[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Albert Einstein Healthcare Network\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":135},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,60,90,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100053874","effects-of-semantic-context-on-criterion-learning-naming-treatment-in-aphasia-100053874",false,"NCT07673198","Effects of Semantic Context on Criterion-learning Naming Treatment in Aphasia","Word Retrieval in Aphasia","Inclusion Criteria:\n\n* English as a native or primary language\n* Adults with stroke who are at least 6 months post-onset\n\nExclusion Criteria:\n\n* History of comorbid neurological diagnoses, such as Multiple Sclerosis or Parkinson's Disease\n* History of a learning disability that significantly impacted language development, such as developmental language disorder\n* Insufficient stamina to participate in the protocol","ALL","18 Years","89 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","Aphasia is a disorder of spoken and written language, most commonly following a stroke. It is estimated that between 2.5 and 4 million Americans are living with aphasia today. A common problem in aphasia involves difficulty retrieving known words in the course of language production and comprehension. The overarching goal of this project is to develop and test early efficacy, efficiency, and the tolerability of a lexical treatment for aphasia in multiple-session regimens that are comprised of retrieval practice, distributed practice, and training dedicated to the elicitation of correct retrievals. The aim of this work is to add to and refine the evidence base for the implementation and optimization of these elements in the treatment of production and comprehension deficits in aphasia, and make important steps towards an ultimate goal of self-administered lexical treatment grounded in retrieval practice principles (RPP) to supplement traditional speech-language therapy that is appropriate for People with Aphasia (PWA) from a broad level of severity of lexical processing deficit in naming and\u002For comprehension. This project cumulatively builds on prior work to develop a theory of learning for lexical processing impairment in aphasia that aims to ultimately explain why and for whom familiar lexical treatments work, and how to maximize the benefits they confer.",[27],"Aphasia",[29,30,31,32,33],"anomia","retrieval practice","word-finding problem","communication disorder","naming impairment","NOT_YET_RECRUITING","2026-07-10",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":21},"2026-08",{"date":42,"type":21},"2028-08",{"name":44,"class":45},"Albert Einstein Healthcare Network","OTHER",1,{"id":48,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":50,"briefSummary":25,"conditions":51,"keywords":52,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":59,"locationsCount":46},"100644757",{"count":20,"type":21},[24],[27],[29,30,31,32,33],"2026-06-23",{"date":55,"type":38},"2026-06-29",{"date":57,"type":21},"2026-07",{"date":42,"type":21},{"name":44,"class":45},{"id":61,"slug":62,"hasResults":11,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":22,"phases":70,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},"100596351","efficacy-and-mechanisms-of-virtual-reality-treatment-of-phantom-leg-painhome-based-treatment-100596351","NCT07044323","Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment","PLP Home-Based","Inclusion Criteria:\n\n* Age 18 -100\n* Capacity to provide Informed Consent\n* Unilateral above or below knee amputation more than 3 months prior to enrollment\n* Absence of cognitive impairment, operationally defined as a Montreal Cognitive Assessment score of 18 or greater1.\n* Pain averaged over the preceding 1 month in the phantom limb rated as greater than 4 on a scale of 0-10.\n\nExclusion Criteria:\n\n* History of significant medical or neurological disorder such as stroke or moderate to severe traumatic brain injury (operationally defined as loss of consciousness for more than 30 minutes)\n* History of significant or poorly controlled psychiatric disorders\n* Substantial depression or anxiety affecting their ability to perform tasks necessary for the study.\n* Current abuse of alcohol or drugs, prescription or otherwise\n* Nursing a child, pregnant, or intent to become pregnant during the study","100 Years",{"count":69,"type":21},44,[24],"After amputation of an arm or leg, up to 90% of subjects experience a \"phantom limb\", a phenomenon characterized by persistent feelings of the missing limb. Many subjects with a phantom limb experience intense pain in the missing extremity that is often poorly responsive to medications or other interventions. The study will explore the feasibility and efficacy of a home-based, active VR treatment for phantom limb pain (PLP).",[73,74],"Phantom Pain Following Amputation of Lower Limb","Amputation",[76,77,78,79],"pain","phantom limb","lower limb amputation","treatment","RECRUITING","2025-08-07",{"date":83,"type":38},"2025-08-08",{"date":85,"type":38},"2025-06-16",{"date":87,"type":21},"2026-05-31",{"name":44,"class":45},3,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100533439","unlocking-movement-potential-enhancing-parkinsons-disease-treatment-with-robotic-eksoskeleton-100533439","NCT06225830","Unlocking Movement Potential: Enhancing Parkinson's Disease Treatment With Robotic EksoSkeleton","Utilization of Robotic EksoSkeleton to Achieve High Dosing, Intensity, and Complexity of Gait in Treatment of People With Parkinson's Disease","Inclusion Criteria:\n\n1. Physician diagnosed idiopathic Parkinson's disease\n2. All Hoehn and Yahr (H\\&Y) stages will be eligible for inclusion in the study\n3. Able to consent to participation in the research study\n4. Pt agreeable to participate in 45-60 minutes of high intensity (RPE 14-17 for 30 minutes) gait training\u002F physical therapy.\n5. Sufficient upper extremity strength to use a front wheeled walker\n6. Pt to have self- reported walking\u002Fbalance deficits\n7. Age: Over age 18\n8. Must be able to tolerate at least 15 min upright\n9. Weigh 220 pounds (100kg) or less\n10. Approximately between 5'0\" and 6'4\" tall\n11. Have near normal range of motion in hips, knees, and ankles \"Can you stand up and straighten your knees even for just a second?\" or \"Can you lay flat and straighten your knees so there is no bend in the knee?\"\n\nExclusion Criteria:\n\n1. Currently involved in another intervention study or physical therapy course of care\n2. Concurrent neurological disease\n3. Leg length discrepancy, self-reported.\n4. Spinal instability\n5. Unresolved deep vein thrombosis\n6. Severe muscular or skeletal pain\n7. Open skin ulcerations on buttocks or other body surfaces in contact with exoskeleton or harness\n8. Pregnancy\n9. Cognitive impairments - unable to follow 2 steps commands and communicate for pain or to stop session\n10. Participant requires the assistance of more than one therapist to transfer safely.\n11. Uncontrolled or severe orthostatic hypotension that limits standing tolerance; defined as sustained, symptomatic drops in systolic and diastolic blood pressure when moving from sitting to standing\n12. Active heterotrophic ossification (HO), hip dysplasia or hip\u002Fknee axis abnormalities\n13. Colostomy\n14. History of long bone fractures secondary to osteoporosis\n15. Unable to sustain current medication regimen. Participant reports change in Parkinson's Medication in the past week.\n16. Any reason the therapist may deem as harmful to the participant to enroll or continue in the study",{"count":98,"type":21},24,[24],"The goal of this study is to see how well therapy with the Eksobionic Exoskeleton (Esko) works for people with Parkinson's disease (PWPD). Esko is a robotic device that provides high repetition and intensity training. The investigators will examine its impact on walking, balance, and quality of life before, during and after an eight-week intervention program. The results will lay the groundwork for future trials, potentially leading to long-term improvements in mobility and quality of life for PWPD.",[102],"Parkinson Disease","2025-07-06",{"date":105,"type":38},"2025-07-10",{"date":107,"type":38},"2024-06-04",{"date":109,"type":21},"2026-06",{"name":44,"class":45},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":124,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":46},"100518268","getupgo-a-randomized-controlled-trial-of-an-intervention-to-enhance-physical-activity-after-tbi-100518268","NCT06028334","GetUp&Go: A Randomized Controlled Trial of an Intervention to Enhance Physical Activity After TBI","GetUp&Go: A Randomized Controlled Trial of a Theory-Based Intervention to Enhance Physical Activity in Chronic, Moderate-Severe Traumatic Brain Injury","Inclusion Criteria:\n\n* Age ≥18\n* TBI (open or closed), sustained at least 6 months prior to enrollment, of at least complicated-mild\u002Fmoderate severity as evidenced by loss or alteration of consciousness ≥ 30 minutes; and\u002For post-traumatic amnesia (PTA) ≥ 24 hours, not due to intoxication\u002Fsedation and documented prospectively from the injury; and\u002For positive neuroimaging findings consistent with TBI\n* Fully weight bearing on lower limbs and able to walk indoors and outdoors without the assistance of another person\n* Cognitively able to participate in treatment as judged by ability to travel independently within the community\n* Able to communicate adequately in English for participation in the treatment protocols\n* Informed consent given by participant\n\nExclusion Criteria:\n\n* Contraindications to increasing PA as judged by study physician, using an exam based on published screening tools\n* Medical or psychiatric instability, including current psychosis or severe uncontrolled substance misuse, as assessed using items from the SCID\u002FMINI\u002FASSIST, or suicidal ideation with intent or plan, as assessed by the Columbia-Suicide Severity Rating Scale, screening version\n* Significant physical or intellectual disability predating the TBI\n* Neurodegenerative disorder, e.g., Parkinson's disease\n* Insufficiently inactive, i.e., reporting \\> 23 weekly moderate\u002Fvigorous activity units on the Godin Leisure-Time Exercise Questionnaire\n* Planned surgery or other hospitalization during the succeeding 9 months\n* Physical or sensory disability (e.g., blindness; severe bimanual incoordination) that prevents use of a smartphone",{"count":119,"type":21},70,[24],"The goal of this clinical trial is to evaluate GetUp\\&Go, a program for promoting increased physical activity in individuals at least 6 months post moderate-to-severe traumatic brain injury. GetUp\\&Go is a remotely delivered 10-week program that includes one-on-one sessions with a therapist and a mobile health application (RehaBot).\n\nThe main question is whether participants in the 10-week GetUp\\&Go program increase their physical activity, and exhibit associated benefits in mental and physical health, relative to those who are put on a waitlist.\n\n* Question 1: Do participants who receive immediate treatment with GetUp\\&Go show more increased physical activity, measured by accelerometer activity counts per day, and improve more on secondary outcomes, such as self-reported physical activity, emotional function, fatigue, sleep, pain, and health-related quality of life, compared to their baseline, relative to those who are put on a waitlist?\n* Question 2: Do participants who have continued access to the mobile health component of the intervention, RehaBot, show better maintenance of physical activity gains compared to those who no longer have access to RehaBot?\n* Question 3: Are individual participant characteristics associated with participants' response to the treatment program?",[123],"Traumatic Brain Injury",[125,126],"physical activity","mobile health","2025-03-18",{"date":129,"type":38},"2025-03-20",{"date":131,"type":38},"2023-12-19",{"date":133,"type":21},"2027-08-31",{"name":44,"class":45},""]