[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Armed Forces Institute of Dentistry, Pakistan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":237},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,41,67,93,114,144,171,193,214],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100624458","comparison-of-anesthetic-efficacy-of-2-lidocaine-inferior-alveolar-nerve-ianb-block-versus-primary-buccal-infilteration-with-4-articaine-in-symptomatic-irreversible-pulpitissip-in-mandibular-first-molars-100624458",false,"NCT07409896","Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars","IANB SIP EPT","Inclusion Criteria:\n\n* Systemically healthy patients classified as ASA I, aged 18-55 years.\n* Permanent mandibular first molar tooth requiring endodontic therapy.\n* Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.\n* Normal periapical radiographic appearance (no evidence of periapical pathology).\n* Moderate pain as assessed by the Heft-Parker VAS (\\>54 mm and \\\u003C114 mm).\n* Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).\n* Positive response to electric pulp testing.\n* Outcome assessed must be pulpal anesthesia\n\nExclusion Criteria:\n\n* • Pregnant or lactating mothers.\n\n  * Teeth with reversible pulpitis, previously treated, or with calcified canals.\n  * Teeth with severe periodontal disease or periapical radiolucency.\n  * Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.\n  * Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).\n  * History of allergy to 4% articaine, lidocaine, or epinephrine.\n  * Systemic diseases, immunocompromised states, or significant anxiety\u002Fmental health disorders.\n  * History of vasovagal syncope on local anesthetic administration","ALL","18 Years","55 Years",{"count":20,"type":21},330,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.",[27],"Anesthetic Efficacy","NOT_YET_RECRUITING","2026-02-07",{"date":31,"type":32},"2026-02-13","ACTUAL",{"date":34,"type":21},"2026-02-01",{"date":36,"type":21},"2027-02-01",{"name":38,"class":39},"Armed Forces Institute of Dentistry, Pakistan","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100622803","comparative-evaluation-of-post-obturation-pain-after-root-canal-treatment-using-tricalcium-silicate-vs-resin-based-sealers-100622803","NCT07388368","Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate vs Resin-Based Sealers","A Comparative Evaluation of Post Obturation Pain After Root Canal Treatment Using Tricalcium Silicate Versus Resin-based Sealers in Cases With Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n* • Patients of age group 18 to 60 years\n\n  * Healthy patients with ASA class 1 and 2\n  * Patients of both genders\n  * Teeth diagnosed as symptomatic irreversible pulpitis\n  * Single as well as multirooted teeth\n\nExclusion Criteria:\n\n* Teeth with calcified or previously treated canals\n* Immunocompromised or mentally handicapped patients\n* Pregnant or lactating mothers\n* Teeth with periodontal probing depths of 5 mm or more\n* Cracked or un restorable teeth\n* Teeth where root canal instrumentation could not reach within 2 mm of the radiographic apex","60 Years",{"count":50,"type":21},118,[24],"This is a randomized controlled trial comparing the mean and standard deviation of postobturation pain using two different sealers: a tricalcium silicate-based sealer (CeraSeal) and a resin-based sealer (Endoplus) in patients with symptomatic irreversible pulpitis undergoing root canal treatment.",[54],"Pain",[56,57,58,59],"root canal sealar","postobturation pain","bioceramic sealer","resin based sealar","2026-01-30",{"date":62,"type":32},"2026-02-05",{"date":34,"type":21},{"date":65,"type":21},"2027-08-01",{"name":38,"class":39},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},"100603676","we-will-assess-zirconia-crown-restoring-endodontically-treated-posterior-teeth-with-two-finish-line-designs-and-two-occlusal-reduction-schemes-100603676","NCT07139613","We Will Assess Zirconia Crown Restoring Endodontically Treated Posterior Teeth With Two Finish Line Designs and Two Occlusal Reduction Schemes","Evaluation of Zirconia Crown Restoring Endodontically Treated Posterior Teeth With Two Finish Line Designs and Two Occlusal Reduction Schemes(a Randomized Clinical Trial)","Inclusion Criteria:\n\n* patients from both genders.\n* age range 18-65 years.\n* patients with endodontically treated posterior teeth.\n\nExclusion Criteria:\n\n* vital teeth\n* anterior teeth.\n* edentulous patient.\n* patient with history of significant systemic diseases.",true,"65 Years",{"count":77,"type":21},66,[24],"Endodontically treated posterior teeth will be restored with zirconia crowns with two finish line designs(feather edge and rounded shoulder) and two occlusal reduction schemes(flat and planer).The crowns were designed with exocad software program .After cementation clinical performance in terms of marginal adaptation ,marginal discoloration, fracture and secondary caries was evaluated at 3 subsequent follow-up visits every 3months for 1 year.",[81],"Zirconia Crowns",[83],"Zirconia crowns assessment with two finish line design and two occlusal reduction schemes","2025-08-22",{"date":86,"type":32},"2025-08-24",{"date":88,"type":21},"2025-08",{"date":90,"type":21},"2026-10",{"name":38,"class":39},2,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":111,"leadSponsor":113,"locationsCount":40},"100603917","proximal-contact-tightness-of-zirconia-crowns-digital-intraoral-scanning-vs-conventional-impressions-100603917","NCT07142746","Proximal Contact Tightness of Zirconia Crowns: Digital Intraoral Scanning vs Conventional Impressions","Comparative Evaluation of Proximal Contact Tightness in Zirconia Crowns: Direct Digital Intraoral Scanning vs. Conventional Impressions Fabrication Method, A Randomized Control Trial.","PCT","Inclusion Criteria:\n\n* Patients seeking definitive full coverage ceramic crowns for molars.\n* Patients in age group of 18- 47 years.\n* Patients with healthy adjacent and opposing teeth.\n* Patients with healthy periodontium.\n\nExclusion Criteria:\n\n* Patients with grade 1 mobility in adjacent or opposing teeth.\n* Patients with diastema in posterior teeth.\n* Patients having severe malocclusion associated with traumatic occlusion.\n* Patients with temporomandibular joint disorders.",{"count":102,"type":21},75,[24],"We will be comparing the proximal contacts of zirconia crowns and adjacent natural teeth in two groups. One receiving crowns fabricated via digital intra oral scanning means. And the other group recieving crowns fabricated via the dental impression method using trays and impression material.",[106,81],"Proximal Contacts","2025-08-19",{"date":109,"type":32},"2025-08-27",{"date":88,"type":21},{"date":112,"type":21},"2026-07",{"name":38,"class":39},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":126,"conditions":127,"keywords":131,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":40},"100591472","phase-2-effect-of-pre-medication-with-anti-inflammatory-drugsibuprofen-and-dexamethasoneon-post-endodontic-pain-100591472","NCT06980870","Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain","Effect of Pre-medication With Anti-inflammatory Drugs(Ibuprofen and Dexamethasone)on Post-Endodontic Pain With Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n1. Permanent teeth with acutely inflamed pulp without swelling or draining sinus.\n2. Patients of either gender aged between 18-50 years old.\n3. Systemically healthy patients.\n4. Patients who agree to attend for recall appointments and provide a written consent.\n\nExclusion Criteria:\n\n1. Patients on preoperative analgesics and antibiotics.\n2. Teeth with calcified canals and previously treated teeth.\n3. Pregnant and lactating mothers.\n4. Patients who are immunocompromised, anxious and mentally handicapped.\n5. Patients who are allergic to any of the test medications.","50 Years",{"count":123,"type":21},130,[125],"PHASE2","Effect of pre-medication with anti-inflammatory drugs(ibuprofen and dexamethasone)on Post-Endodontic pain with symptomatic irreversible pulpitis",[128,129,130],"Post-endodontic Pain","Ibuprofen","Dexamethasone",[132,133,134],"post-endodontic pain","ibuprofen","dexamethasone","RECRUITING","2025-05-17",{"date":138,"type":32},"2025-05-20",{"date":140,"type":32},"2025-02-15",{"date":142,"type":21},"2025-06-15",{"name":38,"class":39},{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":4,"eligibilityCriteria":150,"healthyVolunteers":74,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":4,"studyType":22,"phases":155,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":40},"100591079","phase-2-postoperative-pain-comparison-of-two-root-canal-sealers-in-irreversible-pulpitis-100591079","NCT06975761","Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis","A COMPARATIVE EVALUATION OF POST-OPERATIVE PAIN AFTER ROOT CANAL THERAPY USING TWO DIFFERENT ENDODONTIC SEALERS IN PATIENTS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS","Inclusion Criteria:\n\n1. Permanent mandibular first molar with irreversible pulpitis without swelling and sinus.\n2. Patients of male gender between 20-40 years of age.\n3. Systemically healthy patients with no other co morbidity classified as ASA-I\n4. Patients who agree to attend for re call appointments and provide a written consent\n\nExclusion Criteria:\n\n\\- 1. Teeth with calcified canals and previously treated teeth. 2. Mandibular molars with reversible pulpitis. 3. Pregnant and lactating mothers. 4. Patients who are immunocompromised, anxious, mentally ill. 5. Cases of root fracture. 6. Patients who consumed analgesics 12-24 hrs before primary root canal therapy.\n\n7\\. Patients who are allergic to any of the medications being tested.","20 Years","40 Years",{"count":154,"type":21},62,[125],"This study, approved by the Institutional Ethics Review Committee, AFID (Annex \"A\"), will involve 62 eligible patients from the Operative Dentistry Department, Armed Forces Institute of Dentistry. Patients (and their guardians) will receive a detailed explanation in Urdu, and written informed consent will be obtained (Annex \"B\").\n\nStudy Design:\n\nRandomized Controlled Trial: Patients will be randomly divided into two equal groups using a scientific random number table.\n\nInclusion Screening: Includes medical history, clinical examination, periapical radiographs.\n\nTreatment Protocol:\n\nRoot canal therapy under local anesthesia with rubber dam isolation.\n\nWorking length determined using DentaPort ZX apex locator, confirmed with radiograph.\n\nInstrumentation: ProTaper Universal hand files up to F2 with 5.25% NaOCl irrigation.\n\nPatency confirmed with #10 K-file between each instrument change.\n\nFinal flush with 17% EDTA.\n\nCalcium hydroxide used as intracanal medicament for microbial control.\n\nTemporary restoration using Cavit.\n\nRecall and Evaluation: After 1 week, asymptomatic patients (VAS score 0 and dry canals) will be selected for obturation.\n\nObturating Materials:\n\nGroup 1: AD Seal + F2 single cone gutta-percha (Sure Endo). Group 2: Pulp-dent Sealer + F2 single cone gutta-percha (Sure Endo). Sealers will be mixed per manufacturer's instructions, applied using lentulospiral. The apical extent of the master cone will be confirmed radiographically.\n\nAll procedures will be carried out by a single operator. Final restoration will be done using composite, and patients will be referred for full coverage crowns.\n\nPost-Treatment Pain Assessment:Patients will receive a pain diary with a Visual Analogue Scale (VAS) from 0 (no pain) to 10 (severe pain).\n\nPain will be recorded at 24 hours, 72 hours, and 7 days post-treatment. Analgesic use (type and quantity) will also be noted. Diaries will be collected at the follow-up visit.",[158],"Post Operative Pain After Root Canal Therapy",[160,161,162],"post operative pain","irreversible pulpitis","endodontic sealers","2025-05-08",{"date":165,"type":32},"2025-05-16",{"date":167,"type":32},"2025-04-07",{"date":169,"type":21},"2025-08-07",{"name":38,"class":39},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":74,"sex":16,"minAge":17,"maxAge":121,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":40},"100578046","phase-2-warm-versus-conventional-2-lignocaine-for-ianb-efficacy-100578046","NCT06806202","Warm Versus Conventional 2% Lignocaine for IANB Efficacy","Comparative Evaluation of Anesthetic Efficacy of Warm and Conventional 2% Lignocaine for the Success of Inferior Alveolar Nerve Block (IANB) in Mandibular Permanent Molars: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Permanent teeth with acutely inflamed pulp without swelling or draining sinus.\n* Patient who have carious mandibular molars.\n* Patients of either gender aged between 18-50 years old.\n* Systemically healthy patients.\n* Patients who agree to attend for recall appointments and provide a written consent\n\nExclusion Criteria:\n\n* Patients on preoperative analgesics and antibiotics.\n* Teeth with calcified canals and previously treated teeth.\n* Pregnant and lactating mothers.\n* Patients who are immunocompromised, anxious and mentally handicapped.\n* Patients who are allergic to lignocaine.\n* Non-vital or necrosed teeth.",{"count":179,"type":21},200,[125],"The study compares the anesthetic efficacy of warm versus conventional 2% lignocaine for inferior alveolar nerve block in mandibular molars, evaluating success rates and onset time.",[183,184],"Success of Inferior Alveolar Nerve Block","Inferior Alveolar Nerve Block","2025-01-31",{"date":187,"type":32},"2025-02-03",{"date":189,"type":32},"2024-12-15",{"date":191,"type":21},"2025-03-15",{"name":38,"class":39},{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":74,"sex":16,"minAge":151,"maxAge":152,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":213,"locationsCount":40},"100576473","phase-2-effectiveness-of-cryotherapy-on-endodontic-pain-100576473","NCT06785753","Effectiveness of Cryotherapy on Endodontic Pain","Effectiveness of Intracanal Cryotherapy on Post Operative Pain After Root Canal Therapy in Patients with Symptomatic Apical Periodontitis","Cy","Inclusion Criteria:\n\n* patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis\n* maxillary or mandibular single rooted teeth\n* systemically healthy patients\n* patients having pain score \\\u003C 8\n\nExclusion Criteria:\n\n* patients on preoperative analgesics or antibiotics within past 12 hours\n* teeth with calcified canals and previously treated teeth\n* tooth with immature apices or resorption\n* patients allergic to local anesthesia\n* pregnant or lactating mothers\n* patients who are immunocompromised .",{"count":202,"type":21},60,[125],"This is a randomized , prospective , control trial to assess the effectiveness of intracanal cryotherapy on post operative pain after root canal treatment in patients with symptomatic apical periodontitis",[206],"Post Operative Pain","2025-01-19",{"date":209,"type":32},"2025-01-21",{"date":211,"type":32},"2024-11-07",{"date":163,"type":21},{"name":38,"class":39},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":74,"sex":16,"minAge":4,"maxAge":221,"enrollmentInfo":222,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":228,"overallStatus":135,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":40},"100573086","saline-at-different-temperatures-after-3rd-molar-surgery-100573086","NCT06741696","Saline At Different Temperatures After 3rd Molar Surgery","Does Saline Irrigation At Different Temperatures Affect Pain, Edema, and Trismus After Impacted Third Molar Surgery: a Clinical Trial","Inclusion Criteria:1. Patients who met the requirements of the study, such as attending follow-up sessions and signing the informed consent. 2. Patients with bilateral mandibular asymptomatic vertical third molar teeth with impaction of Class I, level C.22 3. Patients who did not have any significant medical diseases or drug use, were not pregnant, had no allergy, and did not smoke.\n\n\\-\n\nExclusion Criteria:\n\n1 Patients with complicating systemic disease ( American Society of Anesthesiologists : 3- 6). 2. Patients who have second molars with severe periodontal defect or deep periodontal pocket (probing depth \\>4 mm). 3. Patients with poor oral hygiene. 4. Patients with a history of using analgesics 12 hours ago or antibiotics 1 month before. 5. The presence of cysts or tumors around the impacted third molar.\n\n\\-","59 Years",{"count":223,"type":21},48,[24],"This double-blind, single-center, split-mouth, randomized prospective clinical trial was conducted among 48 systemically and periodontally healthy patients who had bilaterally asymptomatic mandibular third molars.",[227],"Post Operative Pain, Acute",[229],"3rd molar surgery, saline irrigation at different temperatures",{"date":231,"type":32},"2024-12-19",{"date":233,"type":32},"2024-10-24",{"date":235,"type":21},"2025-03-30",{"name":38,"class":39},""]