[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Angelina Passaro\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100637978","triglyceride-rich-lipoproteins-and-inflammatory-cytokines-after-oral-fat-loading-as-potential-early-biomarkers-of-the-risk-of-progression-towards-diabetes-and-development-of-complications-lipinfat-diabetes-study-100637978",false,"NCT07602023","Triglyceride-rich LIPoproteins and INflammatory Cytokines After Oral FAT Loading as Potential Early Biomarkers of the Risk of Progression Towards DIABETES and Development of Complications. LIPINFAT Diabetes Study.","LIPINFAT","Inclusion Criteria:\n\n* Males and females aged 50-70 years\n* BMI between 25-30 kg\u002Fm2\n* HbA1c ≤7% for T2D\n* HbA1c ≤6.5% for prediabetes\n* HbA1c ≤5.7% for controls\n* Signed Project Information and Informed Consent Form\n* Signed Data Processing Consent Form\n\nExclusion Criteria:\n\n* Lipid-lowering therapy with ezetimibe, fenofibrate, omega-3 fatty acids, or other drugs that can interfere with lipoprotein absorption and metabolism\n* Chronic Kidney Disease (CKD) with estimated glomerular filtration rate (eGFR) \\\u003C60 ml\u002Fmin and renal impairment (e.g., uACR ≥30 mg\u002Fmmol) for 3 months or more\n* Secondary or syndromic forms of obesity\n* Patients on insulin therapy\n* All acute and chronic conditions that, in the opinion of the investigators, may cause bias.\n* Hospitalization for acute illness or major surgery in the last 6 months\n* Patients on stable therapy for less than 3 months\n* Allergy or intolerance to one or more components of the meal used in the protocol\n* Pregnancy or breastfeeding\n* Habitual consumption of alcoholic beverages (\\>20 g\u002Fday for females and \\>30 g\u002Fday for males) or unwillingness to abstain from alcoholic beverages during the study run-in period\n* All subjects who do not consent to participate in the study","ALL","50 Years","70 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","The aim of the study is to evaluate whether the Oral Fat Loading Test (OFLT) determines a different response in terms of the quantity, quality, and kinetics of triglyceride-rich lipoproteins in subjects with T2D, prediabetics, and control subjects, and whether triglyceride-rich lipoproteins and inflammatory cytokines after OFLT are potential early biomarkers of the risk of progression to diabetes and the development of complications in a general practice setting.\n\nTo address these questions, a hybrid cohort study was designed by identifying three groups of subjects: T2D and prediabetics (exposed and near-exposed) and control subjects (unexposed).",[25],"Prediabetes \u002F Type 2 Diabetes",[27,28,29,30,31,32],"Prediabetes, Type 2 diabetes","Oral Fat Load test","Tryglicerides","Cytokines","lipoproteins","VLDL","RECRUITING","2026-05-14",{"date":36,"type":37},"2026-05-22","ACTUAL",{"date":39,"type":37},"2024-05-14",{"date":41,"type":21},"2028-05-14",{"name":43,"class":44},"Angelina Passaro","OTHER",2,""]