[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Aquilo Sports, LLC\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":40},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":5},"100642091","home-based-lower-extremity-heat-therapy-for-walking-function-in-peripheral-artery-disease-100642091",false,"NCT07653243","Home-Based Lower-Extremity Heat Therapy for Walking Function in Peripheral Artery Disease","A Randomized, Sham-Controlled Trial of Home-Based Lower-Extremity Heat Therapy in Adults With Peripheral Artery Disease","Inclusion Criteria:\n\n* Men and women older than 50 years of age\n* Resting ankle-brachial index (ABI) of \\\u003C0.9 but \\>0.4 in at least one leg\n\nExclusion Criteria:\n\n* Critical limb ischemia (ischemic rest pain or ischemia-related, non-healing wounds or tissue loss\n* Prior amputation\n* Exercise-limiting comorbidity\n* Recent (\\\u003C3 months) lower-extremity revascularization or orthopedic surgery\n* Use of walking aid other than a cane\n* Active treatment for cancer\n* Chronic kidney disease (eGFR \\\u003C30 by MDRD or Mayo or Cockcroft-Gault formula)\n* Class 2 or 3 obesity (BMI ≥ 35 kg\u002Fm2)\n* Unable to fit into water-circulating trousers","ALL","50 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","Lower-extremity peripheral artery disease is associated with impaired walking ability, reduced lower-extremity function, and decreased quality of life. This randomized, sham-controlled clinical trial will evaluate the effects of 12 weeks of home-based lower-extremity heat therapy on walking function and mobility in adults with peripheral artery disease.\n\nA total of 40 participants will be randomized to active lower-extremity heat therapy or sham therapy. Participants assigned to active therapy will complete daily 90-minute home treatment sessions using heated lower-extremity garments. Participants assigned to sham therapy will complete the same treatment schedule using a lower-temperature sham condition.\n\nThe primary outcome is the change in six-minute walk distance from baseline to 12 weeks. Secondary outcomes include changes in leg strength and fatigability, Short Physical Performance Battery score, blood pressure, and patient-reported quality of life.",[26,27],"PAD","PAD - Peripheral Arterial Disease","NOT_YET_RECRUITING","2026-06-12",{"date":31,"type":32},"2026-06-17","ACTUAL",{"date":34,"type":20},"2027-01-01",{"date":36,"type":20},"2029-06-30",{"name":38,"class":39},"Aquilo Sports, LLC","INDUSTRY",""]