[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Angitia Incorporated Limited\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100597753","phase-2-osteogenesis-imperfecta-trial-of-aga2115-for-adults-with-col1a1-andor-col1a2-genetic-variations-idun-100597753",false,"NCT07062588","Osteogenesis Imperfecta Trial of AGA2115 for ADUlts With COL1A1 and\u002For COL1A2 GeNetic Variations (IDUN)","A Phase 2, Multi-center, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study to Evaluate the Safety and Efficacy of AGA2115 in Adults With Type I, III, or IV Osteogenesis Imperfecta (OI)","IDUN","Inclusion Criteria:\n\n* Male or female adults (aged 18 to 75 years inclusive) with a clinical diagnosis of osteogenesis imperfecta Type I, III, or IV with documented genetic testing confirmation of genetic variations in the COL1A1 or COL1A2 genes\n* Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in the protocol\n* BMD T-score of ≤ -1.0 at the lumbar spine, total hip, or femoral neck\n\nExclusion Criteria:\n\n* Vitamin D deficiency\n* Concomitant uncontrolled diseases or conditions that could affect bone metabolism such as hypo-\u002Fhyperparathyroidism, hypo-\u002Fhyperthyroidism, abnormal thyroid function or thyroid disease, or other endocrine disorders\n* Current hyper- or hypocalcemia\n* History of rickets or osteomalacia or any skeletal condition (other than OI) leading to long-bone deformities and\u002For increased risk of fractures\n* Treatment with bisphosphonates within the past 6 months\n* Treatment with teriparatide, abaloparatide, strontium ranelate, or hormone replacement therapy within the past 12 months\n* Treatment with denosumab (or denosumab biosimilars) within the past 2 years\n* Treatment with anti-sclerostin antibody medications (romosozumab, setrusumab, blosozumab) at any time\n* History of myocardial infarction or stroke (or other cardiovascular associated event deemed significant) within the past 12 months\n* Malignancy within the last 5 years\n* Pregnant or breastfeeding women, or women planning to become pregnant during the study\n* Participation in any clinical study within the past 12 months during which the participant was administered any IP (participant must also agree not to enroll in any other clinical study concurrently in which IP is administered)","ALL","18 Years","75 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This study will determine the effect of treatment of AGA2115 in adults with Type I, III, or IV osteogenesis imperfecta versus placebo.",[28],"Osteogenesis Imperfecta (OI)","RECRUITING","2026-05-28",{"date":32,"type":33},"2026-05-29","ACTUAL",{"date":35,"type":33},"2025-12-12",{"date":37,"type":22},"2029-02",{"name":39,"class":40},"Angitia Incorporated Limited","INDUSTRY",27,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100620725","phase-1-a-phase-1-ethnobridging-trial-of-aga2118-in-healthy-japanese-chinese-and-caucasian-participants-atlas-100620725","NCT07361354","A Phase 1 Ethnobridging TriaL of AGA2118 in Healthy Japanese, Chinese, and Caucasian ParticipantS (ATLAS)","A Phase 1, Randomized, Open-Label, Single-Dose Study to Evaluate the Pharmacokinetics of AGA2118 in Healthy Japanese, Chinese, and Caucasian Participants","ATLAS","Inclusion Criteria:\n\n* Healthy males or females, aged 18 to 65 years\n* 25-hydroxyvitamin D ≥30 ng\u002FmL and agree to taking calcium and vitamin D supplements during the study\n* Meet the criteria for Japanese, Chinese, or Caucasian ethnicity\n\nExclusion Criteria:\n\n* Participating or have participated in another clinical trial within the past 6 months\n* Any bone fracture within the past 6 months\n* History of myocardial infarction or stroke within the past 12 months\n* Malignancy within the past 5 years\n* Current hyper- or hypocalcemia\n* Pregnant or breastfeeding women, or women planning to become pregnant during the study",true,"65 Years",{"count":53,"type":22},30,[55],"PHASE1","This study will evaluate the effects of a single dose of AGA2118 in Japanese, Chinese, and Caucasian participants",[58,59],"Healthy Participants","Pharmacokinetic Study",[61,62],"Ethnobridging","Healthy volunteer","2026-01-16",{"date":65,"type":33},"2026-01-23",{"date":67,"type":33},"2026-01-05",{"date":69,"type":22},"2026-11",{"name":39,"class":40},1,""]