[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Andre Russowsky Brunoni\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":39},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":5},"100641092","tdcs-for-late-life-depression-100641092",false,"NCT07657234","tDCS for Late-Life Depression","High-Dose Spaced Bilateral tDCS for Late-Life Depression: Open-Label Pilot Study","Inclusion Criteria:\n\nParticipants must meet all of the following criteria:\n\n1. age 60 years or older;\n2. diagnosis of unipolar major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by the Mini International Neuropsychiatric Interview (MINI);\n3. score of 17 or higher on the 17-item Hamilton Depression Rating Scale (HDRS-17) at screening;\n4. stable antidepressant regimen for at least four weeks prior to enrollment, if applicable;\n5. capacity to provide informed consent;\n6. Clinical Dementia Rating scale of 0 or 0.5.\n\nExclusion Criteria:\n\nParticipants meeting any of the following criteria will be excluded:\n\n1. contraindications to tDCS including metallic cranial implants, skin conditions at electrode sites (eczema, open wounds, burns, lesions), or history of adverse reaction to tDCS;\n2. contraindications to magnetic resonance imaging (MRI) including pacemaker, cochlear implants, ferromagnetic implants, or claustrophobia;\n3. history of seizures or epilepsy;\n4. bipolar disorder, psychotic disorders, or severe personality disorder;\n5. dementia or MoCA score below 17;\n6. substance use disorder within the past six months;\n7. neuromodulation treatment including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), tDCS, or vagus nerve stimulation (VNS) within the past six months;\n8. active suicidal ideation with plan or intent requiring a higher level of care;\n9. concurrent use of medications that substantially lower seizure threshold;\n10. pregnancy.","ALL","60 Years",{"count":19,"type":20},20,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research study is to determine the effectiveness of Transcranial direct current stimulation (tDCS) therapy in the treatment of participants with Late-life depression (LLD).\n\nThe study will evaluate feasibility, safety, and tolerability of high-dose (6mA) bilateral tDCS delivered as three daily sessions, 3 times a week, for 3 weeks in older adults (60 y\u002Fo and older) with late-life depression.",[26],"Late Life Depression (LLD)","NOT_YET_RECRUITING","2026-06-12",{"date":30,"type":31},"2026-06-18","ACTUAL",{"date":33,"type":20},"2026-08",{"date":35,"type":20},"2027-09",{"name":37,"class":38},"Andre Russowsky Brunoni","OTHER",""]