[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Advanced Reconstructive Surgery Alliance\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100604168","targeted-nerve-surgery-for-the-prevention-of-post-mastectomy-pain-syndrome-a-randomized-trial-100604168",false,"NCT07146009","Targeted Nerve Surgery for the Prevention of Post-Mastectomy Pain Syndrome: A Randomized Trial","Inclusion Criteria:\n\n* Adult patients (≥18 years old) undergoing second-stage implant exchange as part of tissue expander based breast reconstruction.\n* Patients with no prior diagnosis of PMPS.\n\nExclusion Criteria:\n\n* Prior nerve surgery in the chest region or chronic pain conditions unrelated to mastectomy.\n* Recent chest radiation (\\\u003C6 months), severe scarring, or active infection.\n* Uncontrolled diabetes, high-dose corticosteroids, or immunosuppressive therapy.\n* Psychiatric or cognitive impairments.\n* Pregnancy, or active lactation.\n* Autologous tissue based breast reconstruction.\n* Participation in another study within 6 months or inability to comply with follow-up.","ALL","18 Years",{"count":18,"type":19},60,"ESTIMATED","INTERVENTIONAL",[22],"NA","Post-Mastectomy Pain Syndrome (PMPS) is a chronic pain condition often caused by neuroma formation and nerve injury following breast cancer surgery. Standard breast reconstruction protocols typically do not address damaged intercostal nerves, leaving patients at risk for persistent nerve-related pain.\n\nProphylactic nerve surgery techniques, such as Targeted Muscle Reinnervation (TMR) and Regenerative Peripheral Nerve Interfaces (RPNI), offer innovative approaches to prevent neuroma formation by managing damaged nerves during surgery. This study will evaluate whether incorporating prophylactic nerve surgery during second-stage implant exchange after tissue expander based breast reconstruction can reduce the incidence of PMPS compared to standard medical therapies.",[25],"Breast Cancer",[27,28,29,30],"Post-mastectomy pain syndrome (PMPS)","Breast reconstruction","Regenerative Peripheral Nerve Interfaces","Targeted Muscle Reinnervation","NOT_YET_RECRUITING","2025-08-21",{"date":34,"type":35},"2025-08-28","ACTUAL",{"date":37,"type":19},"2025-10",{"date":39,"type":19},"2028-02-25",{"name":41,"class":42},"Advanced Reconstructive Surgery Alliance","OTHER_GOV",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100593915","early-phase-1-efficacy-of-glp-1-receptor-agonists-in-treating-upper-and-lower-extremity-lymphedema-100593915","NCT07012642","Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema","Inclusion Criteria:\n\nAdults 18 years or older with unilateral upper or lower extremity lymphedema Limb volume \\> 5% BMI =\\> 23 Oncology clearance if there is a cancer history\n\nExclusion Criteria:\n\nModerate to severe venous insufficiency Actively using GLP-1 RAs Known intolerance or adverse effect to GLP-1 RAs Medical history or morbidity where GLP-1 RAs are contraindicated as per patient's primary care provider such as MEN syndrome or history of thyroid cancer.",{"count":50,"type":19},110,[52],"EARLY_PHASE1","Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which can worsen lymphedema. Although anecdotal evidence suggests benefits of GLP-1 RAs for lymphedema patients, rigorous prospective studies are lacking. This study aims to evaluate the effectiveness of GLP-1 RAs in improving quality of life and clinical outcomes in lymphedema patients, thereby addressing a critical gap in literature and potentially offering a new treatment option.",[55],"Lymphedema",[57],"Efficacy of GLP-1 in lymphedema","RECRUITING","2025-06-01",{"date":61,"type":35},"2025-06-10",{"date":63,"type":35},"2025-04-09",{"date":65,"type":19},"2027-04-09",{"name":41,"class":42},2,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":67},"100534814","phrenic-nerve-reconstruction-for-the-treatment-of-diaphragmatic-paralysis-patient-experiences-and-reported-outcomes-100534814","NCT06243718","Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis: Patient Experiences and Reported Outcomes.","A Grounded Theory of Phrenic Nerve Reconstruction for the Treatment of Diaphragmatic Paralysis - A Biopsychosocial Approach to Surgical Evaluation and Outcomes.","Inclusion Criteria:\n\n* Individuals with a confirmed diagnosis of Diaphragmatic Paralysis.\n* Individuals who are scheduled to undergo phrenic nerve reconstructive surgery for the treatment of Diaphragmatic Paralysis.\n\nExclusion Criteria:\n\n\\- Individuals who do not comprehend the English language.","70 Years",{"count":77,"type":19},45,"OBSERVATIONAL","This study utilizes a grounded theory methodology to explore patient experiences of phrenic nerve reconstructive surgery as a treatment for diaphragmatic paralysis.",[81,82,83],"Diaphragmatic Paralysis","Pain, Chest","Breath Shortness",[85,81,86,87,88],"Grounded Theory","Diaphragm","Respiratory System","Pain","2024-02-05",{"date":91,"type":35},"2024-02-06",{"date":93,"type":35},"2023-10-10",{"date":95,"type":19},"2026-10-10",{"name":41,"class":42},""]