[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Aerospace Center Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":78},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100622761","individualized-open-lung-ventilation-and-postoperative-pulmonary-complications-in-thoracic-surgery-100622761",false,"NCT07387822","Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery","Effect of Individualized Versus Standardized Open-Lung Ventilation on Postoperative Pulmonary Complications in Thoracic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Body mass index between 18 and 30 kg\u002Fm².\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS).\n* Expected duration of one-lung ventilation longer than 1 hour.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Emergency surgery or reoperation.\n* History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.\n* History of heart failure or coronary artery disease.\n* Previous thoracic surgery or mechanical ventilation within 1 month before surgery.\n* Planned postoperative mechanical ventilation.\n* Bilateral thoracic surgery.\n* Participation in another interventional clinical trial.\n* Conversion to open thoracotomy during surgery.","ALL","18 Years","75 Years",{"count":20,"type":21},352,"ESTIMATED","INTERVENTIONAL",[24],"NA","This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative \"Individualized Open Lung Ventilation\" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.\n\nOne-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.",[27,28,29],"Postoperative Pulmonary Complications (PPCs)","One-lung Ventilation (OLV)","Thoracic Surgery, Video Assisted",[31,32,33,34,35,36],"Individualized Open Lung Ventilation","Driving Pressure","PEEP Titration","Lung Recruitment Maneuver","Lung Protective Ventilation","Video-Assisted Thoracic Surgery","NOT_YET_RECRUITING","2026-01-30",{"date":40,"type":41},"2026-02-04","ACTUAL",{"date":43,"type":21},"2026-02-10",{"date":45,"type":21},"2026-05-10",{"name":47,"class":48},"Aerospace Center Hospital","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":49},"100622034","proactive-temperature-management-in-crs-hipec-for-prevention-of-delirium-100622034","NCT07378371","Proactive Temperature Management in CRS-HIPEC for Prevention of Delirium","Proactive Temperature Management and Delirium After Cytoreductive Surgery With HIPEC: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients (aged 18-80 years).\n\nAmerican Society of Anesthesiologists (ASA) physical status of I to III.\n\nScheduled for elective Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Pseudomyxoma Peritonei (PMP).\n\nWritten informed consent obtained from the participant or legally authorized representative.\n\nExclusion Criteria:\n\n* Known diagnosis of dementia, major neurocognitive disorder, or severe psychiatric illness (e.g., schizophrenia) documented in the medical record.\n\nAcute central nervous system pathology likely to confound delirium assessment (e.g., recent stroke, active seizure disorder, or traumatic brain injury).\n\nSevere sensory or language barriers precluding valid cognitive screening (e.g., profound deafness or blindness, or language barriers not correctable with translation).\n\nPreoperative coma, mechanical ventilation, or deep sedation precluding reliable baseline assessment.\n\nEmergency surgery or repeat CRS-HIPEC during the same hospital admission.\n\nHistory of alcohol or substance abuse likely to precipitate withdrawal symptoms.","80 Years",{"count":59,"type":21},174,[24],"This randomized controlled trial evaluates the efficacy of a proactive Goal-Directed Temperature Management (GDTM) protocol in reducing postoperative delirium among patients undergoing Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for pseudomyxoma peritonei.\n\nCRS-HIPEC presents a unique physiological challenge characterized by a biphasic thermal trajectory: potential hypothermia during extensive surgery followed by rapid iatrogenic hyperthermia during perfusion. This study compares a standardized GDTM strategy-which incorporates strict normothermia maintenance and anticipatory pre-cooling prior to perfusion-against standard reactive thermal management. The primary objective is to determine if optimized thermoregulation can attenuate thermal variability and improve early neurocognitive recovery.",[63,64],"Pseudomyxoma Peritonei","Postoperative Delirium (POD)",[66,67,68,69,70],"Cytoreductive Surgery","HIPEC","Hyperthermic Intraperitoneal Chemotherapy","Temperature Management","Goal-Directed Therapy","2026-01-27",{"date":38,"type":41},{"date":74,"type":21},"2026-02-01",{"date":76,"type":21},"2026-05-01",{"name":47,"class":48},""]