[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Andijan State Medical Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":59},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":5},"100629557","predictors-of-androgen-status-decline-in-middle-aged-men-100629557",false,"NCT07476222","Predictors of Androgen Status Decline in Middle-Aged Men","Anthropometric, Functional and Lifestyle Determinants of Decreased Testosterone Levels in Middle-Aged Men: A Population-Based Cross-Sectional Study","TESMEN","Inclusion Criteria:\n\n* Men aged 35-59 years\n* Permanent residence in the Andijan region of Uzbekistan\n* Ability to undergo anthropometric measurements and functional performance tests\n* Ability to complete study questionnaires\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Previously diagnosed hypogonadism requiring hormonal therapy\n* Current testosterone replacement therapy or other medications affecting androgen status\n* Severe cardiovascular, hepatic or renal diseases in the stage of decompensation\n* Acute infectious or inflammatory diseases at the time of examination\n* Severe psychiatric or cognitive disorders limiting participation\n* Clinically significant urological pathology\n* Inability or unwillingness to provide informed consent",true,"MALE","35 Years","59 Years",{"count":22,"type":23},600,"ESTIMATED","OBSERVATIONAL","Age-related decrease in testosterone levels in men is associated with multiple metabolic, functional and psychosocial consequences. Early identification of modifiable factors associated with decreased testosterone levels may contribute to improved prevention of androgen deficiency and related health conditions.\n\nThis population-based analytical cross-sectional observational study aims to investigate anthropometric, functional and lifestyle-related factors associated with decreased total testosterone levels in middle-aged men. Approximately 600 men aged 35-59 years residing in the Andijan region of Uzbekistan will be recruited.\n\nParticipants will undergo comprehensive assessment including anthropometric measurements, functional performance tests, standardized questionnaires and laboratory determination of serum total testosterone levels. Anthropometric variables will include body mass index, waist circumference, hip circumference, waist-to-hip ratio and waist-to-height ratio. Functional status will be assessed using hand-grip strength, five-times chair-stand test, 4-meter walk test, balance assessment and the six-minute walk test. Lifestyle-related factors including physical activity, sleep quality, dietary habits, smoking, alcohol consumption and psychoemotional status will be evaluated using validated questionnaires.\n\nThe study aims to identify determinants of decreased testosterone levels and develop a predictive model for early identification of androgen deficiency in middle-aged men.",[27,28,29,30],"Testosterone Deficiency","Androgen Deficiency","Male Hypogonadism","Late-Onset Hypogonadism",[32,33,34,35,36,37,38,39,40,41,42,43,44,45,46],"Testosterone deficiency","Androgen deficiency","Cross-sectional study","Men's health","Sarcopenia","Waist circumference","Body mass index","Sleep quality","Physical activity","Lifestyle factors","Functional status","Anthropometric factors","Middle-aged men","Male hypogonadism","Screening model","NOT_YET_RECRUITING","2026-05-27",{"date":50,"type":51},"2026-05-29","ACTUAL",{"date":53,"type":23},"2026-06-01",{"date":55,"type":23},"2027-12-31",{"name":57,"class":58},"Andijan State Medical Institute","OTHER",""]