[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Amin Javer\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":97},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100622422","intranasal-platelet-rich-plasma-with-or-without-topical-insulin-for-post-inflammatory-anosmia-100622422",false,"NCT07383415","Intranasal Platelet-Rich Plasma With or Without Topical Insulin for Post-Inflammatory Anosmia","Assessing the Effectiveness of Combined Intranasal Platelet-rich Plasma Plus Topical Insulin Versus Platelet-rich Plasma Alone in the Treatment of Post Inflammatory Anosmia: a Randomized Controlled Trial","PRP-I RCT","Inclusion Criteria:\n\n* Diagnosed with olfactory dysfunction despite olfactory training therapy\n* Loss of smell within the past 5 years\n* Loss of smell occurred after an infection\n* Platelet count is over 150,000 platelets per microliter\n\nExclusion Criteria:\n\nHave a history of or currently have sinonasal tumours Have a history of surgery or radiotherapy for the base of your skull Have been treated with antibiotics in the past month before surgery Have a condition called systemic vasculitis or any bleeding disorder Have a suspected or known allergy to insulin or PRP or Platelet Lysate (PL) Have inhaled drugs (i.e cocaine) in the past 6 months of your enrollment Smell loss is due to a head trauma or after surgery Unable to complete the Sniffin Stick Smell test or questionnaires","ALL","19 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study evaluates whether adding topical insulin to intranasal platelet-rich plasma (PRP) improves smell recovery in adults with post-inflammatory anosmia. Participants will be randomly assigned to receive either intranasal PRP combined with topical insulin or intranasal PRP alone. Changes in olfactory function will be assessed over time to compare the effectiveness and safety of the two treatments.",[27,28],"Anosmia","Inflammatory Anosmia",[30,31],"PRP","PRP-INSULIN","NOT_YET_RECRUITING","2026-01-26",{"date":35,"type":36},"2026-02-03","ACTUAL",{"date":38,"type":21},"2026-03-30",{"date":40,"type":21},"2027-01-01",{"name":42,"class":43},"Amin Javer","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":62,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100622421","phase-3-intra-sinus-povidone-iodine-and-budesonide-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-100622421","NCT07383402","Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis","The Efficacy of Intra-sinus Povidone-iodine\u002FBudesonide Gel Forming Suspension Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis: a Randomized, Double Blind, Placebo-controlled Trial","PVP-I","Inclusion Criteria:\n\nAge 19 years or older Scheduled for Endoscopic Sinus Surgery (ESS)\n\nExclusion Criteria:\n\nCystic fibrosis Systemic vasculitis Known or suspected hypersensitivity to povidone iodine Inhaled drug use (i.e., cocaine) in the preceding 6 months Nasal tumors Known or suspected immunodeficiencies Pregnant women Breast feeding women",{"count":53,"type":21},180,[55],"PHASE3","Endoscopic sinus surgery (ESS) is commonly performed in patients with chronic rhinosinusitis (CRS) to improve sinus drainage and allow better delivery of topical therapies after surgery. Despite surgery, postoperative inflammation can persist and negatively affect healing and outcomes.\n\nThis randomized, double-blind, placebo-controlled clinical trial will evaluate whether intra-sinus administration of a gel-forming suspension containing povidone-iodine and budesonide improves postoperative endoscopic outcomes of the sinus cavities three months following ESS, compared with placebo.",[58],"Chronic Rhinosinusitis (CRS)",[60,61],"Povidone Iodine","Budesonide",{"date":35,"type":36},{"date":38,"type":21},{"date":65,"type":21},"2028-01-01",{"name":42,"class":43},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100551143","phase-2-bupivacaine-and-epinephrine-injection-study-100551143","NCT06456255","Bupivacaine and Epinephrine Injection Study","Bupivacaine With Epinephrine vs Sham Injections During Endoscopic Sinus Surgery: a Double Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 19 years or older\n* Scheduled for primary ESS (including septoplasty)\n\nExclusion Criteria:\n\n* Cystic fibrosis\n* Systemic vasculitis or any bleeding disorders\n* Known or suspected hypersensitivity to bupivacaine or epinephrine\n* Previous sinus surgery\n* Inhaled drug use (i.e., cocaine) in the preceding 6 months\n* Nasal tumors\n* Patients on antiarrhythmics.\n* Patients with history of severe liver illness.\n* Patients identified as high-risk for complications during preoperative assessment with the anesthesiologist (e.g. untreated hypertension, ischemic heart disease, cerebral vascular insufficiency, heart block, peripheral vascular disorder, uncontrolled hyperthyroidism and diabetes)",{"count":75,"type":21},80,[77,55],"PHASE2","Endoscopic sinus surgery (ESS) is a common otolaryngologic procedure that aims to remove the partitions that separate the sinus cavities, remove inflamed tissue, and optimize the sinuses for topical medication use. In this procedure, the surgeon will inject a combination of drugs, local anesthetics, and vasoconstrictors, to reduce bleeding and improve visualization. However, previous studies have shown similar results when injected with only saline. In this study, investigators want to determine if the injection of local anesthesic+vasoconstrictor compared to no injection at all makes any difference in improving the surgeon's visualization during an ESS.",[80,81,82],"Sinus Disease","Anesthesia","Bleeding",[84,85,86],"endoscopic sinus surgery","bupivacaine","epinephrine","RECRUITING","2025-05-12",{"date":90,"type":36},"2025-05-15",{"date":92,"type":36},"2024-11-15",{"date":94,"type":21},"2025-07",{"name":42,"class":43},1,""]