[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Arkin\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":84},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100641392","hybrid-dialectical-behavior-therapy-for-veterans-to-further-reduce-emotion-regulation-problems-and-trauma-symptoms-100641392",false,"NCT07652645","Hybrid Dialectical Behavior Therapy for Veterans to Further Reduce Emotion Regulation Problems and Trauma Symptoms","REfreshment of Dialectical Behaviour Therapy for Veterans to Further Reduce Symptoms and Prevent Relapse of Post-traumatic Stress Disorder and Emotion Regulation Symptoms by Guided Self-Help","REFRESH","Inclusion Criteria:\n\n* Adult veteran (18 years or older), treated at Sinai Center, with knowledge of DBT\n* Primairy diagnosis of PTSD, determined with CAPS-5, resulting from war-related traumas\n* Stable for four weeks on their medication (type and doses)\n* Able to to do online homework assignments and communicate with their therapist via an eHealth platform\n* Dutch speaking\n\nExclusion Criteria:\n\n* Chronic psychosis (psychotic features as comorbidity from PTSD is allowed) or bipolar disorder type 1\n* IQ below 80 or cognitive disorders\n* Severe self-harming behaviour, such as auto-mutilation or suicidal ideations as main problem\n* Following day treatments or other intensive treatment for residual symptoms","ALL","18 Years",{"count":20,"type":21},24,"ESTIMATED","INTERVENTIONAL",[24],"NA","Around 10% of post-active veterans experience post-traumatic stress disorder (PTSD) many years post-mission. PTSD in veterans is frequently associated with challenges in emotion regulation, aggression, suicidality, and financial and psychosocial stress. In 2018, a 12-week clinical treatment programme, the Veterans Intensive Treatment Unit (VIBU), was developed for veterans experiencing these psychiatric symptoms, for whom conventional treatments had proven ineffective. The VIBU provides patients with trauma-focused and dialectical behaviour therapy (DBT). A recent study revealed that the VIBU was effective in reducing psychiatric symptoms. However, a recurrence of symptoms was observed in patients a few months after discharge. Consequently, an aftercare programme consisting of hybrid DBT is offered to consolidate and repeat the DBT skills and apply them in daily life.",[27,28,29],"PTSD","Emotion Regulation Disorders","Substance Abuse",[31,27,32,33,34],"Emotional dysregulation","DBT","Hybrid DBT","Veterans","RECRUITING","2026-06-11",{"date":38,"type":39},"2026-06-17","ACTUAL",{"date":41,"type":39},"2026-06-01",{"date":43,"type":21},"2028-10",{"name":45,"class":46},"Arkin","INDUSTRY",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},"100576752","the-cost-effectiveness-of-generalist-versus-specialist-treatment-for-severe-personality-disorders-100576752","NCT06789380","The (Cost-)Effectiveness of Generalist Versus Specialist Treatment for Severe Personality Disorders'","The (Cost-)Effectiveness of Generalist (GIT-PD) Versus Specialist Treatment (MBT\u002FST) for Severe Personality Disorders (the P-DAET Study): a Pragmatic Randomized Controlled Non-Inferiority Trial.'","P-DAET","Inclusion Criteria:\n\n* 'severe' or 'extreme' personality disorder (PD) according to the alternative model for PDs\n\nExclusion Criteria:\n\n* IQ \\\u003C 75\n* legal incapacity\n* Any mental state disorder that requires prior treatment",{"count":57,"type":21},358,[24],"The goal of this clinical trial is to investigate if generalist treatment (GIT-PD) is non-inferior in improving level op personality functioning compared to specialist treatment (MBT\u002FST) in patients with severe personality disorders. The main questions it aims to answer are:\n\n1. Is generalist treatment (GIT-PD) non-inferior in improving level of personality functioning compared to specialist treatment (MBT\u002FST) in patients suffering from severe personality disorders (PD)?\n2. What patient characteristics predict which patients will benefit more from specialist or generalist treatment?\n\nParticipants will be randomized to either specialist or generalist treatment. Interventions included in specialist treatment are Mentalization-Based Treatment (MBT) and Schema Therapy (ST). Generalist treatment will be offererd following the principles of the Guideline-Informed Treatment for Personality Disorders (GIT-PD), a principle-driven treatment framework based upon common factors and allowing personalized treatment according to patients' needs. All participating institutions offer GIT-PD and MBT and\u002For ST. Before, during and after following this treatment participants will complete measurements at 8 distinct time points.\n\nParticipants will be asked to:\n\n* complete a range of instruments at baseline to enable the construction of a personalized advantage index to predict treatment response based on patient characteristics\n* complete questionnaires at all 7 post-randomization time points\n* undergo a semi-structured interview at 3 time points\n* follow treatment for personality disorders (either GIT-PD or MBT\u002FST)",[61],"Severe Personality Disorder",[63,64,65,66,67,68,69,70,71,72,73,74],"generalist psychotherapy","specialist psychotherapy","personality disorder","AMPD","schema therapy","mentalisation-based treatment","guideline-informed treatment for personality disorders","level of personality functioning","alternative model of personality disorders","GIT-PD","MBT","ST","2025-02-03",{"date":77,"type":39},"2025-02-05",{"date":79,"type":39},"2024-10-21",{"date":81,"type":21},"2028-12",{"name":45,"class":46},5,""]