[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Alexandre P. Joosten\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":47},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100636452","phase-3-methadone-for-enhanced-postoperative-analgesia-in-intermediate-risk-noncardiac-surgery-melody-100636452",false,"NCT07565870","Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)","Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery: A Multicentre Randomized Controlled Trial (MELODY Trial)","MELODY","Inclusion Criteria\n\n* Age ≥18 years\n* Elective intermediate-risk noncardiac surgery under general anesthesia\n* ASA physical status I-III\n* Expected hospital stay ≥24 hours\n* Ability to provide informed consent\n\nExclusion Criteria\n\n* Severe hepatic dysfunction (Child-Pugh C)\n* Severe renal impairment (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m²)\n* Known allergy to methadone or opioids\n* Pregnancy or breastfeeding\n* Chronic opioid use or opioid use disorder\n* Planned use of epidural or regional analgesia\n* Inability to complete study assessments","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Postoperative pain control remains suboptimal for a large proportion of surgical patients and is frequently associated with slower recovery and higher reliance on opioids after surgery. Current intraoperative analgesic approaches predominantly use short-acting opioids, whose rapid pharmacokinetics can lead to variable drug exposure and inconsistent control of nociceptive stimuli.\n\nMethadone has a different pharmacologic profile, combining prolonged μ-opioid receptor activity with N-methyl-D-aspartate receptor antagonism, allowing sustained analgesia following a single intraoperative administration and potentially enhancing postoperative recovery.\n\nThe MELODY trial is a multicentre, randomized, patient-blinded clinical study designed to compare a single intravenous dose of methadone given at induction with conventional short-acting opioid-based anesthesia in adults undergoing intermediate-risk noncardiac surgery. The primary aim is to evaluate whether this strategy leads to improved quality of recovery on the first postoperative day.",[27,28],"Postoperative Pain","Recovery",[30,31,32,33,34],"Methadone","QoR-15","Quality of Recovery","Multimodal Analgesia","General Anesthesia","NOT_YET_RECRUITING","2026-04-29",{"date":38,"type":39},"2026-05-04","ACTUAL",{"date":41,"type":21},"2026-07-01",{"date":43,"type":21},"2027-03-30",{"name":45,"class":46},"Alexandre P. Joosten","OTHER",""]