[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Argyrios Tzouvelekis\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":44},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100615983","phase-3-intravenous-immunoglobulin-for-the-treatment-of-acute-exacerbations-of-idiopathic-pulmonary-fibrosis-100615983",false,"NCT07299695","Intravenous Immunoglobulin for the Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis","A Prospective, Multicenter, Randomized, Open-Label Clinical Trial Evaluating the Efficacy of Intravenous Immunoglobulin in Patients Hospitalized for Acute Exacerbations of Idiopathic Pulmonary Fibrosis.","MERCURION-IPF","Inclusion Criteria:\n\n1. Patients ≥ 18 years of age\n2. Patients with IPF diagnosis that fulfils ATS\u002FERS Consensus Criteria.\n3. Patients hospitalised with a definite or suspected AE-IPF diagnosis, as defined by the international working group criteria and as ascertained by the responsible Primary Investigator.\n\n   The criteria of IPF-AE are as follows:\n   * Previous or concurrent diagnosis of IPF\n   * Acute worsening or development of dyspnoea typically \\\u003C 1 month duration\n   * Computed tomography with new bilateral ground-glass opacity and\u002For consolidation superimposed on a background pattern consistent with usual interstitial pneumonia pattern\n   * Deterioration not fully explained by cardiac failure or fluid overload Patients who fail to meet all 4 criteria due to missing computed tomography should be considered as having \"suspected Acute Exacerbation\".\n\n   A) If the diagnosis of IPF is not previously established, this criterion can be met by the presence of radiologic and\u002For histopathologic changes consistent with usual interstitial pneumonia pattern on the current evaluation.\n\n   B) If no previous computed tomography is available, the qualifier \"new\" can be dropped from the third AE-IPF criterion.\n4. Patient able to understand and sign a written informed consent form. In case of incapacity of the patient, the written informed consent form will be signed by the patients' legally authorized representative.\n\nExclusion Criteria:\n\n1. Patients with acute worsening due to uncontrolled heart failure or pulmonary embolism.\n2. Patients with known hypersensitivity to corticosteroids, IVIG or any component of the study treatment.\n3. Patients with known IgA deficiency (IgA level \\\u003C7 mg\u002FdL)- to preclude IVIG reactions.\n4. Patients without a definite diagnosis of IPF or AE-IPF based on clinical, radiological, laboratory evaluation, and multidisciplinary discussion.\n5. Patients with active malignancy or currently receiving cancer treatment, except for basal cell or squamous cell skin cancer or low-risk prostate cancer (T1 or T2a stage with PSA \\\u003C10 ng\u002FdL). These criteria are aligned with current guidelines.\n6. Patients that have received treatment for \\>14 days within the preceding month with \\>20mg daily prednisone (or equivalent) or any treatment during the last month with immunosuppressants (e.g., cyclophosphamide, mycophenolate etc.) according to already published therapeutic protocols or \\> 1 mg\u002Fkg\u002Fd from more than 7 days in the last 15 days.\n7. Patients participating to another interventional clinical trial.\n8. Patients with documented pregnancy or lactation.\n9. Patients under tutorship or curatorship.\n10. Patients deprived of liberty or under court protection.\n11. Patients who refuse to participate or decline to provide written informed consent.","ALL","18 Years",{"count":20,"type":21},196,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) are sudden and severe worsening episodes that can be life-threatening. Currently, no treatment has been proven to clearly improve outcomes during these events. Inflammation and immune system imbalance are thought to play an important role in causing AE-IPF. Early clinical experience suggests that intravenous immunoglobulin (IVIG) can be beneficial for patients suffering from AE-IPF. This clinical trial aims to determine whether adding IVIG to usual treatment can improve outcomes for patients hospitalized with AE-IPF.",[27,28],"Idiopathic Pulmonary Fibrosis","Acute Exacerbation of Idiopathic Pulmonary Fibrosis",[30,27,31,28],"Acute Exacerbations of Idiopathic Pulmonary Fibrosis","Intravenous Immunoglobulin","RECRUITING","2026-03-12",{"date":35,"type":36},"2026-03-16","ACTUAL",{"date":38,"type":36},"2026-01-25",{"date":40,"type":21},"2028-12",{"name":42,"class":43},"Argyrios Tzouvelekis","OTHER",""]