[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Afyonkarahisar Health Sciences University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":648},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,48,74,107,134,160,185,205,235,263,293,318,342,369,396,423,446,468,494,517,541,567,587,606,625],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100630040","repetitive-transcranial-magnetic-stimulation-in-cardiac-autonomic-dysfunction-100630040",false,"NCT07482501","Repetitive Transcranial Magnetic Stimulation in Cardiac Autonomic Dysfunction","The Effect of Repetitive Transcranial Magnetic Stimulation on Cardiac Autonomic Dysfunction in Patients With Stroke","Inclusion Criteria:\n\n* Participants aged 35-80 years admitted to the Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Unit for neurological rehabilitation after stroke\n* Participants with a history of stroke of at least 3 months\n* Neurologically and medically stable participants willing to participate regularly in the study\n* Participants capable of following commands\n\nExclusion Criteria:\n\n* Serious cardiac disease, uncontrolled hypertension\n* Epilepsy or history of antiepileptic drug use\n* Intracranial metallic implants\n* Inner ear implants\n* Malignancy\n* Active infection\n* Skin infection or open wound in the intervention area\n* Brain lesions or medications that may alter the seizure threshold\n* Increased intracranial pressure\n* Uncontrolled migraine\n* Fracture or surgery on the hemiplegic side within the last 6 months\n* Pregnancy","ALL","35 Years","80 Years",{"count":21,"type":22},44,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to investigate the effects of repetitive transcranial magnetic stimulation (rTMS) added to conventional neurological rehabilitation on heart rate variability (HRV), quality of life, upper extremity muscle strength and autonomic symptoms in patients with stroke.",[28,29,30],"Stroke","Autonomic Dysfunction","Hemiparesis",[32,33,34],"Repetitive Transcranial Magnetic Stimulation","Hemiplegia","Neurological Rehabilitation","RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":39},"2026-03-26",{"date":43,"type":22},"2026-11-15",{"name":45,"class":46},"Afyonkarahisar Health Sciences University","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100571953","repetitive-transcranial-magnetic-stimulation-therapy-in-spinal-cord-injury-related-neuropathic-pain-100571953","NCT06726954","Repetitive Transcranial Magnetic Stimulation Therapy in Spinal Cord Injury Related Neuropathic Pain","Efficacy of Repetitive Transcranial Magnetic Stimulation Therapy in Neuropathic Pain Associated With Spinal Cord Injury; Randomized Controlled Trial","Inclusion Criteria:\n\nAged 18-75 years Physician-diagnosed spinal cord injury for at least 3-months Neuropathic pain for at least 3-months Pain not attributable to any other conditions\n\nExclusion Criteria:\n\n* Having an important comorbid disease such as severe heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, uncontrolled hypertension,arrhythmia, pacemaker)\n* Neurodegenerative disease\n* Epilepsy\n* History of antiepileptic drug use\n* Cognitive dysfunction\n* Lower extremity peripheral nerve injury\n* Increased intracranial pressure or uncontrolled migraine\n* Infection on the skin in the application area.\n* Having a brain lesion or a history of drug use that will affect the seizure threshold.\n\nAny TMS-related contraindications, for example:\n\n* Pacemaker\n* Metallic implant\n* Previous seizure\n* Psychiatric disorders (excluding depression and anxiety)\n* Malignancy\n* Current pregnancy","18 Years","75 Years",{"count":58,"type":22},63,[25],"The aim of our study is to investigate the effect of different protocols of high-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) therapy added to the rehabilitation program on neuropathic pain,depression, quality of life and quality of sleep compared to each other and placebo group in participants with spinal cord injury.",[62,63],"Spinal Cord Injuries","Neuropathic Pain",[65,66,63],"Transcranial Magnetic Stimulation","Spinal Cord Injury",{"date":68,"type":39},"2026-06-26",{"date":70,"type":39},"2024-12-16",{"date":72,"type":22},"2026-12-30",{"name":45,"class":46},{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":17,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100637687","game-based-handwashing-education-in-preschool-children-100637687","NCT07607717","Game-Based Handwashing Education in Preschool Children","The Effect of a Game-Based Handwashing Education on Handwashing Behavior in Preschool Children","Inclusion Criteria:\n\n* Participation in at least 80% of the planned 8 game sessions (at least 7 sessions)\n* Children aged 60-83 months enrolled in the preschool education institution where the research is conducted\n* Children who have the cognitive ability to understand the given instructions and who do not have any physical condition preventing them from performing handwashing behavior\n* Children for whom written parental consent for participation in the study has been obtained\n* Children whose primary caregiver agrees to complete the parent observation form provided within the scope of the study, has Turkish literacy skills, and provides informed voluntary consent\n\nExclusion Criteria:\n\n* Children outside the 60-83 months age range\n* Children with a physical disability that may prevent them from performing handwashing behavior\n* Children with cognitive impairments at a level that would make it difficult to understand the given instructions and actively participate in the game\n* Children for whom written parental consent for participation in the study has not been obtained\n* Children whose parents\u002Fcaregivers do not agree to complete the parent observation form provided within the scope of the study, do not have Turkish literacy skills, or do not provide informed voluntary consent",true,"60 Months","83 Months",{"count":85,"type":22},108,[25],"This study aims to evaluate the effect of a game-based handwashing education program, which will be developed based on the Health Belief Model, on the handwashing behaviors of preschool children. Preschool children are considered more vulnerable to respiratory and gastrointestinal infections due to their immature immune systems and close contact with peers in school settings.\n\nWithin the scope of this project, a game called \"Clean Hands\" will be developed and a game-based handwashing education program will be implemented. The study will be conducted using a quasi-experimental pretest-posttest control group design with children aged 60-83 months attending two preschools with similar demographic characteristics. Children will be assigned to intervention and control groups.\n\nChildren in the intervention group will participate in the developed game as a group activity once a week for eight weeks. The control group will not receive any game-based intervention during the study period; however, the same game will be provided to the control group after completion of the intervention sessions.\n\nData will be collected using teacher observation forms, parent observation forms, handwashing step sequencing assessment forms, and handwashing behavior discrimination assessment forms. The findings are expected to contribute to the development of effective game-based health education strategies for preschool children.",[89],"Handwashing Behavior",[91,92,93,94,95,96,97],"Hand Hygiene","Preschool Children","Game-Based Learning","Health Belief Model","Health Education","Behavior Change","School Health","NOT_YET_RECRUITING","2026-05-21",{"date":101,"type":39},"2026-05-26",{"date":103,"type":22},"2026-10-01",{"date":105,"type":22},"2027-02-01",{"name":45,"class":46},{"id":108,"slug":109,"hasResults":12,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":12,"sex":17,"minAge":114,"maxAge":19,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":47},"100573777","comparison-of-the-effects-of-mirror-therapyrtms-and-robotic-assisted-hand-therapy-in-stroke-patients-100573777","NCT06750692","Comparison of the Effects of Mirror Therapy,rTMS and Robotic-assisted Hand Therapy in Stroke Patients","Comparison of the Effects of Mirror Therapy,Repetitive Transcranial Magnetic Stimulation and Robotic-assisted Hand Therapy Added to Neurological Rehabilitation on Upper Extremity Functions, Quality of Life and Pain in Stroke Patients","Inclusion Criteria:\n\n* Patients who applied to Afyonkarahisar Health Sciences University Hospital Physical Medicine and Rehabilitation Polyclinic with the diagnosis of hemiplegia after a cerebrovascular accident in the inpatient ward or as an outpatient for neurological rehabilitation after taking the anamnesis and physical examination, who met the inclusion criteria and eliminated the exclusion criteria\n* Female and male patients between the ages of 40-80\n* stroke at least 3 months ago\n* voluntarily agreed to participate in the study regularly, whose health status is suitable for rehabilitation and who are medically stable\n* mini mental test score of 15 and above\n* Neurologically stable patient\n\nExclusion Criteria:\n\n* significant comorbidities such as serious heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, arrhythmia, pacemaker) and uncontrolled hypertension\n* history of epilepsy, antiepileptic drug use\n* intracranial metal objects\n* intraauricular implants\n* cognitive dysfunction\n* upper extremity peripheral nerve injuries\n* malignancy\n* active infection\n* skin infections or open wounds in the application area\n* inflammatory diseases\n* orthopedic injuries that may limit maximum effort capacity\n* brain lesion or drug use history that may affect the seizure threshold\n* increased intracranial pressure\n* uncontrolled migraine\n* severe spasticity in the hand (MAS≥3)\n* contracture in the hand\n* have had a fracture or surgery on the hemiplegic side in the last 6 months\n* severe visual impairment\n* severe depression","40 Years",{"count":116,"type":22},120,[25],"The aim of the study is to investigate the comparison of the effects of mirror therapy, Repetitive Transcranial Magnetic Stimulation and robot-assisted hand therapy added to conventional neurological rehabilitation on upper extremity function, quality of life and pain in stroke.",[28,120,63,121,122],"Upper Extremity Dysfunction","Quality of Life","Neurologic Disorder",[124,32,125],"Mirror Therapy","Hand-Finger Robot","2026-03-11",{"date":128,"type":39},"2026-03-12",{"date":130,"type":39},"2024-12-27",{"date":132,"type":22},"2026-06-20",{"name":45,"class":46},{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":141,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":151,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":47},"100534824","comparison-of-ultrasound-guided-injection-with-median-nerve-decompression-surgery-in-carpal-tunnel-syndrome-100534824","NCT06243848","Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome","Comparison of Ultrasound-Guided Injection With Traditional Median Nerve Decompression Surgery in Patients With Carpal Tunnel Syndrome: Randomized Controlled Study","Inclusion Criteria:\n\n* The presence of symptoms such as nocturnal, posture-related, or movement-related paresthesias, along with possible pain, in the area supplied by the median nerve in the hand, lasting for more than 3 months.\n* Confirmation of mild, moderate or severe CTS through electrophysiological testing.\n* Numbness and loss of sensation in the hand's regions innervated by the median nerve, as well as weakness in the thenar muscles innervated by the median nerve.\n* Positive results on either the Phalen test and\u002For Tinel sign.\n\nExclusion Criteria:\n\n* Individuals who may exhibit symptoms mimicking carpal tunnel syndrome, such as cervical radiculopathy, polyneuropathy, brachial plexopathy, or thoracic outlet syndrome.\n* Patients who have received a previous injection into the carpal tunnel within the past 6 months.\n* Thenar muscle atrophy.\n* A history of prior carpal tunnel surgery.\n* Regular usage of systemic nonsteroidal anti-inflammatory drugs and corticosteroids.\n* Pregnancy\n* Patients diagnosed with rheumatoid arthritis, systemic lupus erythematosus, gout, systemic sclerosis, dermatomyositis, or polymyositis.\n* Malignancy.\n* Active infections",{"count":142,"type":22},60,[25],"The aim of this study is to compare ultrasound-guided perineural injection of the median nerve with classic minimal incision surgical technique for median nerve decompression in patients diagnosed with mild, moderate, and severe carpal tunnel syndrome.",[146,147,148,149,150],"Musculoskeletal Diseases","Median Nerve Disease","Carpal Tunnel Syndrome","Ultrasound-Guided Injection","Surgery",[148,149,152],"Median Nerve Decompression","2026-03-10",{"date":128,"type":39},{"date":156,"type":39},"2024-01-25",{"date":158,"type":22},"2026-05-24",{"name":45,"class":46},{"id":161,"slug":162,"hasResults":12,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":81,"sex":17,"minAge":167,"maxAge":19,"enrollmentInfo":168,"targetDuration":4,"studyType":169,"phases":4,"briefSummary":170,"conditions":171,"keywords":174,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":47},"100496326","the-relationship-between-ultrasonographic-findings-and-sleep-quality-in-carpal-tunnel-syndrome-100496326","NCT05742776","The Relationship Between Ultrasonographic Findings and Sleep Quality in Carpal Tunnel Syndrome","The Relationship Between Ultrasonographic Findings and Sleep Quality in Patients With Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patients diagnosed with CTS according to the criteria of the American Academy of Neurology\n\nExclusion Criteria:\n\n* Patients with radiculopathy, brachial plexopathy, thoracic outlet syndrome and traumatic nerve injury that may affect the median nerve\n* History of Carpal tunnel surgery\n* Pregnancy\n* Malignancy\n* Thyroid diseases\n* Amyloidosis\n* Systemic lupus erythematosus, Rheumatoid arthritis, Systemic sclerosis, Gout, Dermatomyositis, Polymyositis\n* Obstructive sleep apnea","20 Years",{"count":116,"type":22},"OBSERVATIONAL","The aim of our study is to determine the relationship between disease severity and sleep quality in CTS patients and to compare the findings with healthy controls.",[146,147,148,172,173],"Ultrasound","Sleep Quality",[148,175,176],"Ultrasonographic evaluation","Pittsburgh Sleep Quality Index","2026-03-06",{"date":179,"type":39},"2026-03-09",{"date":181,"type":39},"2023-02-23",{"date":183,"type":22},"2026-07-01",{"name":45,"class":46},{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":17,"minAge":167,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":47},"100488814","transcranial-magnetic-stimulation-therapy-in-neuropathic-painful-spinal-cord-injury-patients-100488814","NCT05645003","Transcranial Magnetic Stimulation Therapy in Neuropathic Painful Spinal Cord Injury Patients","Effect of Repetative Transcranial Magnetic Stimulation Therapy on Neuropathic Pain in Patients With Spinal Cord Injury","Inclusion Criteria:\n\nBetween the ages of 20-70, who applied to the AFSU Physical Medicine and Rehabilitation inpatient service with the diagnosis of spinal cord injury and\n\n* Having spinal cord injury with neurophatic pain at least six months ago,\n* Able to follow two-stage verbal commands,\n* Agreeing to participate in the study voluntarily and regularly,\n* Patients who are medically stable (no previous myocardial infarction, no musculoskeletal problems) will be included in our study.\n\nExclusion Criteria:\n\nHaving an important comorbid disease such as severe heart disease (aortic stenosis, angina, hypertrophic cardiomyopathy, arrhythmia, pacemaker) and uncontrolled hypertension,\n\n* Epilepsy,\n* History of antiepileptic drug use,\n* Intracranial metal object,\n* Presence of in-ear implant,\n* Cognitive dysfunction,\n* Lower extremity peripheral nerve injury,\n* With malignancy and active infection,\n* Infection on the skin in the application area,\n* Having an open wound,\n* Having inflammatory disease,\n* Orthopedic injuries that can limit maximum effort contractions,\n* Having a brain lesion or a history of drug use that will affect the seizure threshold,\n* Patients with increased intracranial pressure or uncontrolled migraine will not be included.","70 Years",{"count":142,"type":22},[25],"The aim of our study is to investigate the effect of high-frequency Repetitive Transcranial Magnetic Stimulation(rTMS) therapy applied to the dorsolateral PFC (DLPFC) area on neuropathic pain in patients with spinal cord injury. In this area, there are very few studies on the effectiveness of rTMS treatment added to medical treatment in neuropathic pain. In addition, the number of studies comparing the effect of rTMS therapy applied to the DLFPC area is very few.",[62,63,197],"Neurological Diseases or Conditions",[32,34],{"date":179,"type":39},{"date":201,"type":39},"2022-11-15",{"date":203,"type":22},"2026-03-31",{"name":45,"class":46},{"id":206,"slug":207,"hasResults":12,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":81,"sex":17,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":217,"briefSummary":218,"conditions":219,"keywords":223,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":4},"100627204","effect-of-play-dough-slime-and-plush-toys-on-dental-anxiety-and-pain-in-children-during-dental-treatment-100627204","NCT07445594","Effect of Play Dough, Slime, and Plush Toys on Dental Anxiety and Pain in Children During Dental Treatment","Evaluation of the Effectiveness of Play Dough, Slime, and Plush Toys on Dental Anxiety, Pain Perception, and Salivary Cortisol Levels in Children During Dental Treatment","PLAY-DENT","Inclusion Criteria:\n\n1. Children aged 6-10 years requiring restorative dental treatment.\n2. Indication for dental treatment under local anesthesia.\n3. Ability to understand and respond to dental anxiety and pain assessment scales (CFSS-DS and Wong-Baker Faces Scale).\n4. Children classified as ASA I or ASA II.\n5. No prior exposure to the distraction materials used in the study during dental treatment.\n6. Written informed consent obtained from parents or legal guardians.\n\nExclusion Criteria:\n\n1. Presence of systemic diseases or medical conditions affecting stress response or contraindicating routine dental treatment\n2. History of psychiatric, neurological, or developmental disorders that may impair cooperation or communication\n3. Use of medications influencing anxiety, pain perception, heart rate, or cortisol levels\n4. Requirement for sedation or general anesthesia for dental treatment\n5. Acute dental infection or emergency treatment requiring immediate intervention\n6. Refusal of participation by the child or parent\u002Flegal guardian","6 Years","10 Years",{"count":216,"type":22},90,[25],"This study aims to evaluate the effectiveness of tactile distraction materials, including play dough, slime, and plush toys, on dental anxiety, pain perception, and physiological stress responses in children undergoing dental treatment. Ninety children aged 6-10 years receiving restorative dental treatment under local anesthesia were randomly assigned to one of four groups: play dough, slime, plush toy, or control group without distraction. Dental anxiety and pain levels were assessed using validated psychometric scales, while physiological stress responses were evaluated through heart rate monitoring and salivary cortisol measurements. The study seeks to determine whether simple non-pharmacological distraction techniques can improve behavioral cooperation and reduce anxiety and pain perception during pediatric dental procedures. Findings may contribute to the development of child-friendly dental management strategies and enhance the quality of pediatric dental care.",[220,221,222],"Dental Anxiety","Dental Pain","Behavioral Management",[220,224,221,225,226],"Distraction Techniques","Behavior Management","Salivary Cortisol","2026-02-27",{"date":229,"type":39},"2026-03-03",{"date":231,"type":22},"2026-02-17",{"date":233,"type":22},"2026-06-01",{"name":45,"class":46},{"id":236,"slug":237,"hasResults":12,"nctId":238,"briefTitle":239,"officialTitle":240,"acronym":4,"eligibilityCriteria":241,"healthyVolunteers":81,"sex":242,"minAge":55,"maxAge":114,"enrollmentInfo":243,"targetDuration":4,"studyType":169,"phases":4,"briefSummary":245,"conditions":246,"keywords":249,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":47},"100619112","physiological-and-biochemical-responses-to-blood-flow-restriction-training-100619112","NCT07340385","Physiological and Biochemical Responses to Blood Flow Restriction Training","The Effects of Training History on Physiological and Biochemical Responses in Blood Flow Restriction Strength Training","Inclusion Criteria:\n\n* Voluntary participation of healthy adults\n* Age between 18 and 40 years\n* No history of orthopedic pathology or current symptoms affecting the lower extremities\n* For individuals with prior training experience: engagement in strength training at least two days per week for the past year across different sports disciplines\n* For individuals new to strength training: no regular participation in strength training within the past six months\n\nExclusion Criteria:\n\n* History of hypertension, cardiovascular diseases, peripheral vascular diseases, deep vein thrombosis, neurological disorders, obesity, or a diagnosis of diabetes\n* Current or previous diagnosis of cancer\n* Individuals who do not consent to participate in the study","MALE",{"count":244,"type":22},30,"This study is designed to examine the short-term and long-term effects of blood flow restriction exercise training on physiological and biochemical markers in individuals who are new to strength training and in experienced athletes training at different load levels. This exercise method involves placing a special inflatable cuff around the upper part of the thigh. The cuff partially limits blood flow to the area, which helps the muscles work more effectively during exercise. The cuff will be applied only to the individual's dominant leg (the leg you use more often in daily activities), but all exercises will be performed using both legs. The exercise program will last for a total of six weeks and will be carried out twice per week. The pressure applied by the cuff will be individually adjusted based on each participant's physical characteristics to ensure safety and comfort. The study will include a total of 30 healthy participants aged between 18 and 40 years. Participants will be divided into two groups: individuals who have recently started strength training and experienced athletes with different levels of training experience.",[247,248],"Healthy Individuals","Trained Athletes",[250,251,252,253,254],"Strength Training","Oxidative Stress","Growth Factors","Biochemical Markers","Muscle Thickness","2026-02-12",{"date":257,"type":39},"2026-02-13",{"date":259,"type":39},"2026-01-20",{"date":261,"type":22},"2027-03-20",{"name":45,"class":46},{"id":264,"slug":265,"hasResults":12,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":269,"eligibilityCriteria":270,"healthyVolunteers":81,"sex":17,"minAge":213,"maxAge":214,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":279,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":47},"100625328","determination-of-the-effects-of-stainless-steel-crowns-cemented-with-resin-cements-on-interleukin-10-12-18-levels-in-gingival-crevicular-fluid-100625328","NCT07421206","DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID","Determination of the Effects of Stainless Steel Crowns Cemented With Resin Cements on Interleukin-10, Interleukin-12, and Interleukin-18 Levels in Gingival Crevicular Fluid","SSC-CYTO","Inclusion Criteria:\n\nChildren aged 6-10 years\n\nSystemically healthy pediatric patients\n\nPresence of bilateral mandibular second primary molars (teeth 75 and 85) requiring stainless steel crown restoration\n\nAbsence of clinical signs of active periodontal disease\n\nCooperative behavior sufficient to allow dental treatment and gingival crevicular fluid sampling\n\nWritten informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\nPresence of systemic diseases or medical conditions affecting periodontal health or immune response\n\nUse of antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the last month\n\nPoor oral hygiene or untreated periodontal disease\n\nTeeth with pulpal pathology, mobility, or advanced root resorption\n\nHistory of allergy to dental materials used in the study\n\nLack of parental consent or inability to complete follow-up examination",{"count":272,"type":22},45,[25],"This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10 (IL-10), interleukin-12 (IL-12), and interleukin-18 (IL-18) levels in gingival crevicular fluid in pediatric patients. The study included 45 systemically healthy children aged 6-10 years. Stainless steel crowns were placed on the mandibular second primary molars (teeth 75 and 85) in each patient; tooth 75 was cemented with a self-adhesive resin cement (G-Cem ONE™, GC, Japan), while tooth 85 was cemented using a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan). Plaque index, gingival index, and bleeding on probing were recorded before treatment and one week after cementation. Gingival crevicular fluid samples were collected at the same time points, and IL-10, IL-12, and IL-18 levels were analyzed using the ELISA method. A statistically significant reduction in plaque index values was observed in both cement groups at the one-week follow-up (p\\\u003C0.001), whereas no significant differences were found in gingival index or bleeding on probing values (p\\>0.05). IL-10 and IL-12 levels did not change significantly in either group, whereas IL-18 levels decreased significantly in the resin cement group and were significantly higher in the glass ionomer cement group postoperatively. These findings suggest that although different cementation materials used for stainless steel crowns yield similar short-term clinical periodontal outcomes, material-related differences may exist in gingival biological responses, particularly with respect to IL-18 levels.",[276,277,278],"Dental Caries","Gingival Inflammation","Periodontal Response to Dental Restorative Materials",[280,281,282,283,284,285],"Stabnless steel crown","gingival crevicular fluid","interleukin-10","interleukin-12","interleukin-18","resin cement",{"date":287,"type":39},"2026-02-19",{"date":289,"type":22},"2026-02-16",{"date":291,"type":22},"2026-05-30",{"name":45,"class":46},{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":4,"eligibilityCriteria":299,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":300,"targetDuration":4,"studyType":23,"phases":302,"briefSummary":303,"conditions":304,"keywords":306,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":317},"100615557","comparison-of-rest-splints-vs-high-intensity-laser-therapy-in-carpal-tunnel-syndrome-100615557","NCT07294157","Comparison of Rest Splints vs High-Intensity Laser Therapy in Carpal Tunnel Syndrome","Comparison of the Effects of Rest Splints and High-Intensity Laser Therapy on Pain, Function, Nerve Conduction Studies, and Grip Strength in Patients With Carpal Tunnel Syndrome","Inclusion Criteria:\n\n* Patients aged 18-75 years who have been diagnosed with carpal tunnel syndrome based on their medical history, physical examination, clinical findings, and electromyography(EMG) results, who have applied to the outpatient clinic for physical therapy, and who have no contraindications for treatment will be included in the study after obtaining their consent.\n\nExclusion Criteria:\n\n* Diabetes Mellitus\n* Hypothyroidism\n* Acromegaly\n* Rheumatic Diseases\n* Polyneuropathy\n* Ipsilateral brachial plexopathy and traumatic nerve injury in the upper extremity\n* Previous injection into the carpal tunnel within the last 6 months and physical therapy\n* Pregnancy\n* History of malignant tumors\n* Patients with cochlear implants\n* Acquired Immunodeficiency Syndrome\n* History of neck and\u002For shoulder surgery\n* Corticosteroid consumption, analgesic medication use\n* Epilepsy\n* Skin lesion",{"count":301,"type":22},78,[25],"The aim of this study is to compare the effectiveness of rest splints and high-intensity laser therapy(HILT) added to physical therapy programs for patients with carpal tunnel syndrome in terms of pain, function, nerve conduction studies, and grip strength.",[305],"Carpal Tunnel Syndrome (CTS)",[148,307,308],"Physical Therapy Modalities","Electromyography veya Nerve Conduction","2026-01-12",{"date":311,"type":39},"2026-01-13",{"date":313,"type":39},"2025-12-15",{"date":315,"type":22},"2026-09-15",{"name":45,"class":46},2,{"id":319,"slug":320,"hasResults":12,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":325,"minAge":55,"maxAge":4,"enrollmentInfo":326,"targetDuration":4,"studyType":169,"phases":4,"briefSummary":327,"conditions":328,"keywords":330,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":47},"100619056","validity-and-reliability-of-the-prafab-100619056","NCT07339657","Validity and Reliability of the PRAFAB","Evaluation of the Validity and Reliability of the Protection, Amount, Frequency, Compliance, Body Image (PRAFAB) Questionnaire in Women With Urinary Incontinence","Inclusion Criteria:\n\n* Being 18 years of age or older\n* Have been diagnosed with urinary incontinence by a urologist\n* Be female\n\nExclusion Criteria:\n\n* Being pregnant,\n* Being in the early postpartum period,\n* Have been diagnosed with bladder cancer, diabetic nephropathy, a history of central nervous system damage, congenital urological disorders, urinary tract infection, neurogenic bladder, severe cognitive impairment, and severe psychiatric illness.","FEMALE",{"count":58,"type":22},"PRAFAB assesses both the objective and subjective aspects of urinary incontinence. While differing from other questionnaires in this respect, it consists of only five questions. Today, there is a need for multidimensional and easy-to-use scales that can assess the effects of incontinence on quality of life. Therefore, the aim of this study is to conduct a Turkish validity and reliability study of the PRAFAB questionnaire in women with urinary incontinence.",[329],"Urinary Incontinence",[331,332,333],"urinary incontinence","validity","reliability","2026-01-05",{"date":336,"type":39},"2026-01-14",{"date":338,"type":39},"2024-10-15",{"date":340,"type":22},"2026-08-15",{"name":45,"class":46},{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":81,"sex":325,"minAge":55,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":355,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":361,"lastUpdatePostDateStruct":362,"startDateStruct":364,"completionDateStruct":366,"leadSponsor":368,"locationsCount":4},"100616991","the-effect-of-art-based-mandala-coloring-activity-on-postpartum-anxiety-and-postpartum-depression-100616991","NCT07312812","The Effect of Art-Based Mandala Coloring Activity on Postpartum Anxiety and Postpartum Depression","Inclusion Criteria:\n\n* Able to speak and understand Turkish\n* Voluntarily agree to participate in the study and have signed the informed consent form\n* 18 years of age or older\n* Literate\n* Have not received any psychiatric diagnosis and are not currently receiving psychological or psychiatric support (therapy, counseling, or medication treatment)\n* Have not experienced any complications during delivery\n* Have a newborn with no malformation or anomaly\n* Have a newborn with no complications\n\nExclusion Criteria:\n\n* Have previously received psychological or psychiatric treatment or are receiving such treatment during the data collection period,\n* Have a serious neurological or psychiatric disorder that affects cognitive functioning,\n* Have serious health problems that prevent communication or participation in the study,\n* Have not provided informed consent,\n* Are unable to speak or understand Turkish,\n* Have experienced complications during delivery,\n* Have a newborn with a malformation or anomaly,\n* Have a newborn with any complications.","49 Years",{"count":142,"type":22},[25],"The postpartum period is a critical time for women's physical and psychological health, during which significant hormonal, emotional, and social changes occur. During this period, many women experience increased stress, anxiety, and emotional vulnerability while adapting to new parental responsibilities and caring for a newborn. When these challenges are not adequately managed, they may contribute to the development of postpartum anxiety and postpartum depression, which can negatively affect maternal well-being, mother-infant bonding, breastfeeding practices, and child development. Despite the importance of postpartum mental health, non-pharmacological and easily accessible supportive interventions remain limited.\n\nThis randomized controlled experimental study aims to evaluate the effect of a structured, art-based mandala coloring activity on postpartum anxiety and postpartum depression among postpartum women. The study will be conducted at Afyonkarahisar Health Sciences University Health Practice and Research Center, Obstetrics and Gynecology Clinic, and will include women who have recently given birth at this institution. Eligible participants will be randomly assigned to either an intervention group or a control group.\n\nWomen in the intervention group will receive individual training in mandala coloring before hospital discharge and will be provided with mandala coloring materials for home use. They will be encouraged to engage in the mandala coloring activity over an eight-week period and will be followed through regular telephone contacts. In addition to monitoring participation in the activity, individualized supportive counseling will be provided based on participants' needs. Women in the control group will receive routine postpartum care without any additional intervention.\n\nPostpartum anxiety and postpartum depression levels will be assessed at multiple time points during the study to examine changes over time. This study seeks to determine whether mandala coloring, as a low-cost and non-pharmacological art-based activity, may serve as a supportive approach to improve psychological well-being during the postpartum period. The findings may contribute to the development of accessible interventions aimed at supporting maternal mental health in the early postpartum period.",[353,354],"Postpartum Depression","Postpartum Anxiety",[356,357,358,359,360],"woman","postpartum","depression","anxiety","mandala","2026-01-03",{"date":363,"type":39},"2026-01-07",{"date":365,"type":22},"2026-01-15",{"date":367,"type":22},"2026-04-15",{"name":45,"class":46},{"id":370,"slug":371,"hasResults":12,"nctId":372,"briefTitle":373,"officialTitle":374,"acronym":4,"eligibilityCriteria":375,"healthyVolunteers":12,"sex":17,"minAge":376,"maxAge":192,"enrollmentInfo":377,"targetDuration":4,"studyType":23,"phases":379,"briefSummary":380,"conditions":381,"keywords":384,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":47},"100571952","effect-of-exercise-gene-expression-and-histone-modifications-in-patients-with-hemiplegia-100571952","NCT06726941","Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia","Effect of Exercise on Neuroplasticity-Related Gene Expression and Histone Modifications in Patients With Hemiplegia","Inclusion Criteria:\n\n1. Participants who applied to Afyonkarahisar Health Sciences University Physical Therapy and Rehabilitation Clinic for rehabilitation purposes and had a stroke for the first time\n2. Participants with ischemia as the etiology of stroke\n3. Participants between the ages of 25-70\n4. Drugs that have been used for at least 1 month and up to 6 months after a cerebrovascular accident\n\nExclusion Criteria:\n\n1. Participants whose stroke etiology is other than ischemia\n2. Participants with clinically significant neurological disease other than stroke\n3. Participants with systemic and musculoskeletal diseases that will not tolerate neurological rehabilitation and prevent them from participating","25 Years",{"count":378,"type":22},48,[25],"The aim of this study is to demonstrate the effect of routine exercise program on neuroplasticity through histone acetylation and gene expression changes in acute stroke survivors from an epigenetic perspective and to investigate the correlation of epigenetic effects with its effects on motor function and quality of life.",[382,383],"Ischemic Stroke, Acute","Acute Hemiparesis",[385,386,387],"ischemic stroke","acute hemiplegia","epigenetics","2025-11-22",{"date":390,"type":39},"2025-11-25",{"date":392,"type":39},"2024-12-20",{"date":394,"type":22},"2026-09-09",{"name":45,"class":46},{"id":397,"slug":398,"hasResults":12,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":403,"targetDuration":4,"studyType":169,"phases":4,"briefSummary":405,"conditions":406,"keywords":411,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":422,"locationsCount":47},"100597961","plantar-sensation-position-sense-and-weight-bearing-asymmetry-related-to-balance-and-mobility-post-stroke-100597961","NCT07065292","Plantar Sensation, Position Sense, and Weight-Bearing Asymmetry Related to Balance and Mobility Post-Stroke","Investigation of the Relationship Between Plantar Sensation, Lower Extremity Position Sense, and Weight-Bearing Asymmetry With Posture, Balance, and Mobility in Individuals With Chronic Stroke","Inclusion Criteria:\n\n* Diagnosis of stroke confirmed by a physician (via official report)\n* Minimum of 6 months since stroke onset\n* Aged 18 years or older\n* Mini-Mental State Examination score ≥ 20\n* Brunnstrom lower extremity stage ≥ 3\n* Ability to complete assessments with or without walking aids\n* Voluntary participation\n\nExclusion Criteria:\n\n* Additional neurological, metabolic, or orthopedic conditions\n* Severe vision or hearing impairments\n* Modified Ashworth Score of 4 in any lower limb muscle",{"count":404,"type":22},22,"This study aims to examine how sensory deficits and weight-bearing asymmetry affect posture, balance, and mobility in individuals with chronic stroke. The research focuses on evaluating the relationships between plantar foot sensation, lower extremity position sense, and asymmetrical weight distribution with functional abilities such as walking and postural control.\n\nParticipants will undergo non-invasive assessments, including sensation tests, mobility and balance evaluations, and postural measurements. A total of 24 individuals with chronic stroke who are receiving physiotherapy at a rehabilitation center in Konya, Türkiye, will be included.\n\nThe results of this observational, cross-sectional study may contribute to a better understanding of the sensory-motor interactions in stroke survivors and support the development of more targeted rehabilitation strategies.",[407,408,409,410],"Chronic Stroke","Sensory Impairments","Postural Control","Balance",[407,412,413,414,415],"Somatosensory Function","Plantar Sensation","Balance Assessment","Weight-Bearing Asymmetry","2025-07-03",{"date":418,"type":39},"2025-07-15",{"date":420,"type":39},"2025-05-20",{"date":259,"type":22},{"name":45,"class":46},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":325,"minAge":55,"maxAge":430,"enrollmentInfo":431,"targetDuration":4,"studyType":23,"phases":433,"briefSummary":434,"conditions":435,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":438,"lastUpdatePostDateStruct":439,"startDateStruct":441,"completionDateStruct":443,"leadSponsor":445,"locationsCount":47},"100593333","tech-assisted-exercise-training-in-chronic-neck-pain-100593333","NCT07005076","Tech-Assisted Exercise Training in Chronic Neck Pain","Investigation of the Effects of Technology-Assisted Exercises in Individuals With Chronic Neck Pain","Inclusion Criteria:\n\n* Non-specific neck pain diagnosis\n* Having neck pain persisting for at least 3 months\n* Having the ability to speak and comprehend Turkish fluently\n* A pain score of 3 or higher according to the Numerical Rating Scale\n* A score of 5 or higher on the Neck Disability Index\n\nExclusion Criteria:\n\n* Having a history of spinal surgery.\n* Having an additional musculoskeletal disorder affecting the cervical region and upper extremities (e.g., scoliosis, rheumatoid arthritis, fibromyalgia, etc.).\n* Receiving physical therapy and\u002For other treatments for any reason within the last 6 months.\n* Having a diagnosed psychiatric disorder.\n* Having a vestibular pathology.\n* Having visual problems despite using visual aids.\n* Being pregnant.\n* Having a neurological deficit that may affect balance.\n* Discontinuing or being unable to complete the treatment process.","59 Years",{"count":432,"type":22},42,[25],"In this study, women with chronic neck pain residing in Afyonkarahisar, Turkey, will participate in an exercise-based intervention. Both the control and experimental groups will engage in conventional exercise programs; however, the experimental group will also receive an additional technology-assisted exercise program. It is anticipated that these interventions will positively impact participants' daily living activities and functional abilities. The study aims to assess whether the inclusion of technology-supported exercises leads to superior outcomes compared to conventional exercises alone. The findings are expected to provide valuable evidence on the effectiveness of integrating technology-assisted exercise programs into physiotherapy and rehabilitation practices for women with chronic neck pain.",[436,437],"Chronic Neck Pain","Exercise Training Therapy","2025-05-27",{"date":440,"type":39},"2025-06-05",{"date":442,"type":39},"2025-05-01",{"date":444,"type":22},"2025-12",{"name":45,"class":46},{"id":447,"slug":448,"hasResults":12,"nctId":449,"briefTitle":450,"officialTitle":451,"acronym":4,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":453,"targetDuration":4,"studyType":23,"phases":454,"briefSummary":455,"conditions":456,"keywords":458,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":465,"leadSponsor":467,"locationsCount":317},"100581181","effects-of-adding-balneotherapy-to-a-physical-therapy-program-in-patients-with-chronic-lumbar-radiculopathy-100581181","NCT06846970","Effects of Adding Balneotherapy to a Physical Therapy Program in Patients With Chronic Lumbar Radiculopathy","The Effect of Adding Balneotherapy to the Physical Therapy Program on Neuropathic Pain, Disability, Daily Living Activities, and Sleep Quality in Patients With Chronic Lumbar Radiculopathy","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years who have been diagnosed with chronic lumbar radiculopathy based on medical history, physical examination, clinical findings, lumbar MRI, and EMG results, and who present to the outpatient clinic for physical therapy without any contraindications for treatment, will be included in the study after obtaining their informed consent.\n\nExclusion Criteria:\n\n* Patients with thermoregulation disorders or sensory deficits\n* Patients with lesions that impair skin integrity\n* Patients with decompensated heart failure\n* Patients with advanced heart, liver, or kidney failure\n* Patients with advanced, uncontrolled peripheral venous insufficiency\n* Patients with a history of epilepsy or seizures\n* Patients with pregnancy, malignancy, or a recent surgical operation\n* Patients in the acute exacerbation phase of rheumatic diseases\n* Patients with severe anemia\n* Patients with tuberculosis\n* Patients with febrile infectious diseases\n* Patients with diseases associated with bleeding disorders\n* Patients who have undergone regular balneotherapy in the past three months\n* Patients with polyneuropathy or peripheral nerve damage\n* Patients with muscle weakness detected during examination\n* Patients with prostheses\n* Patients with a history of lumbar surgery Exclusion Criteria for Balneotherapy\n* Patients with thermoregulation disorders or sensory deficits\n* Patients with lesions that impair skin integrity\n* Patients with decompensated heart failure\n* Patients with advanced heart, liver, or kidney failure\n* Patients with advanced, uncontrolled peripheral venous insufficiency\n* Patients with a history of epilepsy or seizures\n* Patients with pregnancy, malignancy, or a recent surgical operation\n* Patients in the acute exacerbation phase of rheumatic diseases\n* Patients with severe anemia\n* Patients with tuberculosis\n* Patients with febrile infectious diseases\n* Patients with diseases associated with bleeding disorders\n* Patients who have undergone regular balneotherapy in the past three months\n* Patients with polyneuropathy or peripheral nerve damage",{"count":116,"type":22},[25],"The aim of this study is to investigate the effects of adding balneotherapy to the conventional physical therapy program on neuropathic pain, disability, daily living activities, and sleep quality in patients with chronic lumbar radiculopathy.",[457],"Lumbar Radiculopathy",[459,460],"Chronic Lumbal Radiculopathy","balneotherapy","2025-03-19",{"date":463,"type":39},"2025-03-21",{"date":461,"type":39},{"date":466,"type":22},"2025-12-31",{"name":45,"class":46},{"id":469,"slug":470,"hasResults":12,"nctId":471,"briefTitle":472,"officialTitle":473,"acronym":4,"eligibilityCriteria":474,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":475,"targetDuration":4,"studyType":23,"phases":477,"briefSummary":478,"conditions":479,"keywords":481,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":4},"100579517","effect-of-music-during-wound-debridement-100579517","NCT06825325","Effect of Music During Wound Debridement","Effect of Music on Pain Relief, Anxiety Reduction, and Feelings of Safety in Patients Undergoing Wound Debridement","Inclusion Criteria:\n\n* 18 years of age or above,\n* Visiting the hospital due to diabetic foot,\n* Requiring wound debridement,\n* Having wound debridement at least once before,\n* Without hearing\u002Fspeech impairment,\n* Without a diagnosis of psychiatric disorders,\n* Without any professional training in music,\n* and volunteered to participate.\n\nExclusion Criteria:\n\n* Patients under 18 years of age,\n* Visiting the hospital for other wound causes,\n* Having debridement before and after toe amputation,\n* Having wound debridement for the first time\n* With hearing\u002Fspeech impairment,\n* With a diagnosis of psychiatric disorders,\n* With any kind of professional training in music,\n* and not willing to participate in the study.",{"count":476,"type":22},200,[25],"This randomized controlled intervention study aims to investigate the effect of music played before the debridement on patients' anxiety, pain, and sense of safety.\n\nThe study will be carried out with two groups: The control and the intervention groups with 100 participants for each group. While the control group participants will receive standard care, the intervention group participants will listen to selection of Sufi music before the debridement in addition to standard care.",[480],"Debridement",[480,482,483,484,485],"Music","Pain","Anxiety","Sense of Safety","2025-02-15",{"date":488,"type":39},"2025-02-19",{"date":490,"type":22},"2025-02-26",{"date":492,"type":22},"2026-02-26",{"name":45,"class":46},{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":506,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":47},"100575786","effect-of-music-during-toe-amputation-100575786","NCT06776809","Effect of Music During Toe Amputation","Effect of Music Listened During Toe Amputation on Patients' Anxiety, Pain, Sense of Safety and Surgical Fear","Inclusion Criteria:\n\n* 18 years of age or above,\n* Having a toe amputation under spinal anesthesia due to diabetic foot,\n* Without hearing\u002Fspeech impairment,\n* Without a diagnosis of psychiatric disorders,\n* Without any professional training in music,\n* and volunteered to participate.\n\nExclusion Criteria:\n\n* Patients under 18 years of age,\n* With hearing\u002Fspeech impairment,\n* With a diagnosis of psychiatric disorders,\n* With any kind of professional training in music,\n* and not willing to participate in the study.",{"count":116,"type":22},[25],"This randomized controlled intervention study aims to investigate the impact of music played during toe amputation on patients' anxiety, pain, sense of safety, and fear of surgery.\n\nThe study will be carried out with two groups: The control and the intervention groups with 60 participants for each group. While the control group participants will receive standard care, the intervention group participants will listen to selection of Sufi music during the whole amputation procedure in addition to standard care.",[505],"Amputation",[505,507,482,483,484,508,485],"Toe amputation","Surgical fear","2025-02-09",{"date":511,"type":39},"2025-02-11",{"date":513,"type":22},"2025-02-12",{"date":515,"type":22},"2026-01-06",{"name":45,"class":46},{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":4,"eligibilityCriteria":523,"healthyVolunteers":12,"sex":17,"minAge":167,"maxAge":524,"enrollmentInfo":525,"targetDuration":4,"studyType":23,"phases":527,"briefSummary":528,"conditions":529,"keywords":531,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":540,"locationsCount":47},"100578213","the-effect-of-hypnosis-on-periodontal-treatment-100578213","NCT06808373","The Effect of Hypnosis on Periodontal Treatment","The Effect of Hypnosis on Healing in Patients Undergoing Phase I Periodontal Therapy","Inclusion Criteria:\n\nBeing between the ages of 20-65 Not having any systemic disease Having chronic periodontal disease Having the ability to understand the study and answer questions\n\nExclusion Criteria:\n\nHaving any systemic disease Being under 20 or over 65 Not having any periodontal disease","65 Years",{"count":526,"type":22},50,[25],"Treatment of periodontal diseases relies on the mechanical removal of microbial dental plaque, calculus, and necrotic cementum from root surfaces in both supra- and subgingival areas to control inflammation in periodontal tissues. As in all dental treatments, dental phobia and dental anxiety are common challenges in initial periodontal therapy. Hypnosis is among the traditional non-pharmacological behavior management techniques used to manage stress and improve pain tolerance. It is known that hypnosis is effective in anxiety control in dentistry. The use of salivary levels of inflammatory mediators released during the disease is a valid method for assessing the progression of periodontal disease and healing after treatment. In this study, the effect of hypnosis on healing in patients undergoing Phase I periodontal therapy will be evaluated by comparing the mean differences in cytokine levels between case and control groups",[530,220],"Peridontal Disease",[532],"periodontitis, hypnosis, dental anxiety","2025-01-30",{"date":535,"type":39},"2025-02-05",{"date":537,"type":39},"2024-11-18",{"date":539,"type":22},"2026-11-18",{"name":45,"class":46},{"id":542,"slug":543,"hasResults":12,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":192,"enrollmentInfo":548,"targetDuration":4,"studyType":23,"phases":550,"briefSummary":551,"conditions":552,"keywords":556,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":47},"100575214","the-effects-of-whirlpool-and-contrast-bath-in-patients-with-complex-regional-pain-syndrome-after-distal-radius-fracture-100575214","NCT06769373","The Effects of Whirlpool and Contrast Bath in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture","The Effects of Whirlpool Bath and Contrast Bath Treatments on Pain, Disability, Functionality and Grip Strength in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture","Inclusion Criteria:\n\n* Patients with complex regional pain syndrome type-1 (CRPS-type 1) after distal radius fracture, who were followed conservatively (long\u002Fshort arm splint-cast) between the ages of 18-70, who applied to AFSU Physical Medicine and Rehabilitation Clinic. It is planned to use the Budapest diagnostic criteria for the diagnosis of CRPS Type 1.\n\nExclusion Criteria:\n\n* Orthopedic injuries (other accompanying orthopedic fractures, such as ulna fracture, carpal bone fractures),\n* Other system injuries,\n* Patients whose distal radius fractures were surgically treated,\n* Patients who had previously undergone surgery on the same upper extremity,\n* Nerve, tendon and artery injuries accompanying the fracture,\n* Other neurological, orthopedic or rheumatological problems affecting the same upper extremity,\n* Serious cardiovascular disease,\n* Presence of active infection, active dermatitis, skin diseases such as pemphigus, febrile diseases,\n* Presence of a fixed catheter in the area,\n* Impaired temperature sensationin in the area.",{"count":549,"type":22},40,[25],"The aim of our study is to investigate the effects of whirlpool bath and contrast bath treatments on pain, disability, functionality and grip strength in patients with complex regional pain syndrome after distal radius fracture.",[553,554,555],"Distal Radius Fracture","Complex Regional Pain Syndrome Type I","Complex Regional Pain Syndrome",[557,558,559],"Whirlpool","Contrast bath","hydrotherapy","2025-01-28",{"date":533,"type":39},{"date":563,"type":22},"2025-01-31",{"date":565,"type":22},"2025-06-15",{"name":45,"class":46},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":524,"enrollmentInfo":574,"targetDuration":576,"studyType":169,"phases":4,"briefSummary":577,"conditions":578,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":586,"locationsCount":4},"100570471","chronotype-and-myofascial-pain-syndrome-100570471","NCT06707675","Chronotype and Myofascial Pain Syndrome,","Chronotype and Quality of Life in Patients with Myofascial Pain Syndrome, a Cross-Sectional Study","Inclusion Criteria:\n\n* neck-back pain for at least 3 months\n* diagnosis of myofascial pain syndrome by anamnesis and physical examination\n\nExclusion Criteria:\n\n* Cervical Radiculopathy\u002FMyelopathy\n* Recent injection or physical therapy within the last 3 months\n* Neck and shoulder surgery\n* Neurological and inflammatory diseases\n* Pregnancy\n* Malignancy",{"count":575,"type":22},500,"1 Day","The aim of this study is to examine chronotype preferences in myofascial pain syndrome and to investigate its relationship with pain severity, disability and quality of life.",[579],"Myofascial Pain Syndrome, Diffuse","2024-11-27",{"date":582,"type":39},"2024-12-02",{"date":584,"type":22},"2024-12-15",{"date":565,"type":22},{"name":45,"class":46},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":4,"eligibilityCriteria":593,"healthyVolunteers":12,"sex":17,"minAge":594,"maxAge":56,"enrollmentInfo":595,"targetDuration":4,"studyType":23,"phases":596,"briefSummary":597,"conditions":598,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":600,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":604,"leadSponsor":605,"locationsCount":4},"100570074","balneotherapy-in-hand-osteoarthritis-100570074","NCT06702514","Balneotherapy in Hand Osteoarthritis","Effectiveness of Balneotherapy in the Treatment of Hand Osteoarthritis: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Between the ages of 50-75\n* Hand osteoarthritis diagnosed according to ACR criteria\n\nExclusion Criteria:\n\n* Non-cooperative patients\n* Trauma or surgery to the hand region in the last 6 months\n* Infection\n* Infection, loss of sensation, metal implant in the treatment area\n* Injection to the hand joints in the last 3 months\n* Physical therapy and rehabilitation to the hand region in the last 3 months\n* Balneotherapy in the last 3 months\n* Inflammatory rheumatic diseases\n* NSAI use\n* Planning pregnancy during pregnancy or treatment\n* Malignancy\n* Presence of a neurological disease\n* Hand-wrist entrapment neuropathy\n* Loss of muscle strength or sensation in the hand\n* Uncontrolled cardiopulmonary disease\n* Open wound\n* Orthopedic condition that would prevent entering the spa","50 Years",{"count":526,"type":22},[25],"There are a limited number of studies in the literature on the effectiveness of balneotherapy in hand osteoarthritis. The aim of this study was to evaluate the effects of balneotherapy on pain, manual skills, functionality and quality of life in patients with hand osteoarthritis who have undergone balneotherapy.",[599],"Hand Osteoarthritis","2024-11-21",{"date":602,"type":39},"2024-11-25",{"date":584,"type":22},{"date":313,"type":22},{"name":45,"class":46},{"id":607,"slug":608,"hasResults":12,"nctId":609,"briefTitle":610,"officialTitle":611,"acronym":4,"eligibilityCriteria":612,"healthyVolunteers":12,"sex":17,"minAge":55,"maxAge":524,"enrollmentInfo":613,"targetDuration":4,"studyType":23,"phases":614,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":618,"lastUpdatePostDateStruct":619,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":4},"100569342","high-and-low-level-laser-therapy-in-de-quervains-tenosynovitis-100569342","NCT06692998","High and Low Level Laser Therapy in De Quervain's Tenosynovitis","Comparison of the Efficacy of High and Low Level Laser Therapy in the Treatment of De Quervain's Tenosynovitis: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Between18-65 years of age\n* Wrist pain for more than 3 weeks\n* Finkelstein test positive\n* Ability to understand commands\n\nExclusion Criteria:\n\n* Physical therapy, injections, or surgery in the upper extremity in the last 3 months\n* Fracture or trauma in the upper extremity in the last 6 months\n* Radiating pain due to cervical discopathy\n* Infection, loss of sensation, metal implant in the treatment area\n* Inflammatory rheumatic diseases\n* NSAID use\n* Pregnancy or planning pregnancy during treatment\n* Malignancy\n* Pathology in the wrist on radiograph",{"count":549,"type":22},[25],"The aim in this study was to compare the effects of high and low power laser treatments in the treatment of de Quervein tenosynovitis clinically and ultrasonographically.",[617],"DeQuervain Tendinopathy","2024-11-20",{"date":600,"type":39},{"date":621,"type":22},"2024-12-01",{"date":623,"type":22},"2025-12-01",{"name":45,"class":46},{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":4,"eligibilityCriteria":631,"healthyVolunteers":12,"sex":17,"minAge":114,"maxAge":19,"enrollmentInfo":632,"targetDuration":4,"studyType":23,"phases":634,"briefSummary":635,"conditions":636,"keywords":637,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":642,"lastUpdatePostDateStruct":643,"startDateStruct":644,"completionDateStruct":645,"leadSponsor":647,"locationsCount":4},"100569329","robot-assisted-therapy-in-chronic-stroke-patients-100569329","NCT06692829","Robot-Assisted Therapy in Chronic Stroke Patients","Investigation of the Effects of Robot-Assisted Therapy Added to Conventional Therapy on Hand Functions, Spasticity and Quality of Life in Patients With Chronic Stroke: A Randomized Controlled Trial","Inclusion Criteria:\n\n* who were 3 months post-CVA\n* whose health status was suitable for rehabilitation\n* who could understand commands with a mini mental test score of 15 and above.\n\nExclusion Criteria:\n\n* Patients with persistent upper extremity pain on the hemiplegic side (VAS\\>40)\n* severe spasticity in the hand (MAS≥3)\n* contracture in the hand\n* fracture or surgery on the hemiplegic side within the last 6 months\n* botulinum toxin injection into the upper extremity within the last 6 months\n* skin ulcers\n* brainstem or cerebellar lesions\n* neglect or apraxia\n* severe visual defects\n* severe depression",{"count":633,"type":22},80,[25],"Considering the paucity of studies on robotic hand therapy, larger-scale and long-term follow-up studies are needed. The aim in this study is to demonstrate the effectiveness of robot-assisted hand therapy in patients with chronic stroke and to compare this effectiveness in patients with different Brunnstrom stages.",[28,33],[638,639,640,641],"stroke","hemiplegia","robotic rehabilitation","hand function","2024-11-15",{"date":537,"type":39},{"date":621,"type":22},{"date":646,"type":22},"2025-08-01",{"name":45,"class":46},""]