[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Auburn University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":405},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,40,76,101,124,147,177,205,227,248,278,306,335,357,380],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100640206","brief-single-session-body-neutrality-program-for-lgbtq-adults-in-central-alabama-100640206",false,"NCT07621081","Brief Single-Session Body Neutrality Program for LGBTQ+ Adults in Central Alabama","Inclusion Criteria:\n\n* At least 18 years old,\n* Identify as LGBTQ+,\n* Currently living in one of the following AL counties: Lee, Dallas, Lowndes, Autauga, Coosa, Elmore, Tallapoosa, Macon, or Russell\n* Have internet access (either via computer\u002Ftablet, mobile phone, or community center \\[e.g., library\\])\n\nExclusion Criteria:\n\n* Being less than 18 years old,\n* Identifying as cisgender and heterosexual,\n* Not living in central AL,\n* Not having internet access.",true,"ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","LGBTQ+ individuals tend to have elevated risks for eating disorders (ED), possibly due to minority stress. For LGBTQ+ individuals living in rural Alabama, they tend to experience high levels of anti-LGBTQ+ structural stigma and limited access to LGBTQ+-specific resources, which engender compounded risk for ED development and reduced access to care. Brief digital single-session intervention that incorporates psychoeducation about minority stress and body neutrality may be efficacious in reducing ED risk and improve positive body image among LGBTQ+ adults in rural areas. Prior research from another lab developed a single-session intervention (Project Body Neutrality) among LGBTQ+ adolescents indicated immediate positive changes in body image constructs and psychological well-being. The present project evaluates and adapts Project Body Neutrality, specifically for LGBTQ+ adults in a rural high-stigma, low-resource region.",[26],"Body Image","NOT_YET_RECRUITING","2026-05-27",{"date":30,"type":31},"2026-06-02","ACTUAL",{"date":33,"type":20},"2026-08-02",{"date":35,"type":20},"2028-08-02",{"name":37,"class":38},"Auburn University","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":39},"100585869","cannabis-and-processing-emotions-study-100585869","NCT06907979","Cannabis and Processing Emotions Study","Experimental Manipulation of the Emotional Salience of Cannabis Use-Related Information in Regular Cannabis Users","CAPE","Inclusion Criteria:\n\n* Meets criteria for current, severe Cannabis Use Disorder (CUD), as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) during the screening interview\n* Reports engagement in cannabis use at least four days per week, on average, over the past year\n* Provide a urine sample positive for tetrahydrocannabinol (THC)\n* Able to read and write in English\n* Has used cannabis at least 20 days in the past month\n* Endorses at least 10 distinct (of 40 possible) cannabis use-related problems across the screening interview and Lab Visit 1 questionnaires\n\nExclusion Criteria:\n\n* Other non-cannabis illicit substance use more than once per month, on average, over the past year\n* Current DSM-5 moderate or severe Alcohol Use Disorder, as assessed by the Structured Clinical Interview (SCID) for the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) during the screening interview\n* History of bipolar I or psychosis spectrum disorders, as assessed by the SCID for DSM-5 during the screening interview\n* Acute suicidality requiring treatment escalation, as assessed during the screening interview\n* Currently taking any daily psychotropic medication\n* Failure to meet standard MRI inclusion criteria (i.e., no presence of claustrophobia; cardiac pacemakers; neural pacemakers; surgical clips in the brain or blood vessels; surgically implanted metal plates, screws, or pins; cochlear implants; implanted uterine devices; metal braces; other metal objects in the body; history of significant injury to the brain or spinal cord; or pregnancy)\n* Medical contraindications for transcranial magnetic stimulation (TMS; i.e., presence of a neurological disorder known to alter risk for seizures \\[e.g., stroke, aneurysm, brain surgery, structural brain lesion, brain injury, frequent\u002Fsevere headaches\\], current medication therapy known to alter seizure threshold \\[e.g., clomipramine, Monoamine Oxidase inhibitors, imipramine, clozapine\\], recurrent seizures or epilepsy or family history of hereditary epilepsy, pregnancy, metallic implants in the body or other devices that may be affected by magnetic fields, or significant heart disease or cerebrovascular disease)\n* History of allergies to cosmetics\u002Flotions or EEG gel\n* History of migraines\n* Currently engaged in treatment for Cannabis Use Disorder","50 Years",{"count":50,"type":20},24,[23],"The goal of this study is to test a causal neural mechanism of cannabis use-related problem recognition in individuals with severe cannabis use disorder using a non-invasive form of neuromodulation called transcranial magnetic stimulation (TMS). The main question it aims to answer is:\n\n-Does manipulating neural activity in the medial orbitofrontal cortex of the brain affect cannabis use-related problem recognition?\n\nResearchers will compare three forms of theta burst stimulation (TBS; sham, intermittent, and continuous) in each participant to see if manipulations in neural activity lead to changes in cannabis use-related problem recognition.\n\nParticipants will complete a screening interview about their mental health and substance use history and complete four in-person laboratory sessions, which involve questionnaires, four brief magnetic resonance imaging (MRI) scans, three TBS sessions, and three electroencephalogram (EEG) sessions. Participants will also be asked to provide urine samples and take saliva and\u002For breathalyzer tests at some of the lab visits.",[54],"Cannabis Use Disorder, Severe",[56,57,58,59,60,61,62,63,64,65,66],"cannabis","cannabis use disorder","emotional salience","problem recognition","problem awareness","transcranial magnetic stimulation","theta burst stimulation","TMS","TBS","medial orbitofrontal cortex","mOFC","RECRUITING","2026-05-05",{"date":70,"type":31},"2026-05-06",{"date":72,"type":31},"2026-01-22",{"date":74,"type":20},"2027-05",{"name":37,"class":38},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":39},"100630548","forge-ahead-feasibility-of-yoga-to-improve-cognitive-function-100630548","NCT07489105","Forge AHEAD: Feasibility of Yoga to Improve Cognitive Function","Engaging Stakeholders and Patients to Evaluate the Feasibility of Yoga to Improve Cognitive Function in Rural Heart Failure Patients in the Deep South","Forge AHEAD","Inclusion Criteria:\n\n* Heart failure diagnosis\n* Aged 55 years or older\n\nExclusion Criteria:\n\n* Traumatic brain injury, co-existing neurological and psychiatric disorders\n* Implanted defibrillator or metal objects, left ventricular assist device placement, or cardiac transplant\n* Substance abuse\n* Unable to perform yoga due to physical limitations or severity of illness\n* Currently engaged in a yoga program","55 Years",{"count":86,"type":20},20,[23],"The investigators will conduct a two-phase pilot study to test the feasibility and acceptability of a 12-week Chair Yoga intervention for 20 heart-failure patients. Using a patient-centered approach, investigators will involve stakeholders in designing the protocol, gather patient feedback, and refine the protocol accordingly.",[90,91,92],"Heart Failure","Rural Health","Engagement, Patient","2026-03-21",{"date":95,"type":31},"2026-03-25",{"date":97,"type":31},"2025-07-24",{"date":99,"type":20},"2027-12-31",{"name":37,"class":38},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":48,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":39},"100537152","using-tms-to-understand-neural-processes-of-social-motivation-100537152","NCT06274112","Using TMS to Understand Neural Processes of Social Motivation","Personalized Neuromodulation Targeting Dysregulated Motivational Responses Underlying Social Avoidance Behavior","Inclusion Criteria:\n\n* A diagnosis of Major Depressive Disorder OR a diagnosis of Social Anxiety Disorder (assessed\u002Fconfirmed at screening visit).\n* Scoring above clinical threshold on a measure of social avoidant behavior (assessed\u002Fconfirmed at phone screen).\n\nExclusion Criteria:\n\n* Unstable psychotropic medication regimen (i.e., changes in psychotropic medication or dosage in past 3 months).\n* Current or lifetime diagnosis of Bipolar Disorder.\n* A diagnosis of substance use disorder within past 12 months.\n* A diagnosis of psychotic-spectrum disorder such as Schizophrenia.\n* Pregnancy or probable pregnancy.\n* Medical illness or medical treatment that would preclude or inhibit study participation.\n* Neurological disorder associated with brain damage.\n* History of seizures or head trauma with loss of consciousness \\> 5 minutes.\n* Family history of epilepsy or personal epilepsy\u002Fseizures\n* Ferromagnetic implants or ferrmagnetic objects within body (e.g., pacemaker).","25 Years",{"count":19,"type":20},[23],"The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation.\n\nParticipant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks.\n\nAdults in the Auburn\u002FOpelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.",[113,114,115],"Social Avoidant Behavior","Major Depressive Disorder","Social Anxiety Disorder","2026-03-01",{"date":118,"type":31},"2026-03-03",{"date":120,"type":31},"2025-09-30",{"date":122,"type":20},"2029-07-31",{"name":37,"class":38},{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":15,"sex":16,"minAge":132,"maxAge":108,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":39},"100609866","multimodal-immune-and-neuroendocrine-assessment-in-drinkers-100609866","NCT07220148","Multimodal Immune and Neuroendocrine Assessment in Drinkers","Multimodal Assessment of Neural, Neuroendocrine, and Immune Cue Responses in Binge Drinkers in the Laboratory and Real World","MIND","Inclusion Criteria:\n\nIn this study, researchers will recruit 234 individuals who report binge use of alcohol or who consume alcohol moderately with no episodes of binge drinking. All participants will be recruited from the community primarily through advertisements in local newspapers, online venues like craigslist, flyers, and list-serve emails, as well as through radio and other media advertisements.\n\nInclusion Criteria\n\nAll Participants:\n\n* Male and Females between the ages of 21-25\n* able to read and write in English and complete study evaluations\n* able to provide negative breathalyzer and negative toxicology screenings for substances at all study appointments\n* able to provide written and verbal consent.\n* Must be a beer drinker (not exclusively), to ensure subjects are not averse to the taste of beverages presented in the ATT\n* BMI of 18-35\n\nBinge Drinkers:\n\n• At least twice per month binge drinking and weekly alcohol use of at least 8 standard drinks\u002Fweek females or 15 or more drinks for males for the past year, with binge drinking defined as drinking enough alcohol that brings blood alcohol concentration to 0.08 percent or higher in about 2 hours, which is typically equivalent to consuming 5 or more drinks for males, or 4 or more drinks for females.\n\nSocial Drinkers:\n\n• at least weekly alcohol use for the past 6 months not to exceed 7 standard drinks\u002Fwk for women and 14 standard drinks\u002Fweek for males, with no episodes of binge drinking in the past year\n\nExclusion Criteria:\n\nAll Participants:\n\n* Any psychotic disorder or current psychiatric symptoms requiring specific attention, including active symptoms of psychosis or suicidal\u002Fhomicidal ideation\n* meets criteria for current or past moderate or severe substance use disorder\n* women who are pregnant or lactating\n* inability to give informed consent\n* any contraindications for MRI (e.g., medical devices in the body, claustrophobia, etc)\n* current PTSD or acute stress disorder\n* other illicit drug use as determined by a urine drug screen","21 Years",{"count":134,"type":20},234,[23],"The goal of this clinical trial is to better understand how blood flow in the brain, levels of the hormone, cortisol, and levels of an immune factor, interleukin-6, change in response to pictures of alcohol versus water pictures of water in healthy people who regularly consume alcohol. Researchers will learn about how the brain processes our environment and how it relates to people's drinking behaviors. This information is important because it may allow us to develop new treatments for Alcohol Use Disorders.\n\nParticipants will be asked to fill out psychological questionnaires at the first appointment. Then, they will do MRI scans with blood draws at visits 2-6. After each MRI scan, participants will undergo the Alcohol Taste Test, which involves drinking beer.\n\nThere will be a total of 3 visits at baseline, 2 visits one year later, and 2 visits one year after that. Each visit will last 2 hours. Each year, participants will do 21 days of surveys on a smart phone (4 surveys a day; each survey takes less than 2 minutes). The total time commitment for the entire study will be 23 hours.",[138],"Alcohol Drinking","2025-10-21",{"date":141,"type":31},"2025-10-23",{"date":143,"type":20},"2026-04",{"date":145,"type":20},"2031-12",{"name":37,"class":38},{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":21,"phases":158,"briefSummary":159,"conditions":160,"keywords":162,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":39},"100487012","a-combined-neurofeedback-tms-intervention-for-alcohol-use-disorder-100487012","NCT05621538","A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder","CNT","Inclusion Criteria:\n\n1. Age 19-65\n2. Receiving treatment for Alcohol Use Disorder\n\nExclusion Criteria:\n\n1. MRI Contraindications\n\n   1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)\n   2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr\n   3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS\n2. TMS Contraindications\n\n   1. Has ever had a seizure, or has a family history of epilepsy\n   2. Taking medications or substances that lower the seizure threshold\n   3. Implanted devices that are in the head or rely on physiological signals\n   4. History of neurological disease, such as stroke or brain tumor\n   5. Head injury with loss of consciousness greater than 30 minutes\n   6. Actively withdrawing from alcohol\n3. Family history of schizophrenia or presence of psychotic symptoms","19 Years","65 Years",{"count":157,"type":20},90,[23],"The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and\u002For TMS intervention in individuals seeking treatment for Alcohol Use Disorder.\n\nAfter an initial visit, participants will come in once a week for four (4) weeks for an intervention session, which may or may not include TMS and MRI. Participants will be contacted for monthly follow-ups (remotely) for up to 12 months and will be asked to come in for two MRI follow-ups at 6 and 12 months.",[161],"Alcohol Use Disorder",[163,164,63,165,166,167,168],"treatment seeking","alcohol","neurofeedback","supplemental intervention","heavy drinking","problems with drinking","2025-10-02",{"date":171,"type":31},"2025-10-07",{"date":173,"type":31},"2025-10-01",{"date":175,"type":20},"2026-03-31",{"name":37,"class":38},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":21,"phases":186,"briefSummary":187,"conditions":188,"keywords":190,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":39},"100486240","influence-of-tms-on-attention-modulation-100486240","NCT05611502","Influence of TMS on Attention Modulation","A Combined Neurofeedback- TMS Intervention for Alcohol Use Disorder - Aim 2","TAM","Inclusion Criteria:\n\n1\\. Age 18 or Older\n\n2A. (Drinker Group): Reports consuming 4 \\[if female\\]\u002F 5 \\[if male\\] or more standard drinks on one occasion at least 2 times a month AND\u002FOR reports consuming more than 7 \\[if female\\]\u002F 14 \\[if male\\] standard drinks per week on average\n\n2B. (Healthy Volunteer Group): Reports consuming 4 \\[if female\\]\u002F 5 \\[if male\\] or more standard drinks on one occasion less than once a month AND reports consuming less than 7 \\[if female\\]\u002F 14 \\[if male\\] standard drinks per week on average\n\nExclusion Criteria:\n\n1. MRI Contraindications\n\n   1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos)\n   2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr\n   3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS\n2. TMS Contraindications\n\n   1. Has ever had a seizure, or has a family history of epilepsy\n   2. Taking medications or substances that lower the seizure threshold\\*\n   3. Implanted devices that are in the head or rely on physiological signals\n   4. History of neurological disease, such as stroke or brain tumor\n   5. Head injury with loss of consciousness greater than 30 minutes\n   6. Actively withdrawing from alcohol\n3. Family history of schizophrenia or presence of psychotic symptoms",{"count":19,"type":20},[23],"The purpose of this study is to help understand how attention processes influence brain engagement during emotion and social cognition. The investigators also want to know if these processes are associated with drinking alcohol.\n\nParticipation includes three study visits of about 2 hours each over approximately a month. The first visit involves a magnetic resonance imaging (MRI) scan and answering survey questions. Each of the next two visits will involve a session of transcranial magnetic stimulation (TMS, a non-invasive brain stimulation technique) followed by another MRI scan.\n\nPeople in the Auburn\u002FOpelika area 19 or older are eligible to participate. People who drink alcohol and people who do not drink or don't drink very much are invited to participate.",[189],"Drinking, Alcohol",[164,191,63,192,193,194,195,196,197,198],"attention","binge drinking","emotion","social cognition","moral","MRI","frontal eye fields","moral cognition",{"date":171,"type":31},{"date":201,"type":31},"2022-08-11",{"date":203,"type":20},"2025-12-31",{"name":37,"class":38},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":211,"targetDuration":4,"studyType":21,"phases":213,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":226},"100559554","phase-1-targeting-minority-stressors-to-improve-eating-disorder-symptoms-in-sexual-minority-individuals-with-eating-disorders-100559554","NCT06565637","Targeting Minority Stressors to Improve Eating Disorder Symptoms in Sexual Minority Individuals With Eating Disorders","Inclusion Criteria:\n\n* age 18 to 65 years\n* identify as lesbian, gay, bisexual, other non-heterosexual identities\n* meet criteria for a Diagnostic and Statistical Manual - 5 (DSM-5) eating disorder (i.e., anorexia nervosa, bulimia nervosa, binge eating disorder, other specified feeding or eating disorder)\n* reports current (past 12 months) experience with discrimination due to sexual orientation;\n* speaks English\n* has internet access and a working webcam\n* reside (and plan to continue to reside for the study duration) in California or one of the Psychology Interjurisdictional Compact (PSYPACT) states\n* able to provide informed consent\n\nExclusion Criteria:\n\n* inability to speak\u002Fread English\n* active suicidal plans or intent\n* other major untreated psychiatric diagnoses (e.g., untreated bipolar disorder, untreated psychosis)\n* body mass index below 17.0, a standard clinical cutoff used to denote moderate-severe underweight that may be indicated for a higher level of medical care than standard outpatient treatment",{"count":212,"type":20},30,[214],"PHASE1","The goal of this clinical trial is to learn if a new intervention (Promoting Resilience to Improve Disordered Eating; PRIDE) can decrease internalized stigma and increase the ability to cope effectively with stressors in sexual minority populations diagnosed with eating disorders. The main question it aims to answer is:\n\nWill an eating disorders treatment focused on decreasing internalized stigma and increasing sexual minority stress coping self efficacy in sexual minority populations? Participants Will\n\n* Complete a telephone screen with study staff to determine preliminary eligibility for the study\n* Undergo a behavioral eligibility screening that includes structured clinical interviewing in order to determine proper diagnosis of an eating disorder along with ensuring absence of non-eating disorder diagnoses\n* Complete self-report measures to determine study eligibility\n* Attend up to 14 weekly therapy sessions as part of the PRIDE intervention, where participants will work with qualified clinicians to address eating pathology and disordered body image along with developing effective strategies for coping with sexual minority stressors\n* Complete surveys upon completion of the intervention 3 and 6 months post follow-up",[217,218],"Eating Disorders","Sexual Minorities",{"date":220,"type":31},"2025-10-06",{"date":222,"type":31},"2025-02-28",{"date":224,"type":20},"2026-07-01",{"name":37,"class":38},2,{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":231,"acronym":232,"eligibilityCriteria":233,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":155,"enrollmentInfo":234,"targetDuration":4,"studyType":21,"phases":236,"briefSummary":237,"conditions":238,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":39},"100461167","pilot-of-reconnecting-to-internal-sensations-and-experiences-in-undergraduates-100461167","NCT05285111","Pilot of Reconnecting to Internal Sensations and Experiences in Undergraduates","RISE","Inclusion Criteria:\n\n* Low interoceptive awareness\n* History of suicidal ideation or attempt\n* 18 or older\n\nExclusion Criteria:\n\n\\*Below the age of 18",{"count":235,"type":20},200,[23],"Project RISE is a randomized control trial. The intervention consists of four modules that focus on multiple aspects of interoception including: body awareness, body sensations\u002Fmovement, eating, health and self-care, emotional awareness, and understanding the self in relation to others. The comparator condition is called \"Health Habits\" and is matched for time and attention; participants complete modules related to healthy habits such as financial planning, hygiene, stretching, and healthy eating. Variables of interest include self-report measures of interoception, eating pathology, suicidality, physiological measures of interoception (electrocardiograph; ECG; pain tolerance measured via algometer), and an implicit association test (IAT) with death and life stimuli (meant to measure implicit associations with suicidality). The population will be college students, with current or past suicidality or low interoception.",[239,240],"Suicidal Ideation","Eating Disorder Symptom","2025-09-29",{"date":169,"type":31},{"date":244,"type":31},"2021-09-01",{"date":246,"type":20},"2026-12",{"name":37,"class":38},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":21,"phases":259,"briefSummary":260,"conditions":261,"keywords":265,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":39},"100602993","digital-intervention-for-physical-activity-100602993","NCT07130734","Digital Intervention for Physical Activity","Digitally-Delivered Intervention to Prompt Physical Activity","DPA","Inclusion Criteria:\n\n* Between the ages of 19 and 40 years\n* Verbally fluent in English (i.e., must be able to speak or understand English)\n* No uncorrected visual or hearing impairment\n* Moderate depressive symptoms or greater of at least 10 or higher on the Patient Health Questionnaire-8 screening instrument\n* Eligible to participate in physical activity\n* Physically inactive (i.e., engaging in less than 150 min of weekly moderate-to-vigorous physical activity)\n* Owns an Apple or Android mobile device, willing to download the Pathverse app , and willing to keep the device on during the study period\n* Not currently pregnant\n\nExclusion Criteria:\n\n\\- Participants will not qualify for the current study if they do not meet the above inclusion criteria.","40 Years",{"count":258,"type":20},50,[23],"The present study will assess the effects of a four-week digitally delivered intervention on physical activity and depressive symptoms among adults experiencing at least moderate depressive symptoms. The main questions this research aims to answer are:\n\n* Does a digitally-delivered intervention increase physical activity levels?\n* Does a digitally-delivered intervention reduce symptoms of depression?\n\nResearchers will compare an intervention promoting physical activity to a passive control (does not receive the intervention) group to see if the intervention reduces depressive symptoms and increases physical activity levels.\n\nParticipants will:\n\n* Visit the laboratory at two separate time points before group assignment, separated by one week of physical activity monitoring\n* Be randomly assigned to complete four weeks of a digital intervention prompting engagement in physical activity or have their mental health symptoms monitored over four weeks (i.e., passive control group)\n* Visit the laboratory at two separate time points after the intervention, separated by one week of physical activity monitoring",[262,263,264],"Depression - Major Depressive Disorder","Anxiety","Stress",[266,267,268,269],"Physical Activity","Digital Intervention","Depression","Mobile Application","2025-09-12",{"date":272,"type":31},"2025-09-18",{"date":274,"type":20},"2025-09-22",{"date":276,"type":20},"2026-05",{"name":37,"class":38},{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":11,"sex":16,"minAge":285,"maxAge":286,"enrollmentInfo":287,"targetDuration":4,"studyType":21,"phases":288,"briefSummary":289,"conditions":290,"keywords":293,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":305},"100603496","optimizing-dimensions-of-reinforcement-100603496","NCT07137273","Optimizing Dimensions of Reinforcement","Optimizing Dimensions of Reinforcement to Enhance Behavioral Interventions","Inclusion Criteria:\n\nAt least 6 years of age\n\nDocumented neurodevelopmental condition\n\nEngagement in problem behavior (e.g., aggression, self-injury, property destruction) that can be measured during study sessions\n\nAbility to follow simple instructions\n\nAbility to participate in tabletop choice-based tasks\n\nAvailability to complete all scheduled study sessions\n\nProvision of informed consent by participant or legally authorized representative\n\nExclusion Criteria:\n\nSevere sensory or motor impairments that would prevent participation in tabletop tasks\n\nCurrent or recent participation (within the past 30 days) in another interventional behavioral research study that could interfere with study outcomes\n\nMedical or behavioral conditions judged by investigators to pose a safety risk or interfere with data collection","6 Years","17 Years",{"count":212,"type":20},[23],"This study is designed to better understand how certain features of reinforcement affect learning and motivation in individuals with intellectual and developmental disabilities (IDD). Participants will take part in a series of structured teaching sessions that involve simple tasks and reward-based feedback. By changing the timing and amount of rewards, we aim to learn how these factors influence the ability to acquire and maintain new skills. This information may help improve behavioral interventions for individuals with IDD in the future. The study does not involve medications or procedures intended to change participants' health status.",[291,292],"Intellectual Disabilities (F70-F79)","Autism",[294,295,296],"Operant Conditioning","Neurodevelopmental disorders","Behavioral interventions","2025-08-21",{"date":299,"type":31},"2025-08-27",{"date":301,"type":31},"2024-10-07",{"date":303,"type":20},"2026-08",{"name":37,"class":38},3,{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":314,"enrollmentInfo":315,"targetDuration":4,"studyType":21,"phases":316,"briefSummary":317,"conditions":318,"keywords":322,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":39},"100520857","potassium-hydration-cardiovascular-and-kidney-study-phacks-100520857","NCT06062017","Potassium, Hydration, Cardiovascular, and Kidney Study (PHACKs)","The Effects of Water and Potassium Supplementation on Cardiovascular and Kidney Function in Young Adults","PHACKs","Inclusion Criteria:\n\n* Between the ages of 18-30 years\n* Resting blood pressure no higher than 150\u002F90 mmHg\n* BMI below 35 kg\u002Fm2\n* Free of any metabolic disease (e.g., diabetes) kidney disease, pulmonary disorders (e.g., COPD), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer.\n\nExclusion Criteria:\n\n* Have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood.\n* Are currently pregnant or trying to become pregnant.\n* take any of the following medications that are contraindicated with potassium supplementation:\n* Renin-angiotensin-aldosterone system (RAAS) blockers: Candesartan , Eprosartan, Irbesartan, Losartan, Olmesartan, Telmisartan\n* Non -steroidal anti-inflammatory medications: Aspirin, Ibuprofen, Naproxen\n* Non-selective beta-blockers: Pindolol, Penbutolol, Oxprenolol, Propranolol, Nadolol, Sotalol, Timolol, Tertatolol\n* Calcineurin inhibitors: Cyclosporine\n* Heparin (or other blood thinning medications)","30 Years",{"count":19,"type":20},[23],"Compared with White Adults, Non-Hispanic Black Adults are at an elevated risk of developing cardiovascular disease (CVD) and end stage chronic-kidney disease (CKD), two of the leading causes of death in the United States. Inadequate hydration status is associated with risk factors for both CVD and CKD. Prior data show that Black individuals are less likely to be adequately hydrated when compared with their White counterparts. Further, socioeconomic factors have been shown to influence hydration practices. Inadequate hydration influences certain hormones that regulate blood volume and impact blood pressure, but increasing potassium intake may provide some positive effects on normalizing these hormones and blood pressure. Black adults, in particular, are more likely to consume less potassium, have inadequate hydration, and tend to have higher blood pressure. As such, there is a critical need for effective strategies to address racial disparities in hydration and resultant health consequences; as well as establish the role of socioeconomic factors contributing to hydration. Therefore, the investigators are seeking to test the investigators' central hypothesis that water with a potassium supplement will improve hydration and cardiovascular health in young White adults (n = 20, 10 females, 10 males), and to a greater extent in young Black Adults (n = 20, 10 females, 10 males. The investigators will assess measures of blood pressure, arterial stiffness, and biomarkers in the urine and blood samples prior to and following a 14-day hydration intervention of 1) bottled water and 2) bottled water with potassium supplementation (2000mg potassium\u002Fday).",[319,320,321],"Blood Pressure","Hydration","Vascular Disease Risk",[323,320,324,325,326],"Racial disparities","Blood pressure","Vascular function","Potassium","2025-02-25",{"date":329,"type":31},"2025-02-27",{"date":331,"type":31},"2024-11-06",{"date":333,"type":20},"2027-07",{"name":37,"class":38},{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":342,"targetDuration":4,"studyType":21,"phases":344,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":39},"100556957","early-phase-1-curcumin-and-egcg-supplementation-to-improve-serum-bdnf-and-mood-disturbance-100556957","NCT06531863","Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance","A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin Gallate Supplementation on Serum Brain Derived Neurotrophic Factor and Mood Disturbance in Adults","Inclusion Criteria:\n\n* Adults age 18-50\n* Depression subscale score of \\>9\u002F21 on the DASS-21\n* No change in medications or supplements over the past 3 months\n* Can read and speak English\n\nExclusion Criteria:\n\n* Currently consume curcumin or green tea daily\n* Currently, pregnant, nursing, or trying to become pregnant\n* Currently diagnosed with a perimenopausal disorder",{"count":343,"type":20},64,[345],"EARLY_PHASE1","The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores \\>9. The main questions it aims to answer are:\n\nDoes curcumin and EGCG supplementation improve mood disturbance symptomology? Does curcumin and EGCG supplementation increase serum BDNF? Researchers will compare intervention versus placebo.\n\nParticipants will consume an 8-week supplement of both:\n\n* 1,330mg\u002Fday curcumin\n* 350mg\u002Fday epigallocatechin gallate (EGCG)",[348],"Mood Disturbance","2025-02-13",{"date":351,"type":31},"2025-02-14",{"date":353,"type":31},"2024-09-30",{"date":355,"type":20},"2025-08-01",{"name":37,"class":38},{"id":358,"slug":359,"hasResults":11,"nctId":360,"briefTitle":361,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":16,"minAge":285,"maxAge":286,"enrollmentInfo":363,"targetDuration":4,"studyType":21,"phases":365,"briefSummary":366,"conditions":367,"keywords":369,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":379,"locationsCount":226},"100572357","a-single-arm-pilot-trial-for-mitigating-relapse-of-severe-problem-behavior-100572357","NCT06732219","A Single-Arm Pilot Trial for Mitigating Relapse of Severe Problem Behavior","We will include individuals between the ages of 6 to 17 with IDD who have at least one topography of SPB that is maintained by social positive (e.g., attention, access to preferred items) reinforcement. The age range is driven by the need to maximize the number of participants; there is no evidence to suggest that age is a relevant variable regarding relapse of SPB.",{"count":364,"type":20},10,[23],"The goal of this study is to improve how we teach self-control and communication skills to children and adolescents with challenging behaviors. Researchers aim to find ways to make behavior-change treatments more effective and long-lasting, even when the environment or reinforcement schedules change.\n\nThe main questions this study will answer are:\n\nCan innovative techniques help children maintain learned skills, such as asking for attention or waiting for rewards, when faced with new people, places, or situations? How do cognitive and behavioral factors, like memory, timing, and decision-making, affect the success of treatments?\n\nParticipants in this study will:\n\nComplete assessments to identify preferred activities and understand the causes of challenging behaviors.\n\nLearn communication skills to replace challenging behaviors, such as tantrums or crying, with more appropriate actions like asking for attention.\n\nParticipate in activities designed to understand their individual responses to different types of rewards and delays.",[368],"Challenging Behavior",[370,371,372],"neurodevelopmental disorders","autism","challenging behavior","2024-12-09",{"date":375,"type":31},"2024-12-13",{"date":377,"type":31},"2024-11-14",{"date":303,"type":20},{"name":37,"class":38},{"id":381,"slug":382,"hasResults":11,"nctId":383,"briefTitle":384,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":387,"enrollmentInfo":388,"targetDuration":4,"studyType":21,"phases":389,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":4},"100557485","pilot-mri-study-on-osteopathic-manipulation-for-myofascial-pain-syndrome-100557485","NCT06538727","Pilot MRI Study on Osteopathic Manipulation for Myofascial Pain Syndrome","A Feasibility and Pilot Study of an MRI Study to Investigate Changes After Osteopathic Manipulation Therapy in Patients With Myofascial Pain Syndrome","Inclusion Criteria:\n\n* MPS of the upper back with MTrPs as specified by Travell and Simons, with the confirmation of ultrasound procedure.\n* Normal neurological examination including manual muscle testing, sensory exam, and deep tendon reflexes.\n* English-speaking.\n* Age 18 - 64 and reside in the community.\n\nExclusion Criteria:\n\n* Malignancy.\n* Major psychiatric disorders, such as bipolar disorder and depression.\n* Cognitive impairment\n* Skin lesion(s) on the shoulders and upper back.\n* Systematic pain condition, such as Fibromyalgia.\n* Previous surgical procedures in the spine, shoulder, and\u002For back within six months.\n* Pregnancy.\n* BMI of 40 or higher.\n* Any health conditions that prevent participants from performing the experimental procedure\n* Any contraindications of MRI procedure such as implantable cardiac devices (pacemakers, defibrillator, etc.), aneurysm clips, or metallic shoulder and\u002For spinal cord implants or screws.","64 Years",{"count":86,"type":20},[23],"The goal of this clinical trial is to conduct MRI studies on adults with myofascial pain syndrome (MPS) to identify important MRI biomarkers that respond to OMT (osteopathic manipulation therapy) and investigate the feasibility of implementing MRI study and OMT in this population. The main outcomes of the study include:\n\n* Determine whether biomarkers measured by MRI can differentiate normal tissues and MTrP (myofascial trigger point).\n* Test the responsiveness of the biomarkers identified by MRI to the proposed intervention, OMT, in patients with MPS of the upper back.\n\nResearchers will compare participants who will receive one session of OMT (Group 1 - Experimental Condition) and participants who will not receive any treatment (Group 2 - Control Condition) to see how the MRI-identified biomarkers respond to the intervention.\n\nParticipants will complete the following:\n\n* Clinical screening\n* MRI measures\n* Battery of self-report surveys\n* Clinical\u002FPhysical Function Assessment",[392],"Myofascial Pain Syndrome",[394,395,392,396],"Myofascial Pain","MPS","Myofascial Trigger Point","2024-07-31",{"date":399,"type":31},"2024-08-06",{"date":401,"type":20},"2024-08-31",{"date":403,"type":20},"2025-06-30",{"name":37,"class":38},""]