosis of a genetic disorder\n* Use of medications that may affect bladder and bowel functions\n\nFor Typically Developing Children\n\n* Presence of a neurological anomaly affecting bladder and bowel functions\n* Lack of parental consent to participate in the study\n* Having experienced trauma or undergone surgery affecting bladder and bowel functions within the past 6 months\n* Use of medications that may influence bladder and bowel functions","5 Years","12 Years",{"count":59,"type":22},100,"Many neurodevelopmental, psychiatric, and medical disorders are commonly associated with intellectual disability. The presence of neurodevelopmental and psychiatric (NDP) comorbidities has been reported to negatively impact the clinical outcomes of bowel or bladder dysfunction.\n\nPediatric bladder and bowel dysfunction (BBD) is a common but underdiagnosed condition characterized by a spectrum of lower urinary tract symptoms and is often associated with constipation. Lower urinary tract symptoms include dysuria, urinary urgency, daytime incontinence, and enuresis, while bowel symptoms include constipation and encopresis. Most BBD cases are functional and not neurogenic in origin.\n\nIn children with special needs, all types of urinary incontinence are reported to occur more frequently compared to children without developmental or behavioral disabilities. Intellectual disability (IQ \\\u003C70) is also identified as a significant risk factor for urinary incontinence, with prevalence increasing as IQ decreases. In these children, lower urinary tract symptoms such as overactive bladder, dysfunctional voiding, and low fluid intake are also observed. Furthermore, according to support plans and medical records, 94% of individuals with intellectual and multiple disabilities experience constipation. Interestingly, lower levels of intellectual disability (profound and severe ID) have been associated with a lower prevalence of constipation.\n\nAlthough there are studies in the literature examining bladder and bowel functions separately in specific diagnostic groups with intellectual disability, the number of studies that assess bladder and bowel functions together in children with any form of intellectual disability is limited. Moreover, to our knowledge, there is no study in the literature that evaluates bladder and bowel functions along with child participation and parental quality of life in children with intellectual disability.\n\nBased on this gap in the literature, the aim of our study is to examine bladder and bowel functions, participation, and quality of life in children with intellectual disability",[62,63],"Intellectual Disability","Healthy Subjects","2026-06-16",{"date":66,"type":40},"2026-06-17",{"date":68,"type":40},"2025-09-28",{"date":70,"type":22},"2026-12-02",{"name":46,"class":47},{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":82,"briefSummary":76,"conditions":84,"keywords":86,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":48},"100599005","the-effect-of-the-model-based-care-decision-support-system-in-pediatric-intensive-care-on-nurses-decision-making-and-opinions-100599005","NCT07078864","The Effect of the Model-Based Care Decision Support System in Pediatric Intensive Care on Nurses' Decision Making and Opinions","Inclusion Criteria:\n\n* Nurses with at least 6 months of experience in intensive care\n* Nurses actively involved in direct patient care\n* Nurses who voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Nurses who are temporarily on leave due to reasons such as maternity leave or unpaid leave",true,{"count":80,"type":22},35,"INTERVENTIONAL",[83],"NA",[85],"Pediatric Intensive Care Nurses",[87,88,89,90],"Decision support system","Watson human care model","Family-centered care model","Pediatric Intensive Care","NOT_YET_RECRUITING","2026-05-21",{"date":94,"type":40},"2026-05-22",{"date":96,"type":22},"2026-06-15",{"date":98,"type":22},"2027-01-15",{"name":46,"class":47},{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":108,"targetDuration":4,"studyType":81,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":48},"100639936","the-effect-of-self-acupressure-on-blood-pressure-stress-and-well-being-levels-in-individuals-with-hypertension-100639936","NCT07577973","The Effect of Self-Acupressure on Blood Pressure, Stress, and Well-Being Levels in Individuals With Hypertension","The Effect of Self-Acupressure on Blood Pressure, Stress, and Well-Being Levels in Individuals With Hypertension: A Three-Arm Randomized Controlled Trial","SAPH","Inclusion Criteria:\n\n1. Aged 18-65 years\n2. Diagnosed with primary hypertension (Stage 1 or 2)\n3. Systolic blood pressure 130-179 mmHg or diastolic 80-109 mmHg\n4. Taking antihypertensive medication\n5. Able to understand and communicate in Turkish\n6. Willing to provide written informed consent\n\nExclusion Criteria:\n\n1. Secondary hypertension\n2. Pregnancy or lactation\n3. Severe cardiovascular disease (heart failure, myocardial infarction within 6 months)\n4. Stroke history within 6 months\n5. Skin lesions or infection at acupressure sites (HT7, LI4, PC6, EX3)\n6. Peripheral neuropathy affecting sensation\n7. Current use of anticoagulant therapy\n8. Participation in another clinical trial within 30 days",{"count":109,"type":22},72,[83],"This randomized controlled trial examines the effects of nurse-led self-acupressure at HT7, LI4, PC6, and EX3 points on blood pressure, stress, and well-being in adults with primary hypertension. Participants are randomized to real acupressure, sham acupressure, or usual care groups for 2 weeks.",[113],"PRIMARY HYPERTENSION",[115],"Acupressure Hypertension Self-care Nursing Stress Well-being Randomized Controlled Trial","2026-05-12",{"date":118,"type":40},"2026-05-14",{"date":120,"type":22},"2026-06",{"date":122,"type":22},"2026-10",{"name":46,"class":47},{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":131,"enrollmentInfo":132,"targetDuration":134,"studyType":23,"phases":4,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":48},"100611991","turkish-adaptation-of-the-csq-vr-100611991","NCT07247773","Turkish Adaptation of the CSQ-VR","Turkish Validity and Reliability of CyberSickness in Virtual Reality Questionnaire","Inclusion Criteria:\n\n* Voluntary agreement to participate in the study\n* Ability to stand and walk independently\n\nExclusion Criteria:\n\n* Presence of amblyopia, strabismus, or pathologies impairing focus, depth perception, or normal 3D vision\n* Failure on the butterfly test of the Titmus stereotest","30 Years",{"count":133,"type":22},42,"1 Day","The Cybersickness in Virtual Reality Questionnaire (CSQ-VR) is a tool designed to measure the presence and intensity of cybersickness symptoms experienced in VR. The CSQ-VR is an adapted and improved version of the Cybersickness section of the Virtual Reality Neuroscience Questionnaire (VRNQ). The aim of this study is to examine the validity and reliability of the Turkish version of the CSQ-VR.",[137],"Healthy Volunteers",[139,140],"Virtual Reality","Cybersickness","2026-05-06",{"date":143,"type":40},"2026-05-11",{"date":145,"type":40},"2025-12-15",{"date":147,"type":22},"2028-01-15",{"name":46,"class":47},{"id":150,"slug":151,"hasResults":12,"nctId":152,"briefTitle":153,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":12,"sex":17,"minAge":156,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":81,"phases":160,"briefSummary":161,"conditions":162,"keywords":167,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":170,"startDateStruct":171,"completionDateStruct":172,"leadSponsor":174,"locationsCount":48},"100612214","patient-specific-3d-action-observation-training-in-parkinsons-disease-100612214","NCT07250672","Patient-Specific 3D Action Observation Training in Parkinson's Disease","Examining the Effect of Action Observation Training Using Patient-Specific 3D Records in Parkinson's Patients","Inclusion Criteria:\n\n* Voluntary agreement to participate in the study\n* Clinical diagnosis of Parkinson's disease confirmed by a neurologist\n* Ongoing treatment with antiparkinsonian medication\n* Hoehn and Yahr (H-Y) stage ≤ 3\n* Ability to walk independently\n\nExclusion Criteria:\n\n* Presence of additional neurological disorders other than Parkinson's disease\n* Change in medication dosage within the past month\n* Score of ≥ 10 on the Simulator Sickness Questionnaire\n* Presence of amblyopia, strabismus, or pathologies impairing focus, depth perception, or normal 3D vision\n* Failure on the butterfly test of the Titmus stereotest (greater than 3,552 seconds of arc)","50 Years","85 Years",{"count":159,"type":22},24,[83],"Although studies exist demonstrating the effects of single-session action observation training on bradykinesia in patients with Parkinson's disease, research investigating the long-term application of such training remains limited. Furthermore, the broader literature indicates that action observation training has typically been conducted in simulated environments or by using recordings obtained from healthy individuals. The aim of the present study is to examine the effects of action observation training, delivered in a fully immersive virtual reality environment using each patient's own 3D motion recordings, on bradykinesia and other disease-related parameters.",[163,139,164,165,166],"Parkinson Disease","Action Obervation Training","Immersive Virtual Reality","3d Recording",[168,169],"Parkinson","Virtual reality",{"date":143,"type":40},{"date":145,"type":40},{"date":173,"type":22},"2027-08-15",{"name":46,"class":47},{"id":176,"slug":177,"hasResults":12,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":182,"targetDuration":134,"studyType":23,"phases":4,"briefSummary":184,"conditions":185,"keywords":188,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":48},"100635317","association-between-periodontal-status-and-the-prevalence-of-entamoeba-gingivalis-and-trichomonas-tenax-100635317","NCT07551115","Association Between Periodontal Status and the Prevalence of Entamoeba Gingivalis and Trichomonas Tenax","Prevalence of Entamoeba Gingivalis and Trichomonas Tenax in Saliva and Subgingival Plaque Samples Among Periodontology Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Participants aged 18 years or older.\n* Having at least 10 natural teeth.\n* Willingness to undergo periodontal examination and providing written informed consent.\n* Includes both periodontally healthy individuals and patients with gingivitis or periodontitis.\n\nExclusion Criteria:\n\n* Use of systemic antibiotics within the last 3 months.\n* Use of chlorhexidine or similar antiseptic mouthwashes within the last month.\n* Having received any periodontal treatment within the last 3 months.\n* Receiving immunosuppressive therapy or having a serious systemic immune deficiency.\n* Pregnancy or breastfeeding.",{"count":183,"type":22},120,"This prospective observational study aims to investigate the prevalence and clinical significance of two oral protozoa, Entamoeba gingivalis and Trichomonas tenax, among patients attending the Bolu Abant İzzet Baysal University Faculty of Dentistry, Department of Periodontology. While the oral microbiome typically maintains a delicate balance, disruptions in this ecosystem are thought to trigger periodontal diseases. Recent evidence suggests that these parasites may contribute to increased inflammation and tissue destruction, potentially playing a role in the etiology of gingivitis and periodontitis.\n\nThe study will include 120 participants aged 18 and older who meet the inclusion criteria. Following the collection of demographic data and oral hygiene habits via a questionnaire, a single calibrated examiner will perform comprehensive clinical periodontal examinations. Measurements will include plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment loss (CAL), and gingival recession (GR) based on the 2017 World Workshop Classification of Periodontal and Peri-Implant Diseases and Conditions.\n\nTo detect the presence of parasites, unstimulated whole saliva samples and subgingival plaque samples from the deepest periodontal pockets will be collected from each participant. These samples will be analyzed immediately at the Parasitology Laboratory using light microscopy (10X and 40X magnification) to identify live trophozoites. By evaluating the relationship between parasite prevalence and periodontal status, this research aims to contribute to the limited literature on oral protozoa in Turkey and increase clinical awareness regarding their impact on oral health.",[186,187],"Gingivitis and Periodontal Diseases","Periodontitis",[189,190,191,192],"gingivitis","periodontitis","Entamoeba Gingivalis","Trichomonas Tenax","2026-05-04",{"date":195,"type":40},"2026-05-08",{"date":197,"type":40},"2025-12-22",{"date":199,"type":22},"2026-09",{"name":46,"class":47},{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":17,"minAge":208,"maxAge":209,"enrollmentInfo":210,"targetDuration":4,"studyType":81,"phases":212,"briefSummary":213,"conditions":214,"keywords":218,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":48},"100527789","virtual-reality-based-mirror-therapy-100527789","NCT06152328","Virtual Reality Based Mirror Therapy","A New Perspective on Mirror Therapy: The Effect of Leap Motion-Based Multi-Axis Immersive Virtual Reality Mirror Therapy (LISA) on Upper Extremity Functions in Individuals With Stroke","Inclusion Criteria:\n\n* Have a ischemic stroke\n* Stroke duration not less than 2 months and not more than 6 months\n* Individuals with a score of 2b and 3 according to the Thrombolysis in cerebral infarction (TICI) scale\n* A score of 2 and above according to the upper extremity motor assessment of the NIH stroke scale\n* Intact depth perception in the Titmus Stereopsis assessment\n* A score of 24 and above in the Mini-mental test and\n* Independent sitting balance\n\nExclusion Criteria:\n\n* Additional neurologic diseases\n* Have a head injury\n* Have a brain tumor\n* Prior cranial surgery\n* Psychological disorder or mental problem\n* Previous stroke\n* Aphasia and apraxia\n* Upper extremity amputation","40 Years","80 Years",{"count":211,"type":22},56,[83],"The aim of this study is to examine the effectiveness of 3D virtual reality assisted mirror therapy based rehabilitation applications compared to classical methods used in stroke rehabilitation.",[215,216,217],"Stroke","Upper Extremity Paresis","Upper Extremity Paralysis",[219,220,221],"Rehabilitation","Virtual Reality Immersion Therapy","Mirror Movement Therapy","2026-05-02",{"date":224,"type":40},"2026-05-07",{"date":226,"type":40},"2024-04-01",{"date":96,"type":22},{"name":46,"class":47},{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":78,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":248,"locationsCount":48},"100633768","oral-hygiene-periodontal-status-and-quality-of-life-100633768","NCT07530978","ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE","EVALUATION OF THE EFFECT OF INDIVIDUALS' ORAL HYGIENE HABITS AND PERIODONTAL STATUS ON QUALITY OF LIFE","Inclusion Criteria:\n\n* Individuals aged 18 years and older\n* Patients presenting to the Department of Periodontology Individuals willing to participate and provide informed consent\n\nExclusion Criteria:\n\n* Use of antibiotics or anti-inflammatory drugs within the last 3 months\n* History of periodontal treatment within the last 6 months\n* Pregnancy or lactation\n* Individuals unable to complete the questionnaire",{"count":237,"type":22},160,"This cross-sectional study aims to evaluate the relationship between oral hygiene habits, periodontal status, and oral health-related quality of life in adult individuals. A total of approximately 160 participants attending the Department of Periodontology will be included. Periodontal status will be assessed using standard clinical parameters, including probing depth, clinical attachment loss, bleeding on probing, and plaque index. In addition, the Periodontal Inflamed Surface Area (PISA) will be calculated to quantify inflammatory burden. Oral health-related quality of life will be evaluated using the OSHIP-Perio questionnaire, a validated patient-reported outcome measure specific to periodontal conditions. The study will investigate the association between clinical periodontal findings, oral hygiene practices, and quality of life outcomes. The findings are expected to provide a comprehensive understanding of both clinical and patient-centered aspects of periodontal disease and contribute to improved individualized treatment approaches.",[240,241,187],"Periodontal Diseases","Gingivitis","2026-04-25",{"date":244,"type":40},"2026-04-30",{"date":246,"type":40},"2025-10-15",{"date":96,"type":22},{"name":46,"class":47},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":81,"phases":258,"briefSummary":259,"conditions":260,"keywords":263,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":48},"100624694","the-effect-of-pink-noise-and-the-quiet-night-intervention-on-sleep-parameters-in-intensive-care-unit-patients-a-single-center-randomized-controlled-trial-100624694","NCT07412964","The Effect of Pink Noise and the Quiet Night Intervention on Sleep Parameters in Intensive Care Unit Patients: A Single-Center Randomized Controlled Trial","The Effect of Pink-Brown Noise and the Quiet Time Intervention on Sleep Parameters in Intensive Care Unit Patients: A Single-Center, Randomized Controlled Trial","Inclusion Criteria:\n\n* Inclusion Criteria:\n* Adults aged 18 years and older\n* Patients admitted to the adult intensive care unit\n* Expected ICU stay of at least one night\n* Ability to tolerate non-invasive sleep-related interventions (earplugs, eye mask, or acoustic masking)\n* Informed consent obtained from the patient or legally authorized representative\n\nExclusion Criteria:\n\nExclusion Criteria:\n\n* Severe hearing impairment preventing use of acoustic interventions\n* Severe cognitive impairment or coma preventing sleep assessment\n* Use of continuous deep sedation\n* Diagnosed sleep disorders requiring pharmacological treatment\n* Skin conditions preventing use of wrist-worn actigraphy",{"count":257,"type":22},18,[83],"Sleep disruption is common in adult intensive care unit (ICU) patients and is often worsened by environmental noise and nighttime care activities. Poor sleep may negatively affect recovery and well-being.\n\nThis single-center, three-arm randomized controlled trial will evaluate the short-term effects of two non-pharmacological interventions-(1) pink-brown noise masking and (2) a quiet time intervention-on objective sleep parameters in adult ICU patients, compared with standard care.\n\nSleep outcomes will be measured using actigraphy-based wearable monitoring, including total sleep time, sleep efficiency, sleep onset latency, wake after sleep onset, and number of awakenings. Results are expected to support evidence-based nursing approaches to improve sleep in ICU patients.",[261,262],"Sleep Disturbance","Intensive Care Units",[262,264,265,266,261],"Noise","Sound Masking","Actigraphy","2026-04-17",{"date":269,"type":40},"2026-04-22",{"date":271,"type":22},"2026-05",{"date":273,"type":22},"2027-01",{"name":46,"class":47},{"id":276,"slug":277,"hasResults":12,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":282,"targetDuration":4,"studyType":81,"phases":284,"briefSummary":285,"conditions":286,"keywords":289,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":304,"locationsCount":305},"100625317","the-effect-of-emotional-freedom-technique-on-parents-anxiety-level-newborn-hearing-screening-100625317","NCT07421063","The Effect of Emotional Freedom Technique on Parents' Anxiety Level: Newborn Hearing Screening","Emotional Freedom Technique for Parental Anxiety Regarding Newborn Hearing Screening","Inclusion Criteria:\n\n* Parents of neonates who are undergoing the newborn hearing screening (NHS) for the first time.\n* Ability to communicate effectively in the native language without language barriers.\n* No prior experience or training in applying the Emotional Freedom Technique (EFT).\n* Voluntary agreement to participate in the study and completion of the informed consent form.\n\nExclusion Criteria:\n\n* Known history of diagnosed psychiatric disorders or epilepsy.\n* Situations where the neonate is crying or being breastfed immediately prior to the intervention or during the assessment.\n* The scheduled hearing screening procedure is initiated before the 30-35-minute study protocol is completed.\n* Occurrence of any acute situational triggers or environmental distractions that may interfere with the stability of anxiety measurements.",{"count":283,"type":22},70,[83],"Newborn hearing screening (NHS) is a standard procedure that often triggers acute anxiety in parents. While Emotional Freedom Technique (EFT) has demonstrated efficacy in reducing psychological distress across various clinical settings, its specific application to parental anxiety during the neonatal screening period remains under-researched. This study addresses this gap by investigating the impact of a targeted EFT intervention on anxiety levels in mothers awaiting their newborns' first hearing tests.\n\nThe primary objective is to determine if a brief, 15-minute EFT session reduces maternal anxiety more effectively than a standard waiting period. Participants are randomly assigned to either an intervention group, where they perform a structured acupoint tapping sequence, or a control group that receives no active intervention. Anxiety is assessed using validated scales immediately before and after the 15-minute period to capture acute changes in distress. The researchers hypothesize that applying EFT regarding the procedure will significantly reduce parental anxiety levels compared to the non-intervention group.",[287,288],"Anxiety","Parental Anxiety",[290,291,292,293,294,295,296,297],"Emotional Freedom Technique","Parental Health","Tapping","Complementary Therapies","Neonatal Screening","Acupressure","EFT","Newborn Hearing Screening","2026-04-10",{"date":300,"type":40},"2026-04-15",{"date":302,"type":40},"2026-03-31",{"date":199,"type":22},{"name":46,"class":47},2,{"id":307,"slug":308,"hasResults":12,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":313,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":315,"conditions":316,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":48},"100634091","gas6-and-soluble-mertk-in-periodontal-diseases-100634091","NCT07535177","Gas6 and Soluble MerTK in Periodontal Diseases","Evaluation of Gas6 and Soluble MerTK Levels in Gingival Crevice Fluid in Individuals With Periodontal Health, Gingivitis, and Periodontitis","Inclusion Criteria:\n\n* Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)\n* Individuals who have not used antibiotics within the last 3 months\n* Individuals not taking any medications known to affect periodontal tissues\n* Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis\n* Individuals with at least 16 natural teeth, excluding third molars\n* Individuals aged 18 years and older\n\nExclusion Criteria:\n\n* Pregnant or lactating individuals\n* Individuals who have received periodontal treatment within the last 6 months\n* Current smokers",{"count":314,"type":22},90,"This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.",[187],"2026-04-09",{"date":319,"type":40},"2026-04-16",{"date":321,"type":40},"2026-03-25",{"date":323,"type":22},"2026-05-20",{"name":46,"class":47},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":81,"phases":333,"briefSummary":334,"conditions":335,"keywords":337,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":4},"100633292","the-effect-of-proprioceptive-neuromuscular-facilitation-on-haemodynamic-responses-in-a-neurological-intensive-care-100633292","NCT07524790","The Effect of Proprioceptive Neuromuscular Facilitation on Haemodynamic Responses in a Neurological Intensive Care","The Effect of Proprioceptive Neuromuscular Facilitation on the Ankle-Brachial Index and Haemodynamic Responses in Patients in a Neurological Intensive Care Unit: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Patients being monitored in the neurology intensive care unit\n* Aged 18 years or over\n* Haemodynamically stable\n* No orthopaedic condition preventing the performance of passive joint movements in the upper and lower limbs\n* A signed informed consent form from a patient's next of relative for participation in the study\n\nExclusion Criteria:\n\n* Presence of haemodynamic instability\n* Fractures, contractures or serious orthopaedic conditions in the upper or lower limbs that restrict movement\n* Diagnosis or suspicion of deep vein thrombosis\n* Severe peripheral arterial disease\n* Serious cardiac arrhythmia that may prevent exercise",{"count":159,"type":22},[83],"Although there are studies examining the effect of actively performed PNF exercises on haemodynamic responses in intensive care patients and healthy individuals, there are no studies investigating their effect on circulation and haemodynamic responses in unconscious patients. Therefore, this study was designed to investigate the acute effects of proprioceptive neuromuscular facilitation (PNF) exercises on peripheral circulation and haemodynamic responses in patients admitted to a neurological intensive care unit.\n\nHypotheses:\n\nH1-1: Passively administered PNF exercises have beneficial effects on peripheral circulation.\n\nH2-1: Passively administered PNF exercises have beneficial effects on haemodynamic responses.",[336],"Neurologic Disorder",[338,339,340],"Proprioceptive Neuromusculer Facilitation","Neurological Intensive Care","Haemodynamic Responses",{"date":342,"type":40},"2026-04-13",{"date":344,"type":22},"2026-05-15",{"date":346,"type":22},"2027-05-15",{"name":46,"class":47},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":355,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":369,"leadSponsor":371,"locationsCount":48},"100632079","neuropathic-pain-catastrophizing-and-adherence-in-sais-100632079","NCT07509021","Neuropathic Pain, Catastrophizing, and Adherence in SAIS","The Relationship Between Neuropathic Pain, Pain Catastrophizing, and Adherence-Related Behavior in Subacromial Impingement Syndrome","Inclusion Criteria:\n\n* Unilateral subacromial impingement syndrome lasting at least 3 months\n* Planned to start a 10-session physical therapy program\n* Willing and able to provide informed consent\n\nExclusion Criteria:\n\n* Upper extremity entrapment neuropathy or polyneuropathy\n* History of diabetes mellitus\n* Inflammatory rheumatic disease, infection, or malignancy\n* Frozen shoulder\n* History of shoulder fracture, dislocation, or surgery\n* Complete rotator cuff tear on magnetic resonance imaging\n* Calcific tendinitis\n* Shoulder steroid injection or physical therapy within the previous 3 months\n* Use of medication for neuropathic pain\n* Pregnancy\n* Cognitive impairment preventing completion of questionnaires",{"count":356,"type":22},75,"Subacromial impingement syndrome is one of the most common causes of shoulder pain and may negatively affect daily activities and quality of life. While shoulder pain is usually considered nociceptive, some patients may also have a neuropathic pain component, which can influence symptom severity and treatment outcomes. In addition, psychological factors such as pain catastrophizing and adherence-related behavior may play an important role in recovery.\n\nThis prospective observational study aims to evaluate the presence of neuropathic pain in patients with subacromial impingement syndrome and to investigate its relationship with pain catastrophizing and adherence-related behavior. Patients undergoing a standard physical therapy program will be assessed at the beginning and after completion of treatment using validated clinical scales.\n\nThe findings of this study may help to better understand the interaction between pain characteristics, psychological factors, and adherence-related behavior, and contribute to the development of more individualized rehabilitation strategies",[359],"Subacromial Impingement Syndrome",[359,361,362,363,364],"Neuropathic Pain","Pain Catastrophizing","Shoulder Pain","Adherence-related behavior","2026-04-02",{"date":367,"type":40},"2026-04-08",{"date":365,"type":40},{"date":370,"type":22},"2026-08-01",{"name":46,"class":47},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":78,"sex":379,"minAge":18,"maxAge":4,"enrollmentInfo":380,"targetDuration":4,"studyType":81,"phases":382,"briefSummary":383,"conditions":384,"keywords":387,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":398,"leadSponsor":400,"locationsCount":48},"100631979","tele-nursing-supported-mindfetalness-anxiety-and-prenatal-attachment-100631979","NCT07507721","Tele-Nursing-Supported Mindfetalness: Anxiety and Prenatal Attachment","The Effect of Tele-nursing-Supported Mindfetalness Method on Maternal Anxiety and Prenatal Attachment: A Mixed Methods Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 years or older\n* Being at the 28th week of gestation\n* Having a singleton pregnancy\n* Being primiparous\n* Being literate\n* Having access to and the ability to use a mobile device and internet connection (personal or via spouse) compatible with the tele-nursing application\n* Volunteering to participate in the study and providing informed consent (Araştırmaya katılmaya gönüllü olmak ve bilgilendirilmiş onam vermek)\n\nExclusion Criteria:\n\n* Having a high-risk pregnancy (e.g., preterm labor threat, preeclampsia, gestational diabetes, placenta previa, or cardiac disease).\n* Presence of diagnosed fetal health complications (e.g., intrauterine growth restriction \\[IUGR\\], fetal anomalies).\n* Currently monitoring fetal movements using any other conventional fetal movement counting methods.\n* Presence of any communication barriers (e.g., hearing, speech, or language impairments).\n* History or current diagnosis of chronic or psychiatric illness.\n* Conception through assisted reproductive techniques (ART) (e.g., IVF).","FEMALE",{"count":381,"type":22},68,[83],"The goal of this clinical trial is to compare the effects of tele-nursing-supported Mindfetalness method versus Mindfetalness alone method on maternal anxiety and prenatal attachment in pregnant women. The main questions it aims to answer are:\n\n* H1: Tele-nursing-supported Mindfetalness method will significantly reduce state anxiety (STAI-S) levels in pregnant women over time compared to Mindfetalness alone method.\n* H2: Tele-nursing-supported Mindfetalness method will significantly reduce trait anxiety (STAI-T) levels in pregnant women over time compared to Mindfetalness alone method.\n* H3: Tele-nursing-supported Mindfetalness method will significantly increase prenatal attachment (PAI) levels in pregnant women over time compared to Mindfetalness alone method.\n\nResearches will compare tele-nursing-supported Mindfetalness to Mindfetalness alone to see if tele-nursing support significiantly reduces state and trait anxiety levels and significiantly increases prenatal attachment levels in pregnant women over time.\n\nParticipants will;\n\n* Attend a single, face-to-face Mindfetalness training session at the beginning of the study to learn technique and application procedures correctly.\n* Practice Mindfetalness method daily for 15 minutes throughout the 8-week study period.\n* Complete a daily compliance tracking chart to record their adherence to the Mindfetalness method of their practice.\n* Complete the State-Trait Anxiety Inventory (STAI) and the Prenatal Attachment Inventory (PAI) at baseline and during 4th and 8th-week follow-up measurements to track changes over time.",[385,386],"Tele-nursing","Fetal Movement",[388,389,390,391,392,393],"maternal anxiety","prenatal attachment","mindfetalness","tele-nursing","randomized controlled trial","mixed methods","2026-04-01",{"date":396,"type":40},"2026-04-07",{"date":300,"type":22},{"date":399,"type":22},"2027-04-01",{"name":46,"class":47},{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":405,"acronym":4,"eligibilityCriteria":406,"healthyVolunteers":12,"sex":17,"minAge":407,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":419,"locationsCount":48},"100599782","musculoskeletal-disorders-of-postgraduate-dentistry-students-and-specialist-dentists-100599782","NCT07088965","Musculoskeletal Disorders of Postgraduate Dentistry Students and Specialist Dentists","Inclusion Criteria\n\n* Being between 25 and 60 years of age\n* Having a stable professional career\n\nExclusion Criteria\n\n* Having physical conditions such as rheumatoid arthritis or fibromyalgia\n* Being retired\n* Being an undergraduate student\n* Having a history of any major accident, trauma, or medical condition causing permanent musculoskeletal disability","25 Years","60 Years",{"count":314,"type":22},"This study aimed to assess the prevalence of MSDs and the level of ergonomics knowledge among dentists who are specializing in different branches or have completed specialist training.",[412,413],"Musculoskeletal Diseases","Work-related Injury","2026-03-27",{"date":394,"type":40},{"date":417,"type":40},"2025-05-15",{"date":344,"type":22},{"name":46,"class":47},{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":12,"sex":379,"minAge":18,"maxAge":157,"enrollmentInfo":426,"targetDuration":4,"studyType":81,"phases":428,"briefSummary":429,"conditions":430,"keywords":432,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":438,"startDateStruct":439,"completionDateStruct":441,"leadSponsor":443,"locationsCount":305},"100569662","investigation-of-the-effects-of-complex-decongestive-physiotherapy-on-sleep-quality-and-quality-of-life-in-women-with-breast-cancer-related-lymphedema-100569662","NCT06697158","Investigation of the Effects of Complex Decongestive Physiotherapy on Sleep Quality and Quality of Life in Women With Breast Cancer Related Lymphedema","Inclusion Criteria:\n\n* Participants must be aged between 18 or 85 years,\n* with a diagnosis of unilateral lymphedema in the upper extremity following breast cancer surgery\n* stage 2 lymphedema confirmed by a doctor\n* voluntary consent to participate in the study.\n\nExclusion Criteria:\n\n* refusal to participate in the study\n* development of lymphedema due to primary causes, presence of bilateral upper extremity lymphedema\n* active soft tissue infection in the lymphedematous arm\n* mental or cognitive disorders\n* inability to communicate or cooperate\n* acute deep vein thrombosis, arterial insufficiency in the upper extremity, systemic diseases that could cause edema other than lymphedema (e.g., renal failure, liver failure, heart failure)\n* use of sleep medications or antidepressants",{"count":427,"type":22},31,[83],"Breast cancer is the most common type of cancer among women globally and has the highest mortality rate. Surgical interventions are typically required in the treatment of breast cancer, but these procedures can lead to complications such as infection, seroma, hematoma, cellulitis, and particularly lymphedema due to disruptions in the physiology of axillary lymphatic vessels.\n\nBreast Cancer-Related Lymphedema (BCRL) commonly develops within the first two years following surgical intervention and its incidence varies depending on the surgical method used. The incidence of lymphedema after Sentinel Lymph Node Biopsy (SLNB) is around 5%, whereas it increases to 30-50% after Axillary Lymph Node Dissection (ALND).\n\nBCRL significantly impacts the quality of life (QoL) through physical symptoms such as swelling, pain, tightness, and limited range of motion, as well as psychosocial issues including depression, social isolation, and sleep disturbances. Sleep disorders, in particular, are associated with depression and contribute to a further decline in QoL.\n\nIn the treatment of BCRL, both conservative (non-surgical) and surgical methods are traditionally employed. Complex Decongestive Physiotherapy (CDP) is considered the gold standard for the conservative management of lymphedema. CDP comprises a two-phase treatment process. The first phase, known as the \"Decongestion Phase,\" generally lasts 2-4 weeks and includes manual lymphatic drainage (MLD), skin care, compression therapy with multi-layered short-stretch bandages, and muscle-pumping exercises. The second phase, the \"Maintenance Phase,\" is more prolonged and aims to sustain the results achieved in Phase 1. It includes compression with low-stretch elastic garments, skin care, exercises, and patient-administered MLD as needed.\n\nThe primary objectives of CDP are to improve lymphatic circulation, reduce swelling, pain, and tightness, increase the range of motion, and ultimately improve the QoL. Studies have shown that CDP significantly enhances sleep quality and QoL in women with BCRL.\n\nHowever, most existing studies examine all stages of BCRL without comparing the effects of CDP across different stages. The impact of CDP on sleep and QoL may vary depending on the stage of BCRL, highlighting the need for specific research on its effects in particular populations. Furthermore, many studies lack follow-up data, leaving the Maintenance Phase of CDP largely unexplored.\n\nThis study aims to investigate the effects of CDP, including both the Decongestion and Maintenance phases, on sleep quality and QoL specifically in women with Stage II BCRL.",[431],"Breast Cancer Related Lymphedema",[433,434,435,436,437],"Breast Cancer-Related Lymphedema","Physiotherapy and Rehabilitation","Sleep Quality","Local Tissue Fluid","Quality of Life",{"date":394,"type":40},{"date":440,"type":40},"2024-01-01",{"date":442,"type":22},"2027-03-01",{"name":46,"class":47},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":17,"minAge":451,"maxAge":157,"enrollmentInfo":452,"targetDuration":4,"studyType":81,"phases":454,"briefSummary":455,"conditions":456,"keywords":459,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":472,"locationsCount":48},"100629226","robot-assisted-gait-training-vs-visual-feedback-balance-training-in-stroke-100629226","NCT07471919","Robot-Assisted Gait Training vs Visual Feedback Balance Training in Stroke","Comparison of Robot-Assisted Gait Training and Visual Feedback Balance Training on Balance and Gait Outcomes in Patients With Stroke","Inclusion Criteria:\n\n* Age 21-85 years\n* Diagnosis of ischemic or hemorrhagic stroke confirmed by clinical and radiological findings\n* Functional Ambulation Category (FAC) ≥ 3\n* Modified Ashworth Scale ≤ 2 (lower extremity)\n* Ability to understand and follow simple verbal instructions\n* Mini-Mental State Examination (MMSE) score ≥ 23\n\nExclusion Criteria:\n\n* Unstable cardiopulmonary conditions\n* Severe musculoskeletal disorders affecting standing or walking\n* Severe aphasia preventing participation in assessments\n* Severe visual impairment interfering with balance testing","21 Years",{"count":453,"type":22},60,[83],"Stroke frequently leads to balance impairment and gait dysfunction, increasing fall risk and limiting functional independence. Technology-assisted rehabilitation approaches such as robot-assisted gait training and visual feedback balance training have been shown to improve balance and mobility in stroke patients.\n\nThis randomized, assessor-blinded clinical trial aims to compare the effects of robot-assisted gait training and visual feedback balance training on balance and gait outcomes in patients with subacute and chronic stroke. Both interventions are part of routine clinical rehabilitation practice. Participants will be evaluated at baseline and after 4 weeks of intervention using clinical balance, gait, and functional assessments.",[215,457,458],"Gait Impairment","Balance Impairment",[460,461,462,463,464],"Stroke rehabilitation","Robot-assisted gait training","Visual feedback balance training","Balance impairment","Gait impairment","2026-03-16",{"date":467,"type":40},"2026-03-18",{"date":469,"type":40},"2026-03-15",{"date":471,"type":22},"2026-08-15",{"name":46,"class":47},{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":78,"sex":480,"minAge":481,"maxAge":482,"enrollmentInfo":483,"targetDuration":4,"studyType":81,"phases":485,"briefSummary":486,"conditions":487,"keywords":492,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":500,"completionDateStruct":502,"leadSponsor":504,"locationsCount":48},"100602084","effect-of-dehydration-on-sleep-quality-cognitive-skills-and-electromyographic-responses-in-combat-athletes-100602084","NCT07118904","Effect of Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses in Combat Athletes","The Effect of Acute Dehydration on Sleep Quality, Cognitive Skills, and Electromyographic Responses During Maximum Contraction in Combat Athletes","Inclusion Criteria:\n\n* Voluntary participation\n* Being combat athletes with prior rapid weight loss experience\n* No existing health conditions\n* No orthopedic injuries\n\nExclusion Criteria:\n\n* Using of sleep-related medications\n* Complications During the Intervention: Participants who experience any complications during experimental intervention.","MALE","17 Years","28 Years",{"count":484,"type":22},12,[83],"This study examines the effects of rapid dehydration-induced weight loss on combat athletes' sleep quality, cognitive skills, and isokinetic strength performance. The research documents both benefits and risks of weight-cutting practices for athletes, coaches, and medical staff in weight-class sports. Findings will guide safer weight management approaches and inform potential revisions to international weigh-in protocols, while contributing valuable insights to sports science.",[488,489,490,491],"Dehydration","Weight Loss","Weight Cycling","Sleep",[493,494,435,495,496,497],"Athletic Performance","Cognitive Skills","Isokinetic strength","EMG Response","Anticipation Time","2026-03-12",{"date":465,"type":40},{"date":501,"type":40},"2025-08-18",{"date":503,"type":22},"2026-08-30",{"name":46,"class":47},{"id":506,"slug":507,"hasResults":12,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":78,"sex":379,"minAge":4,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":81,"phases":513,"briefSummary":514,"conditions":515,"keywords":517,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":525,"leadSponsor":527,"locationsCount":48},"100626819","effectiveness-of-a-sleep-hygiene-education-in-female-para-athletes-100626819","NCT07440589","Effectiveness of a Sleep Hygiene Education in Female Para Athletes","Effectiveness of a Sleep Hygiene Education in Female Para Athletes: A Mixed-Methods Study Using PSQI, Sleep Behaviour, and Qualitative Experiences","Inclusion Criteria:\n\n* Being an elite athlete who is a member of the Turkey Women's National Sitting Volleyball Team.\n* Actively participating in regular training sessions and competitions.\n* Willingness to participate in the planned sleep hygiene education program throughout the study period.\n* Having sufficient cognitive capacity to complete the Pittsburgh Sleep Quality Index (PSQI) and the Athlete Sleep Behavior Questionnaire (ASBQ).\n* Agreeing to participate in focus group interviews.\n* Providing voluntary participation and signing an informed consent form.\n\nExclusion Criteria:\n\n* Inability to participate regularly in training sessions during the study period due to acute injury, illness, or surgical intervention.\n* Failure to attend the education program or assessment procedures regularly.\n* Incomplete completion of data collection instruments or non-participation in focus group interviews.",{"count":484,"type":22},[83],"It is imperative to recognise elite female sitting volleyball players as a high-risk group with regard to sleep deprivation. However, there is a paucity of research investigating the efficacy of sleep hygiene education for this demographic.\n\nThe objective of this study is to The present study aims to examine the effect of sleep hygiene education on sleep quality and behaviour in elite female sitting volleyball players using mixed methods.",[516],"Sleep Hygiene",[518,519,520],"Sleep hygiene","Para-Athlete","Sleep Behaviour","2026-02-26",{"date":523,"type":40},"2026-02-27",{"date":523,"type":22},{"date":526,"type":22},"2026-03-30",{"name":46,"class":47},{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":4,"eligibilityCriteria":534,"healthyVolunteers":12,"sex":17,"minAge":535,"maxAge":536,"enrollmentInfo":537,"targetDuration":4,"studyType":81,"phases":539,"briefSummary":540,"conditions":541,"keywords":546,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":553,"lastUpdatePostDateStruct":554,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":4},"100625136","effects-of-spiral-strapping-systems-on-upper-limb-function-in-unilateral-spastic-cerebral-palsy-100625136","NCT07418710","Effects Of Spiral Strapping Systems On Upper Limb Function In Unilateral Spastic Cerebral Palsy","The Effect Of Different Spiral Strapping Systems On Upper Extremity Functionality, Hand Skills, And Grip Strength In Children With Unilateral Spastic Cerebral Palsy","Inclusion Criteria:\n\nDiagnosis of unilateral spastic cerebral palsy\n\nAge between 4 and 15 years\n\nManual Ability Classification System (MACS) levels I-III\n\nPresence of spasticity graded as 1, 1+, or 2 on the Modified Ashworth Scale in at least two of the following upper limb muscle groups: shoulder internal rotators, elbow flexors, forearm pronators, wrist flexors, finger flexors, or thumb adductors\n\nCommunication Function Classification System (CFCS) levels I-II\n\nGross Motor Function Classification System (GMFCS) levels I-III\n\nAbility to actively participate in upper limb rehabilitation interventions\n\nWritten informed consent provided by parents or legal guardians\n\nExclusion Criteria:\n\nUpper limb botulinum toxin injection or upper limb surgery within the last 6 months\n\nPresence of fixed contractures in the upper limb joints that may interfere with assessment or intervention protocols\n\nSevere behavioral or communication problems that would prevent participation in the study procedures\n\nUncontrolled or treatment-resistant epilepsy","4 Years","15 Years",{"count":538,"type":22},27,[83],"The purpose of this clinical study is to learn whether two different spiral strapping systems can improve arm and hand use in children with unilateral spastic cerebral palsy. These strapping systems are used to support the arm in a more functional position and to help children control their movements during daily activities.\n\nThis study aims to answer the following main questions:\n\nDoes spiral strapping help children use their arm and hand more effectively in daily activities?\n\nDoes spiral strapping improve hand skills and grip strength?\n\nIs there a difference in effect between the two spiral strapping systems?\n\nTo answer these questions, researchers will divide participants into three groups. One group will receive a standard rehabilitation program plus TheraTogs® spiral strapping. A second group will receive the same rehabilitation program plus TogRite™ spiral strapping. The third group will receive the rehabilitation program only.\n\nParticipants will:\n\nTake part in rehabilitation sessions twice a week for eight weeks.\n\nUse spiral strapping during some sessions, depending on their group.\n\nComplete arm and hand assessments at the beginning and at the end of the study.\n\nThe results of this study may help develop simple and practical rehabilitation approaches that support children with cerebral palsy in becoming more independent in daily life.",[542,543,544,545],"Cerebral Palsy (CP)","Hand Grip Strength","Upper Extremity Function","Spasticity",[547,548,549,550,551,552],"cerebral palsy","upper extremity function","spasticity","hand grip strength","orthoses","hand skill","2026-02-16",{"date":555,"type":40},"2026-02-18",{"date":557,"type":22},"2026-02-15",{"date":559,"type":22},"2027-02-15",{"name":46,"class":47},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":568,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":570,"conditions":571,"keywords":576,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":577,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":4},"100624560","emotional-eating-sleep-quality-mental-state-and-metabolic-syndrome-100624560","NCT07411222","Emotional Eating, Sleep Quality, Mental State and Metabolic Syndrome","The Mediating Role of Emotional Eating and Sleep Quality in the Relationship Between Mental State and Metabolic Syndrome in Individuals With Schizophrenia and Bipolar Disorder","Inclusion Criteria:\n\n* Being registered with the Bolu İzzet Baysal Mental Health and Diseases Hospital Community Mental Health Center,\n* Having a severe chronic psychiatric illness (Schizophrenia Spectrum and Other Psychotic Disorders and Bipolar Disorder) followed by the Bolu İzzet Baysal Mental Health and Diseases Hospital Community Mental Health Center for at least 6 months,\n* Being in remission (Complete Remission (Pre-Remission): Symptoms remaining below threshold values for at least 2 months (8 weeks). A state of improvement lasting more than 2 months is generally referred to as \"remission\"),\n* Schizophrenia remission definition: 8 diagnostically significant symptoms were selected from the Positive and Negative Syndrome Scale.\n* Bipolar disorder remission definition: Complete remission is defined as the absence of acute attacks and the presence of minimal\u002Fvery mild symptoms.\n* Being between 18-65 years of age,\n* Being able to understand what is read and give written consent.\n\nExclusion Criteria:\n\n* Having a diagnosis of mental retardation,\n* Having other neurocognitive disorders, primarily dementia, according to DSM-V (as it can affect the ability to make decisions and give correct answers),\n* Not being able to speak or understand Turkish.",{"count":569,"type":22},78,"In predominantly medication-naïve schizophrenic patients, those exhibiting partial metabolic disorders have significantly worse sleep quality and sleep onset time; poor sleep predicted metabolic dysregulation even after controlling for confounding factors. Mental health, sleep, and eating behavior interact in ways that strongly influence the risk of obesity and MetS. Emotional eating (eating in response to emotions rather than hunger) is central to this network and appears to be closely associated with psychiatric illnesses, particularly depression, anxiety, and sleep disorders. There is a continuing need to elucidate the frequency, level, and relationship of emotional eating with other factors in individuals with SMI. Therefore, this study aims to elucidate this complex relationship, thereby shedding light on new ways to reduce metabolic risks in psychiatric patients.",[30,31,572,573,574,491,575],"Psychiatric Issue","Metabolic Syndrome","Emotional Eating","Mediating",[30,31,573,574,491],"2026-02-11",{"date":579,"type":40},"2026-02-13",{"date":581,"type":22},"2026-04",{"date":583,"type":22},"2026-12",{"name":46,"class":47},{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":592,"enrollmentInfo":593,"targetDuration":4,"studyType":81,"phases":595,"briefSummary":596,"conditions":597,"keywords":602,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":609,"startDateStruct":611,"completionDateStruct":613,"leadSponsor":615,"locationsCount":48},"100600606","short-term-effects-of-antihypertensive-drugs-on-postural-balance-and-fall-risk-100600606","NCT07099677","Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk","The Effect of Antihypertensive Medication Use on Fall Risk: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 75 years\n* Newly diagnosed with primary hypertension\n* No prior use of antihypertensive medication\n* No history of neurological, vestibular, orthopedic, or psychiatric conditions affecting balance\n* Able to walk independently without assistive devices\n* Provided written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Secondary hypertension\n* Known diagnosis of vestibular disorders (e.g., BPPV, Ménière's disease)\n* Use of medications that may affect balance (e.g., sedatives, psychotropic drugs)\n* History of falls due to trauma unrelated to balance\n* Cognitive impairment preventing proper test participation\n* Inability to complete the assessments at follow-up timepoints (2nd and 4th week)","75 Years",{"count":594,"type":22},186,[83],"The goal of this clinical trial is to compare the short-term effects of three commonly prescribed antihypertensive drug classes (beta-blockers, ACE inhibitors, and calcium channel blockers) on postural balance and fall risk in adults with newly diagnosed primary hypertension. The main questions it aims to answer are:\n\n* Do different antihypertensive drugs affect objective balance performance and fall risk?\n* What are the effects of these medications on dizziness and fear of falling?\n\nResearchers will use a balance analysis system (Biodex Balance System) and self-reported scales (Dizziness Handicap Inventory and Falls Efficacy Scale) to assess outcomes. Participants will:\n\n* Be randomly assigned to one of three drug groups (metoprolol, ramipril, or amlodipine)\n* Be evaluated at baseline (prior to treatment), at 2 weeks, and at 4 weeks after starting treatment\n* Complete balance tests and questionnaires at each time point\n\nThis study aims to provide clinical insight into how commonly used blood pressure medications may impact balance and fall risk in real-world settings.",[598,599,600,601],"Hypertension","Fall Risk","Postural Balance","Fear of Falling",[603,604,598,605,606,607],"Antihypertensive drugs","Fall risk","Medication-related falls","Postural balance","Randomized controlled trial","2026-02-10",{"date":610,"type":40},"2026-02-12",{"date":612,"type":40},"2025-08-01",{"date":614,"type":22},"2026-06-30",{"name":46,"class":47},{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":621,"acronym":622,"eligibilityCriteria":623,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":209,"enrollmentInfo":624,"targetDuration":4,"studyType":81,"phases":626,"briefSummary":627,"conditions":628,"keywords":632,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":608,"lastUpdatePostDateStruct":639,"startDateStruct":640,"completionDateStruct":641,"leadSponsor":642,"locationsCount":48},"100601933","multisensory-and-cognitive-interventions-in-the-icu-effects-on-health-and-recovery-100601933","NCT07116941","Multisensory and Cognitive Interventions in the ICU: Effects on Health and Recovery","Effects of Multisensory and Cognitive Interventions Applied in the Intensive Care Unit on Physiological, Psychological and Functional Outcomes","MICU-CARE","Inclusion Criteria:\n\n* Age between 18 and 80 years\n* Underwent coronary artery bypass grafting (CABG) or other open-heart surgery\n* Admitted to the ICU postoperatively and eligible for early mobilization\n* Hemodynamically stable (within normal blood pressure and heart rate ranges, without inotropic support)\n* Alert and able to communicate\n\nExclusion Criteria:\n\n* Diagnosis of ICU delirium or altered mental status\n* Severe hemodynamic instability\n* Presence of neurological disease or significant cognitive impairment\n* Significant sensory deficits (e.g., severe hearing or vision loss)\n* Known allergy or psychological sensitivity to auditory or olfactory stimuli (e.g., aromatherapy or music)",{"count":625,"type":22},125,[83],"The goal of this clinical trial is to examine the effects of sensory and cognitive stimulation on physiological, psychological, and functional recovery in adult patients after cardiac surgery who are treated in the intensive care unit (ICU). The main questions it aims to answer are:\n\n* Does sensory and\u002For cognitive stimulation reduce anxiety and improve hemodynamic stability in ICU patients?\n* Does it enhance physical function and independence during early rehabilitation in the ICU?\n\nResearchers will compare four groups:\n\n1. Standard care (control),\n2. Cognitive stimulation,\n3. Auditory stimulation (music),\n4. Multisensory stimulation (touch + smell)\n\nto assess which intervention is most effective in improving recovery parameters.\n\nParticipants will:\n\n* Be randomly assigned to one of four groups during early mobilization in the ICU\n* Receive a 30-minute intervention session depending on group assignment\n* Be evaluated for heart rate, blood pressure, oxygen saturation, anxiety (VAS), physical function (PFIT, FIM), and satisfaction before and after the session",[629,630,631],"Coronary Artery Bypass Graft (CABG)","Cardiac Surgery Subjects","Postoperative Care",[633,634,635,636,287,637,638],"Early Mobilization","Intensive Care Unit","Cardiac Surgery","Multisensory Intervention","Non-pharmacological Intervention","Rehabilitation in ICU",{"date":610,"type":40},{"date":612,"type":40},{"date":614,"type":22},{"name":46,"class":47},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":78,"sex":17,"minAge":18,"maxAge":408,"enrollmentInfo":650,"targetDuration":4,"studyType":81,"phases":652,"briefSummary":653,"conditions":654,"keywords":656,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":658,"lastUpdatePostDateStruct":659,"startDateStruct":661,"completionDateStruct":663,"leadSponsor":665,"locationsCount":305},"100595952","virtual-reality-mirrors-therapy-usability-100595952","NCT07039136","Virtual Reality Mirrors Therapy Usability","Feasibility and Usability of Immersive VR Mirror Therapy for Upper Limb Rehabilitation","Inclusion Criteria:\n\n* Stereo acuity score of 3552 arc\u002Fsec in the Titmus Fly Test\n* No prior virtual reality experience\n\nExclusion Criteria:\n\n* Severe sensory impairments (vision or hearing)\n* Being diagnosed with neurological disorders",{"count":651,"type":22},172,[83],"Mirror therapy has been shown to support motor recovery by stimulating neural mechanisms through visual feedback. Recent technological advancements, particularly in virtual reality (VR), have enabled the development of more immersive and interactive rehabilitation tools. This study focuses on evaluating the usability of a novel, Leap Motion-based Virtual Reality Mirror Therapy (VRMT) system designed to enhance upper limb rehabilitation in stroke patients by combining traditional mirror therapy principles with engaging, gamified digital environments.",[655,215],"Healthy",[139,657],"Mirror Therapy","2026-02-03",{"date":660,"type":40},"2026-02-05",{"date":662,"type":40},"2025-06-28",{"date":664,"type":22},"2026-11-30",{"name":46,"class":47},""]