[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Al Hayah University In Cairo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":278},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,40,61,86,107,127,145,165,182,200,219,238,255],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100632445","residual-eccentric-strength-deficits-and-deep-scar-tissue-thickness-in-patients-with-tennis-leg-100632445",false,"NCT07513779","Residual Eccentric Strength Deficits and Deep Scar Tissue Thickness in Patients With Tennis Leg","Residual Eccentric Strength Deficits of Gastrocnemius Muscle and Deep Scar Tissue Thickness in Patients With Tennis Leg: A Cross-Sectional Study","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* History of unilateral plantar flexor muscle tear (tennis leg) involving the medial gastrocnemius, confirmed by diagnostic ultrasound\n* Ultrasound diagnostic criteria: hypoechoic or anechoic fluid collection between the medial gastrocnemius and soleus muscles, with partial or complete disruption of the normal muscle fiber architecture at the myotendinous junction\n* Grade I (mild strain, \\\u003C10% fiber involvement) or Grade II (moderate partial tear, 10-90% fiber involvement) injury\n* At least 3 months post-injury\n* Clinically healed with return to daily activities\n* Ability to perform maximal eccentric plantar flexion as assessed by the Eccentric Heel Raise Test (Single-Leg) (Chen et al., 2009)\n\nExclusion Criteria:\n\n* Bilateral calf injuries\n* Grade III (severe\u002Fcomplete) gastrocnemius muscle rupture\n* Previous Achilles tendon rupture or surgery\n* Previous injuries or surgeries to the lower extremity (other than the index tennis leg injury)\n* Neurological disorders affecting lower limb function\n* Current acute pain or re-injury at the time of assessment\n* Other lower-limb musculoskeletal injuries affecting performance\n* Systemic inflammatory or connective tissue diseases\n* Popliteal cyst rupture\n* Deep vein thrombosis\n* Isolated Achilles tendon rupture\n* Muscle tumor","ALL","18 Years","40 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","This study investigates the relationship between the thickness of deep scar tissue and residual weakness in the calf muscles of patients who have recovered from a condition known as \"tennis leg.\" Tennis leg is a common calf muscle injury caused by a partial tear of the inner part of the gastrocnemius (calf) muscle at the point where muscle meets tendon. While patients often return to daily activities after healing, many continue to experience hidden weakness in their calf muscles, particularly during activities that require the muscle to lengthen under load (eccentric contractions), such as walking downhill, running, or landing from a jump.\n\nThis study uses diagnostic ultrasound imaging to measure the thickness of scar tissue that forms inside the muscle after injury. It also uses an isokinetic dynamometer to objectively measure the eccentric (lengthening) strength of the calf muscles. By comparing the injured leg to the uninjured leg in the same person, the study determines whether patients with thicker scar tissue have greater residual strength deficits.\n\nThe study enrolls adults aged 18 to 40 years who have had a confirmed unilateral calf muscle tear at least 3 months ago and have returned to normal daily activities. No treatment or intervention is provided. All assessments are performed at a single time point. Understanding how scar tissue relates to persistent muscle weakness could help clinicians better predict long-term outcomes, design more effective rehabilitation programs, and make more informed decisions about when patients are ready to return to sport and physical activity.",[25,26],"Tennis Leg","Muscle Contusion","RECRUITING","2026-03-31",{"date":30,"type":31},"2026-04-07","ACTUAL",{"date":33,"type":21},"2026-04-15",{"date":35,"type":21},"2026-08-15",{"name":37,"class":38},"Al Hayah University In Cairo","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":17,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":39},"100605731","frontalaxial-and-self-body-image-in-scoliosis-100605731","NCT07166328","Frontal\u002FAxial and Self Body Image In Scoliosis","RELATIONSHIP BETWEEN AXIAL AND FRONTAL BACK ASYMMETRY WITH SELF BODY IMAGE IN ADOLESCENT IDIOPATHIC SCOLIOSIS","Inclusion Criteria:\n\n* Both gender's adolescent idiopathic scoliosis Age from 11 to 18 years Body mass index 20-25Kg\u002Fm2 Moderate cobb's angle 25\u002F45 degree Participation should be normal ambulatory Major thoracic curve\n\nExclusion Criteria:\n\n* leg length discrepancy Any mental condition Defects of spinal vertebrae Previous history of spine or lower extremities surgery","11 Years",{"count":20,"type":21},"What is the relationship between frontal and axial back asymmetric parameters with self body image in adolescent idiopathic scoliosis Age This study will investigate the relationship between frontal and axial back asymmetry with self body image in adolescent idiopathic scoliosis Delimitations : patients will be diagnosed by orthopedic surgeon with adolescent idiopathic scoliosis Delimitations Age 11 to 18 years BMI fron 20 to 24.9kg\u002Fm2 Moderate cobbs angle 25-45 degrees Major thoacic curve Self body image will be ass by TAPS questionnaire which evaluate self image and satisfaction",[51,52],"Scoliosis Idiopathic Adolescent","Scolosis","2025-09-03",{"date":55,"type":31},"2025-09-10",{"date":57,"type":31},"2025-09-01",{"date":59,"type":21},"2025-11-01",{"name":37,"class":38},{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":70,"targetDuration":4,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":39},"100586654","timing-of-specific-exercise-therapy-after-breast-cancer-surgery-early-versus-delayed-initiation-100586654","NCT06918184","Timing of Specific Exercise Therapy After Breast Cancer Surgery: Early Versus Delayed Initiation","Timing of Specific Exercise Therapy After Breast Cancer Surgery: A Single-Center, Parallel-Group Randomized Controlled Trial Comparing Early (\u003C1 Week Postoperative) Versus Delayed (3 Weeks Postoperative) Initiation for Optimized Upper Limb Function","BEST-Timing","Inclusion Criteria:\n\n* Women aged 18-65 years.\n* Scheduled to undergo breast cancer surgery with axillary node dissection.\n* At risk for upper limb morbidity based on preoperative assessment.\n* Able to provide informed consent and complete study questionnaires.\n* Willing and able to attend scheduled physiotherapy sessions and follow-up evaluations.\n\nExclusion Criteria:\n\n* Diagnosis of recurrent or metastatic breast cancer.\n* Concurrent participation in another rehabilitation intervention or clinical trial.\n* Severe comorbidities (e.g., uncontrolled cardiovascular disease, severe orthopedic conditions) that preclude safe participation.\n* History of previous shoulder surgery or chronic upper extremity musculoskeletal disorders unrelated to breast cancer treatment.\n* Inability to understand or complete study materials in English.\n* Pregnancy or lactation.","65 Years",{"count":71,"type":21},140,"INTERVENTIONAL",[74],"NA","This single-center, parallel-group randomized controlled trial (RCT) will compare two timings for initiating specific exercise therapy after breast cancer surgery. The study tests whether early initiation (within the first postoperative week) versus delayed initiation (at 3 weeks postoperative) results in superior upper limb function at 6 months as measured by the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire. Secondary outcomes include pain intensity (Visual Analog Scale, VAS) and wound-related complications such as drainage time and hematoma incidence.",[77],"Breast Cancer","2025-04-05",{"date":80,"type":31},"2025-04-09",{"date":82,"type":21},"2025-04-15",{"date":84,"type":21},"2026-11-15",{"name":37,"class":38},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":93,"targetDuration":4,"studyType":72,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":39},"100586537","rct-comparing-upper-body-vs-combined-exercise-protocols-during-active-diabetic-foot-ulcer-treatment-100586537","NCT06916663","RCT Comparing Upper Body vs. Combined Exercise Protocols During Active Diabetic Foot Ulcer Treatment","A Prospective, Three-Arm, Assessor-Blinded Randomized Controlled Trial Comparing Upper Body Exercise, Combined Non-Weight Bearing Exercise, and Standard Care for Improving Cardiorespiratory Fitness and Supporting Wound Healing in Patients Undergoing Active Diabetic Foot Ulcer Treatment","Inclusion Criteria:\n\nAge: Adults aged 18 years or older. Diagnosis: Confirmed diagnosis of Type 1 or Type 2 diabetes. Active DFU: Presence of a diabetic foot ulcer under active treatment, as documented by the wound care team.\n\nWound Stability: Ulcer size that meets protocol criteria (e.g., \\\u003C2 cm² or ≥2 cm²) and without critical limb ischemia.\n\nAbility to Exercise: Medical clearance from a physician to safely participate in unsupervised upper body and non-weight bearing exercises.\n\nCompliance: Capacity and willingness to adhere to the study protocol, including scheduled exercise sessions and offloading procedures.\n\nGlycemic Control: Stable glycemic control medications regimen for at least 4 weeks prior to enrollment.\n\nInformed Consent: Ability to provide written informed consent.\n\nExclusion Criteria:\n\nCritical DFU Complications: Ulcers with signs of critical limb ischemia, severe infection (e.g., osteomyelitis), or wound deterioration that contraindicates participation.\n\nCardiovascular Limitations: Unstable cardiac conditions (e.g., uncontrolled arrhythmias, recent myocardial infarction within 6 months), severe heart failure, or any other condition contraindicating exercise.\n\nNeurological or Musculoskeletal Limitations: Conditions that significantly impair upper body or core exercise performance (e.g., severe arthritis, recent upper body injury).\n\nCognitive Impairment: Significant cognitive or psychiatric disorders that would limit the ability to provide informed consent or adhere to the intervention protocol.\n\nConcurrent Participation: Enrollment in another clinical trial or exercise program that conflicts with the study protocol.\n\nOther Medical Risks: Any other condition, as determined by the study physician, that places the participant at increased risk of adverse events during exercise (e.g., severe peripheral vascular disease not amenable to offloading).",{"count":94,"type":21},153,[74],"This randomized controlled trial (RCT) aims to evaluate the effectiveness of two different structured exercise interventions compared to standard care during active diabetic foot ulcer (DFU) treatment. Participants will be allocated to one of three groups: Upper Body Exercise (UBE), Combined Exercise (CE), or Standard Care Control (SC). The interventions are designed to improve cardiorespiratory fitness-as measured by changes in VO₂peak-and other secondary clinical, metabolic, vascular, inflammatory, muscular, and quality-of-life outcomes while ensuring proper offloading and wound management.",[98],"Diabetic Foot Ulcer","2025-04-01",{"date":101,"type":31},"2025-04-08",{"date":103,"type":21},"2025-04-22",{"date":105,"type":21},"2027-04-23",{"name":37,"class":38},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":72,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":39},"100586536","comparing-hilt-steroid-injection-and-manual-therapy-for-frozen-shoulder-100586536","NCT06916650","Comparing HILT, Steroid Injection, and Manual Therapy for Frozen Shoulder","Comparative Effectiveness of High-Intensity Laser Therapy Versus Corticosteroid Injection Versus Manual Therapy, Each Combined With Standard Exercise, for Frozen Shoulder (Adhesive Capsulitis): A Randomized Controlled Trial","Inclusion Criteria:\n\nAge between 40 and 70 years, inclusive. Clinical diagnosis of primary (idiopathic) frozen shoulder, defined by shoulder pain and ≥50% restriction in passive external rotation compared to the contralateral (unaffected) shoulder.\n\nSymptom duration between 3 and 9 months. Average shoulder pain intensity ≥ 4 on a 10-cm Visual Analogue Scale (VAS) over the past week.\n\nNormal or age-appropriate radiographic findings of the glenohumeral joint (ruling out significant arthritis, fractures, calcific tendinitis).\n\nWillingness and ability to attend scheduled treatment\u002Fassessment sessions. Ability to understand study procedures and provide written informed consent.\n\nExclusion Criteria:\n\nSecondary frozen shoulder (e.g., post-traumatic, post-surgical, related to systemic disease like diabetes - clarify if diabetes is excluded or just secondary FS from diabetes).\n\nClinical or imaging evidence of significant rotator cuff tear requiring specific management.\n\nRadiographic evidence of moderate to severe glenohumeral osteoarthritis (e.g., Kellgren-Lawrence grade ≥ 3).\n\nPrevious surgery on the index shoulder. Significant neurological disorders affecting shoulder or upper extremity function (e.g., cervical radiculopathy, stroke).\n\nReceived a corticosteroid injection in the index shoulder within the past 3 months.\n\nKnown contraindications to corticosteroid injections (e.g., uncontrolled diabetes, allergy, local infection).\n\nKnown contraindications to High-Intensity Laser Therapy (e.g., active malignancy in the treatment area, photosensitivity, pacemaker over treatment area).\n\nCurrent participation in another interventional clinical trial for shoulder pain.","70 Years",{"count":116,"type":21},180,[74],"This study compares three common treatments for frozen shoulder when added to a standard exercise program: High-Intensity Laser Therapy (HILT), a corticosteroid (steroid) injection into the shoulder joint, and hands-on manual therapy by a physical therapist. A fourth group will receive only the standard exercise program. The goal is to see which combination works best to reduce shoulder pain and improve shoulder function over 6 months. The main outcomes are changes in pain (VAS scale) and shoulder disability (SPADI questionnaire) at 12 weeks.",[120],"Frozen Shoulder",{"date":101,"type":31},{"date":123,"type":21},"2025-04-25",{"date":125,"type":21},"2027-08-01",{"name":37,"class":38},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":134,"targetDuration":4,"studyType":72,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":139,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":39},"100586538","hilt-dose-optimization-for-knee-osteoarthritis-pain-100586538","NCT06916676","HILT Dose Optimization for Knee Osteoarthritis Pain","Optimal High-Intensity Laser Therapy (HILT) Parameters for Pain and Function in Patients With Moderate Knee Osteoarthritis: A Randomized Controlled Trial","Inclusion Criteria:\n\nAge between 45 and 75 years, inclusive. Clinical diagnosis of knee osteoarthritis according to American College of Rheumatology (ACR) criteria (knee pain plus at least 3 of 6: age \\>50, morning stiffness \\\u003C30 min, crepitus, bony tenderness, bony enlargement, no palpable warmth).\n\nRadiographic evidence of knee osteoarthritis corresponding to Kellgren-Lawrence grade II or III in the target knee.\n\nAverage knee pain intensity ≥ 4 on a 10-cm Visual Analogue Scale (VAS) during weight-bearing activities in the past week.\n\nWillingness and ability to attend 3 sessions per week for 4 weeks and attend all assessment sessions.\n\nExclusion Criteria:\n\nPrevious surgery on the index knee (including arthroscopy within the last year or joint replacement).\n\nDiagnosis of inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis, gout).\n\nIntra-articular corticosteroid or hyaluronic acid injection in the index knee within the last 3 months.\n\nClinically significant comorbidities that could interfere with participation or assessment (e.g., severe uncontrolled cardiovascular disease, severe pulmonary disease, significant neurological deficits affecting the lower limb).\n\nPresence of skin conditions (e.g., infection, open wounds, eczema, photosensitivity disorders) in the area designated for laser treatment.\n\nCurrent use of anticoagulant medication (e.g., warfarin, DOACs) due to potential risk, unless stable and cleared by physician. (Consider if this is truly necessary based on HILT mechanism).\n\nHistory of cancer in the treatment area or active malignancy elsewhere. Known photosensitivity or use of photosensitizing medications. Pregnancy, planning pregnancy, or breastfeeding. Participation in another interventional clinical trial within the last 30 days. Inability to understand or communicate in the study language.",{"count":71,"type":21},[74],"This study aims to find the best settings (dose) for High-Intensity Laser Therapy (HILT) to reduce pain and improve function in people with moderate knee osteoarthritis. Participants will be randomly assigned to receive one of three different doses of HILT (low, medium, or high) or a sham (placebo) laser treatment, three times a week for four weeks. The main outcomes measured will be changes in knee pain (using a pain scale) and knee function (using a questionnaire) from the beginning to the end of the 4-week treatment period.",[138],"Knee Osteoarthritis",{"date":101,"type":31},{"date":141,"type":21},"2025-04-23",{"date":143,"type":21},"2027-06-01",{"name":37,"class":38},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":152,"targetDuration":4,"studyType":72,"phases":154,"briefSummary":155,"conditions":156,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":162,"leadSponsor":164,"locationsCount":39},"100586326","mechanical-modalities-vs-standard-care-for-edema-and-pain-management-after-drf-fixation-100586326","NCT06913920","Mechanical Modalities vs. Standard Care for Edema and Pain Management After DRF Fixation","A Two-Arm, Single-Blinded Randomized Controlled Trial Evaluating the Effectiveness of Mechanical Modalities Combined With Standard Therapy Versus Standard Therapy Alone for Edema and Pain Management After Distal Radius Fracture Fixation","Inclusion Criteria:\n\nAdults aged 18 years or older. Undergoing surgical treatment for distal radius fracture with stable internal fixation.\n\nAble to initiate formal rehabilitation approximately 2 weeks postoperatively. Willing and able to attend in-clinic therapy sessions at the outpatient hand therapy center.\n\nExclusion Criteria:\n\nUnstable fixation or need for further surgical intervention. Pre-existing conditions that would significantly affect upper limb function (e.g., severe arthritis, neurological disorders).\n\nHistory of skin conditions or allergies that contraindicate the use of mechanical devices.\n\nAny contraindication to mechanical modalities (for example, severe peripheral vascular disease).\n\nInability to comply with study procedures or follow-up visits. Pregnant or breastfeeding individuals.",{"count":153,"type":21},50,[74],"This single-blinded, randomized controlled trial (RCT) will evaluate the added benefit of mechanical modalities (continuous passive motion (CPM) and intermittent pneumatic compression (IPC)) when integrated into standard therapy for managing postoperative edema and pain in patients undergoing distal radius fracture (DRF) fixation. The primary outcomes are edema volume (measured via volumeter) and pain intensity (Numeric Pain Rating Scale, NPRS) at 6 weeks post-operation. Secondary outcomes include wrist\u002Fforearm range of motion (ROM), grip strength, Patient-Rated Wrist Evaluation (PRWE), and adverse events.",[157],"Distal Radius Fractures","2025-03-31",{"date":160,"type":31},"2025-04-06",{"date":82,"type":21},{"date":163,"type":21},"2026-01-15",{"name":37,"class":38},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":172,"targetDuration":4,"studyType":72,"phases":173,"briefSummary":174,"conditions":175,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":176,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":39},"100586327","static-vs-dynamic-progressive-splinting-for-persistent-wrist-stiffness-after-drf-100586327","NCT06913933","Static vs. Dynamic Progressive Splinting for Persistent Wrist Stiffness After DRF","A Two-Arm, Parallel-Group Randomized Controlled Trial Comparing Static Progressive Splinting Versus Dynamic Splinting for Improving Wrist PROM\u002FAROM in Patients With Persistent Post-DRF Stiffness","Inclusion Criteria:\n\nAdults aged 18 years or older. At least 8 weeks post distal radius fracture (operative or nonoperative) who have completed standard rehabilitation.\n\nDemonstrated persistent wrist stiffness with ≤50% of contralateral wrist extension or flexion.\n\nCapable of providing written informed consent and complying with study procedures\n\nExclusion Criteria:\n\nPresence of complex regional pain syndrome (CRPS) or active fracture healing issues.\n\nHistory of significant wrist pathology unrelated to the DRF. Uncontrolled medical conditions that would interfere with splint application or therapy.\n\nKnown skin conditions or allergies that preclude orthosis use. Inability or unwillingness to adhere to the intervention protocol or follow-up schedule.\n\nPregnant or breastfeeding individuals.",{"count":153,"type":21},[74],"This randomized controlled trial will compare the effectiveness of static progressive splinting versus dynamic splinting for treating persistent wrist stiffness in adults ≥18 years old at least 8 weeks post distal radius fracture (DRF) injury. Both splinting modalities are provided as an adjunct to one weekly supervised therapy session over a 6-week period. The primary outcomes are wrist active and passive range of motion (AROM\u002FPROM) measured using goniometry, with secondary outcomes including patient-reported wrist function (PRWE), overall satisfaction, and adverse events.",[157],{"date":160,"type":31},{"date":178,"type":21},"2025-04-17",{"date":180,"type":21},"2026-04-17",{"name":37,"class":38},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":189,"targetDuration":4,"studyType":72,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":39},"100586324","supervised-vs-home-based-vs-no-therapy-for-uncomplicated-distal-radius-fracture-in-younger-adults-100586324","NCT06913894","Supervised vs. Home-Based vs. No Therapy for Uncomplicated Distal Radius Fracture in Younger Adults","Supervised Therapy Versus a Standardized Home-Based Program Versus No Formal Therapy for Uncomplicated, Nonoperatively Treated Distal Radius Fracture in Adults Under 50: A Three-Arm, Parallel-Group Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 18-50 years. Diagnosed with an extra-articular, stable distal radius fracture treated nonoperatively with a short-arm cast for approximately 4-6 weeks.\n\nThe fracture is uncomplicated (no significant soft-tissue injury, no evidence of CRPS, and no other major complications).\n\nWilling to provide written informed consent and comply with follow-up assessments.\n\nExclusion Criteria:\n\nIntra-articular or unstable fracture patterns. Surgical intervention planned or performed for the distal radius fracture. Presence of significant comorbidities (e.g., chronic inflammatory arthritis or severe neurological impairment affecting the injured limb).\n\nFracture complications such as CRPS or major soft-tissue injury. Inability to comply with study procedures or follow-up assessments. Pregnant or breastfeeding individuals.",{"count":190,"type":21},96,[74],"This three-arm, parallel-group RCT will compare the effectiveness of three rehabilitation strategies following conservative treatment of an uncomplicated distal radius fracture in adults under 50 years old. The study will compare:\n\nSupervised Therapy: Outpatient physical therapy sessions plus a daily home exercise program Home-Based Program: A structured, detailed home exercise program with weekly telephone follow-up No Therapy (minimal intervention): Standard minimal instruction via an educational brochure The primary outcome is the Patient-Rated Wrist Evaluation (PRWE) measured at 6 weeks and 6 months.",[157],{"date":160,"type":31},{"date":196,"type":21},"2025-04-21",{"date":198,"type":21},"2026-04-21",{"name":37,"class":38},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":207,"targetDuration":4,"studyType":72,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":214,"startDateStruct":215,"completionDateStruct":216,"leadSponsor":218,"locationsCount":39},"100586322","consensus-based-vs-standardized-physiotherapy-for-fibromyalgia-100586322","NCT06913868","Consensus-Based vs. Standardized Physiotherapy for Fibromyalgia","Efficacy of a Consensus-Based Physiotherapy Approach Compared to Standardized Usual Care for the Management of Fibromyalgia: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\nAge: Adults (≥ 18 years of age).\n\nDiagnosis: Diagnosis of fibromyalgia according to the 2016 Revisions to the 2010\u002F2011 Fibromyalgia Diagnostic Criteria (This is the most current and recommended criteria). This requires:\n\nWidespread Pain Index (WPI) ≥ 7 and Symptom Severity Scale (SSS) score ≥ 5 OR WPI 3-6 and SSS score ≥ 9.\n\nGeneralized pain, defined as pain in at least 4 of 5 regions (left upper, right upper, left lower, right lower, axial).\n\nSymptoms have been present at a similar level for at least 3 months. A diagnosis of fibromyalgia is valid irrespective of other diagnoses. A diagnosis of fibromyalgia does not exclude the presence of other clinically important illnesses.\n\nPain Intensity: Average pain intensity of ≥ 4\u002F10 on the Numeric Pain Rating Scale (NPRS) over the past week. (This ensures participants have clinically significant pain).\n\nNociplastic Pain Features:\n\nCSI score ≥ 40. TSK score ≥ 37. Informed Consent: Willingness and ability to provide written informed consent.\n\nExclusion Criteria:\n\nRed Flags: Presence of \"red flags\" indicating serious underlying pathology that could mimic fibromyalgia or contraindicate exercise, such as:\n\nUnexplained weight loss. Fever or night sweats. Recent significant trauma. Neurological signs suggestive of spinal cord compression (e.g., bowel or bladder dysfunction, saddle anesthesia).\n\nSuspected malignancy. Acute inflammatory disease. Neurological Disorders: Significant neurological deficits (e.g., multiple sclerosis, Parkinson's disease) that would interfere with participation in the study or confound outcome assessment.\n\nPsychiatric Disorders: Uncontrolled or severe psychiatric disorders (e.g., active psychosis, severe major depression with suicidal ideation) that would preclude informed consent or adherence to the study protocol. Note: Mild to moderate, stable depression or anxiety, common in fibromyalgia, should not be an exclusion criterion.\n\nOverlapping Pain Conditions: Presence of other significant, active pain conditions that could confound the assessment of fibromyalgia-related pain and function, such as:\n\nActive inflammatory arthritis (e.g., rheumatoid arthritis, lupus) requiring ongoing systemic treatment.\n\nSevere osteoarthritis requiring imminent joint replacement. Active, untreated neuropathic pain conditions (e.g., diabetic neuropathy, post-herpetic neuralgia). Note: Stable, well-managed comorbidities should not be exclusionary.\n\nCurrent Pain Management: Current participation in other pain management programs or interventions that specifically overlap with the study interventions (e.g., another structured physiotherapy program, cognitive behavioral therapy specifically for pain). Note: Patients on stable doses of pain medication should not be excluded.\n\nExercise Contraindications: Inability to participate in exercise therapy due to medical conditions (e.g., severe cardiovascular disease, uncontrolled hypertension).\n\nPregnancy: Current pregnancy or planning to become pregnant during the study period. (Pregnancy can affect pain perception and exercise tolerance).\n\nMedication Changes: Recent changes (within the past 4 weeks) in pain-related medications (e.g., opioids, antidepressants, anticonvulsants) or planned changes during the study period. Note: Stable medication regimens are acceptable.\n\nLitigation: Current involvement in litigation related to their fibromyalgia or chronic pain.",{"count":208,"type":21},200,[74],"This study compares a new, consensus-based physiotherapy program to standard physiotherapy for people with fibromyalgia. The new program uses recommendations from experts, including education about pain, personalized exercise, and strategies to improve coping skills. We will measure how much pain people have, how well they can function, and their beliefs about pain. The goal is to see if the new program is better than standard care at reducing pain and improving function in individuals with fibromyalgia.",[212,213],"Chronic Pain","Fibromyalgia",{"date":160,"type":31},{"date":196,"type":21},{"date":217,"type":21},"2028-04-21",{"name":37,"class":38},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":226,"targetDuration":4,"studyType":72,"phases":228,"briefSummary":229,"conditions":230,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":237,"locationsCount":39},"100586274","long-term-multidisciplinary-physiotherapy-for-breast-cancer-survivors-a-randomized-controlled-trial-100586274","NCT06913244","Long-Term Multidisciplinary Physiotherapy for Breast Cancer Survivors: A Randomized Controlled Trial","Long-Term Multidisciplinary Physiotherapy for Breast Cancer Survivors: Evaluation of the 12-Month Effectiveness on Pain, Upper Limb Function, and Cancer-Related Fatigue in a Multi-Center, Parallel-Group Randomized Controlled Trial","Inclusion Criteria:\n\nWomen aged between 18 and 65 years. History of breast cancer surgery (with or without axillary lymph node dissection).\n\nCompleted acute cancer treatment (surgery, chemotherapy, and\u002For radiation) at least 6 months prior to enrollment.\n\nCurrently in the survivorship phase, with no active evidence of disease.\n\nExperiencing persistent sequelae related to treatment, such as:\n\nModerate to severe pain (e.g., VAS score ≥ 30 on a 0-100 scale), and\u002For Upper limb dysfunction, and\u002For Cancer-related fatigue (as measured by FACIT-Fatigue). Able to understand and provide written informed consent.\n\nExclusion Criteria:\n\nDiagnosis of recurrent or metastatic breast cancer. Currently receiving active cancer treatment (chemotherapy, radiation for active disease, or immunotherapy).\n\nParticipation in another interventional trial targeting pain or rehabilitation within the past 3 months.\n\nPresence of severe comorbidities (e.g., uncontrolled cardiovascular disease, severe orthopedic or neurological conditions) that would preclude safe participation in physiotherapy.\n\nAny physical or psychological condition that, in the opinion of the investigator, would interfere with participation or adherence to the study protocol (e.g., severe cognitive impairment).\n\nPregnancy or breastfeeding.",{"count":227,"type":21},146,[74],"This multi-center randomized controlled trial (RCT) evaluates the long-term (12-month) effectiveness of a standardized multidisciplinary physiotherapy program versus standard care on persistent pain, upper limb (UL) dysfunction, and cancer-related fatigue (CRF) in breast cancer survivors. The study also examines improvements in quality of life and psychological well-being. The standardized intervention combines specific exercise therapy, manual therapy, education, and mind-body interventions and is designed to produce sustained benefits beyond the acute rehabilitation phase.",[77,231],"Breast Cancer Female","2025-03-30",{"date":160,"type":31},{"date":141,"type":21},{"date":236,"type":21},"2027-01-01",{"name":37,"class":38},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":245,"targetDuration":4,"studyType":72,"phases":247,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":251,"startDateStruct":252,"completionDateStruct":253,"leadSponsor":254,"locationsCount":39},"100586275","cost-effectiveness-of-eswt-plus-rehabilitation-vs-rehabilitation-alone-in-post-burn-scars-100586275","NCT06913257","Cost-Effectiveness of ESWT Plus Rehabilitation vs Rehabilitation Alone in Post-Burn Scars","Cost-Effectiveness Analysis of Extracorporeal Shock Wave Therapy (ESWT) Combined With Standard Rehabilitation Versus Standard Rehabilitation Alone in Managing Post-Burn Scars: A Randomized Controlled Trial With Integrated Economic Evaluation","Inclusion Criteria:\n\nAdults aged 18-65 years. Documented hypertrophic scars following a burn injury, with scars present and stable for at least 6 months.\n\nModerate to severe scar severity as measured by a standardized clinical assessment.\n\nExperiencing significant pain and\u002For pruritus related to the scar, with a baseline VAS score of ≥4.\n\nAble to provide informed consent and comply with study procedures. Employed or engaged in daily activities such that indirect costs (absenteeism\u002Freduced productivity) can be recorded.\n\nExclusion Criteria:\n\nPregnant or lactating women. Individuals with previous surgical scar revision or other invasive scar treatments within the last 6 months.\n\nPatients with comorbid conditions (e.g., severe cardiovascular disease, uncontrolled diabetes) that could interfere with rehabilitation or ESWT.\n\nActive skin infection in the area of the scar. Use of concurrent investigational therapies for scar management.",{"count":246,"type":21},104,[74],"This randomized controlled trial (RCT) will evaluate the cost-effectiveness of combining extracorporeal shock wave therapy (ESWT) with standard rehabilitation versus standard rehabilitation alone for the management of hypertrophic post-burn scars in adults. The study will assess clinical outcomes-such as pain intensity, pruritus, and scar quality-alongside economic outcomes including cost per quality-adjusted life year (QALY) gained, direct medical costs, and indirect costs (e.g., absenteeism and reduced productivity). Results will inform health policy and resource allocation decisions for advanced burn rehabilitation interventions.",[250],"Hypertrophic Scar",{"date":160,"type":31},{"date":103,"type":21},{"date":143,"type":21},{"name":37,"class":38},{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":69,"enrollmentInfo":263,"targetDuration":4,"studyType":72,"phases":265,"briefSummary":266,"conditions":267,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":272,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":39},"100586276","virtual-reality-adjunct-for-procedural-pain-and-anxiety-management-in-burn-wound-care-100586276","NCT06913270","Virtual Reality Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care","Efficacy of Virtual Reality as an Adjunct for Procedural Pain and Anxiety Management in Burn Wound Care: A Single-Center, Randomized Controlled Trial","VR-Burn","Inclusion Criteria:\n\nAdult burn patients (18-65 years) with confirmed partial-thickness burns. Scheduled for routine dressing changes. Able to provide informed consent. Baseline pain score of ≥4\u002F10 during a dressing change session.\n\nExclusion Criteria:\n\nPatients with cognitive impairment preventing comprehension of the intervention.\n\nHistory of severe motion sickness or visual impairments that preclude the use of VR devices.\n\nPatients with contraindications to standard analgesic care.",{"count":264,"type":21},100,[74],"This randomized controlled trial is designed to evaluate the efficacy of immersive virtual reality (VR) as an adjunct to standard analgesia during dressing changes in adult burn patients. The study compares an intervention group receiving standard care combined with an immersive VR distraction (using a head-mounted display displaying an engaging virtual environment) versus a control group receiving standard care plus non-VR distraction (watching a nature video on a tablet). The primary outcomes include procedural pain intensity measured by the Visual Analog Scale (VAS) and anxiety levels measured by the State-Trait Anxiety Inventory (STAI). Secondary outcomes include patient satisfaction and physiological parameters (heart rate and blood pressure) recorded during the procedure. This trial addresses the critical gap of heterogeneity and small sample sizes noted in previous VR studies for burn care pain management (Dascal et al., 2017).",[268,269,270,271],"Burns","Burn Wound","Procedural Pain","Anxiety Acute",{"date":160,"type":31},{"date":274,"type":21},"2025-04-12",{"date":276,"type":21},"2026-05-25",{"name":37,"class":38},""]