[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Alaa Sada\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100637013","phase-2-tirzepatide-following-adrenalectomy-in-mild-autonomous-cortisol-secretion-100637013",false,"NCT07573163","Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion","A Randomized Clinical Trial of Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Diagnosis of MACS, defined as morning cortisol \\>1.8 mcg\u002FdL after a 1 mg dexamethasone suppression test\n* Elevated blood pressure (SBP ≥120 mmHg or DBP ≥80 mmHg per the 2025 American College of Cardiology\u002FAmerican Heart Association \\[ACC\u002FAHA\\] criteria, or current use of antihypertensive medication)\n* BMI ≥27\n* Undergoing or having undergone adrenalectomy for the treatment of MACS\n\nExclusion Criteria:\n\n* Bilateral adrenal lesions\n* Adrenal malignancy\n* Concurrent primary aldosteronism with MACS\n* Current use of GLP-1 receptor agonists\n* Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2)\n* Pregnancy or breastfeeding","ALL","18 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","Mild Autonomous Cortisol Secretion (MACS) is a condition in which an adrenal gland produces excess cortisol and is associated with high blood pressure, diabetes, and weight gain. Surgical removal of the adrenal gland (adrenalectomy) is standard treatment, but some patients continue to have metabolic health problems after surgery.\n\nThis randomized study will evaluate whether treatment with tirzepatide after adrenalectomy improves metabolic outcomes in patients with MACS compared with adrenalectomy alone.",[26,27],"Mild Autonomous Cortisol Secretion (MACS)","Adrenalectomy; Status",[29,30,31],"adrenalectomy","MACS","mild autonomous cortisol secretion","NOT_YET_RECRUITING","2026-06-29",{"date":35,"type":36},"2026-07-01","ACTUAL",{"date":38,"type":20},"2026-07",{"date":40,"type":20},"2028-12-31",{"name":42,"class":43},"Alaa Sada","OTHER",""]