[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ankara Etlik City Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":662},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,68,0,25,[9,45,76,108,134,159,186,216,246,268,303,327,348,370,392,410,435,462,484,518,530,560,585,608,635],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100053240","menstrual-status-anesthetic-consumption-and-ponv-100053240",false,"NCT07456202","Menstrual Status, Anesthetic Consumption, and PONV","Impact of Menstrual Phases and Menopause on Intraoperative Anesthetic Consumption and Postoperative Nausea and Vomiting: A Prospective Observational Study","Inclusion Criteria:\n\n* Female patients aged 18 to 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Age outside the specified range (younger than 18 or older than 65 years)\n* Male patients\n* American Society of Anesthesiologists (ASA) physical status ≥ IV\n* Severe systemic comorbidities (e.g., significant cardiovascular, hepatic, renal, or pulmonary disease)\n* Conversion from laparoscopic to open cholecystectomy\n* History of alcohol, drug, or substance abuse\n* Visual or hearing impairment interfering with study assessments\n* Current hormone replacement therapy\n* Use of oral contraceptives\n* Preoperative nausea or vomiting\n* History of severe postoperative nausea and vomiting\n* Neurological or psychiatric disorders affecting assessment reliability\n* Hemodynamic instability during surgery\n* Postoperative admission to intensive care unit\n* Acute cholecystitis at the time of surgery\n* Refusal to participate or inability to provide informed consent","FEMALE","18 Years","65 Years",{"count":21,"type":22},120,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study aims to evaluate the association between menstrual phase (determined by postoperative serum progesterone levels), intraoperative anesthetic consumption, and the incidence and severity of postoperative nausea and vomiting (PONV) in female patients undergoing cholecystectomy. Intraoperative anesthetic requirements will be recorded, and postoperative nausea and vomiting will be assessed using standardized scoring systems.",[26],"Menstrual Cycle",[28,29,30,31],"Anesthetic Consumption","Luteal Phase","Follicular Phase","Postoperative Nausea and Vomiting","RECRUITING","2026-07-10",{"date":35,"type":36},"2026-07-13","ACTUAL",{"date":38,"type":36},"2026-03-07",{"date":40,"type":22},"2026-08-16",{"name":42,"class":43},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":70,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":44},"100053415","blind-intubation-through-the-tulip-airway-versus-direct-laryngoscopy-100053415","NCT07681453","Blind Intubation Through the Tulip Airway Versus Direct Laryngoscopy","Comparison of Blind Endotracheal Intubation Through the Tulip Oropharyngeal Airway and Direct Laryngoscopy by Novice Operators: A Randomized Crossover Manikin Study","Inclusion Criteria:\n\n* Voluntary participation in the study\n* Anesthesia technician students with no prior airway management experience\n* Age ≥ 18 years\n* Willingness to participate in simulation-based intubation procedures\n\nExclusion Criteria:\n\n* Prior advanced airway management experience (e.g., regular intubation practice in clinical settings)\n* Refusal to participate or withdraw consent\n* Inability to complete simulation procedures for any reason",true,"ALL",{"count":55,"type":22},60,"INTERVENTIONAL",[58],"NA","This is a randomized crossover mannequin study comparing two airway management techniques in novice operators: blind endotracheal intubation via the Tulip oropharyngeal airway versus direct laryngoscopy. The study aims to evaluate and compare the success rate and performance characteristics of both methods under simulated conditions in order to assess their effectiveness in airway management training and practice.",[61],"Airway Management",[63,64,65,66,67,68,69],"Airway management","endotracheal intubation","Tulip airway","direct laryngoscopy","simulation study","crossover trial","anesthesia education",{"date":35,"type":36},{"date":72,"type":36},"2026-07-06",{"date":74,"type":22},"2026-08-10",{"name":42,"class":43},{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":53,"minAge":83,"maxAge":18,"enrollmentInfo":84,"targetDuration":4,"studyType":56,"phases":85,"briefSummary":86,"conditions":87,"keywords":92,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":44},"100645133","effect-of-endotracheal-tube-cuff-pressure-management-on-postoperative-sore-throat-in-pediatric-laparoscopic-appendectomy-100645133","NCT07678086","Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy","The Effect of Intraoperative Endotracheal Tube Cuff Pressure on Postoperative Sore Throat in Pediatric Patients Undergoing Laparoscopic Appendectomy: A Prospective Randomized Controlled Trial.","Inclusion Criteria:\n\n* Pediatric patients aged 6-18 years\n* Patients with ASA physical status classification I-III\n* Patients scheduled for laparoscopic appendectomy\n* Voluntary written informed consent from the patient's legal guardian\u002Fparent after being informed in detail about the purpose and method of the study..\n\nExclusion Criteria:\n\n* Patients under 6 years of age\n* Patients with ASA IV or higher\n* Patients with preoperative sore throat\n* Patients who have not completed the preoperative fasting period\n* Patients who received intraoperative nasogastric tube\n* Patients who received intraoperative N₂O\n* Patients with complicated appendicitis diagnosis\n* Patients who underwent two or more intubation attempts\n* Patients with surgery duration longer than 2 hours\n* Patients with predicted or likely airway difficulties\n* Patients who underwent conversion from intraoperative laparoscopy to laparotomy\n* Presence of tracheal pathology\n* Congenital anomalies affecting the airway\n* Presence of known upper\u002Flower respiratory tract disease\n* Patients requiring planned postoperative mechanical ventilation\n* Patients in shock\n* Patients with decompensated heart failure or respiratory failure\n* Patient or legal representative's refusal to participate in the study\n* Patients with a history of smoking","6 Years",{"count":55,"type":22},[58],"Abstract Objective:\n\nThe aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed surgery for appendicitis). The goal is to see if maintaining the pressure in this cushion within a safe, specific range (15-18 mmHg) helps prevent or reduce sore throat, hoarseness, and discomfort, which are common postoperative complications in children.\n\nStudy Design:\n\nThis is a prospective, randomized, controlled study. Sixty children aged 6 to 18 years scheduled for laparoscopic appendectomy will be included. Participants will be randomly assigned to two equal groups: Group A (Control Group): Breathing tube cuff pressure is adjusted using the standard \"feeling\" (finger palpation) method common in routine practice. Group B (Intervention Group): Breathing tube cuff pressure is measured throughout the surgery using a medical pressure sensor (manometer) and maintained within a safe range (15-18 mmHg). Research Questions: Does actively monitoring airway pressure reduce the number of children experiencing postoperative sore throat? Does this method reduce the severity of sore throat, cough, hoarseness, or other respiratory discomfort compared to the standard method? What will happen?\n\nDuring surgery, respiratory and heart rate measurements will be recorded every 15 minutes for all participants. After surgery, researchers will visit participants (and their parents) at 2, 6, and 24 hours postoperatively to assess the presence of sore throat, discomfort, or hoarseness. No additional medications or invasive procedures will be used for this study; only how we manage airway pressure will be compared.",[88,89,90,91],"Appendicitis Acute","Postoperative Sore Throat, Cough, Hoarseness","Airway Complications","Respiratory Complications",[93,94,95,96,97,63,98],"Endotracheal tube cuff pressure","Post-anesthetic complications","Pressure transducer","Laparoscopic appendectomy","Pediatric anesthesia","postoperative sore throat","NOT_YET_RECRUITING","2026-06-28",{"date":102,"type":36},"2026-07-01",{"date":104,"type":22},"2026-06-30",{"date":106,"type":22},"2026-08-25",{"name":42,"class":43},{"id":109,"slug":110,"hasResults":12,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":56,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":44},"100630497","efficacy-of-cognitive-behavioral-therapy-administered-in-patients-with-dyssynergic-defecation-100630497","NCT07488442","Efficacy of Cognitive Behavioral Therapy Administered in Patients With Dyssynergic Defecation","An Evaluation of the Efficacy of Cognitive Behavioral Therapy Administered in Conjunction With Pelvic Floor Exercises in Patients With Dyssynergic Defecation","Inclusion Criteria:\n\n1. A history of constipation lasting longer than one year\n2. Chronic constipation as defined by the Rome IV criteria\n3. Being between the ages of 18 and 55\n4. Findings consistent with dyssynergic defecation on anorectal manometry and balloon defecography\n5. Exclusion of organic and metabolic causes of chronic constipation\n\nExclusion Criteria:\n\n1. Active bowel disease\n2. Presence of an active anal fissure\n3. History of major abdominal surgery\n4. Presence of a neurological disorder\n5. Presence of a serious psychiatric disorder\n6. Use of medications that cause constipation","55 Years",{"count":117,"type":22},26,[58],"The aim of this study is to evaluate the effectiveness of cognitive-behavioral therapy when used in conjunction with lifestyle modifications and pelvic floor rehabilitation.",[121],"Dyssynergic Defaecation",[123,124,125],"Dyssynergic Defecation","Cognitive Behavioral Therapy","Pelvic Floor Rehabilitation","2026-06-16",{"date":128,"type":36},"2026-06-17",{"date":130,"type":36},"2026-03-30",{"date":132,"type":22},"2026-09-30",{"name":42,"class":43},{"id":135,"slug":136,"hasResults":12,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":56,"phases":144,"briefSummary":145,"conditions":146,"keywords":148,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":155,"startDateStruct":156,"completionDateStruct":157,"leadSponsor":158,"locationsCount":44},"100630498","effectiveness-of-video-based-or-written-pelvic-floor-education-in-postpartum-women-100630498","NCT07488455","Effectiveness of Video-Based or Written Pelvic Floor Education in Postpartum Women","An Evaluation of the Effectiveness of Video-Based or Written Pelvic Floor Education on Knowledge Levels and Pelvic Floor Function in Postpartum Women","Inclusion Criteria:\n\n1. Be between the ages of 18 and 45\n2. Single pregnancy\n3. Full-term delivery\n4. Be willing to participate in the study\n5. Be literate in Turkish\n\nExclusion Criteria:\n\n1. Presence of fecal or urinary incontinence prior to pregnancy\n2. Presence of neurological or orthopedic problems that could cause pelvic floor dysfunction\n3. Presence of psychiatric illness or cognitive impairment that makes it difficult to answer questions\n4. History of pelvic surgery\n5. History of high-risk pregnancy (preeclampsia, eclampsia, multiple pregnancy, etc.)","45 Years",{"count":143,"type":22},141,[58],"The aim of this study is to evaluate the effect of written or visual information provided outside of routine postpartum follow-up on pelvic floor knowledge and pelvic floor function in women during the postpartum period.",[147],"Postpartum Pelvic Floor Function and Symptoms",[149,150,151,152,153,154],"postpartum","knowledge","pelvic floor dysfunction","education","video-based","written",{"date":128,"type":36},{"date":130,"type":36},{"date":132,"type":22},{"name":42,"class":43},{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":56,"phases":169,"briefSummary":170,"conditions":171,"keywords":173,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":180,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":44},"100608566","comparison-of-effectiveness-of-low-dose-laser-and-transcutaneous-electrical-stimulation-in-hemiplegic-shoulder-100608566","NCT07203222","Comparison of Effectiveness of Low Dose Laser and Transcutaneous Electrical Stimulation in Hemiplegic Shoulder","Comparison of the Efficacy of Low-Dose Laser and Transcutaneous Electrical Nerve Stimulation in Subacute Hemiplegic Shoulder Pain, and the Effect of Treatments on Upper Extremity Function and Quality of Life","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* Patients with shoulder pain on the hemiplegic side \\*Mini mental state examination ≥ 25\n* History of stroke within the last 2 weeks to 6 months\n* Patients with shoulder pain scoring 40-100 points on the visual analogue scale (moderate to severe) will be included.\n\nExclusion Criteria:\n\n* Patients who refuse to provide written consent or attend follow-up visits\n* Being under 18 years of age\n* Patients with motor aphasia\n* Patients who have had a shoulder injection within the last 3 months\n* Patients who have undergone upper extremity botulinum toxin application within the last 6 months\n\n  \\*Pregnant women or those planning to become pregnant\n* Inflammatory rheumatic disease\n* Patients who have undergone shoulder injury and surgery prior to stroke\n* Patients with other conditions that could explain shoulder pain\n* Patients with complex regional pain syndrome\n* Patients with a history of epilepsy, pacemaker, or arrhythmia diagnosis\n* Malignancy\n* Diseases such as Alzheimer's or dementia that cause cognitive impairment -History of psychiatric disorders such as major depression or personality disorders\n* Alcohol and drug addiction","75 Years",{"count":168,"type":22},45,[58],"The primary aim of this study is to compare the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) and Low Level Laser Therapy (LLLT), which are analgesic modalities that play an important role in the treatment of this frequently encountered complication. The secondary aim of the study is to evaluate its effectiveness on upper extremity function, quality of life, sleep, and fatigue.",[172],"Hemiplegic Shoulder Pain",[174,175,176,177,178,179],"Hemiplegic shoulder pain","Low Dose Laser","TENS","Ultrasonographic evaluation","Upper extremity function","stroke",{"date":128,"type":36},{"date":182,"type":36},"2025-09-24",{"date":184,"type":22},"2026-08-31",{"name":42,"class":43},{"id":187,"slug":188,"hasResults":12,"nctId":189,"briefTitle":190,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":193,"minAge":18,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":197,"conditions":198,"keywords":204,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":44},"100643495","intraoperative-driving-pressure-and-postoperative-lung-ultrasound-score-in-robot-assisted-radical-prostatectomy-100643495","NCT07610824","Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Robot-Assisted Radical Prostatectomy","Evaluation of the Relationship Between Intraoperative Driving Pressure and Postoperative Lung Ultrasound Score in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria:\n\n* Male patients aged between 18 and 80 years.\n\nScheduled for elective robot-assisted laparoscopic radical prostatectomy.\n\nAmerican Society of Anesthesiologists (ASA) physical status I, II, or III.\n\nWillingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n\nSevere obstructive or restrictive pulmonary disease (e.g., severe COPD, uncontrolled asthma).\n\nBody Mass Index (BMI) \\> 35 kg\u002Fm\\^2.\n\nPre-existing severe lung pathology or active pulmonary infection.\n\nHemodynamic instability or severe cardiovascular disease (e.g., severe heart failure, recent myocardial infarction).\n\nRequirement for postoperative mechanical ventilation.\n\nEmergency surgery.","MALE","80 Years",{"count":196,"type":22},76,"The primary objective of this study is to evaluate the relationship between intraoperative driving pressure and postoperative lung ultrasound scores in patients undergoing robot-assisted laparoscopic radical prostatectomy. During this specific surgery, factors such as pneumoperitoneum and patient positioning can significantly affect respiratory mechanics. Postoperative lung condition will be objectively assessed using the lung ultrasound score (LUS). The findings may provide valuable insights for optimizing intraoperative mechanical ventilation strategies.",[199,200,201,202,203],"Mechanical Ventilation","Postoperative Pulmonary Complications (PPCs)","Prostatic Neoplams","Driving Pressure","Lung Ultrasonography Score",[205,206,207],"driving pressure","lung ultrasonography score","postoperative pulmonary comlications","2026-06-09",{"date":210,"type":36},"2026-06-11",{"date":212,"type":22},"2026-05-30",{"date":214,"type":22},"2026-09-15",{"name":42,"class":43},{"id":217,"slug":218,"hasResults":12,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":194,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":44},"100643633","comparison-of-m-tapa-and-external-oblique-intercostal-block-for-intraoperative-opioid-consumption-in-laparoscopic-cholecystectomy-100643633","NCT07595679","Comparison of M-TAPA and External Oblique Intercostal Block for Intraoperative Opioid Consumption in Laparoscopic Cholecystectomy","Comparison of M-TAPA and External Oblique Intercostal Plane Block on Intraoperative Analgesia and Opioid Consumption Guided by Skin Conductance Algesimeter in Laparoscopic Cholecystectomy","MTAPA-EOI","Inclusion Criteria:\n\n* Patients aged 18-80 years\n* ASA physical status I-III\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Patient refusal\n* Known allergy to local anesthetics\n* Chronic opioid use or opioid dependence\n* Neurological or psychiatric disorders affecting pain perception\n* Use of medications affecting autonomic nervous system activity, such as beta-blockers\n* Infection at the injection site\n* Coagulopathy or anticoagulant therapy\n* Pregnancy",{"count":225,"type":22},80,"This prospective observational study is designed to evaluate the effects of modified thoracoabdominal nerve block through perichondrial approach (M-TAPA) and external oblique intercostal (EOI) plane block on intraoperative analgesia and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. Abdominal wall blocks are widely used to improve perioperative analgesia; however, their impact on intraoperative opioid requirements when guided by objective nociception monitoring remains unclear.\n\nAll patients will receive standardized general anesthesia. Intraoperative analgesia will be guided using the Skin Conductance Algesimeter (SCA), which reflects sympathetic nervous system activity by measuring fluctuations in skin conductance. The SCA parameter \"peaks per second (PPS)\" will be used to assess nociceptive responses. Remifentanil infusion will be titrated according to SCA values to maintain adequate analgesia. Dose adjustments will be performed at predefined intervals, and changes will be considered valid only if sustained for a minimum duration.\n\nPatients will receive either M-TAPA or EOI block as part of routine clinical practice. The choice of block will not be influenced by the investigators, in accordance with the observational design of the study. Data will be collected prospectively during the intraoperative period and postoperative follow-up.\n\nThe primary outcome of the study is the time-weighted average intraoperative remifentanil infusion rate (µg\u002Fkg\u002Fmin). Secondary outcomes include total intraoperative remifentanil consumption (µg\u002Fkg), intraoperative hemodynamic parameters (heart rate and mean arterial pressure), frequency of deviations in SCA values from the target range, postoperative pain scores assessed using a numeric rating scale (NRS), time to first analgesic requirement, and total rescue analgesic consumption.\n\nPerioperative analgesia will be standardized. All patients will receive intravenous dexketoprofen toward the end of surgery as part of routine clinical practice. Rescue analgesia will be provided with intravenous dexketoprofen when clinically indicated. Additional outcomes include postoperative nausea and vomiting and perioperative complications.\n\nThis study aims to provide objective data on the opioid-sparing effects of different abdominal wall block techniques when intraoperative analgesia is guided by nociception monitoring. The findings may contribute to optimizing analgesic strategies and improving perioperative pain management in laparoscopic surgery.",[228,229],"Laparoscopic Cholecystectomy Surgery","Perioperative Analgesia",[231,232,233,234,235,236,237,238],"M-TAPA","External Oblique Intercostal Block","Abdominal Wall Block","Skin Conductance Algesimeter","Remifentanil","Opioid Consumption","Laparoscopic Cholecystectomy","Intraoperative Analgesia","2026-06-06",{"date":208,"type":36},{"date":242,"type":36},"2026-05-15",{"date":244,"type":22},"2026-09",{"name":42,"class":43},{"id":247,"slug":248,"hasResults":12,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":194,"enrollmentInfo":254,"targetDuration":4,"studyType":56,"phases":256,"briefSummary":257,"conditions":258,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":263,"startDateStruct":264,"completionDateStruct":265,"leadSponsor":267,"locationsCount":4},"100643126","comparison-of-90-and-120-arm-positions-in-costoclavicular-block-100643126","NCT07586670","Comparison of 90° and 120° Arm Positions in Costoclavicular Block","Effect of Arm Abduction Degree ( 90° vs. 120° ) on Block Onset Time and Block Success in Costoclavicular Brachial Plexus Block in Patients Undergoing Hand, Wrist and Forearm Surgery: A Prospective Randomized Controlled Trial","COSTO-RCT","Inclusion Criteria:\n\n* Patients aged between 18 and 80 years.\n* Patients scheduled for elective upper extremity surgery (hand, wrist, forearm).\n* Patients classified as ASA I-III.\n* Patients who provide informed consent after being informed about the study.\n\nExclusion Criteria:\n\n* History of previous surgery, scar tissue, tumor, or trauma that may alter brachial plexus anatomy.\n* Presence of infection, hematoma, severe edema, burn, or open wound at the block application site.\n* Known allergy to local anesthetics or other medications used in the study.\n* Coagulopathy, use of anticoagulants, or platelet count \\\u003C 100,000\u002Fmm³.\n* History of peripheral neuropathy, neurological deficit, cervical radiculopathy, or CRPS.\n* Pregnancy or breastfeeding.\n* Patients with BMI \\\u003C 18 kg\u002Fm².\n* Patients with BMI \\> 35 kg\u002Fm².\n* Severe cardiac, pulmonary, renal, or hepatic failure.\n* Mental retardation, communication difficulties, or lack of cooperation.\n* Deformity, amputation, or large mass in the surgical extremity that may interfere with sensorimotor assessment.\n* Preoperative significant sensory loss, motor weakness, or signs of neurological disease.\n* Severe anemia (Hb \\\u003C 9 g\u002FdL) or polycythemia (Hb \\> 18 g\u002FdL).\n* Psychiatric disorders, substance abuse, or any condition that may interfere with study compliance.",{"count":255,"type":22},106,[58],"The costoclavicular approach of the infraclavicular brachial plexus block is widely used for upper extremity surgeries due to its reliable anatomy and high success rates. Patient positioning, particularly the degree of arm abduction, may influence the spread of local anesthetic and the characteristics of the block. However, the optimal arm abduction angle during this procedure remains unclear.\n\nThis prospective randomized controlled trial aims to investigate the effect of two different arm abduction angles (90° and 120°) on block onset time and block success in patients undergoing hand, wrist, and forearm surgery under ultrasound-guided costoclavicular brachial plexus block.\n\nPatients will be randomly assigned to one of two groups according to the degree of arm abduction. The primary outcome is block onset time. Secondary outcomes include block success, sensory and motor block characteristics, perfusion index changes, hemodynamic parameters, readiness for surgery at 15 and 20 minutes, block performance time, need for additional anesthesia, postoperative neurological evaluation at 4 and 24 hours, complications, and patient satisfaction.\n\nThe findings of this study are expected to provide evidence on optimal patient positioning to improve the effectiveness and reliability of ultrasound-guided costoclavicular brachial plexus block.",[259,260,261,262],"Perfusion Index","Upper Extremity Surgery","Brachial Plexus Block","Regional Anaesthesia",{"date":208,"type":36},{"date":242,"type":22},{"date":266,"type":22},"2026-08-27",{"name":42,"class":43},{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":194,"enrollmentInfo":275,"targetDuration":4,"studyType":56,"phases":277,"briefSummary":278,"conditions":279,"keywords":285,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":297,"startDateStruct":298,"completionDateStruct":300,"leadSponsor":302,"locationsCount":44},"100643654","comparison-of-iv-analgesia-protocols-after-the-regional-blocks-effect-diminishes-in-thoracic-surgery-100643654","NCT07610408","Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery","Comparison of the Effectiveness of Intravenous Analgesia Protocols Used After the Duration of Block Action for Postoperative Pain Control in Thoracic Surgery","Inclusion Criteria:\n\n1. \\- Patients aged 18 to 80 years.\n2. \\- ASA (American Society of Anesthesiologists) Physical Status Score of I-III.\n3. \\- Body Mass Index (BMI) between 18 and 35 kg\u002Fm².\n4. \\- Undergoing elective thoracic surgery via Video-Assisted Thoracoscopic Surgery (VATS).\n5. \\- Voluntary participation confirmed by signing the written Informed Consent Form.\n\nExclusion Criteria:\n\n1. \\- Age below 18 or above 80 years.\n2. \\- Advanced organ failure (e.g., severe hepatic or renal impairment).\n3. \\- ASA physical status \\> III.\n4. \\- History of chronic pain treatment or long-term opioid use.\n5. \\- BMI \\\u003C 18 kg\u002Fm² or \\> 35 kg\u002Fm².\n6. \\- Pregnancy or breastfeeding.\n7. \\- Limited cooperation due to dementia or uncontrolled psychiatric disorders.\n8. \\- Communication barriers (inability to communicate in the native language).\n9. \\- History of substance or drug abuse.\n10. \\- Known allergy or contraindication to the study drugs (Fentanyl, Tramadol, or Ibuprofen).\n11. \\- Contraindication to regional block placement (e.g., infection at the injection site).",{"count":276,"type":22},135,[58],"The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory performance in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS). While regional blocks like Erector Spinae Plane (ESP) block provide effective early analgesia, their effect typically diminishes after 8-12 hours, leading to potential 'rebound pain.' This study specifically investigates the period following the duration of the regional block's action. The primary goal is to evaluate which IV PCA protocol better controls pain (Visual Analog Scale scores) and supports better respiratory performance (measured by incentive spirometry) during the first 72 hours post-surgery",[280,281,282,283,284],"Postoperative Pain After Thoracic Surgery","Postoperative Pain","Thoracic Surgery, Video Assisted","Patient Controlled Analgesia","Acute Pain",[286,287,288,289,290,291,292,293,294,295,296],"Video-Assisted Thoracoscopic Surgery","VATS","Erector Spinae Plane Block","ESP","Patient-Controlled Analgesia","PCA","IV analgesia","Incentive spirometry","Opioid-sparing","Postoperative pain after thoracic surgery","Rebound Pain",{"date":208,"type":36},{"date":299,"type":36},"2026-06-02",{"date":301,"type":22},"2026-10-15",{"name":42,"class":43},{"id":304,"slug":305,"hasResults":12,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":194,"enrollmentInfo":310,"targetDuration":4,"studyType":56,"phases":311,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":324,"leadSponsor":326,"locationsCount":44},"100640161","map--versus-cardiac-index-guided-hemodynamic-management-in-colorectal-surgery-100640161","NCT07609680","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Colorectal Surgery: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for colorectal surgery\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study",{"count":55,"type":22},[58],"This prospective randomized trial aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing colorectal surgery. Patients will be randomly assigned to receive either mean arterial pressure-guided or cardiac index-guided intraoperative hemodynamic management.\n\nColorectal surgery is a major abdominal procedure associated with prolonged operative times, significant fluid shifts, blood loss, and hemodynamic instability. These factors can contribute to impaired renal perfusion and subsequent postoperative renal dysfunction. Although mean arterial pressure is widely used to guide intraoperative hemodynamic management, blood pressure alone may not adequately reflect systemic blood flow or regional tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine levels from the preoperative baseline to 72 hours postoperatively. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, intensive care unit (ICU) and hospital length of stay, and 30-day mortality.",[314,315],"Colorectal Cancer","Intraoperative Hemodynamic Management",[317,318,319,320],"Colorectal surgery","Cardiac index","Mean arterial pressure","Hemodynamic management",{"date":322,"type":36},"2026-06-03",{"date":299,"type":36},{"date":325,"type":22},"2027-12-28",{"name":42,"class":43},{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":19,"enrollmentInfo":333,"targetDuration":4,"studyType":56,"phases":334,"briefSummary":335,"conditions":336,"keywords":340,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":343,"startDateStruct":344,"completionDateStruct":345,"leadSponsor":347,"locationsCount":44},"100626942","comparison-of-postoperative-analgesic-effects-of-quadro-iliac-plane-block-and-transversus-abdominis-plane-blocks-in-inguinal-hernia-surgery-100626942","NCT07442188","Comparison of Postoperative Analgesic Effects of Quadro-iliac Plane Block and Transversus Abdominis Plane Blocks in Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I-III.\n* Patients with a body mass index (BMI) between 18 and 30 kg\u002Fm².\n* Patients scheduled to undergo unilateral inguinal hernia repair under general anesthesia in the operating room.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 65 years.\n* Patients with an ASA physical status classification of IV or higher.\n* Patients with advanced comorbidities.\n* Patients with a history of bleeding diathesis.\n* Patients with infection at the site of the planned procedure.\n* Patients with a BMI below 18 kg\u002Fm² or above 30 kg\u002Fm².",{"count":55,"type":22},[58],"Inguinal hernia repair is one of the most commonly performed surgical procedures worldwide. Despite being classified as a minor surgical intervention, moderate to severe postoperative pain is reported in approximately 60% of patients. In a subset of these patients, acute postoperative pain may persist and evolve into chronic post-surgical inguinal pain, significantly affecting quality of life.\n\nIn recent years, beyond the use of systemic intravenous analgesics, ultrasound-guided fascial plane blocks have been increasingly incorporated into multimodal analgesia protocols with the aim of reducing postoperative opioid consumption and improving pain control. However, the current literature does not provide definitive evidence regarding the superiority of one block technique over another in this surgical population.\n\nThe primary objective of the present study is to compare the analgesic efficacy of the Quadro-iliac Plane Block (QIPB) and the transversus abdominis plane block (TAPB) in patients undergoing inguinal hernia repair.",[337,338,339],"Peripheral Nerve Block","Pain Management","Hernia, Inguinal",[341,342],"Quadro Iliac Plane Block","Transversus Abdominis Plane Block",{"date":322,"type":36},{"date":299,"type":36},{"date":346,"type":22},"2026-10-19",{"name":42,"class":43},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":19,"enrollmentInfo":355,"targetDuration":4,"studyType":56,"phases":356,"briefSummary":357,"conditions":358,"keywords":360,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":367,"leadSponsor":369,"locationsCount":44},"100639262","flow-controlled-versus-volume-controlled-ventilation-in-lumbar-disc-herniation-surgery-100639262","NCT07614555","Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery","Comparison of Flow-Controlled and Volume-Controlled Ventilation During Lumbar Disc Herniation Surgery: A Prospective Randomized Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* ASA physical status I-III\n* Body Mass Index between 18 and 30 kg\u002Fm²\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or \\> 65 years\n* Known or previously diagnosed pulmonary disease\n* Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ \\\u003C 50% predicted, severe restrictive or obstructive pathology)\n* Patients with markedly altered lung anatomy or function due to prior major thoracic surgery\n* Patients who were dependent on supplemental oxygen therapy in the preoperative period\n* ASA physical status IV or higher\n* Refusal or inability to provide informed consent",{"count":225,"type":22},[58],"This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc herniation surgery under general anesthesia.\n\nAdult patients aged 18-65 years, with ASA physical status I-III and a body mass index of 18-30 kg\u002Fm², will be allocated to receive either FCV or VCV during routine intraoperative mechanical ventilation. Ventilatory parameters, including peak airway pressure, plateau pressure, pulmonary compliance, EtCO₂, SpO₂, and arterial blood gas variables, will be recorded at predefined time points after intubation.\n\nThe primary endpoint is the PaO₂ value measured after 20 minutes in the prone position.\n\nBy comparing respiratory mechanics and oxygenation between the two ventilation modes, this study aims to contribute to the optimization of intraoperative ventilatory management in lumbar disc herniation surgery.",[359,199],"Lumbar Disc Herniation Surgery",[361,362,359],"Flow-Controlled Ventilation","Volume-Controlled Ventilation","2026-05-28",{"date":365,"type":36},"2026-06-01",{"date":363,"type":36},{"date":368,"type":22},"2026-11-26",{"name":42,"class":43},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":19,"enrollmentInfo":377,"targetDuration":4,"studyType":56,"phases":378,"briefSummary":379,"conditions":380,"keywords":382,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":389,"leadSponsor":391,"locationsCount":44},"100638017","comparison-of-analgesic-effects-of-acb-versus-acb-combined-with-bifes-block-in-meniscopathy-surgery-100638017","NCT07603323","Comparison of Analgesic Effects of ACB Versus ACB Combined With BiFeS Block in Meniscopathy Surgery","Comparison of Analgesic Effects of Adductor Canal Block Versus Adductor Canal Block Combined With BiFeS (Biceps Femoris Short Head) Block in Meniscopathy Surgery","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) score I-II-III\n* Body Mass Index (BMI) between 18-30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patients under 18 and over 65 years of age\n* ASA score IV and above\n* Patients with a history of bleeding diathesis\n* BMI below 18 or above 30 kg\u002Fm2",{"count":276,"type":22},[58],"Meniscopathy surgeries are commonly associated with moderate postoperative pain, particularly during early mobilization and rehabilitation. Inadequate postoperative analgesia may negatively affect functional recovery, delay ambulation, increase opioid consumption, and contribute to opioid-related adverse effects. Therefore, effective multimodal analgesic strategies are of considerable importance in patients undergoing arthroscopic knee procedures.\n\nAdductor canal block (ACB) is a widely used regional anesthesia technique that provides effective analgesia while largely preserving quadriceps muscle strength. However, its limited effect on posterior knee capsule innervation may result in insufficient control of posterior knee pain. Recently, the biceps femoris short head (BiFeS) block has been described as a novel motor-sparing fascial plane block targeting the posterolateral knee capsule and may provide additional analgesic benefit when combined with ACB.\n\nIn this study, it was aimed to compare the postoperative analgesic efficacy of adductor canal block alone and adductor canal block combined with BiFeS block in patients undergoing surgery for meniscopathy.",[381,337,338],"Meniscopathy Surgery",[381,383,384],"Adductor Canal Block","Biceps Femoris Short Head Block","2026-05-27",{"date":387,"type":36},"2026-05-29",{"date":385,"type":36},{"date":390,"type":22},"2027-05-21",{"name":42,"class":43},{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":194,"enrollmentInfo":399,"targetDuration":4,"studyType":56,"phases":400,"briefSummary":401,"conditions":402,"keywords":404,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":406,"startDateStruct":407,"completionDateStruct":408,"leadSponsor":409,"locationsCount":44},"100638458","map--versus-cardiac-index-guided-hemodynamic-management-in-whipple-surgery-100638458","NCT07603336","MAP- Versus Cardiac Index-Guided Hemodynamic Management in Whipple Surgery","Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Pancreaticoduodenectomy: A Prospective Randomized Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with American Society of Anesthesiologists physical status II-III\n* Patients with estimated glomerular filtration rate ≥60 mL\u002Fmin\u002F1.73 m²\n* Patients scheduled for pancreaticoduodenectomy \u002F Whipple procedure\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 80 years\n* Patients with estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients with American Society of Anesthesiologists physical status other than II-III\n* Patients who refuse to participate in the study\n* Patients who withdraw consent at any stage of the study",{"count":55,"type":22},[58],"This prospective randomized study aims to compare the effects of two intraoperative hemodynamic management strategies on early postoperative renal function in patients undergoing pancreaticoduodenectomy. Patients will be allocated to either mean arterial pressure-guided hemodynamic management or cardiac index-guided hemodynamic management during surgery.\n\nPancreaticoduodenectomy is a major abdominal surgical procedure associated with prolonged operative duration, considerable fluid shifts, blood loss, and hemodynamic instability. These factors may contribute to impaired renal perfusion and postoperative renal dysfunction. Although mean arterial pressure is commonly used to guide intraoperative hemodynamic management, blood pressure alone may not fully reflect systemic blood flow or tissue perfusion. Cardiac index-guided management may provide a more direct assessment of global circulatory adequacy.\n\nThe primary outcome of the study is the change in serum creatinine level from the preoperative baseline value to the postoperative 72nd hour. Secondary outcomes include intraoperative hemodynamic variables, fluid and vasopressor requirements, urine output, postoperative renal function parameters, length of intensive care unit and hospital stay, and 30-day mortality.",[403,315],"Whipple Procedure",[405,318,319,320],"Whipple procedure",{"date":363,"type":36},{"date":385,"type":36},{"date":325,"type":22},{"name":42,"class":43},{"id":411,"slug":412,"hasResults":12,"nctId":413,"briefTitle":414,"officialTitle":415,"acronym":4,"eligibilityCriteria":416,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":19,"enrollmentInfo":417,"targetDuration":4,"studyType":56,"phases":419,"briefSummary":420,"conditions":421,"keywords":423,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":44},"100631603","recto-intercostal-fascial-plane-block-in-cholecystectomy-100631603","NCT07502833","Recto-intercostal Fascial Plane Block in Cholecystectomy","Recto-intercostal Fascial Plane Block Reduces Intraoperative Opioid and Volatile Anesthetic Use: a Randomized Trial in Cholecystectomy","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Known allergy to local anesthetics\n* Coagulopathy or anticoagulant therapy\n* Infection at the injection site\n* Body weight less than 75 kg\n* Severe hepatic or renal dysfunction\n* Pregnancy or breastfeeding",{"count":418,"type":22},64,[58],"This study aims to evaluate whether an ultrasound-guided recto-intercostal fascial plane block performed before surgical incision in patients undergoing laparoscopic cholecystectomy reduces intraoperative opioid and volatile anesthetic consumption. Additionally, the study assesses its effects on postoperative pain and the incidence of nausea and vomiting.",[338,422],"Recto Intercostal Nerve Block",[424,425,426,427],"cholecystektomy","rectointercostal facial plane block","opioid consumption","postoperative pain","2026-05-23",{"date":385,"type":36},{"date":431,"type":36},"2026-01-03",{"date":433,"type":22},"2026-05-25",{"name":42,"class":43},{"id":436,"slug":437,"hasResults":12,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":442,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":444,"conditions":445,"keywords":448,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":44},"100638126","cortisol-levels-and-mortality-in-septic-shock-icu-patients-100638126","NCT07582926","Cortisol Levels and Mortality in Septic Shock ICU Patients","Prognostic Value of Cortisol Levels in Critically Ill Patients With Sepsis and Septic Shock: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age 18 years or older\n* Admission to the intensive care unit for more than 24 hours\n* Presence of a clinically or microbiologically confirmed source of infection\n* Diagnosis of sepsis or septic shock during ICU stay\n\nExclusion Criteria:\n\n* Pregnancy\n* Known disorders of the hypothalamic-pituitary-adrenal (HPA) axis\n* Known disorders affecting cortisol secretion 4.Long-term systemic glucocorticoid use (≥3 months)",{"count":443,"type":22},183,"This prospective observational study aims to evaluate the prognostic value of cortisol levels and their dynamic changes in critically ill patients with sepsis and septic shock admitted to the intensive care unit. Cortisol plays a crucial role in maintaining hemodynamic stability and modulating the inflammatory response during critical illness, and relative adrenal insufficiency has been associated with worse clinical outcomes.\n\nAdult patients admitted to the intensive care unit with sepsis or septic shock will be enrolled and followed prospectively. Serum cortisol levels will be measured, and their association with clinical outcomes, including intensive care unit mortality, 28-day mortality, and 90-day mortality, will be analyzed. In addition, the relationship between cortisol levels and disease severity scores such as SOFA and APACHE, as well as laboratory parameters including inflammatory biomarkers, will be evaluated.\n\nThe findings of this study are expected to contribute to the early identification of high-risk patients and improve prognostic assessment in critically ill patients with sepsis and septic shock.",[446,447],"Sepsis","Septic Shock",[449,450,451,452,453],"sepsis","septic shock","cortisol","mortality","intensive care unit","2026-05-14",{"date":456,"type":36},"2026-05-18",{"date":458,"type":22},"2026-05-01",{"date":460,"type":22},"2026-12-01",{"name":42,"class":43},{"id":463,"slug":464,"hasResults":12,"nctId":465,"briefTitle":466,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":19,"enrollmentInfo":469,"targetDuration":4,"studyType":56,"phases":471,"briefSummary":472,"conditions":473,"keywords":475,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":477,"lastUpdatePostDateStruct":478,"startDateStruct":480,"completionDateStruct":481,"leadSponsor":483,"locationsCount":44},"100634618","comparison-of-the-analgesic-effects-of-tfpb-in-renal-transplantation-surgery-100634618","NCT07542028","Comparison of the Analgesic Effects of TFPB in Renal Transplantation Surgery","Comparison of the Analgesic Effects of Transversalis Fascia Plane Block in Renal Transplantation Surgery","Inclusion Criteria:\n\n* Patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) score III\n* Body Mass Index (BMI) between 18-30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Patients under 18 and over 65 years of age\n* Patients with an ASA score other than III\n* Patients with a history of bleeding diathesis\n* BMI below 18 or above 30 kg\u002Fm2",{"count":470,"type":22},50,[58],"Renal transplantation is a major surgical procedure associated with significant postoperative pain, particularly due to lower abdominal incision, deep tissue dissection, and extensive surgical manipulation. Effective postoperative pain control is therefore of great importance in this patient population, as inadequate analgesia may impair early mobilization, delay recovery, increase opioid consumption, and contribute to opioid-related adverse effects. In addition, optimal analgesic management may improve patient comfort and support enhanced postoperative outcomes.\n\nNerve blocks reduces opioid consumption in the postoperative period by providing better pain control and therefore has advantages such as fewer side effects and less risk of pulmonary and cardiac complications.\n\nIn this study; it was aimed to compare the analgesic effectiveness of transversalis fascia plane block in the postoperative period in patients who underwent renal transplantation.",[474,337,338],"Renal Transplantation",[474,476],"Transversalis Fascia Plane Block","2026-04-27",{"date":479,"type":36},"2026-04-28",{"date":477,"type":36},{"date":482,"type":22},"2027-10-18",{"name":42,"class":43},{"id":485,"slug":486,"hasResults":12,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":490,"eligibilityCriteria":491,"healthyVolunteers":12,"sex":193,"minAge":18,"maxAge":4,"enrollmentInfo":492,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":494,"conditions":495,"keywords":497,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":511,"lastUpdatePostDateStruct":512,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":516,"locationsCount":517},"100606866","quality-of-life-functional-and-cognitive-outcomes-in-patients-with-metastatic-hormone-sensitive-prostate-cancer-100606866","NCT07181122","Quality of Life, Functional and Cognitive Outcomes in Patients With Metastatic Hormone-Sensitive Prostate Cancer","Prospective Observational Evaluation of Quality of Life, Functional Status, and Cognitive Outcomes in Patients With Metastatic Hormone-Sensitive Prostate Cancer Undergoing Androgen Receptor Pathway Inhibitor Therapy","PRO-MIND","Inclusion Criteria:\n\n* Age ≥18 years\n* Histologically or cytologically confirmed metastatic hormone-sensitive prostate cancer (mHSPC)\n* Planned initiation of androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor (abiraterone, apalutamide, or enzalutamide) as part of routine clinical care\n* Ability to complete patient-reported outcome questionnaires (FACT-Cog, FACT-F, PHQ-9, PSQI)\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Prior systemic therapy for metastatic prostate cancer (except ≤3 months of ADT)\n* Known history of severe cognitive impairment that precludes completion of questionnaires\n* Concurrent active malignancy requiring systemic treatment\n* Inability to comply with study procedures or follow-up\n* Any condition judged by the investigator to compromise participation or data integrity",{"count":493,"type":22},102,"This prospective observational study will evaluate quality of life, functional status, and cognitive outcomes in men with metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen receptor pathway inhibitors (ARPIs) in addition to standard androgen deprivation therapy. ARPIs in this study include abiraterone acetate, apalutamide, enzalutamide, and darolutamide, depending on local availability. A total of 102 patients will be enrolled from two academic oncology centers in Türkiye.\n\nParticipants will be assessed at baseline, 3 months, and 6 months using validated Turkish versions of established questionnaires: Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Functional Assessment of Cancer Therapy-Fatigue (FACT-F), Patient Health Questionnaire-9 (PHQ-9), and Pittsburgh Sleep Quality Index (PSQI). Clinical parameters, ECOG performance status, routine laboratory results, and treatment-related adverse events will also be recorded.\n\nThe primary outcomes are longitudinal changes in FACT-Cog and FACT-F scores. Secondary outcomes include changes in depression, sleep quality, laboratory results, and adverse events. This study will provide real-world evidence on how ARPI therapy affects cognitive health and quality of life in patients with mHSPC.",[496],"Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)",[498,499,500,501,502,503,504,505,506,507,508,509,510],"Prostate cancer","mHSPC","Androgen receptor pathway inhibitors","Abiraterone","Apalutamide","Enzalutamide","Darolutamide","Quality of life","Cognitive function","Fatigue","Depression","Sleep quality","Patient-reported outcomes","2026-04-26",{"date":479,"type":36},{"date":514,"type":36},"2025-10-22",{"date":214,"type":22},{"name":42,"class":43},2,{"id":519,"slug":4,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":520,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":521,"keywords":522,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":527,"leadSponsor":529,"locationsCount":44},"100628020",{"count":21,"type":22},[26],[28,29,30,31],"2026-04-25",{"date":525,"type":36},"2026-04-30",{"date":38,"type":36},{"date":528,"type":22},"2026-06-15",{"name":42,"class":43},{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":52,"sex":53,"minAge":537,"maxAge":538,"enrollmentInfo":539,"targetDuration":540,"studyType":23,"phases":4,"briefSummary":541,"conditions":542,"keywords":547,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":552,"lastUpdatePostDateStruct":553,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":44},"100633151","comparison-of-two-airway-devices-i-gel-and-air-q-in-children-aged-1-10-years-during-general-anesthesia-100633151","NCT07522957","Comparison of Two Airway Devices (I-Gel and Air-Q) in Children Aged 1-10 Years During General Anesthesia","Effect of I-gel and Air-Q SP LMAs on Oropharyngeal Leak Pressure and Gastric Insufflation in Children: An Ultrasonography-Guided Randomized Study","Inclusion Criteria:\n\n* Children aged 1-10 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective (non-emergency) surgery under general anesthesia\n* Planned use of a supraglottic airway device for airway management\n* Written informed consent obtained from a parent or legal guardian\n\nExclusion Criteria:\n\n* History of conditions associated with increased risk of aspiration (e.g., gastroesophageal reflux)\n* Known or predicted difficult airway (e.g., Mallampati score ≥ 3)\n* Congenital or acquired abnormalities of the face, neck, or upper airway\n* Active upper respiratory tract infection\n* Presence of significant pulmonary disease (e.g., asthma, bronchopulmonary dysplasia, cystic fibrosis)\n* Body mass index above the 95th percentile for age (morbid obesity)\n* Emergency surgery\n* Previous complications related to supraglottic airway device use\n* Failure of device placement or need to switch to an alternative airway management technique\n* Refusal of participation by parent or legal guardian","1 Year","10 Years",{"count":55,"type":22},"1 Day","This study aims to compare two commonly used airway devices (I-gel and Air-Q) in children aged 1-10 years undergoing general anesthesia for surgery. These devices help doctors keep the airway open and support breathing during the operation. The study will evaluate how well each device works, how easy they are to place, and whether they cause air to enter the stomach. Ultrasound will be used to safely check the position of the device and detect any air in the stomach. The results of this study may help improve the safety and effectiveness of airway management in children during anesthesia.",[543,544,545,61,546],"Anesthesia General","Ultrasonography","Laryngeal Mask Airways","Child",[63,548,549,544,550,551],"Laryngeal mask airway","Pediatric patients","Gastric insufflation","Supraglottic airway devices","2026-04-21",{"date":554,"type":36},"2026-04-23",{"date":556,"type":22},"2026-04",{"date":558,"type":22},"2026-05",{"name":42,"class":43},{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":565,"acronym":4,"eligibilityCriteria":566,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":567,"enrollmentInfo":568,"targetDuration":4,"studyType":56,"phases":570,"briefSummary":571,"conditions":572,"keywords":574,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":578,"startDateStruct":580,"completionDateStruct":582,"leadSponsor":584,"locationsCount":44},"100627666","effectiveness-of-tms-on-spasticity-and-balance-for-patients-with-ms-100627666","NCT07451600","Effectiveness of TMS on Spasticity and Balance for Patients With MS","The Effect of Transcranial Magnetic Stimulation on Spasticity and Balance in Patients Diagnosed With Multiple Sclerosis","Inclusion Criteria:\n\n* Being between the ages of 18 and 60\n* Having been diagnosed with multiple sclerosis for more than six months\n* Having spasticity levels between 1 and 3 on the Modified Ashworth Scale (MAS) in the evaluated extremity\n* Having an EDSS SCORE between 0 and 6.5\n* Voluntarily participating in the study\n\nExclusion Criteria:\n\n* Poor general health (heart failure, COPD, etc.)\n* Presence of wound lesions on the skin\n* Presence of metal implants in the body\n* Pregnancy\n* Presence of a severe infection\n* Diagnosis of malignancy\n* Presence of a bleeding disorder\n* Use of a pacemaker\n* Presence of cardiac rhythm disorder\n* Presence of neurological disease other than multiple sclerosis\n* History of epilepsy\n* History of alcohol use\n* Change in medication within the last 6 months\n* Refusal to participate in the study","60 Years",{"count":569,"type":22},24,[58],"Recently, non-invasive brain stimulation modalities such as transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation have become treatment options. Among these methods, rTMS is a non-invasive brain stimulation technique that can affect descending corticospinal pathways, thereby modulating cortical excitability in the motor area where it is applied. This study will examine the effect of rTMS application on spasticity and balance in patients with multiple sclerosis. In addition, the indirect effects of the applications on gait pattern, joint range of motion, and pain will be evaluated.",[573],"Multiple Sclerosis",[573,575,576,577],"TMS","Spasticity","Balance",{"date":579,"type":36},"2026-04-03",{"date":581,"type":36},"2026-03-01",{"date":583,"type":22},"2026-11-30",{"name":42,"class":43},{"id":586,"slug":587,"hasResults":12,"nctId":588,"briefTitle":589,"officialTitle":590,"acronym":4,"eligibilityCriteria":591,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":592,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":607,"locationsCount":44},"100611136","deep-learning-for-musculoskeletal-complications-in-breast-cancer-100611136","NCT07236658","Deep Learning for Musculoskeletal Complications in Breast Cancer","AI-Powered Deep Learning Models for Prospective Prediction of Musculoskeletal Complications After Breast Cancer Surgery: Focus on Lymphedema, Axillary Web Syndrome, Neuropathy, and Pain","Inclusion Criteria:\n\nFemale sex Age ≥18 years Scheduled for surgery due to unilateral breast cancer\n\nExclusion Criteria:\n\nInability to comply with follow-up visits Bilateral breast cancer Male breast cancer Children (\\\u003C18 years) Pregnant women Postpartum women Breastfeeding women Individuals in intensive care Impaired consciousness Legally incapacitated individuals",{"count":593,"type":22},133,"Survival after breast cancer has increased due to early diagnosis and advances in treatment methods. Musculoskeletal problems related to cancer and its treatment constitute a significant part of the daily practice of physiatrists and rehabilitation specialists involved in oncological rehabilitation.\n\nLymphedema can occur at any stage of a patient's life following breast cancer. Patients with breast cancer-related lymphedema require lifelong treatment, and as the stage of lymphedema progresses, response to therapy decreases. Advanced stages of lymphedema negatively affect functional status, and patients experience difficulties in performing activities of daily living.\n\nAxillary web syndrome (AWS) is characterized by a taut cord extending from the axilla to the volar surface of the wrist, typically appearing within the first 8 weeks postoperatively. AWS can complicate the administration of radiotherapy. Shoulder dysfunction may occur independently or in association with AWS. In particular, scapular dyskinesis developing after mastectomy can lead to secondary shoulder conditions such as rotator cuff syndrome or adhesive capsulitis, which are commonly observed in these patients.\n\nPeripheral neuropathy is frequently seen in patients receiving chemotherapy, adversely affecting daily life and sometimes preventing continuation of treatment. Other complications related to chemotherapy and radiotherapy include cardiotoxicity, pulmonary toxicity, fatigue, osteoporosis, and cognitive impairment.\n\nThere are also specific painful syndromes that may occur after breast cancer, including post-mastectomy pain syndrome, phantom breast pain, and musculoskeletal symptoms associated with aromatase inhibitors. All these conditions can significantly impair daily functioning and even hinder continuation of cancer treatment. Therefore, predicting these complications and implementing or developing preventive interventions is crucial.\n\nIf it is possible to predict the early development of lymphedema, axillary web syndrome, peripheral neuropathy, and painful syndromes after breast cancer, early intervention may prevent progression. This study is designed to develop and validate a predictive model using deep learning methods to determine the risk of these complications in patients undergoing breast cancer surgery. Among deep learning architectures, ResNet50, AlexNet, GoogleNet, and UNet, which have been widely used in recent studies, are planned to be implemented.\n\nAdditionally, based on the results of this study, a risk calculation program will be developed, allowing clinicians to input baseline patient data and calculate the individual patient's risk for each complication prior to treatment. No specific risk is expected in the study.",[596,597,598,599,600],"Postmastectomy Lymphedema Syndrome","Breast Cancer Surgery Pain","Osteoporosis Secondary","Shoulder Adhesive Capsulitis","Axillary Web Syndrome",{"date":602,"type":36},"2026-03-31",{"date":604,"type":36},"2025-07-01",{"date":606,"type":22},"2027-01-01",{"name":42,"class":43},{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":616,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":618,"conditions":619,"keywords":623,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":628,"lastUpdatePostDateStruct":629,"startDateStruct":631,"completionDateStruct":632,"leadSponsor":634,"locationsCount":4},"100629267","multimodal-approach-in-the-diagnosis-of-septic-aki-100629267","NCT07472452","MULTIMODAL APPROACH IN THE DIAGNOSIS OF SEPTIC AKI","A MULTIMODAL APPROACH TO PREDICTING SEPSIS-RELATED ACUTE RENAL INJURY: A PROSPECTIVE COHORT STUDY","SEPTIC AKI","Inclusion Criteria:\n\n* Adults ≥18 years\n* Diagnosis of sepsis (per Sepsis-3 clinical criteria)\n* RRI measurement feasible at bedside\n* Informed consent from participant or legally authorized representative\n\nExclusion Criteria:\n\n* End-stage kidney disease (chronic dialysis) or baseline eGFR \\\u003C15mL\u002Fmin\u002F1.73 m²\n* Kidney transplant recipient\n* Anatomic\u002Ftechnical barrier precluding reliable renal Doppler (RRI) assessment\n* Pregnancy",{"count":617,"type":22},130,"In recent studies, it has been reported that the renal resistance index is effective in detecting sepsis-related acute renal failure (SA-AKI) in the early period. Similarly, urinary biomarkers \\[TIMP-2\\]\\*\\[IGFBP-7\\], released in response to tubular epithelial cell stress, have been reported to indicate the presence of acute renal injury (AKI) early on, before functional loss occurs (increased creatinine). This observational study aims to evaluate the renal resistance index and urinary biomarker variation in patients diagnosed with sepsis and to investigate their usefulness in the early detection of renal dysfunction that may develop after sepsis.",[620,446,621,622],"Acute Kidney Injury","Critical Illness","Renal Resistive Index",[624,625,626,446,627],"Renal Resistive Index (RRI)","Cell Cycle Arrest Biomarkers","Intensive Care Units","Sepsis-Associated AKI","2026-03-13",{"date":630,"type":36},"2026-03-16",{"date":130,"type":22},{"date":633,"type":22},"2027-01-30",{"name":42,"class":43},{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":640,"acronym":4,"eligibilityCriteria":641,"healthyVolunteers":12,"sex":53,"minAge":18,"maxAge":4,"enrollmentInfo":642,"targetDuration":4,"studyType":56,"phases":644,"briefSummary":645,"conditions":646,"keywords":648,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":44},"100627188","transdiscal-vs-paravertebral-neurolytic-splanchnic-nerve-block-for-upper-abdominal-cancer-pain-100627188","NCT07445386","Transdiscal vs Paravertebral Neurolytic Splanchnic Nerve Block for Upper Abdominal Cancer Pain","Comparison of Transdiscal and Paravertebral Approaches for Neurolytic Splanchnic Nerve Block in the Treatment of Upper Abdominal Cancer Pain","Inclusion Criteria:\n\n* Severe abdominal pain (NRS \\> 6) due to upper intra-abdominal organ malignancies (such as gastric, pancreatic, or hepatic cancer).\n* Failure of pain control with conservative treatment modalities.\n\nExclusion Criteria:\n\n* Presence of local anatomical variations\n* Localized or systemic infection involving the procedural site\n* Pregnancy\n* Coagulopathy\n* Presence of unstable psychiatric disorders",{"count":643,"type":22},56,[58],"This study aims to compare the efficacy of fluoroscopy-guided paravertebral (PV) and transdiscal (TD) approaches for splanchnic nerve neurolysis in patients with upper abdominal cancer-related pain (e.g., gastric, pancreatic, and hepatic malignancies). Treatment response will be assessed using the Numerical Rating Scale (NRS), and the impact of both techniques on quality of life will be evaluated with the EORTC QLQ-C30 questionnaire.",[647],"Cancer Pain",[649,650,651,652,653],"Splanchnic Nerves","Nerve Block","Abdominal Pain","Pancreatic Neoplasms","Liver Neoplasms","2026-02-25",{"date":656,"type":36},"2026-03-03",{"date":658,"type":36},"2026-02-16",{"date":660,"type":22},"2026-09-16",{"name":42,"class":43},""]