[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Azienda Unita Sanitaria Locale di Piacenza\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":187},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,72,102,132,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100053736","effects-of-using-advanced-neurorehabilitation-technologies-in-upper-limb-motor-function-and-capacity-recovery-in-people-with-stroke-100053736",false,"NCT07698405","Effects of Using Advanced NEUROrehabilitation TECHnologies in Upper Limb Motor Function and Capacity Recovery in People With Stroke","NEURO-TECH","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* First-ever unilateral ischemic or hemorrhagic stroke;\n* Presence of upper limb motor impairment;\n* Modified Ashworth Scale (MAS) \\\u003C 3;\n* Montreal Cognitive Assessment (MoCA) \\> 24;\n* Medically stable and able to participate in an intensive rehabilitation programme;\n* Ability to understand and follow study procedures;\n* Written informed consent.\n\nExclusion Criteria:\n\n* Diagnosis of severe aphasia, based on medical records, preventing participation;\n* Bilateral hemisphere lesions;\n* Severe and unstable medical conditions (e.g. untreated seizure, heart failure) that preclude participation in rehabilitation;\n* Other neurological and\u002For psychiatric diseases;\n* Recent and unstabilized upper limb fracture.","ALL","18 Years",{"count":19,"type":20},25,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the effect of a personalized technology-based rehabilitative intervention on Upper Limb (UL) motor function and capacity recovery in People with Stroke (PwS). The study is single-cohort study in which eligible participants will undergo baseline and follow-up clinical and instrumental assessments over a 4-5 week period.\n\nThe intervention consists of a personalized and specific upper limb technology-based rehabilitation programme delivered three times per week for a total of 12-15 sessions. Each session lasts approximately one hour and is integrated with conventional rehabilitation treatments.\n\nPrimary outcomes include Fugl-Meyer Assessment for Upper Extremity (FMA-UE) and Action Research Arm Test (ARAT). Secondary outcomes include instrumental assessment of active range of motion and grip strength.",[24],"Stroke",[24,26,27,28,29],"Technology-Assisted Rehabilitation","Robotics","Virtual Reality","Motor Recovery","RECRUITING","2026-07-07",{"date":33,"type":34},"2026-07-13","ACTUAL",{"date":36,"type":34},"2026-06-15",{"date":38,"type":20},"2027-08",{"name":40,"class":41},"Azienda Unita Sanitaria Locale di Piacenza","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100632772","telemedicine-guided-uptitration-of-therapy-in-chronic-heart-failure-100632772","NCT07518030","Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure","TELEHEART Trial: Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure","TELEHEART","Inclusion criteria: Participants must meet all of the following criteria:\n\n1. Provision of written informed consent.\n2. Age ≥18 years.\n3. Recent diagnosis of HFrEF, defined according to ESC criteria, established in either an inpatient or outpatient setting.\n4. No prior initiation of GDMT for HF at the time of enrollment, or treatment limited to a single agent with potential disease-modifying effects prescribed for a different clinical indication.\n5. Availability of adequate digital literacy, either by the patient or a caregiver, defined as the ability to use electronic devices for remote communication (phone\u002Fvideo calls), transmission of vital parameters (body weight, blood pressure, heart rate), and interaction with digital health tools. In cases of insufficient patient digital skills, the presence of a caregiver with adequate digital competence is acceptable.\n6. Any etiology of HF is eligible, including ischemic, valvular, primary or infiltrative cardiomyopathies, iatrogenic or toxic causes, and tachycardia-induced cardiomyopathy.\n\nExclusion Criteria:\n\n* Ongoing treatment with two or more guideline-directed heart failure medications at the time of HFrEF diagnosis\n* Presence of severe comorbidities or clinical instability requiring prolonged or continuous hospital management\n* Estimated life expectancy \\\u003C12 months\n* Pregnancy or breastfeeding",{"count":52,"type":20},80,"INTERVENTIONAL",[55],"NA","This is a single-center, randomized, open-label, no-profit interventional trial designed to evaluate the effectiveness of a telemedicine-based follow-up strategy compared with standard ambulatory care in patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF). The study aims to determine whether telemedicine-guided management improves the optimization of guideline-directed medical therapy (GDMT), measured as change in GDMT score at 6 months. Patients will be randomized to either a telemedicine group, involving remote multiparametric monitoring and structured teleconsultations, or a standard-of-care group based on conventional in-person follow-up. Secondary objectives include the assessment of safety, treatment adherence, quality of life, and heart failure-related urgent visits, emergency department access, and hospitalizations. This study will provide evidence on the role of telemedicine in facilitating early and effective optimization of heart failure therapy and improving clinical management in a real-world setting.",[58],"Heart Failure With Reduced Ejection Fraction (HFrEF)",[60,61,62,63],"Heart failure with reduced ejection fraction","Telemedicine","Guidelines direct medical therapy","Uptitration","2026-05-15",{"date":66,"type":34},"2026-05-18",{"date":68,"type":34},"2026-03-20",{"date":70,"type":20},"2028-06-01",{"name":40,"class":41},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":53,"phases":81,"briefSummary":82,"conditions":83,"keywords":89,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":42},"100619458","effects-of-music-on-procedural-pain-in-distal-radius-fracture-reduction-100619458","NCT07344883","Effects of Music on Procedural Pain in Distal Radius Fracture Reduction","Effects of Music on Pain in Orthopedic Patients With Distal Radius Fractures Undergoing Non-surgical Reduction: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients of both sexes, 18 years of age or older\n* Patients with distal radius fracture requiring non-surgical (closed) reduction\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Patients with severe hearing impairment\n* Patients diagnosed with cognitive or psychiatric disorders\n* Patients requiring emergency\u002Furgent intervention\n* Open fractures (exposed fractures)",{"count":80,"type":20},192,[55],"This randomized controlled trial (RCT) evaluates the effectiveness of music as a complementary intervention for pain control during non-surgical reduction of distal radius fractures in orthopedic patients. Distal radius fractures are among the most common traumatic injuries presenting to emergency departments and are frequently associated with intense procedural pain and significant physiological stress responses. Despite standard pharmacological analgesia, optimal pain management during fracture reduction remains a clinical challenge, and evidence regarding non-pharmacological adjuncts in the emergency orthopedic setting is still limited The study will enroll 192 adult patients admitted to the orthopedic emergency departments of AUSL Piacenza and AOU Parma with distal radius fractures requiring closed reduction. Participants will be randomly assigned (1:1:1) to one of three groups: a 20-minute session of patient-preferred music, a 20-minute session of standardized music selected by a music therapist, or standard care without music. Pain intensity will be assessed using the Numerical Rating Scale (NRS), while physiological stress will be evaluated through heart rate and blood pressure measurements, collected at baseline (T0) and 20 minutes later (T1), immediately after the reduction procedure The trial is designed as a prospective, randomized, controlled study with blinded data analysis, and all data will be collected and managed in compliance with current privacy and data protection regulations. By generating robust evidence on a low-cost, safe, and easily implementable intervention, the PolSound trial aims to improve procedural pain management and patient experience in emergency orthopedic care, potentially supporting the integration of music-based interventions into standard analgesic protocols.",[84,85,86,87,88],"Pain","Blood Pressure","Heart Rate","Music Therapy","Nursing",[90,91,92],"nursing","musictherapy","pain","NOT_YET_RECRUITING","2026-01-08",{"date":96,"type":34},"2026-01-15",{"date":98,"type":20},"2026-02",{"date":100,"type":20},"2027-02",{"name":40,"class":41},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":111,"conditions":112,"keywords":117,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":131},"100606326","radiologic-features-of-rheumatoid-arthritis-interstitial-lung-disease-at-chest-high-resolution-computed-tomography-100606326","NCT07174102","Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed Tomography","Radiologic Features of Patients With Rheumatoid Arthritis Related Interstitial Lung Disease at Chest High Resolution Computed Tomography","Inclusion Criteria:\n\n* patients able to give their informed consent\n* at least aged 18 years\n* patients undergoing High-Resolution Computed Tomography (HRCT) for clinical needs at any point in their medical history\n* patients with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis or connective tissue disease\n\nExclusion criteria:\n\nPatients younger than 18 and unable to give their informed consent.",{"count":110,"type":20},500,"Lung involvement is one of the most frequent extra articular involvements of rheumatoid arthritis (RA). RA related lung involvement can affect parenchyma, airway, vascular tree and serosa. Among all possible manifestations of lung disease, interstitial lung disease is the most severe being able to compromise quality of life and survival and involves about 20% of patients with rheumatoid arthritis (RA). However, chest high resolution computed tomography (HRCT) features of RA, with or without interstitial lung involvement, have not been clearly defined. Such features have been mostly investigated on small populations of RA patients, often including patients with connective tissue diseases (CTDs), namely systemic sclerosis, mixed connective tissue disease, idiopathic inflammatory myopathies, making difficult to discriminate possible specific features of RA interstitial lung disease (ILD).\n\nThe aims of this observational longitudinal study are to investigate: i) chest HRCT features of RA (frequency of radiologic HRCT patterns, fibrosis, nodules, bronchiectasis, etc.), associated or not to ILD; ii) possible associations between chest HRCT features and demographic, clinical and serologic characteristics of RA; iii) specific chest HRCT features of RA ILD, compared to idiopathic pulmonary fibrosis (IPF) and CTD ILD (i.e., primary Sjogren syndrome, idiopathic inflammatory myopathies, etc), according to the Centres availability.\n\nConsecutive, unselected, DICOM files of chest HRCT of adult RA patients (regardless a previous diagnosis of ILD) will be evaluated by an expert thoracic radiologist blinded to patients' clinical history.\n\nHRCT patterns, presence of fibrosis and other lung abnormalities (cysts, nodules, pleural effusion, etc) will be recorded. In patients with RA ILD possible associations with demographic and clinical disease features will be also analysed (such as sex, disease duration, disease duration at ILD diagnosis, presence of ACPA, rheumatoid factor, ANA), inclusion of previous therapies.\n\nAfter 2 years, new HRCT and lung function tests will be collected for each enrolled patients when available, to evaluate possible changes of lung involvement over time.",[113,114,115,116],"Reumatoid Arthritis","Interstitial Lung Disease Due to Systemic Disease (Disorder)","Idiopathic Pulmonary Fibrosis (IPF)","Connective Tissue Disease (CTD)",[118,119,120,121,122],"rheumatoid arthritis","Interstitial lung disease","connective tissue disease","idiopathic pulmonary fibrosis","high resolution computed tomography","2025-09-11",{"date":125,"type":34},"2025-09-15",{"date":127,"type":34},"2025-01-08",{"date":129,"type":20},"2035-01",{"name":40,"class":41},5,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":53,"phases":141,"briefSummary":142,"conditions":143,"keywords":147,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":4},"100593595","effects-of-music-on-preoperative-anxiety-in-patients-with-femoral-fractures-undergoing-surgery-100593595","NCT07008482","Effects of Music on Preoperative Anxiety in Patients With Femoral Fractures Undergoing Surgery","Effects of Music on Preoperative Anxiety in Patients With Femoral Fractures Scheduled for Surgical Intervention: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients of both sexes, 18 years of age or older\n* Patients with femur fracture who are candidates for surgery\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with a diagnosis of hearing loss\n* Patients diagnosed with cognitive or psychiatric disorders\n* Patients undergoing emergency\u002Femergency surgery",{"count":140,"type":20},154,[55],"This randomized controlled trial (RCT) investigates the effectiveness of music therapy in reducing preoperative anxiety among elderly patients with femoral fractures. Preoperative anxiety is known to worsen physiological stability, increase pain perception, and negatively impact recovery, yet specific evidence on non-pharmacological interventions like music therapy in the orthogeriatric setting is lacking.\n\nThe study will enroll 154 adult patients admitted to the Orthogeriatrics Unit for elective femoral fracture surgery. Participants will be randomly assigned to receive either a 20-minute session of music therapy or standard care. Anxiety will be measured using the APAIS scale, and pain will be assessed with the NRS scale, both before and after the intervention.\n\nThe trial is designed as a blinded, prospective RCT, with data collected and managed under current privacy regulations. By generating robust data on this low-cost, safe intervention, the study aims to improve preoperative management and patient outcomes in orthopedic surgical care.",[144,84,145,146,87],"Anxiety","Surgery","Femoral Fractures",[148,149,150,151],"NURSING","MUSICTHERAPY","ANXIETY","PAIN","2025-08-11",{"date":154,"type":34},"2025-08-12",{"date":156,"type":20},"2025-09",{"date":158,"type":20},"2026-07",{"name":40,"class":41},{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":166,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":168,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":93,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100582852","neoadjuvant-chemotherapy-for-elderly-with-pancreatic-head-cancer-100582852","NCT06868693","Neoadjuvant Chemotherapy for Elderly with Pancreatic Head Cancer","Pancreatic Cancer of the Head: Effect of Neoadjuvant Chemotherapy in Elderly People - a Multicenter Observational Study","PEACE","Inclusion Criteria\n\n* Patients aged ≥ 70 years\n* Patients with resectable or BR PDAC who underwent curative treatment (NAT followed by surgery and upfront surgery)\n* Patients with Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) \\> 2\n* Patients able to provide informed consent, whenever possible\n\nExclusion Criteria\n\n* Patients not meeting the inclusion criteria.\n* Pancreatic cancer of pancreatic body and tail.\n* Patients with metastatic disease.\n* Patients with locally advanced or metastatic pancreatic cancer","70 Years","100 Years",{"count":171,"type":20},240,"The goal of this observational retrospective cohort study is to evaluate the efficacy and safety of neoadjuvant chemotherapy (NAT) in elderly patients with resectable or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC). The study includes patients aged ≥70 years who have undergone NAT followed by surgery or upfront surgery.\n\nThe main questions it aims to answer are:\n\nDoes NAT improve overall survival (OS) and progression-free survival (PFS) in elderly patients compared to upfront surgery? What is the impact of NAT on R0 resection rates, conversion rates in BR tumors, and the need for vascular resection? How does the toxicity profile of different NAT regimens affect treatment outcomes and patient tolerability? Researchers will compare NAT followed by surgery vs. upfront surgery to determine differences in oncologic outcomes and postoperative complications.\n\nParticipants will:\n\nBe retrospectively identified from hospital records. Be classified based on treatment received (NAT vs. upfront surgery). Undergo data collection on tumor characteristics, treatment regimens, surgical details, and survival outcomes.\n\nThis study aims to refine patient selection criteria for NAT in elderly patients, guiding personalized treatment strategies to optimize survival and quality of life.",[174,175,176,177,178],"Pancreatic Cancer Resectable","Pancreatic Cancer Stage II","Neoadjuvant Therapy","Elderly","Borderline Pancreatic Inoperable Cancer","2025-03-08",{"date":181,"type":34},"2025-03-11",{"date":183,"type":20},"2026-01-01",{"date":185,"type":20},"2026-12",{"name":40,"class":41},""]