[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Al-Azhar University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":653},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,92,0,25,[9,45,74,103,132,152,176,197,224,252,279,300,323,352,383,410,432,453,479,503,534,554,576,604,628],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100645064","effect-of-co-enzyme-q10-and-vitamin-c-alone-or-in-combination-after-a-surgical-gingival-depigmentation-100645064",false,"NCT07677826","Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation","Ffect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation a Randomized Clinical Study","Effect of Coe","Inclusion Criteria:\n\n* Systemically healthy patient of both genders aged from 18-45 years.\n* Presence of bilateral physiologic gingival pigmentation in the anterior maxillary or mandibular region DOPI grades III-IV only.\n* Good oral hygiene.\n* Thick gingival phenotype.\n\nExclusion Criteria:\n\n* Patient clinically diagnosed with periodontitis.\n* Pregnant or lactating females.\n* Patient with previous treatment of gingival hyperpigmentation.\n* History of hypersensitivity to any study material.\n* Patients who are active or previous smokers.",true,"ALL","18 Years","45 Years",{"count":23,"type":24},20,"ESTIMATED","INTERVENTIONAL",[27],"NA","This study aims to assess the clinical effectiveness of Co-enzyme Q10 and Vitamin C, applied individually or in combination after surgical gingival depigmentation.",[30,31],"Depigmentation Treatment","Depigmentation","RECRUITING","2026-06-29",{"date":35,"type":36},"2026-07-01","ACTUAL",{"date":38,"type":36},"2026-03-02",{"date":40,"type":24},"2026-12-20",{"name":42,"class":43},"Al-Azhar University","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":12,"sex":19,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":25,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100644916","twin-block-and-lipus-for-tmj-outcomes-in-skeletal-class-ii-patients-100644916","NCT07676695","Twin-Block and LIPUS for TMJ Outcomes in Skeletal Class II Patients","Evaluation of the Efficacy of Early Treatment of Skeletal Class II Patients With Twin-block in Conjunction With Low Intensity Pulsed Ultrasound on Temporomandibular Joint Region: a Prospective Clinical Trial","AlAzharU","Inclusion Criteria:\n\n* Skeletal class II due to retrognathic mandible.\n* Angle's class II Molar relationship.\n* All patients involved in the study were in stages II and III based on the modified cervical vertebral maturation stages (CVMS) by Bacetti et al.5\n* Proclined upper incisors\n* Increased overjet \\> 5 mm.\n* Aligned lower arch or average inclination\n* Minimal crowding of lower arch.\n* No history of previous orthodontic treatment.\n\nExclusion Criteria:\n\n* Skeletal class II due to prognathic maxilla.\n* Patient with gross facial asymmetry.\n* Previous orthodontic or orthopedic treatment.\n* Clinical signs and symptoms of any Temporomandibular joint disorders.\n* Increased anterior facial vertical dimension.\n* Poor oral hygiene.","10 Months","14 Months",{"count":56,"type":24},24,[27],"Evaluation of the efficacy of early treatment of skeletal class II patients with twin-block in conjunction with low intensity pulsed ultrasound on temporomandibular joint region: a prospective clinical trial",[60],"CLASS II DIVISION 1 MALOCCLUSION",[62,63,64,65],"Class II div 1","Twin Block","CBCT","LIPUS","2026-06-27",{"date":68,"type":36},"2026-06-30",{"date":70,"type":36},"2026-06-18",{"date":72,"type":24},"2027-06-30",{"name":42,"class":43},{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":18,"sex":81,"minAge":20,"maxAge":21,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100645234","pupillary-light-reflex-to-predict-post-spinal-hypotension-in-elective-cesarean-delivery-100645234","NCT07678723","Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery","Pupillary Light Reflex for Predicting Hypotension Risk After Spinal Anesthesia for Elective Cesarean Section: A Prospective Observational Cohort Study","Inclusion Criteria:\n\nASA II Term pregnancy ≥37 weeks Singleton pregnancy Elective cesarean section Age 18-45 years Written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders Diabetes mellitus Cardiovascular disease Neurological or autonomic disorders Ophthalmic disease Medications affecting autonomic function BMI \\>40 kg\u002Fm² Failed spinal anesthesia","FEMALE",{"count":83,"type":24},200,"OBSERVATIONAL","This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.",[87,88,89],"Hypotension","Spinal Anesthesia","Cesarean Delivery",[91,92,88,87,93,94],"Pupillary Light Reflex","Pupillometry","Cesarean Section","Obstetric Anesthesia","NOT_YET_RECRUITING","2026-06-25",{"date":35,"type":36},{"date":99,"type":24},"2026-06-28",{"date":101,"type":24},"2026-10-31",{"name":42,"class":43},{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":12,"sex":19,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":25,"phases":115,"briefSummary":116,"conditions":117,"keywords":121,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":44},"100644677","omega-3-plus-low-dose-aspirin-in-smokers-with-stage-iii-periodontitis-100644677","NCT07673185","Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis","Clinical and Biochemical Evaluation of the Effect of Omega-3 Fatty Acids Plus Low-Dose Aspirin as an Adjunct to Non-Surgical Periodontal Therapy in Smoker Patients With Stage III Periodontitis: A Randomized Double-Blind Placebo-Controlled Clinical Trial","OASP","Inclusion Criteria:\n\n* \\- Male or female smokers aged 30 to 50 years.\n* Diagnosed with Stage III periodontitis according to the 2017 World Workshop classification.\n* Probing pocket depth (PPD) ≥ 5 mm.\n* Clinical attachment loss (CAL) ≥ 5 mm.\n* Presence of at least 20 natural teeth.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* \\- Systemic diseases affecting periodontal health.\n* Pregnancy or lactation.\n* Periodontal treatment within the previous 6 months.\n* Use of antibiotics or anti-inflammatory drugs within the previous 6 months.\n* Allergy or hypersensitivity to omega-3 fatty acids or aspirin.\n* Long-term anticoagulant therapy.\n* History of gastric ulcer or bleeding disorders.\n* Participation in another clinical trial within the previous 3 month","30 Years","50 Years",{"count":114,"type":24},40,[27],"This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker patients with Stage III periodontitis. The study compares test and control groups regarding periodontal clinical parameters and gingival crevicular fluid interleukin-1 beta (IL-1β) levels Or other inflammatory markers that will be determined later at baseline, 3 months, and 6 months following treatment",[118,119,120],"Periodontal Disease","Periodontitis (Stage 3)","Smoking Behaviors",[122,123,124],"omega 3","smoker","stage 3","2026-06-23",{"date":33,"type":36},{"date":128,"type":36},"2025-01-15",{"date":130,"type":24},"2026-10-30",{"name":42,"class":43},{"id":133,"slug":134,"hasResults":12,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":25,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":148,"completionDateStruct":149,"leadSponsor":151,"locationsCount":4},"100644446","ncmt-technique-and-jodhpur-technique-and-excimer-laser-in-treatment-of-non-vitiligo-leucoderma-100644446","NCT07662915","NCMT Technique and Jodhpur Technique and Excimer Laser in Treatment of Non Vitiligo Leucoderma","Efficacy and Safety of Melanocyte Keratinocyte Transplantation Procedure Plus 308-nm Excimer Laser in the Treatment of Non-Vitiligo Leukoderma","Inclusion Criteria:\n\n* Age 18 to 60 years.\n* Clinically diagnosed stable non-vitiligo leukoderma.\n* Stable lesion(s) for at least 6 months with no progression.\n* Inadequate response to conventional medical therapy.\n* Presence of two comparable lesions\n* Willingness to participate and provide written informed consent.\n\nExclusion Criteria:\n\n* Vitiligo or suspected active vitiligo.\n* History of keloid or hypertrophic scar formation.\n* Active infection at donor or recipient sites.\n* Bleeding disorders or anticoagulant therapy that cannot be safely discontinued.\n* Pregnancy or lactation.\n* Immunosuppression or uncontrolled systemic disease.\n* Inability to comply with follow-up visits.\n* Unrealistic expectations regarding treatment outcome.","60 Years",{"count":141,"type":24},22,[27],"This study aims to compare the efficacy and safety of Melanocyte Keratinocyte Transplantation Procedure (MKTP) combined with 308-nm excimer laser versus Jodhpur technique combined with 308-nm excimer laser in the treatment of stable non-vitiligo leukoderma. Twenty-two patients with stable depigmented lesions will be enrolled. In each patient, two comparable lesions will be treated using different techniques. Clinical outcomes including percentage of repigmentation, color match, time to onset of repigmentation, complications, and histological changes will be assessed during follow-up to determine the optimal surgical treatment approach for non-vitiligo leukoderma.",[145],"Leukoderma","2026-06-17",{"date":125,"type":36},{"date":35,"type":24},{"date":150,"type":24},"2027-09-01",{"name":42,"class":43},{"id":153,"slug":154,"hasResults":12,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":18,"sex":19,"minAge":159,"maxAge":20,"enrollmentInfo":160,"targetDuration":4,"studyType":25,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100632493","bilogical-assesment-during-intrusion-of-lower-incisors-100632493","NCT07514403","Bilogical Assesment During Intrusion of Lower Incisors","Assessment of the Biological Response of the Corticision During Intrusion of Lower Incisors A Prospective Clinical Study","Inclusion Criteria:\n\n* Patients requiring extraction-based orthodontic treatment\n* Presence of deep overbite requiring lower incisor intrusion\n* Age range: 18-30 years\n* Good general health\n* Good oral hygiene\n\nExclusion Criteria:\n\n* Systemic diseases affecting bone metabolism\n* Previous orthodontic treatment\n* Periodontal disease\n* Smoking\n* Pregnancy or lactation","14 Years",{"count":161,"type":24},16,[27],"biological assesment during intrusion of lower incisors",[165],"Orthodontic Treatment Efficiency",[167],"Orthodontics Malocclusion Corticision","2026-06-13",{"date":170,"type":36},"2026-06-16",{"date":172,"type":24},"2026-08-01",{"date":174,"type":24},"2027-08",{"name":42,"class":43},{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":18,"sex":19,"minAge":183,"maxAge":112,"enrollmentInfo":184,"targetDuration":4,"studyType":25,"phases":185,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":44},"100567227","erythropoietin-gel-effect-on-dental-implant-stability-100567227","NCT06665451","Erythropoietin Gel Effect on Dental Implant Stability","Evaluation of Erythropoietin Gel Effect on Stability of Immediate Implant ( Clinical and Radiographical Study )","Inclusion Criteria:\n\n* All patients Should have nonrestorable teeth in the anterior maxilla indicated for extraction and seeking implant placement.\n* Good general periodontal health and maintenance.\n\nExclusion Criteria:\n\n* Heavy smokers who smoke more than ten cigarettes per day\n* Acute infected socket\n* Ant socket with wall defect.\n* Pregnency\n* Local or systemic conditions that will interfere with bone healing (uncontrolled diabetes mellitus or human immune deficiency virus infections, resonance therapy), bone disorders (hyperparathyroidism, osteoporosis, or Paget's disease.\n* Patients who had subjected to intravenous and\u002For oral bisphosphonate therapy.","20 Years",{"count":56,"type":24},[27],"* Achieving and maintaining long-term osseointegration for dental implants is a key objective in the field of dentistry. The success of osseointegration is influenced by the surface treatment applied to dental implants. Numerous coating techniques have been developed to improve and speed up osseointegration.\n* The aim of the current study is to assess immediate dental implant stability coated with erythropoietin gel, both clinically and radiographically.\n* Materials and Methods: We conducted a randomized controlled clinical trial.The sample will include patients demanding immediate implant treatment in the anterior maxilla . Patients will be randomly allocated into the two groups of the study. The group A will be treated with erythropoietin gel coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla . Group B will be treated with non coated dental implant immediately after extraction of non restorable teeth in the anterior maxilla .\n* The primary outcome variable will be implant stability and the secondary outcome will be crestal marginal bone level and bone density around implants. It will be measured at time of implant placement and reevaluated after 6-months .",[188],"Osseointegration","2026-05-15",{"date":191,"type":36},"2026-05-18",{"date":193,"type":36},"2025-03-15",{"date":195,"type":24},"2026-07",{"name":42,"class":43},{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":203,"eligibilityCriteria":204,"healthyVolunteers":12,"sex":19,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":208,"conditions":209,"keywords":212,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":223},"100575083","the-relation-between-oral-hygiene-and-microbial-load-in-the-oral-cavity-after-restoring-primary-molars-with-two-types-of-ready-made-crowns-100575083","NCT06767670","The Relation Between Oral Hygiene and Microbial Load in the Oral Cavity After Restoring Primary Molars With Two Types of Ready-made Crowns","Evaluation of Oral Hygiene Status in Correlation With Microbial Load in the Oral Cavity Following Restorations of Primary Molars Using Stainless Steel and Bioflex Crowns (Clinical Randomized Trial)","bioflex crown","Inclusion Criteria:\n\n* Participants aged between 4 and 8 years.\n* Pulp therapy treated primary molars on the contralateral side, requiring a full coverage restoration (split-mouth technique).\n* No history of any antibiotic consumption 2 weeks before the procedure.\n* No history of fluoride application 2 weeks before the procedure.\n\nExclusion Criteria:\n\n* Special children with physical disabilities or emotional disturbances.\n* Children are diagnosed with systemic diseases.\n* Grossly destructed teeth with non-restorable crown structure.\n* Primary teeth with shedding or pathological tooth mobility.","4 Years","8 Years",{"count":114,"type":24},"Following the restoration of primary molars with stainless steel and bioflex crowns, an evaluation of the current state of oral hygiene in relation to the amount of microorganisms and gingival health in the oral cavity will be carried out.",[210,211],"Carious Lesion","Ready-made Crowns",[213,214],"primary crowns,","oral health","2026-05-11",{"date":217,"type":36},"2026-05-12",{"date":219,"type":24},"2026-10-05",{"date":221,"type":24},"2027-10-01",{"name":42,"class":43},2,{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":232,"minAge":183,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":25,"phases":236,"briefSummary":237,"conditions":238,"keywords":241,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":44},"100636911","modulation-of-periapical-inflammation-following-nano-sized-intracanal-medication-a-randomized-controlled-clinical-trial-100636911","NCT07571837","Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial","Modulation of Periapical Inflammation Following Nano-Calcium Hydroxide and Nano-Chitosan Intracanal Medications in Endodontic Retreatment Cases: A Randomized Controlled Clinical Trial","Nano-Chitosan","Inclusion Criteria:\n\nPatients have single rooted teeth with root canal form type I. Have previous endodontic therapy with failure. Have periapical radiolucency (PAI score of 3 or 4). Asymptomatic patients who had no pain or swelling, had a negative response to palpation and percussion.\n\nExclusion Criteria:\n\nPatients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation. Systemic disease. Physical or mental disability. Non-restorable teeth. Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly","MALE","40 Years",{"count":235,"type":24},63,[27],"The main cause of endodontic disorders is microbial infection. From the infected pulp tissue, microorganisms can penetrate into the deeper layers of root dentine and propagate a periapical tissue through the apical foramen and lateral canals causing apical periodontitis. Apical periodontitis is an inflammatory condition affecting the periapical area of teeth with a global prevalence of 52% among individuals and 5% at tooth level. At the periapical region, microbes and their products encounter the host immune defense. Innate immune cells combat bacteria through phagocytosis and release anti-microbial substances, while adaptive immune cells initiate both cell-mediated and humoral immune responses. This immune activation also stimulates osteoclasts, leading to bone resorption and creating space for the inflammatory cells' infiltration . During periapical inflammation, immune cells migrate to the periapical area, where they release pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), along with anti-inflammatory cytokines like interleukin-10 (IL-10). These cytokines play crucial roles in modulating inflammation and tissue repair.\n\nMicroRNAs (miRNAs) are evolutionarily conserved small (18-22 nucleotides) single-stranded, noncoding RNAs. It has been well acknowledged that miRNAs influence gene expression at the posttranscriptional level by targeting mRNA 3'-untranslated regions (3'-UTRs). Accumulating evidence has suggested that miRNA expression is related to the clinical and biological features of diverse diseases, and they can be potential biomarkers for diagnosis, treatment, and prognosis. miRNAs have revealed their critical roles in regulating various cellular functions, including proliferation, apoptosis, differentiation, metabolism, and tumorigenesis, by targeting specific mRNAs.\n\nMiR-146a regulates innate immunity, inflammatory responses, and the antiviral pathway. Changes in miR-146a expression have been noted in many human diseases, including autoimmune disorders and cancers. In addition, miR-146a is an important biomarker of disease diagnosis, prevention, and treatment. It is a negative regulator of inflammatory responses by suppressing target gene expression. However, limited data is available regarding the functional role of miR-146a in modulating the inflammatory response of periapical tissues following root canal disinfection in endodontic retreatment cases.\n\nEliminating microorganisms is the primary objective of root canal therapy in order to create an environment as free of bacteria as possible. However, not all root canal treatments are completely successful, and in some cases, the infection persists leading to development of secondary apical periodontitis in previously treated teeth.\n\nDisinfecting the root canal during retreatment is significantly more challenging due to the presence of persistent microorganisms that have settled in the root canal system. These microbes are often resistant to standard irrigations and antimicrobial agents leading to the formation of periradicular lesions. Such bacteria can survive for extended periods around the previously filled root canals. Sodium hypochlorite (NaOCl) is the most widely used irrigant in root canal therapy due to its strong antibacterial effect and its ability to dissolve organic substances. Effective canal cleaning is difficult to achieve without the use of NaOCl at a sufficiently high concentration. However, NaOCl has several drawbacks, including its cytotoxicity which can lead to tissue damage and patient symptoms. Additionally, its strong oxidizing nature negatively affects the mechanical properties of dentin such as microhardness and elastic modulus. NaOCl should be used with caution in endodontic procedures to prevent hypochlorite accidents.\n\nCalcium hydroxide (Ca (OH)2) is the most widely utilized intracanal medication. It has the potential to dissolve tissue, acts as a physical barrier and generates hydroxyl ions, creating an extremely alkaline environment. It has been shown to be quite effective in the treatment of teeth with persistent periapical lesions. To provide optimal endodontic treatment, the root canal system should be thoroughly cleaned of soft-tissue debris, smear layer, and bacteria. Nanoparticles (NPs) have unique characteristics such as smaller sizes, increased surface area to volume ratio, and higher chemical reactivity and charge density leading to greater interaction with the environment and negatively charged bacterial cells, compared to their bulk counterparts. These advantages can be used to design highly anti-microbial agents with maximal therapeutic efficacy and minimal side effects.",[239,240],"Post-operative Pain","Periapical Inflammation",[240,242,230,243],"Nano-Calcium Hydroxide","Endodontic Retreatment","2026-05-03",{"date":246,"type":36},"2026-05-06",{"date":248,"type":36},"2026-02-01",{"date":250,"type":24},"2027-01-30",{"name":42,"class":43},{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":12,"sex":19,"minAge":260,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":25,"phases":264,"briefSummary":265,"conditions":266,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":44},"100636514","maxillary-incisor-intrusion-using-utility-arch-assisted-with-micro-osteoperforations-100636514","NCT07566676","Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations","Evaluation of Dentoalveolar Changes Following Maxillary Incisor Intrusion Using Utility Arch Assisted With Micro-osteoperforations in Deep Bite Cases: A Randomized Clinical Trial","MOPs","Inclusion Criteria:\n\n1. Patients age between 15-25 years.\n2. Patients with overbite ≥ 4 mm.\n3. All permanent teeth erupted (excluding 3rd molars).\n4. No previous orthodontic treatment.\n5. Patients with good oral hygiene and good periodontal health.\n\nExclusion Criteria:\n\n1. Skeletal discrepancies.\n2. Missing maxillary anterior teeth or any kind of tooth\u002Froot shape anomaly.\n3. Patients with root resorption or impacted canines.\n4. Previous history of orthodontic treatment.\n5. Systemic disease interferes with orthodontic tooth movement.\n6. History of trauma affecting the maxillary incisors.\n7. Poor oral hygiene or periodontally compromised patient.\n8. Endodontically treated upper anterior teeth.","15 Years","25 Years",{"count":263,"type":24},18,[27],"Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.",[267,268,269,270],"Deep Bite Malocclusion","Intrusion of Tooth","Orthodontic Tooth Movement","Root Resorption","2026-04-30",{"date":273,"type":36},"2026-05-05",{"date":275,"type":24},"2026-05",{"date":277,"type":24},"2029-06",{"name":42,"class":43},{"id":280,"slug":281,"hasResults":12,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":12,"sex":19,"minAge":159,"maxAge":183,"enrollmentInfo":286,"targetDuration":4,"studyType":25,"phases":288,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":293,"lastUpdatePostDateStruct":294,"startDateStruct":296,"completionDateStruct":297,"leadSponsor":299,"locationsCount":44},"100633021","nano-coated-orthodontic-miniscrews-for-en-mass-retraction-of-the-upper-arch-100633021","NCT07521267","Nano Coated Orthodontic Miniscrews for en Mass Retraction of the Upper Arch","Evaluation of Silver-Hydroxyapatite Nano-coated Versus Uncoated Orthodontic Miniscrews for en Masse Retraction of the Upper Anterior Segment: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Class I orthodontic cases with bimaxillary protrusion of the anterior segment of the upper jaw that need at least extraction for orthodontic treatment.\n* Age 14-20 years.\n* Good oral hygiene with healthy periodontium.\n* Need for an absolute skeletal anchorage.\n* Systemically healthy patients.\n\nExclusion Criteria:\n\n* Patient with craniofacial anomalies (e.g, cleft lip and palate)\n* Presence of systemic diseases or syndromes affecting bone metabolism (e.g, osteoporosis, rickets)\n* Poor oral hygiene or uncooperative patients.\n* Extensive dental caries or untreated periodontal disease.\n* History of trauma or surgery affecting the maxilla or mandible.",{"count":287,"type":24},14,[27],"study will be directed to evaluate silver-hydroxyapatite nano-coated versus uncoated orthodontic miniscrews for en masse retraction of the upper anterior segment.",[291,292,269],"Class I Malocclusion","Maxillary Prognathism","2026-04-08",{"date":295,"type":36},"2026-04-13",{"date":275,"type":24},{"date":298,"type":24},"2029-11",{"name":42,"class":43},{"id":301,"slug":302,"hasResults":12,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":19,"minAge":183,"maxAge":233,"enrollmentInfo":308,"targetDuration":4,"studyType":25,"phases":310,"briefSummary":311,"conditions":312,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":44},"100632441","vitamin-c-for-gingival-depigmentation-100632441","NCT07513727","Vitamin C for Gingival Depigmentation","Clinical and Histological Evaluation of Topical Vitamin C Application Using Three Modalities in Gingival Depigmentation","VitC-DePg","Inclusion Criteria:\n\n\\- 1- Both genders aged from 20-35 years. 2- Patients clinically diagnosed with physiologic gingival melanin pigmentation in the maxillary and mandibular keratinized gingiva.\n\n3- Patients complaining of compromised esthetics. 4- Patients should be systemically free any disease as verified by a medical history diagnostic sheet or via health questionnaire\n\nExclusion Criteria:\n\n\\- 1- Patient clinically diagnosed with periodontitis and \u002F or manifest poor oral hygiene with high plaque and gingival indices 2- Pregnant or lactating females. 3- Patients with clinical diagnosed lesion in the area of interest primarily the gingivae encompassing the maxillary \u002Fmandibular anterior teeth e.g. pigmented lesion of intestinal polyposis syndrome, McCune-Albright syndrome and fibro-osseous lesions as florid osseous dysplasia.\n\n4- Patient with previous treatment of gingival hyperpigmentation. 5- Patients with history of being allergic to the vitamin C. 6- Patients with any systemic disease ( e.g. Addison disease ) or drugs consumed that may cause clinical gingival hyperpigmentation 7- Patients who are active or previous smokers.",{"count":309,"type":24},30,[27],"The purpose of this study is to evaluate the clinical and histopathological efficacy of topical vitamin C applications using three modalities (topical gel, microneedling , and mesotherapy) in gingival depigmentation. Assessment includes clinical evaluation, CIELAB analysis via DOPI, and histopathological examination (Fontana-Masson staining).",[313,314],"Gingival Hyperpigmentation","Gingival Melanin Pigmentation","2026-03-31",{"date":317,"type":36},"2026-04-07",{"date":319,"type":36},"2025-07-29",{"date":321,"type":24},"2026-05-01",{"name":42,"class":43},{"id":324,"slug":325,"hasResults":12,"nctId":326,"briefTitle":327,"officialTitle":328,"acronym":4,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":19,"minAge":205,"maxAge":206,"enrollmentInfo":330,"targetDuration":4,"studyType":25,"phases":331,"briefSummary":332,"conditions":333,"keywords":336,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":4},"100631723","clinical-performance-of-four-restorative-materials-in-primary-molars-100631723","NCT07504393","Clinical Performance of Four Restorative Materials in Primary Molars","Clinical Evaluation of an Alkasite Restoration Material (Cention N) and Self-cure Composite (Stela; SDI) Compared to Conventional Composite and Resin-modified Glass Ionomer in Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n1. Age 4-8 years old.\n2. Primary molars indicated for restorative treatment.\n3. No pulp involvement or history of dental pain.\n4. Cooperative children (Frankl: +ve or ++ve).\n\nExclusion Criteria:\n\n1. Pulp exposure after caries removal or clinical signs of irreversible pulpitis\u002Fnecrosis.\n2. Severe developmental enamel defects or insufficient enamel for bonding.",{"count":5,"type":24},[27],"This randomized clinical trial aims to compare the clinical and radiographic performance of four direct restorative materials used for restoring carious primary molars in children. Eligible children aged 4-8 years with posterior primary molars requiring direct restoration will be randomly allocated (1:1:1:1) to receive one of the following materials: an alkasite restorative material (Cention N), a self-cure bulk-fill resin composite (Stela; SDI), a conventional light-cured nanohybrid resin composite (Beautifil II), or a resin-modified glass ionomer cement (Riva Light Cure). Restorations will be evaluated using the Fédération Dentaire Internationale (FDI) World Dental Federation criteria. Postoperative sensitivity will be assessed at 48 hours using a 0-10 visual analogue scale (VAS). Clinical and radiographic follow-up assessments will be conducted at baseline and at scheduled recall visits",[334,335],"Dental Caries","Primary Molars",[337,338,339,340,341,342,343,344],"stela","Primary molars","Pediatric dentistry","Direct restoration","Cention N","Nanohybrid composite","Resin-modified glass ionomer","FDI criteria","2026-03-27",{"date":315,"type":36},{"date":348,"type":24},"2026-04-01",{"date":350,"type":24},"2026-11",{"name":42,"class":43},{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":19,"minAge":360,"maxAge":361,"enrollmentInfo":362,"targetDuration":4,"studyType":25,"phases":363,"briefSummary":364,"conditions":365,"keywords":369,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":376,"lastUpdatePostDateStruct":377,"startDateStruct":379,"completionDateStruct":380,"leadSponsor":382,"locationsCount":44},"100631401","quad-helix-vs-rme-for-posterior-cross-bite-in-egyptian-children-100631401","NCT07500194","Quad Helix vs RME for Posterior Cross-bite in Egyptian Children","Quad Helix Versus Rapid Maxillary Expanders in the Treatment of Posterior Cross-bite During Mixed Dentition in a Sample of Egyptian Children: A Randomized Clinical Study.","Expansion","Inclusion Criteria:\n\n1. Children aged 9-12 years in the mixed dentition stage\n2. Presence of posterior cross-bite due to transverse maxillary deficiency\n3. No previous history of orthodontic treatment\n4. Good oral hygiene and cooperative behavior\n5. No significant antero-posterior or vertical skeletal discrepancies\n\nExclusion Criteria:\n\n1. Patient with craniofacial anomalies\n2. Presence of systemic diseases or syndromes affecting bone metabolism\n3. Extensive dental caries or untreated periodontal disease\n4. History of trauma or surgery affecting the maxilla or mandible","9 Years","12 Years",{"count":23,"type":24},[27],"This randomized clinical trial aims to evaluate and compare the effectiveness of the Quad Helix (QH) appliance versus Rapid Maxillary Expanders (RME) in treating posterior cross-bite in Egyptian children during the mixed dentition stage. The study will also assess patient comfort and pain levels associated with each appliance.",[366,367,368],"Posterior Crossbite","Maxillary Expansion","Transverse Maxillary Deficiency",[370,371,372,373,374,375],"Quad Helix","Rapid Maxillary Expansion","Posterior cross-bite","Mixed Dentition","Egyptian children","Randomized clinical trials","2026-03-24",{"date":378,"type":36},"2026-03-30",{"date":378,"type":24},{"date":381,"type":24},"2028-03-31",{"name":42,"class":43},{"id":384,"slug":385,"hasResults":12,"nctId":386,"briefTitle":387,"officialTitle":388,"acronym":4,"eligibilityCriteria":389,"healthyVolunteers":12,"sex":19,"minAge":205,"maxAge":206,"enrollmentInfo":390,"targetDuration":4,"studyType":25,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":408,"leadSponsor":409,"locationsCount":44},"100630495","clinical-and-radiographic-outcomes-of-lesion-sterilization-and-tissue-repair-using-zinc-oxide-6-gingerol-mix-versus-triple-antibiotic-paste-in-non-vital-primary-molars-100630495","NCT07488416","Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide\u002F 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars","Comparative Evaluation of Clinical and Radiographic Outcomes of Lesion Sterilization and Tissue Repair Using Zinc Oxide\u002F 6-gingerol Mix Versus Triple Antibiotic Paste in Non-vital Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age from 4 to 8 years.\n* Both sexes\n* Children must have at least two restorable non-vital primary molars\n* Periapical radiolucency.\n* Pain on mastication.\n* Pathological mobility.\n* Internal or external root resorption.\n* Furcation involvement should not extend to the developing tooth germ.\n\nExclusion Criteria:\n\n* Presence of systemic diseases.\n* Teeth with physiological mobility near exfoliation time.\n* Teeth with vital pulp.",{"count":391,"type":24},60,[27],"This study aims to evaluate and compare the clinical and radiographic outcomes of Lesion sterilization and tissue repair using zinc oxide\u002F 6-gingerol mix versus triple antibiotic paste in non-vital primary molars.",[395,396,397,398,399,400,401,402,335],"Clinical Outcomes","Radiographic Outcomes","Lesion Sterilization","Tissue Repair","Zinc Oxide","6-gingerol","Triple Antibiotic Paste","Non-vital","2026-03-18",{"date":405,"type":36},"2026-03-23",{"date":407,"type":36},"2024-10-01",{"date":321,"type":24},{"name":42,"class":43},{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":12,"sex":19,"minAge":183,"maxAge":418,"enrollmentInfo":419,"targetDuration":4,"studyType":25,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":431,"locationsCount":44},"100596152","evaluating-postoperative-pain-and-antibacterial-effect-of-ultrasonic-and-980-nm-diode-laser-combination-100596152","NCT07041736","Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination","A Randomized Controlled Trial Evaluating Postoperative Pain and Antibacterial Effect of Ultrasonic and 980 nm Diode Laser Combination","Postoperative","Inclusion Criteria:\n\n* Patients have mature teeth with closed apex.\n* Single-rooted teeth with root canal form type I.\n* Asymptomatic.\n* Have periapical radiolucency with a diameter of up to 5 mm.\n* Restorable teeth.\n\nExclusion Criteria:\n\n* Patients with symptomatic apical periodontitis.\n* Systemic disease.\n* Physical or mental disability.\n* Root fracture and tooth mobility.","35 Years",{"count":420,"type":24},120,[27],"This study is a parallel randomized controlled clinical trial that was designed and interpreted according to Preferred Reporting Items for Randomized Trial in Endodontics (PRIRATE) 2020 guidelines. Patients of age range between 20 and 35 years old from the outpatient clinic of Endodontic Department, Faculty of Dental Medicine for Girls, Al-Azhar University will participate in this study. These patients have single rooted teeth with necrotic pulp and periapical radiolucency. Patients will be informed about all the study's procedures. They will be included in the study after fulfilling the inclusion criteria and sign an informed consent.Inclusion Criteria:\n\n* Patients have mature teeth with closed apex.\n* Single rooted teeth with root canal form type I.\n* Asymptomatic.\n* Have Periapical radiolucency with diameter up to 5 mm.\n* Restorable teeth.\n\nExclusion Criteria:\n\n* Patients with symptomatic apical periodontitis.\n* Systemic disease.\n* Physical or mental disability.\n* Root fracture and tooth mobility.",[424],"Post Operative Pain","2026-03-15",{"date":427,"type":36},"2026-03-17",{"date":429,"type":36},"2025-08-03",{"date":321,"type":24},{"name":42,"class":43},{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":438,"targetDuration":4,"studyType":25,"phases":439,"briefSummary":440,"conditions":441,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":452,"locationsCount":4},"100628314","implementation-of-timely-management-of-sepsis-and-septic-shock-protocol-in-the-emergency-department-and-intensive-care-unit-a-quality-improvement-project-at-afhj-100628314","NCT07460024","Implementation of Timely Management of Sepsis and Septic Shock Protocol in the Emergency Department and Intensive Care Unit: A Quality Improvement Project at AFHJ","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Clinical suspicion of sepsis or a confirmed diagnosis of sepsis upon admission to the Emergency Department (ED) or Intensive Care Unit (ICU).\n* Presence of symptoms meeting the criteria for the sepsis management protocol during the study period.\n\nExclusion Criteria:\n\n* Patients transferred from other healthcare facilities after sepsis treatment had already been initiated.\n* End-of-life cases or patients with \"Do Not Attempt Resuscitation\" (DNAR) status where data sets are incomplete.\n* Cases with insufficient medical documentation that prevents accurate outcome measurement or bundle compliance tracking.",{"count":420,"type":24},[27],"Study Title: Implementation of a Sepsis Management Protocol at Armed Forces Hospital Jazan (AFHJ).\n\nPurpose: The purpose of this quality improvement project is to determine if implementing a standardized, evidence-based \"sepsis bundle\" can improve the care and survival of patients with sepsis and septic shock in the Emergency Department (ED) and Intensive Care Unit (ICU).\n\nWhat the Study Involves:\n\nResearchers will implement a specific set of clinical guidelines based on the international Surviving Sepsis Campaign. This include:\n\nUsing a scoring system (NEWS2 and SOFA) to identify sick patients earlier.\n\nEnsuring patients receive five critical treatments (the \"one-hour bundle\") within 60 minutes of diagnosis, including blood tests, IV fluids, and antibiotics.\n\nComparison:\n\nThe study will compare the outcomes of 74 patients treated before the protocol was introduced (the \"Pre-protocol group\") to 46 patients treated after the new protocol was put into effect (the \"Protocol group\").\n\nExpected Outcome:\n\nThe goal is to increase the number of patients who receive all necessary treatments within one hour from less than 15% to at least 60%. The study also aims to see if this protocol leads to shorter hospital stays and lower mortality rates.",[442,443,444,445],"Sepsis","Septic Shock","Systemic Inflammatory Response Syndrome (SIRS)","Critical Illness","2026-03-09",{"date":448,"type":36},"2026-03-10",{"date":450,"type":24},"2026-03",{"date":350,"type":24},{"name":42,"class":43},{"id":454,"slug":455,"hasResults":12,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":18,"sex":19,"minAge":460,"maxAge":183,"enrollmentInfo":461,"targetDuration":4,"studyType":25,"phases":462,"briefSummary":463,"conditions":464,"keywords":467,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":474,"completionDateStruct":476,"leadSponsor":478,"locationsCount":44},"100627978","assessment-of-the-locally-administrated-vitamin-d3-and-corticision-efficacy-on-orthodontic-canine-retraction-100627978","NCT07455656","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction","Assessment of the Locally Administrated Vitamin D3 and Corticision Efficacy on Orthodontic Canine Retraction: A Prospective Clinical Study","Inclusion criteria:\n\n1. Orthodontic patients referred for therapeutic extraction of bilateral maxillary first premolars (Angle Class II division 1 cases, with crowding and bimaxillary protrusion).\n2. Fully erupted permanent teeth (except third molar).\n3. Age 13-20 patients.\n4. No previous orthodontic treatment.\n5. Good oral and general health.\n6. No systemic disease or regular medication that could interfere with and\u002For affect orthodontic teeth movement.\n\nExclusion criteria:\n\n1. Patients with impacted canines.\n2. Patients with severe crowding.\n3. Patients with untreated decay or any endodontic lesions.\n4. Patients with thyroid, parathyroid, or renal and liver disease.","13 Years",{"count":161,"type":24},[27],"To study the effect vitamin D effect on orthodontic tooth movement when used in combination with coticision technique, independent t test or an equivalent non-parametric test will be used for comparison. According to a previous study by (S. T. Varughese, et al. (2019) , \"Effect of vitamin D on canine distalization and alveolar bone density using multi-slice spiral CT: a randomized controlled trial",[465,466],"Malocclusions","Canine Retraction",[468,469,470],"Orhodontic tooth movement","Canine retraction","Extraction first premolars","2026-03-03",{"date":473,"type":36},"2026-03-06",{"date":475,"type":36},"2025-08-01",{"date":477,"type":24},"2027-08-01",{"name":42,"class":43},{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":25,"phases":486,"briefSummary":487,"conditions":488,"keywords":490,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":502,"locationsCount":44},"100626091","surgical-clinical-correlation-in-unilateral-conductive-hearing-loss-with-intact-tympanic-membrane-100626091","NCT07431125","Surgical-Clinical Correlation in Unilateral Conductive Hearing Loss With Intact Tympanic Membrane","Inclusion Criteria:\n\n* unilateral conductive hearing loss or mixed HL with intact Tympanic Membrane\n* Average Airborne Gap Above 20 decibels Exclusion Criteria\n* Sensorineural hearing loss\n* Chronic otitis media\n* TM perforation\n* Previous ear surgery",{"count":23,"type":24},[27],"Unilateral conductive hearing loss (UCHL) in the presence of an intact tympanic membrane represents a diagnostic challenge in otologic practice. In the absence of middle ear effusion or tympanic membrane pathology, stapes fixation secondary to otosclerosis is often considered the most probable diagnosis. However, although otosclerosis is traditionally regarded as a bilateral disease, clinical presentation may be unilateral due to asymmetric disease progression or subclinical contralateral involvement. Other etiologies, including congenital ossicular anomalies, ossicular discontinuity, tympanosclerosis without tympanic membrane involvement, or oval window abnormalities, may mimic otosclerosis both clinically and audiologically. Consequently, exploratory tympanotomy remains the gold standard for definitive diagnosis, allowing direct assessment of ossicular chain mobility and confirmation of stapes fixation. Correlating preoperative clinical suspicion with intraoperative findings is therefore essential to better define the true causes of unilateral conductive hearing loss with an intact tympanic membrane.",[489],"Conductive Hearing Loss, Unilateral",[491,492,493,494,495],"Otoscelrosis","Exploration Tympanotomy","stapedectomy","tympanic membrane","conductive hearing loss","2026-02-19",{"date":498,"type":36},"2026-02-24",{"date":500,"type":36},"2026-01-01",{"date":275,"type":24},{"name":42,"class":43},{"id":504,"slug":505,"hasResults":12,"nctId":506,"briefTitle":507,"officialTitle":508,"acronym":4,"eligibilityCriteria":509,"healthyVolunteers":12,"sex":19,"minAge":510,"maxAge":511,"enrollmentInfo":512,"targetDuration":4,"studyType":25,"phases":514,"briefSummary":515,"conditions":516,"keywords":518,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":4},"100625547","effect-of-graphene-oxide-on-vital-and-non-vital-primary-teeth-compared-to-the-conventional-techniques-100625547","NCT07424053","Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques","Effect of Graphene Oxide on Vital and Non-Vital Primary Teeth Compared to the Conventional Techniques: Randomized Multi-Arm Clinical Trial","\\*Inclusion Criteria\\* (First Arm)\n\n* Cooperative child\n* Presence of symptom-free deep carious lesions\n* Presence of at least two-thirds of the root length radiographically; restorable tooth\n\n(Second Arm)\n\n* Primary teeth diagnosed with pulp necrosis, root resorption equal to or less than one-third (with sufficient dental structure for absolute isolation with rubber dam)\n* History of spontaneous pain and mobility incompatible with chronological age, possibly with the presence of a sinus tract or swelling\n* Presence or absence of a radiolucent area in the periapical or furcation region\n\n\\*Exclusion Criteria\\* (First Arm)\n\n* History of systemic diseases\n* Teeth showing clinical and radiographical evidence of pulp degeneration, such as history of spontaneous or nocturnal pain, tenderness to percussion or palpation, pathologic mobility, swelling or fistulous tract, periodontal ligament (PDL) space widening, internal root resorption, external root resorption, furcal radiolucency\u002Finter-radicular bone destruction, and\u002For periapical bone destruction\n* Teeth without a permanent successor\n* Teeth requiring more than 5 minutes to achieve hemostasis during the clinical procedure\n\n(Second Arm)\n\n* Children with a history of allergic reaction to the components of the tested materials\n* Children had used antibiotics in the last three months.\n* Teeth with pulp canal obliteration or internal or external pathological root resorption visible in periapical radiographs\n* Coronal destruction that would prevent absolute isolation with a rubber dam and\u002For restoration","5 Years","10 Years",{"count":513,"type":24},126,[27],"The null hypothesis of the current study suggested that there will be no significant difference regarding the effect of Graphene Oxide (GO), Lesion sterilization and tissue repair (LSTR) and Zinc Oxide and Eugenol on the clinical and radiographic success rate of non-vital pulpotomy of primary teeth and that there will be no significant difference regarding the effect of Graphene Oxide (GO), MTA and Zinc Oxide and Eugenol on the clinical and radiographic success rate of vital pulpotomy of primary teeth.\n\nThe children (n=126) will be divided randomly into 2 arms; each arm has 3 groups, according to the type of pulp therapy dressing, medicament,t and technique of its application as follows:\n\nFirst Arm (Vital Teeth) Group 1: will receive Graphene Oxide using the vital pulpotomy technique (study group, n=21) Group 2: will receive MTA using vital pulpotomy technique (study group, n=21) Group 3: will receive Zinc Oxide and Eugenol using the vital pulpotomy technique (control group, n=21) Second Arm (Non-Vital Teeth) Group A: will receive Graphene Oxide using the non-vital pulpotomy technique (study group, n=21).\n\nGroup B: will receive LSTR using the non-vital pulpotomy technique (study group, n=21).\n\nGroup C: will receive Zinc Oxide and Eugenol using non-vital pulpotomy (Control group, n=21).\n\nClinical and radiographic success will be assessed as primary outcomes, while pain, patient satisfaction,n and time of procedure will be assessed as secondary outcomes.",[517],"Primary Teeth Indicated for Pulp Therapy",[519,520,521,522,523,524,525,526],"LSTR","MTA","Zinc Oxide and Eugenol","Graphene Oxide","Vital pulpotomy","Non Vital Pulpotomy","Primary teeth","Conventional Pulp therapy techniques",{"date":528,"type":36},"2026-02-20",{"date":530,"type":24},"2026-04",{"date":532,"type":24},"2026-12-01",{"name":42,"class":43},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":538,"acronym":4,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":19,"minAge":510,"maxAge":361,"enrollmentInfo":540,"targetDuration":4,"studyType":25,"phases":541,"briefSummary":543,"conditions":544,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":553,"locationsCount":44},"100622822","phase-2-the-effect-of-echinacea-immulant--in-the-treatment-of-cryptosporidiosis-in-immunocompromised-children-100622822","NCT07388615","The Effect of Echinacea (Immulant ®) in the Treatment of CRYPTOSPORIDIOSIS in Immunocompromised Children","Inclusion Criteria:\n\n* Clinical diagnosis of Cryptosporidiosis Disease\n* Age from 5-12 years\n* Immunocompromised children\n* Not receiving any drugs causing immunosuppression\n\nExclusion Criteria:\n\n* Patients undergoing organ transplantation\n* Patients suffering from autoimmune diseases.\n* Patients suffering from hypersensitivity of this plant extract",{"count":391,"type":24},[542],"PHASE2","This study aims to:\n\n1. To evaluate the effectiveness of Immulant ® addition to standard treatment in reducing clinical symptoms of Cryptosporidiosis in immunocompromised children.\n2. To measure the changes in parasite count in stool samples after treatment with Immulant ®.\n3. To assess the safety and tolerability of Immulant ® in children participating in the study.",[545],"Cryptosporidium Infection","2026-01-28",{"date":548,"type":36},"2026-02-05",{"date":550,"type":24},"2026-01-18",{"date":552,"type":24},"2026-08",{"name":42,"class":43},{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":12,"sex":81,"minAge":20,"maxAge":21,"enrollmentInfo":561,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":563,"conditions":564,"keywords":566,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":573,"leadSponsor":575,"locationsCount":44},"100620679","ultrasonographic-onsd-as-a-predictor-of-pdph-in-spinal-anesthesia-for-cesarean-delivery-100620679","NCT07360756","Ultrasonographic ONSD as a Predictor of PDPH in Spinal Anesthesia for Cesarean Delivery","Early Prediction of Post-Dural Puncture Headache Using Ultrasound-Measured Optic Nerve Sheath Diameter in Cesarean Section Patients: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult female patients, aged 18-45 years\n* ASA(American Society of Anesthesiologists) physical status II or III\n* Scheduled for elective cesarean section\n* Undergoing surgery under standardized spinal anesthesia\n\nExclusion Criteria:\n\n* Pre-existing headache disorders (e.g., migraine, chronic tension-type headache)\n* Known ophthalmic conditions (e.g., optic neuropathy, glaucoma)\n* Inability to cooperate with ONSD(Optic Nerve Sheath Diameter) ultrasound measurements or follow-up\n* Allergy to local anesthetics\n* Emergency cesarean section\n* Contraindications to spinal anesthesia:\n\n  * Coagulopathy\n  * Infection at the puncture site\n* Preexisting hypertension on medication\n* Pre-eclampsia with severe features (suggested for separate study)\n* Known cardiac disease with hemodynamic instability\n* Allergy to study drugs\n* Fetal distress or non-reassuring cardiotocography (CTG)\n* Body Mass Index (BMI) \\>40 kg\u002Fm²\n* Refusal to sign informed consent",{"count":562,"type":24},150,"The Optic Nerve Sheath Diameter (ONSD), measured non-invasively by bedside ultrasound, is a well-established surrogate for intracranial pressure (ICP), as the optic nerve sheath is continuous with the intracranial dura mater and its subarachnoid space is filled with cerebrospinal fluid (CSF). While ONSD is typically used to detect elevated ICP (with a cut-off often \\> 5.0-5.7 mm for ICP \\> 20 mmHg), studies investigating PDPH have paradoxically shown a reduction in ONSD post-spinal anesthesia, correlating with the state of intracranial hypotension.\n\nPrevious research has demonstrated that a lower ONSD or a significant decrease in ONSD values 24 hours post-puncture is associated with PDPH development. A study determined that an ONSD at 24 hours of less than 0.40 cm was the best predictor for PDPH. Our study aims to specifically investigate the utility of the immediate change in ONSD to offer a bedside, real-time assessment of risk.",[565],"Cesarean Section Complications",[567,568],"Post-Dural Puncture Headache","Optic Nerve Sheath Diameter","2026-01-17",{"date":571,"type":36},"2026-01-22",{"date":546,"type":24},{"date":574,"type":24},"2026-12-30",{"name":42,"class":43},{"id":577,"slug":578,"hasResults":12,"nctId":579,"briefTitle":580,"officialTitle":581,"acronym":4,"eligibilityCriteria":582,"healthyVolunteers":12,"sex":19,"minAge":583,"maxAge":361,"enrollmentInfo":584,"targetDuration":4,"studyType":25,"phases":586,"briefSummary":587,"conditions":588,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":44},"100620380","probiotic-based-versus-ethyl-lauroyl-arginate-containing-mouthwashes-on-streptococcus-mutans-counts-dental-plaque-accumulation-and-salivary-ph-in-a-group-of-egyptian-school-children-100620380","NCT07356869","Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children","Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Healthy Egyptian schoolchildren aged 6-12 years.\n* Good general health.\n* Mild to moderate dental plaque accumulation.\n* Parental\u002Fcaregiver willingness to provide consent\n\nExclusion Criteria:\n\n* Antibiotic or antimicrobial use within the last month.\n* Allergies to the mouthwash components.\n* Systemic diseases affecting oral health.\n* Orthodontic appliances or extensive dental restorations.","6 Years",{"count":585,"type":24},66,[27],"This study aims to compare the efficacy of probiotic-based mouthwashes versus ethyl lauroyl arginate-containing mouthwashes in reducing Streptococcus mutans count, dental plaque accumulation, and salivary pH among a group of Egyptian schoolchildren.",[589,590,591,592,593,594,595],"Probiotic","Ethyl Lauroyl Arginate","Mouthwashes","Streptococcus Mutans","Dental Plaque","Salivary pH","Children","2026-01-13",{"date":598,"type":36},"2026-01-21",{"date":600,"type":36},"2025-08-15",{"date":602,"type":24},"2026-09-01",{"name":42,"class":43},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":609,"acronym":4,"eligibilityCriteria":610,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":611,"enrollmentInfo":612,"targetDuration":4,"studyType":25,"phases":613,"briefSummary":615,"conditions":616,"keywords":618,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":625,"completionDateStruct":626,"leadSponsor":627,"locationsCount":44},"100619357","phase-3-comparison-of-quadratus-lumborum-and-combined-groin-nerve-blocks-for-postoperative-analgesia-after-open-inguinal-hernia-repair-100619357","NCT07343570","Comparison of Quadratus Lumborum and Combined Groin Nerve Blocks for Postoperative Analgesia After Open Inguinal Hernia Repair.","Comparing Ultrasound-guided Lateral Quadratus Lumborum Block Versus Combined Ilio-inguinal\u002FIlio-hypogastric \u002FGenitofemoral Block for Postoperative Analgesia After Open Inguinal Hernia Repair: A Double-blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18-75 years.\n* ASA physical status I-III.\n* Scheduled for elective unilateral open inguinal hernia repair under standardized spinal anesthesia.\n* Able to understand and use the Visual Analogue Scale (VAS).\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Coagulopathy or current use of anticoagulants contraindicating peripheral nerve blocks.\n* Infection at the injection site.\n* Chronic opioid use (daily opioids \\>2 weeks) or chronic pain syndromes.\n* Body mass index (BMI) \\>40 kg\u002Fm².\n* Conversion to other surgery or bilateral repair.\n* Pregnant patients.\n* Refusal to sign informed consent.","75 Years",{"count":585,"type":24},[614],"PHASE3","This double-blind randomized controlled trial aimes to compares two ultrasound-guided regional techniques-lateral quadratus lumborum block versus combined ilio-inguinal\u002Filio-hypogastric\u002Fgenitofemoral (II-IH-GFN) block-for postoperative analgesia after elective unilateral open inguinal hernia repair under spinal anesthesia in adults.",[617],"Postoperative Analgesia of Inguinal Hernia Repair in Adults",[619,620,621],"Quadratus lumborum [QL] block","Ilioinguinal-iliohypogastric (IIIH) nerve block","Genitofemoral block","2026-01-08",{"date":624,"type":36},"2026-01-15",{"date":546,"type":24},{"date":574,"type":24},{"name":42,"class":43},{"id":629,"slug":630,"hasResults":12,"nctId":631,"briefTitle":632,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":19,"minAge":183,"maxAge":635,"enrollmentInfo":636,"targetDuration":4,"studyType":25,"phases":638,"briefSummary":640,"conditions":641,"keywords":643,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":650,"leadSponsor":652,"locationsCount":44},"100615997","phase-4-perineural-dexamethasone-dexmedetomidine-or-their-combination-to-reduces-rebound-pain-after-supraclavicular-brachial-plexus-block-100615997","NCT07299877","Perineural Dexamethasone, Dexmedetomidine, or Their Combination to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block","Perineural Dexamethasone, Dexmedetomidine or Their Combination: an Effort to Reduces Rebound Pain After Supraclavicular Brachial Plexus Block: A Triple-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* from 20-65 years old\n* and ASA physical status I or II and III,\n* and of either gender,\n* who provided informed, written, and valid consent,\n* were scheduled for elective orthopedic upper limb surgeries for traumatic fractures under Supraclavicular Brachial Plexus Block.\n\nExclusion Criteria:\n\n* Patients with coagulopathies,\n* neurological disorders,\n* hypersensitivity to any of the study drugs, or\n* a history of previous surgeries on the affected limb\n* and those who refused to sign informed consent","65 Years",{"count":637,"type":24},75,[639],"PHASE4","Dexmedetomidine, an α2 adrenoceptor agonist, and dexamethasone, a potent anti-inflammatory steroid, are commonly used, effective, and safe adjuvants to peripheral nerve block (PNB). Both have been found to delay and reduce the incidence of rebound pain (RP), prolong the duration of sensory and motor block, and enhance analgesia without causing significant respiratory depression. Few studies have explored the effectiveness of dexmedetomidine or dexamethasone as sole adjuvants to PNB for preventing or reducing RP. However, no study has directly compared the effectiveness of these two drugs in reducing RP when used as adjuvants to local anesthetic (LA) in PNB. Due to differences in their mechanism of action, their effects on RP may differ significantly. The investigators hypothesized that the combination of dexamethasone and dexmedetomidine reduces the incidence of RP when used as adjuvants to LA in PNB.",[642],"Brachial Plexus Blocks",[644,645],"Dexamethasone","dexmedetomidine",{"date":647,"type":36},"2026-01-09",{"date":649,"type":24},"2025-12-28",{"date":651,"type":24},"2026-10-15",{"name":42,"class":43},""]