[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Austin Health\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100599016","use-of-water-ingestion-in-small-intestine-ultrasound-100599016",false,"NCT07079007","Use of Water Ingestion in Small Intestine Ultrasound","Use of Water Ingestion to Improve Visualisation in Small Intestine Ultrasound (WIVIUS): Single Centre Blinded Crossover Trial","Inclusion Criteria:\n\nAll consecutive patients at baseline scan with:\n\n* Confirmed or suspected Crohn's disease with small bowel involvement\n* Increased bowel wall thickness (\\>3mm) of the terminal ileum\n* Suboptimal luminal distension of the terminal ileum 3cm proximal to ICV and 1cm proximal to diseased segment (defined as \\\u003C8mm)\n* All patients with an ileo-colic anastomosis\n\nExclusion Criteria:\n\n* Presence of an ostomy\n* Adequate distension at baseline scan\n* Patients with ileo-rectal anastomosis or IPAA","ALL","18 Years","80 Years",{"count":20,"type":21},55,"ESTIMATED","OBSERVATIONAL","Small Intestine Contrast Ultrasonography (SICUS) is an ultrasound-based method that explores bowel loops, and is able to identify wall thickness, intestinal motility, bowel wall vascularity and complications such as stenosis or dilatation. Previous studies have utilised oral ingestion of an oral contrast solution (usually PEG dissolved in a volume of water ranging from 250 to 1000mL), in order to increase the sensitivity of ultrasound, especially in stricture detection. Parameters that have been improved include lumen distension to better delineate bowel wall layers, and improved peristalsis. Diffusion of this technique has been limited, in part due to PEG-based agents being costly, time consuming and are not tolerated well in some individuals. Utilisation of water as oral contrast may improve patient tolerability and therefore increase uptake of water ingested intestinal contrast ultrasound (WICUS) as a technique in routine clinical practice. The investigators aim to study the tolerability and the improvement of image quality utilising water as an oral contrast for intestinal ultrasonography.",[25,26],"Crohn Disease (CD)","Intestine Ultrasonography",[28],"small bowel contrast ultrasound","NOT_YET_RECRUITING","2025-07-18",{"date":32,"type":33},"2025-07-22","ACTUAL",{"date":35,"type":21},"2025-07",{"date":37,"type":21},"2026-02",{"name":39,"class":40},"Austin Health","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100586549","food-challenge-at-home-or-in-medical-practice---the-foodchomp-study-100586549","NCT06916819","Food Challenge at Home or in Medical Practice - the FoodCHOMP Study","Food Challenge at Home or in Medical Practice - a Multi-center Randomized Control Trial - FoodCHOMP Study","CHOMP","Inclusion Criteria:\n\n1. Negative (\\\u003C3mm) fresh or extract skin testing to the food implicated within their allergy label\n2. Aged greater than 18 years\n\nExclusion Criteria:\n\n* Evidence of prior sensitisation to challenge food 0 Defined as previously positive skin testing or allergen specific IgEs if available\n* Pregnancy\n* Patients with poorly controlled asthma - defined as an ACQ5 scores \\>1 at the time of enrolment\n* Patients with a history of food reactions that is not-consistent with an IgE mediated process; i.e. exclusively gastrointestinal symptoms, FPIES\n* Patients with a clear history of food-dependent exercise induced anaphylaxis\n* Patients on a concurrent medication which may influence the outcome of the challenge;\n* Antihistamine therapy; Patients receiving more than stress dose steroids (i.e. \\> 50mg QID hydrocortisone \\[or steroid equivalent\\]); Omalizumab\n* Any other illness that, in the investigator's judgement, will substantially increase the risk associated with subject's participation in this study",{"count":51,"type":21},120,"INTERVENTIONAL",[54],"NA","This is a pilot, multi-centre, randomised clinical trial evaluating the safety and feasibility of a home-based oral food challenge in adults with low-risk food allergy labels. Eligible participants are aged 18 years or older and have a self-reported food allergy with negative skin prick testing to the implicated food. Participants will be randomised to either a home-based or standard in-clinic food challenge. The primary aim is to determine the safety of home challenges, measured by the rate of immune-mediated adverse events. Secondary aims include feasibility of recruitment and delivery, protocol adherence, quality of life, and food reintroduction outcomes.",[57],"Food Allergies",[59,60,61],"Food allergy","Food allergy label","Food Challenge","RECRUITING","2025-04-15",{"date":65,"type":33},"2025-04-17",{"date":67,"type":33},"2025-04-16",{"date":69,"type":21},"2026-12-01",{"name":39,"class":40},2,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":78,"targetDuration":4,"studyType":52,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100475336","the-electrx-study---a-neurotechnology-approach-to-the-treatment-of-ibd-100475336","NCT05469607","The ElectRx Study - A Neurotechnology Approach to the Treatment of IBD","Inclusion Criteria:\n\n* All patients aged 18 years or older with Crohn's disease who undergo resection with an endoscopically accessible primary anastomosis which results in macroscopic normality.\n* Patients having a reversal of a temporary ileostomy created after previous surgery for Crohn's disease may be enrolled provided that the reversal of the ileostomy results in a primary anastomosis and macroscopic normality of the remaining bowel.\n* Patients with co-existing perianal disease may be included provided the resection has led to a primary anastomosis and macroscopic normality of the intestine.\n* Patients must have proven history of Crohn's disease based on (clinical, radiologic, endoscopic and histologic criteria).\n\nExclusion Criteria:\n\n* Patients with anastomosis which is endoscopically inaccessible by standard colonoscopy.\n* Patients in whom there is persisting macroscopic abnormality post-surgical resection.\n* Patients with Crohn's disease who have an end stoma (ileostomy or colostomy).\n* Patients for whom endoscopy is not suitable due to co-morbidities or unwell clinical state\n* Inability to give informed consent.\n* Inability to obtain access to the anastomosis at colonoscopy.\n* Suspected perforation of the gastrointestinal tract.\n* Patients who are pregnant or breastfeeding.",{"count":79,"type":21},13,[54],"The purpose of this study is to evaluate the safety of vagal nerve neuromodulation in a cohort of patients operated on for Crohn's disease, in a prospective, single centre, cohort study.",[83],"Crohn Disease",[85,86],"Resectional surgery","Post operative prevention of Crohn's recurrence","2023-02-06",{"date":89,"type":33},"2023-02-08",{"date":91,"type":33},"2022-07-08",{"date":93,"type":21},"2028-07",{"name":39,"class":40},""]